Examining the Efficacy of Capsaicin Nasal Spray in Mixed Rhinitis

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Response rates were 68% and 79% respectively, for the mixed and idiopathinc rhinitis groups.
Response rates were 68% and 79% respectively, for the mixed and idiopathinc rhinitis groups.

HealthDay News — Capsaicin nasal spray is effective for mixed rhinitis patients, who have more than 1 major etiologic factor involved in the mucosal pathology, according to a study published online in Allergy.

Laura Van Gerven, MD, from University Hospitals Leuven in Belgium, and colleagues examined the efficacy of capsaicin nasal spray in mixed rhinitis patients. They compared the efficacy for 28 strictly selected idiopathic rhinitis patients who were included in a trial and 24 idiopathic rhinitis patients who did not meet inclusion criteria (mixed rhinitis patients). All patients were treated with capsaicin 0.1 mM nasal spray; the therapeutic response was assessed at 12 weeks after treatment.

The researchers found that the distribution of patients with a reduction of symptoms was less favorable for the mixed rhinitis vs idiopathic rhinitis population. The percentage of patients with a therapeutic response was 68% and 79%, respectively, for the mixed rhinitis and idiopathic rhinitis patients, which was not statistically significantly different. A major symptom reduction was reported by 32% percent of mixed rhinitis patients. The presence of nasal hyperreactivity (NHR) predicted success of treatment; mixed rhinitis patients with self-reported NHR had significantly better therapeutic response evaluations than those with no NHR (P =.039).

"In conclusion, the capsaicin nasal spray is effective in a broader group of idiopathic rhinitis than the purely selected ones described before," the authors write.

Reference

Van Gerven L, Steelant B, Alpizar YA, Talavera K, Hellings PW. Therapeutic effect of capsaicin nasal treatment in patients with mixed rhinitis unresponsive to intranasal steroids [published online July 16, 2017]. Allergy. doi:10.1111/all.13245

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