Chronic Lung Disease Research in the Pipeline: An Interview With Augustine M.K. Choi, MD

Chronic Lung Disease Research in the Pipeline: An Interview With Augustine M.K. Choi, MD

Pulmonology Advisor sits down with Augustine M.K. Choi, MD, Stephen and Suzanne Weiss Dean of Weill Cornell Medicine to discuss the latest topics in pulmonary medicine.

Examining the Efficacy of Carbon Monoxide Therapy in Idiopathic Pulmonary Fibrosis: An Interview With Augustine M.K. Choi, MD

Examining the Efficacy of Carbon Monoxide Therapy in Idiopathic Pulmonary Fibrosis: An Interview With Augustine M.K. Choi, MD

Pulmonology Advisor sits down with Augustine M.K. Choi, MD, Stephen and Suzanne Weiss Dean of Weill Cornell Medicine to discuss the latest topics in pulmonary medicine.

Role of E-Cigarettes in Asthma Development and Exacerbation

Role of E-Cigarettes in Asthma Development and Exacerbation

Smokers with asthma have been encouraged to switch from conventional to electronic cigarettes, but the latter may still cause respiratory damage.

Food Allergies May Increase Risk for Asthma in Children

Food Allergies May Increase Risk for Asthma in Children

Investigators sought to determine the association between food allergies and the development of asthma.

Identifying New Therapeutics for Pulmonary Diseases: An Interview With Augustine M.K. Choi, MD

Identifying New Therapeutics for Pulmonary Diseases: An Interview With Augustine M.K. Choi, MD

Pulmonology Advisor sits down with Augustine M.K. Choi, MD of Stephen and Suzanne Weiss Dean of Weill Cornell Medicine to discuss the latest topics in pulmonary medicine.

The Potential Pitfalls of Machine Learning Algorithms in Medicine

The Potential Pitfalls of Machine Learning Algorithms in Medicine

The ability of machine learning programs to diagnose medical conditions and predict outcomes is discussed in an opinion article.

Overview of Autophagy Research in COPD: An Interview With Augustine M.K. Choi, MD

Overview of Autophagy Research in COPD: An Interview With Augustine M.K. Choi, MD

Pulmonology Advisor sits down with Augustine M.K. Choi, MD, Stephen and Suzanne Weiss Dean of Weill Cornell Medicine to discuss the latest topics in pulmonary medicine.

FDA Approves First Nebulized Long-Acting Muscarinic Antagonist for COPD

FDA Approves First Nebulized Long-Acting Muscarinic Antagonist for COPD

Adults treated with Lonhala Magnair showed statistically significant and clinically important changes in FEV1 at week 12 vs placebo.

Walking in Polluted Area Blunts Cardiorespiratory Benefits

Walking in Polluted Area Blunts Cardiorespiratory Benefits

Concentrations of black carbon, nitrogen dioxide, and particulate matter were higher in traffic-polluted areas, and linked to more instances of cough, sputum, and shortness of breath.

COPD Adverse Outcomes May Increase With Loop Diuretic Use

COPD Adverse Outcomes May Increase With Loop Diuretic Use

Older patients with COPD who use loop diuretics may be at an increased risk for respiratory-related morbidity and mortality.

Pneumonia Found Infrequently on Chest X-Ray in Children With Acute Asthma Exacerbations

Pneumonia Found Infrequently on Chest X-Ray in Children With Acute Asthma Exacerbations

Chest radiography, a procedure often performed in the emergency department, infrequently changes medical management of children with acute asthma exacerbations.

Asthma Control in Nonobese Patients Improves With Exercise and Diet

Asthma Control in Nonobese Patients Improves With Exercise and Diet

Exercise and diet improves asthma control in nonobese patients with asthma.

Asthma Risk Increased With Atopic Dermatitis Plus Allergic Sensitization

Asthma Risk Increased With Atopic Dermatitis Plus Allergic Sensitization

Atopic dermatitis without concomitant allergic sensitization in children is not associated an increased risk for asthma.

