Allergies

Reduced Perinatal Proteobacteria Exposure Linked to Childhood Wheezing

Reduced Perinatal Proteobacteria Exposure Linked to Childhood Wheezing

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Lower exposure to Proteobacteria in umbilical cord serum was associated with an increased risk for childhood wheezing.

Delabeling Patients as Beta-Lactam Allergic Requires Record Updates

Delabeling Patients as Beta-Lactam Allergic Requires Record Updates

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Changes in allergy records were suggested by the allergy service consult for 62% of the patients.

Additional Symjepi Dosage Strength Approved for Anaphylaxis Treatment

Additional Symjepi Dosage Strength Approved for Anaphylaxis Treatment

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Both doses will be supplied in single-dose, prefilled syringes for manual injection.

Pest Allergies in Urban Adolescents Exacerbate Poorly Controlled Asthma

Pest Allergies in Urban Adolescents Exacerbate Poorly Controlled Asthma

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Cockroach and mouse allergies were most often associated with poorly controlled asthma and exacerbations in urban adolescents.

Allergy, But Not Asthma, Risk Increased in Children of East Asian Descent

Allergy, But Not Asthma, Risk Increased in Children of East Asian Descent

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Children of East Asian-born parents had an increased risk for allergic rhinitis and aeroallergen sensitization compared with children of Caucasian ancestry.

PUFAs Inversely Associated With Asthma in Preschool Children

PUFAs Inversely Associated With Asthma in Preschool Children

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Total omega-3 and omega-6 plasma polyunsaturated fatty acids relative abundances were significantly inversely correlated with asthma/recurrent wheeze and allergic sensitization.

Relationship Between Atopic Disorders May Be Age Dependent

Relationship Between Atopic Disorders May Be Age Dependent

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Although allergic sensitization and hay fever rates increased as children grew older, the rates of asthma dropped.

Addition of High-Dose Guaifenesin Benefits Patient With Chronic Respiratory Conditions

Addition of High-Dose Guaifenesin Benefits Patient With Chronic Respiratory Conditions

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According to the report, the patient complained of a non-productive cough, accumulation of mucus, and post-nasal drip and requested a thorough assessment of her medical conditions.

Asthma Control Not Improved With School-Supervised Inhaled Corticosteroid Use

Asthma Control Not Improved With School-Supervised Inhaled Corticosteroid Use

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In a population of primarily Latino children from low-income households, a program of school-supervised use of once-daily inhaled corticosteroids failed to improve asthma control.

Veta Smart Case, App for Epinephrine Auto-Injectors Now Available

Veta Smart Case, App for Epinephrine Auto-Injectors Now Available

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The Smart Case includes electronics and sensors to monitor the proximity, temperature, presence and removal, and expiration of auto-injectors.

Walgreens to Offer Auvi-Q Nationwide in an Effort to Address Epinephrine Supply Issues

Walgreens to Offer Auvi-Q Nationwide in an Effort to Address Epinephrine Supply Issues

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This effort is in response to epinephrine auto-injector supply issues reported by manufacturers to the Food and Drug Administration (FDA).

Prevalence of Asthma Exacerbations That Also Meet Anaphylaxis Criteria

Prevalence of Asthma Exacerbations That Also Meet Anaphylaxis Criteria

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A total of 8% of patients with asthma exacerbations met the criteria for diagnosing anaphylaxis, with 3.4% having likely experienced anaphylaxis.

Asthma Medicine Recalled Due to Tablet Mix-Up That May Pose Safety Risk

Asthma Medicine Recalled Due to Tablet Mix-Up That May Pose Safety Risk

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The risk of a mixing-up the treatments is especially high for pregnant women, says the Food and Drug Administration (FDA), as losartan is indicated to treat high blood pressure and could harm or kill a fetus.

Novel Epinephrine Nasal Spray for Anaphylaxis Gets Fast Tracked by FDA

Novel Epinephrine Nasal Spray for Anaphylaxis Gets Fast Tracked by FDA

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The bioavailability of the novel epinephrine nasal spray also proved similar to that of intramuscular injection with EpiPen 0.3mg injection.

Single-Administration Treatment for Hereditary Angioedema Gets Orphan Drug Status

Single-Administration Treatment for Hereditary Angioedema Gets Orphan Drug Status

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ADVM-053 is being developed as a single‑administration treatment that could potentially provide sustained levels of the C1 esterase inhibitor protein, which may prevent breakthrough angioedema attacks.

