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α-Gal Sensitization and Coronary Artery Disease: What's the Link?

α-Gal Sensitization and Coronary Artery Disease: What's the Link?

An increase in atheroma burden and plaques with less stable features demonstrated an association with immunoglobulin E to α-Gal.

Cytokine Profiles of Pregnant Women Predict Asthma in Children

Cytokine Profiles of Pregnant Women Predict Asthma in Children

Cytokines produced by mitogen-stimulated immune cells from pregnant women without asthma were shown to be associated with the development of asthma in their children.

Food-Induced Anaphylaxis Risk in Infants, Children

Food-Induced Anaphylaxis Risk in Infants, Children

Respiratory symptoms were more common in older children compared with infants who presented with food-induced anaphylaxis.

Aspirin Desensitization May Improve Alcohol-Induced Symptoms in AERD Patients

Aspirin Desensitization May Improve Alcohol-Induced Symptoms in AERD Patients

In addition to respiratory sensitivity to aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), patients with AERD oftentimes experience an additional allergic reaction when drinking alcohol.

Budesonide With Saline Solution Helpful for Rhinosinusitis

Budesonide With Saline Solution Helpful for Rhinosinusitis

Clinically meaningful benefits were seen in patients with chronic rhinosinusitis, but the treatment effect was imprecise.

Tick-Caused Meat Allergy on the Rise in the United States

Tick-Caused Meat Allergy on the Rise in the United States

Lone star tick is most common in the South, but may be spreading to new areas.

Inhaled IL-13 Monoclonal Antibody Inhibits IL-13 in Animal Asthma Model

Inhaled IL-13 Monoclonal Antibody Inhibits IL-13 in Animal Asthma Model

The eFlow® nebulizer delivered CDP7766 without evidence of degradation, loss of potency, aggregation, or formation of particulates in a model of asthma in cynomolgus macaques.

High Patient Burden With Moderate to Severe Atopic Dermatitis

High Patient Burden With Moderate to Severe Atopic Dermatitis

Many patients with moderate to severe atopic dermatitis have inadequate disease control.

Aspergillus Common in Bronchiectasis Pulmonary Mycobiome, Associated With Exacerbations

Aspergillus Common in Bronchiectasis Pulmonary Mycobiome, Associated With Exacerbations

Bronchiectasis-associated genera included Aspergillus, Cryptococcus, Clavispora, Botrytis, and Alternaria.

Asthma Risk Increased With Early-Onset Persistent Bronchial Hyperresponsiveness

Asthma Risk Increased With Early-Onset Persistent Bronchial Hyperresponsiveness

Children with the early-onset persistent bronchial hyperresponsiveness phenotype had the highest blood eosinophil count and total serum IgE levels as well as sensitization rates.

Cinryze Approved for Pediatric Patients With Hereditary Angioedema

Cinryze Approved for Pediatric Patients With Hereditary Angioedema

The approval was based on data from a randomized, single-blind, multicenter, dose-ranging, crossover study which evaluated the safety and efficacy of Cinryze in 12 pediatric patients (7 to 11 years old).

Subcutaneous Immunotherapy Shows Promise for Allergic Asthma Exacerbations

Subcutaneous Immunotherapy Shows Promise for Allergic Asthma Exacerbations

The mean rate of exacerbations declined significantly after 1 year of subcutaneous immunotherapy in children with moderate to severe allergic asthma exacerbations.

Allergic Rhinitis Has Negative Effect on Quality of Life in Teens

Allergic Rhinitis Has Negative Effect on Quality of Life in Teens

Allergic rhinitis also had a negative effect on daily functioning, sleep, school productivity, and academic performance.

Most Adults Do Not Use Their Epinephrine Auto-Injectors During Reactions

Most Adults Do Not Use Their Epinephrine Auto-Injectors During Reactions

Most adults (52%) reported that an EAI was not used during their most severe reaction, even though it would have been beneficial, 45% said they didn't have it with them at the time.

Pediatric Chronic Rhinosinusitis: Treatment Options to Consider

Pediatric Chronic Rhinosinusitis: Treatment Options to Consider

Because determining an appropriate treatment plan for a patient depends on the subtype of the disease, it is imperative for providers to know and understand the underlying mechanisms of CRS as well as the components included in a medical evaluation of a patient.

Immune-Response Cluster in Infant Respiratory Syncytial Virus Linked With Recurrent Wheeze

Immune-Response Cluster in Infant Respiratory Syncytial Virus Linked With Recurrent Wheeze

A nasal immune-response pattern characterized by lower non-interferon antiviral immune response mediators and higher type 2 and type 17 cytokines was significantly associated with recurrent wheeze at 1 year.

Intranasal Epinephrine for Anaphyalxis Looks Promising in Early Study

Intranasal Epinephrine for Anaphyalxis Looks Promising in Early Study

The pharmacokinetics trial, which included 60 participants with seasonal allergies, also demonstrated rapid drug absorption with the intranasal spray.

Adenoid, Tonsil Removal May Affect Later Respiratory Risks

Adenoid, Tonsil Removal May Affect Later Respiratory Risks

Adenoidectomy and tonsillectomy in children by age 9 were associated with higher long-term risks for respiratory, infectious, and allergic diseases.

Vitamin D Supplementation Reduced Recurrent Wheezing in Premature Black Infants

Vitamin D Supplementation Reduced Recurrent Wheezing in Premature Black Infants

Vitamin D supplementation appears to reduce the recurrent wheezing by 12 months of age in black infants born prematurely.

CD63 Ratio May Predict Allergic Reaction Severity in Peanut Food Challenge

CD63 Ratio May Predict Allergic Reaction Severity in Peanut Food Challenge

Researchers developed a predictive algorithm to identify individuals with a higher risk for severe reactions to the standardized peanut oral food challenge.

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