Progression of Allergic Rhinitis: Worsening Symptoms Over Time
Over 10 years, patients with local allergic rhinitis show worsening of rhinitis, development of asthma, and poor quality of life.
HealthDay News — Patients with local allergic rhinitis show worsening of rhinitis, greater tendency toward development of asthma, and impairment of quality of life after 10 years, but have a similar rate of development of allergic rhinitis with systemic atopy as controls, according to research published online in Allergy.
Carmen Rondon, MD, PhD, from the IBIMA-Regional University Hospital of Málaga in Spain, and colleagues examined the natural history of a population with local allergic rhinitis in a 10-year follow-up study of a cohort of 176 patients with local allergic rhinitis of recent onset and 115 age- and sex-matched controls.
The researchers found that patients with local allergic rhinitis experienced a significant and clinically relevant worsening of the rhinitis after 10 years, with increase of emergency assistance, development of asthma, loss of allergen tolerance, and impairment of quality of life. After 5 years, the worsening became significant, and progressed throughout 10 years. Patients and controls had a similar rate of development of allergic rhinitis with systemic atopy (9.7% vs 7.8%; P =.623). Conversion to systemic atopic occurred after 10 years in 5 patients (3%).
"[Local allergic rhinitis] is a well-differentiated clinical entity with a low rate of development of systemic atopy, a natural evolution towards worsening, and a risk factor for suffering asthma," the authors write.
Rondon C, Campo P, Gracia IE. Local allergic rhinitis is an independent rhinitis phenotype: The results of a 10-years follow-up study [published online August 22, 2017]. Allergy. doi:10.1111/all.13272