Intranasal Omalizumab Use and Systemic Total Immunoglobulin E Levels

Intranasal Omalizumab Use and Systemic Total Immunoglobulin E Levels

Intranasal administration of omalizumab does not result in relevant change of allergen-specific and total IgE levels in patients with birch pollen allergy.

Unnecessary Antibiotic Prescribing Continues in Young Adults With Acute Bronchitis

Unnecessary Antibiotic Prescribing Continues in Young Adults With Acute Bronchitis

Overprescription for uncomplicated acute bronchitis is common despite guidelines recommending against it.

Omalizumab May Be Stepped-Down or Withdrawn in Severe Allergic Asthma

Omalizumab May Be Stepped-Down or Withdrawn in Severe Allergic Asthma

Omalizumab may be safely withdrawn or stepped down in patients with severe allergic asthma.

Inhaled Corticosteroid Use and Fracture Risk in Pediatric Asthma

Inhaled Corticosteroid Use and Fracture Risk in Pediatric Asthma

A population-based study aimed to determine whether inhaled corticosteroid use increased risk of fracture in children with asthma.

Breastfeeding May Decrease Flexural Dermatitis Risk, But Not Asthma

Breastfeeding May Decrease Flexural Dermatitis Risk, But Not Asthma

Exclusive breastfeeding may have a protective effect against flexural dermatitis development in infants, but appears to have no long-term effect on measures of asthma.

CFTR Modulator Therapy With Tezacaftor-Ivacaftor in Cystic Fibrosis

CFTR Modulator Therapy With Tezacaftor-Ivacaftor in Cystic Fibrosis

Effective cystic fibrosis transmembrane conductance regulator modulator therapy may be of benefit in subsets of patients with cystic fibrosis.

Noninvasive Ventilation for Acute Hypercapnic Respiratory Failure Related to COPD

Noninvasive Ventilation for Acute Hypercapnic Respiratory Failure Related to COPD

Noninvasive ventilation may reduce mortality in patients with acute hypercapnic respiratory failure related to COPD.

Asthma Clinical Trials Need to Include Patient-Reported Outcomes

Asthma Clinical Trials Need to Include Patient-Reported Outcomes

More asthma clinical trials will include patient-reported outcomes as they will help guide clinicians' understanding of their patients' disease.

Benralizumab Approved by FDA for Severe Eosinophilic Asthma

Benralizumab Approved by FDA for Severe Eosinophilic Asthma

A significant improvement in lung function and annual asthma exacerbation rate was noted vs placebo.

COPD Hospitalization Outcomes Affected by Obesity

COPD Hospitalization Outcomes Affected by Obesity

Patients with obesity who are hospitalized for an acute exacerbation of COPD may have longer hospital stays and more often require mechanical ventilation.

Effect of Tobacco Smoke Exposure in Children With Asthma

Effect of Tobacco Smoke Exposure in Children With Asthma

Prenatal tobacco smoke exposure appears to be associated with airflow obstruction in children who have asthma.

Severe Steroid-Dependent Asthma Benefits From Dupilumab

Severe Steroid-Dependent Asthma Benefits From Dupilumab

Patients treated with dupilumab experienced fewer asthma exacerbations than the overall population.

Asthma Control With Mobile Health Initiatives

Asthma Control With Mobile Health Initiatives

Mobile devices may help patients with asthma better manage and control their disease.

Asthma Exacerbations Treated With Injectable Dexamethasone Administered Orally

Asthma Exacerbations Treated With Injectable Dexamethasone Administered Orally

Pediatric patients benefited from orally administered injectable dexamethasone for asthma exacerbations.

Internet-Based Survey Identifies Patients With Labile Asthma Control

Internet-Based Survey Identifies Patients With Labile Asthma Control

A survey that was part of the Severe Asthma Research Program found a specific subgroup of patients with asthma who have highly variable asthma control.

