Progression of Allergic Rhinitis: Worsening Symptoms Over Time

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Over 10 years, patients with local allergic rhinitis show worsening of rhinitis, development of asthma, and poor quality of life.
Over 10 years, patients with local allergic rhinitis show worsening of rhinitis, development of asthma, and poor quality of life.

HealthDay News — Patients with local allergic rhinitis show worsening of rhinitis, greater tendency toward development of asthma, and impairment of quality of life after 10 years, but have a similar rate of development of allergic rhinitis with systemic atopy as controls, according to research published online in Allergy.

Carmen Rondon, MD, PhD, from the IBIMA-Regional University Hospital of Málaga in Spain, and colleagues examined the natural history of a population with local allergic rhinitis in a 10-year follow-up study of a cohort of 176 patients with local allergic rhinitis of recent onset and 115 age- and sex-matched controls.

The researchers found that patients with local allergic rhinitis experienced a significant and clinically relevant worsening of the rhinitis after 10 years, with increase of emergency assistance, development of asthma, loss of allergen tolerance, and impairment of quality of life. After 5 years, the worsening became significant, and progressed throughout 10 years. Patients and controls had a similar rate of development of allergic rhinitis with systemic atopy (9.7% vs 7.8%; P =.623). Conversion to systemic atopic occurred after 10 years in 5 patients (3%).

"[Local allergic rhinitis] is a well-differentiated clinical entity with a low rate of development of systemic atopy, a natural evolution towards worsening, and a risk factor for suffering asthma," the authors write.

Reference

Rondon C, Campo P, Gracia IE. Local allergic rhinitis is an independent rhinitis phenotype: The results of a 10-years follow-up study [published online August 22, 2017]. Allergy. doi:10.1111/all.13272

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