First-of-its-Kind Therapy Approved to Prevent Hereditary Angioedema Attacks

First-of-its-Kind Therapy Approved to Prevent Hereditary Angioedema Attacks

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The approval was based on data from 4 clinical trials, including the 26-week Phase 3 HELP (Hereditary Angioedema Long-Term Prophylaxis) study that enrolled 125 patients with HAE aged ≥12 years.

Mucosal Response to Nasal Bacteria Could Affect Chronic Rhinosinusitis

Mucosal Response to Nasal Bacteria Could Affect Chronic Rhinosinusitis

Haemophilus influenzae, Staphylococcus aureus, and Streptococcus pyogenes were found in approximately one-fifth of isolated IgE antibodies via plasmablasts residing in nasal polyps.

FDA Extends Expiration Date for Certain Lots of EpiPen

FDA Extends Expiration Date for Certain Lots of EpiPen

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This date modification beyond the approved 20-month shelf life was based an FDA review of product stability data submitted by Mylan.

Asthma and Allergic Rhinitis May Be Risk Factors for Migraine in Adolescents

Asthma and Allergic Rhinitis May Be Risk Factors for Migraine in Adolescents

Adolescents who have asthma or allergic rhinitis may be at higher risk for developing migraine.

Manufacturers Issue Statements Regarding Epinephrine Auto-Injector Supply

Manufacturers Issue Statements Regarding Epinephrine Auto-Injector Supply

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In May, the Food and Drug Administration posted a drug shortage alert, adding Mylan's EpiPen (epinephrine injection) to the drug shortage list.

First Generic Version of EpiPen Gets FDA Approval

First Generic Version of EpiPen Gets FDA Approval

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Unlike other generic approvals, epinephrine auto-injectors are considered "combination products" because they consist of both a drug and a device, making the approval process more challenging.

Xolair Designated Breakthrough Therapy for Food Allergies

Xolair Designated Breakthrough Therapy for Food Allergies

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The FDA designation was supported by data from 7 studies evaluating the safety and efficacy of Xolair against various food allergens (eg, peanut, milk, egg, others).

OTC Nasal Decongestant Recalled Due to Microbiological Contamination

OTC Nasal Decongestant Recalled Due to Microbiological Contamination

The recalled nasal decongestant has a Lot number of 173089J and an expiration date of 09/19; it is packaged in 0.5 fluid ounce bottles.

FDA Fast-Tracks Plasma Kallikrein Inhibitor for Angioedema Attacks in HAE

FDA Fast-Tracks Plasma Kallikrein Inhibitor for Angioedema Attacks in HAE

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The Company is currently conducting a Phase 3 trial (APeX-2) and a long-term safety study (APeX-S) evaluating 2 doses of the treatment.

Quality of Life in Aspirin-Exacerbated Respiratory Disease vs Asthma Only

Quality of Life in Aspirin-Exacerbated Respiratory Disease vs Asthma Only

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Patients with aspirin-exacerbated respiratory disease had significantly lower levels of depression symptoms and higher quality of life compared with patients with asthma only.

Physicians Can Help Children, Teens Adhere to Eczema Treatment Plan

Physicians Can Help Children, Teens Adhere to Eczema Treatment Plan

Physicians can help children and teens adhere to eczema treatment plants by simplifying treatment, creating reminders, and sharing success stories.

Daily BCX7353 Cuts Rate of Hereditary Angioedema Attacks

Daily BCX7353 Cuts Rate of Hereditary Angioedema Attacks

Oral administration of BCX7353 at dose of 125 mg resulted in lower rate of hereditary angioedema attacks vs placebo.

Asthma Hospitalization Risk in Children From Grass, Weed, and Other Pollens

Asthma Hospitalization Risk in Children From Grass, Weed, and Other Pollens

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Grass, other weeds, and unclassified pollen were significantly associated with increased risk for asthma hospitalization in young children.

Severe Asthma Risk Increased From <i>Aspergillus fumigatus</i> Sensitization

Severe Asthma Risk Increased From Aspergillus fumigatus Sensitization

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Sensitization to Aspergillus fumigatus increased the risk for severe asthma.

α-Gal Sensitization and Coronary Artery Disease: What's the Link?

α-Gal Sensitization and Coronary Artery Disease: What's the Link?

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An increase in atheroma burden and plaques with less stable features demonstrated an association with immunoglobulin E to α-Gal.

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