Montelukast Reduces Need for Rescue Medication in Young Children

Montelukast Reduces Need for Rescue Medication in Young Children

Montelukast therapy reduced the need for rescue medication in young children with recurring wheezing illness.

Atopy May Increase Risk for Asthma Relapse

Atopy May Increase Risk for Asthma Relapse

Investigators evaluated respiratory viruses, atypical bacteria, and atopy on the severity of asthma and the effect on recovery.

Effect of Human Rhinovirus Species on Pediatric Asthma Exacerbation Severity

Effect of Human Rhinovirus Species on Pediatric Asthma Exacerbation Severity

The modifying effect of human rhinovirus on asthma exacerbation severity was examined in a pediatric population.

Use of Antibiotic Prophylaxis in Young Children With Cystic Fibrosis

Use of Antibiotic Prophylaxis in Young Children With Cystic Fibrosis

In children with cystic fibrosis, risk for first detection of S aureus and P aeruginosa was greater in those who had received antibiotic prophylaxis.

Biomarkers Useful for Differentiating Between Asthma and COPD

Biomarkers Useful for Differentiating Between Asthma and COPD

Patients with asthma were found to have higher blood eosinophil counts, fractional exhaled nitric oxide levels, and total serum IgE concentrations compared with patients with COPD.

Long-Term Inhaled Corticosteroid Use Associated With Increased Sputum Bacterial Load in COPD

Long-Term Inhaled Corticosteroid Use Associated With Increased Sputum Bacterial Load in COPD

Salmeterol plus fluticasone was associated with a significant increase in sputum bacterial load in chronic obstructive pulmonary disease, compared to salmeterol alone.

COPD Hospitalization Risk With Rheumatoid Arthritis

COPD Hospitalization Risk With Rheumatoid Arthritis

Rheumatoid arthritis increased the risk of COPD-related hospitalization by 47%.

Asthma Management During Pregnancy: How to Benefit Both Mothers and Infants

Asthma Management During Pregnancy: How to Benefit Both Mothers and Infants

Although some pregnant women discontinue their asthma medications for fear of fetal drug toxicity, they may be putting their babies at greater risk.

Once- vs Twice-Daily Treatment for Controlled Asthma: Examining Outcomes

Once- vs Twice-Daily Treatment for Controlled Asthma: Examining Outcomes

Researchers assessed the efficacy of a once-daily treatment option for controlled asthma.

Beta Blockers Linked to Longer Life Expectancy in COPD

Beta Blockers Linked to Longer Life Expectancy in COPD

In a retrospective analysis, researchers examined the efficacy of beta blocker therapy in prolonging patients' lives.

COPD Hospital Readmission, Mortality Risk Predicted by 3-Variable Score

COPD Hospital Readmission, Mortality Risk Predicted by 3-Variable Score

A 3-variable score that encompasses dyspnea score, prednisone use, and prior hospitalization for COPD exacerbations can predict mortality and readmission risk.

Nebulized Glycopyrrolate Improves Lung Function in Severe COPD With CV Risk Factors

Nebulized Glycopyrrolate Improves Lung Function in Severe COPD With CV Risk Factors

A recent study examined whether nebulized glycopyrrolate is safe to use in patients with severe COPD and comorbid cardiovascular risk factors.

COPD: Concurrent Nebulized Glycopyrrolate, Long-Acting Bronchodilators Safe

COPD: Concurrent Nebulized Glycopyrrolate, Long-Acting Bronchodilators Safe

The safety of concurrently administering nebulized glycopyrrolate with long-acting beta agonists was examined in 3 studies.

Asthma Exacerbations May Be Alleviated With Vitamin D Supplementation

Asthma Exacerbations May Be Alleviated With Vitamin D Supplementation

Asthma exacerbations may be reduced with vitamin D supplementation.

Restrictive Spirometry Pattern Associated With Increased Arterial Stiffness

Restrictive Spirometry Pattern Associated With Increased Arterial Stiffness

Both reduced forced vital capacity and a restrictive spirometry pattern was associated with arterial stiffness in both men and women.

Chronic Respiratory Disease Mortality Rates Increase From 1980 to 2014

Chronic Respiratory Disease Mortality Rates Increase From 1980 to 2014

Mortality rates and changes in mortality rates for chronic respiratory diseases in the United States varied by county, sex, and particular disease type.

Inhaled Corticosteroids Do Not Increase Risk for Pneumonia in COPD

Inhaled Corticosteroids Do Not Increase Risk for Pneumonia in COPD

In contrast to previous study findings, inhaled corticosteroids do not appear to increase risk for pneumonia in patients with COPD with moderate airflow limitation.

Cystic Fibrosis: More Access to Advanced Care Planning, Palliative Care Needed

Cystic Fibrosis: More Access to Advanced Care Planning, Palliative Care Needed

Palliative care access may be limited for patients with cystic fibrosis.

Extrafine-Particle vs Fine-Particle ICS Therapy: Improvements in Asthma Control

Extrafine-Particle vs Fine-Particle ICS Therapy: Improvements in Asthma Control

Compared with fine particle inhaled corticosteroids, extrafine particle inhaled corticosteroids helped patients achieve asthma control.

Montelukast Associated With Depression, Nightmares in Children

Montelukast Associated With Depression, Nightmares in Children

Montelukast is associated with depression, aggression, and nightmares in children.

Response to Omalizumab May Depend on Asthma Severity, Eosinophil Counts

Response to Omalizumab May Depend on Asthma Severity, Eosinophil Counts

Patients with clinical markers of greater asthma severity may experience a more significant reduction of exacerbations when treated with omalizumab.

Updated Guidelines for Noninvasive Ventilation in Acute Respiratory Failure

Updated Guidelines for Noninvasive Ventilation in Acute Respiratory Failure

The European Respiratory Society and American Thoracic Society have released updated guidelines on the use of noninvasive ventilation for acute respiratory failure.

Elderly Patients With Asthma May Have a Distinct Phenotype

Elderly Patients With Asthma May Have a Distinct Phenotype

Asthma in elderly patients presents with increased airway obstruction and mixed inflammation, possibly representing a distinct phenotype.

Targeting Blood Eosinophil Counts in COPD Treatment

Targeting Blood Eosinophil Counts in COPD Treatment

Patients with COPD who have elevated blood eosinophilic levels may benefit from treatment with mepolizumab.

Consequences of Discontinuing Inhaled Corticosteroids in Children With Asthma

Consequences of Discontinuing Inhaled Corticosteroids in Children With Asthma

Children who discontinue inhaled corticosteroids for well-controlled asthma may experience worsening symptoms.

Asthma-Related Quality of Life, Sickness Behavior Linked to Self-Rated Health

Asthma-Related Quality of Life, Sickness Behavior Linked to Self-Rated Health

A greater degree of sickness behavior and poorer asthma-related quality of life were both associated with poorer self-rated health in patients with allergic asthma.

Long-term Benefits of Fluticasone Furoate Plus Vilanterol in Asthma Control

Long-term Benefits of Fluticasone Furoate Plus Vilanterol in Asthma Control

Fluticasone furoate plus vilanterol therapy offers long-term asthma control without serious adverse events.

Preventing Childhood Adverse Respiratory Outcomes With Folic Acid in Pregnancy

Preventing Childhood Adverse Respiratory Outcomes With Folic Acid in Pregnancy

Early initiation of folic acid or prenatal vitamin supplementation may protect the offspring of mothers who have a history of atopy from adverse childhood respiratory outcomes.

ADHD in Cystic Fibrosis: Prevalence, Screening, and Treatment

ADHD in Cystic Fibrosis: Prevalence, Screening, and Treatment

The Adult ADHD Self-Report Scale-v1.1 Symptom Checklist may be able to detect previously undiagnosed ADHD in patients with cystic fibrosis.

Improving Lung Function in Heterogenous Emphysema: Endobronchial Valves vs Standard of Care

Improving Lung Function in Heterogenous Emphysema: Endobronchial Valves vs Standard of Care

Forced expiratory volume in 1 second and length of hospital stay were assess to determine the benefit of endobronchial valve placement vs standard of care in emphysema.

Airway Mucin May Serve as Confirmatory Biomarker for Chronic Bronchitis

Airway Mucin May Serve as Confirmatory Biomarker for Chronic Bronchitis

Current and former smokers with COPD had much higher total airway mucin concentrations compared with patients who had never smoked.

Pneumococcal Vaccination Trends in Work vs Non-Work-Related Asthma

Pneumococcal Vaccination Trends in Work vs Non-Work-Related Asthma

Fewer than half of patients with asthma have received a pneumococcal vaccination.

Sex-Based Differences in Emergency Department Follow-up With Acute Asthma Exacerbations

Sex-Based Differences in Emergency Department Follow-up With Acute Asthma Exacerbations

Identifying gender-based differences in asthma follow-ups is crucial to understanding sex-based differences in health behaviors.

Asthma May Increase Likelihood of Needing Fertility Treatment

Asthma May Increase Likelihood of Needing Fertility Treatment

Good asthma control can improve fertility in women with asthma.

Breastfeeding Linked to Decreased Risk for Childhood Asthma Exacerbations

Breastfeeding Linked to Decreased Risk for Childhood Asthma Exacerbations

When children are breastfed for 6 months or less, the risk for asthma exacerbations decreases.

Treating Early-Stage Chronic Obstructive Pulmonary Disease With Tiotropium

Treating Early-Stage Chronic Obstructive Pulmonary Disease With Tiotropium

In patients with mild or moderate chronic obstructive pulmonary disease, tiotropium improved the decline in FEV1, as well as quality of life.

Diet and Exercise May Improve Asthma Symptoms in Non-obese Patients

Diet and Exercise May Improve Asthma Symptoms in Non-obese Patients

Diet and exercise appeared to improve asthma symptom control, overall fitness, and quality of life.

Moderate to Severe Asthma Exacerbation Rates Examined With Tezepelumab

Moderate to Severe Asthma Exacerbation Rates Examined With Tezepelumab

Researchers examined the efficacy of tezepelumab, a human monoclonal antibody, in treating moderate to severe asthma with non-eosinophilic inflammation.

Potential Role for Statins in COPD Treatment Armamentarium

Potential Role for Statins in COPD Treatment Armamentarium

Patients with COPD and comorbid cardiovascular disease may benefit from statin treatment depending on their C - reactive protein levels.

Is Undiagnosed COPD Common in Patients Living at High Altitudes?

Is Undiagnosed COPD Common in Patients Living at High Altitudes?

After accounting for individual risk factors, living altitude is not associated with variability in COPD prevalence.

Delayed Gastric Motility Post-Lung Transplantation in Patients With No Prior GI Surgery

Delayed Gastric Motility Post-Lung Transplantation in Patients With No Prior GI Surgery

Underlying cystic fibrosis may be a risk factor for the prediction of delayed gastric emptying in patients who undergo lung transplantation.

Systematic Review of Adverse Drug Events in Children With Asthma

Systematic Review of Adverse Drug Events in Children With Asthma

Pediatric patients with asthma are at the highest risk for adverse drug events, particularly with inhaled corticosteroids.

Treating Eosinophilic COPD With Mepolizumab

Treating Eosinophilic COPD With Mepolizumab

Two phase 3 clinical trials examined mepolizumab 100 or 300 mg vs placebo to treat moderate-to-severe COPD exacerbations.

Lower Respiratory Tract Infection: Symptom Duration and Severity With Oral Prednisolone

Lower Respiratory Tract Infection: Symptom Duration and Severity With Oral Prednisolone

Oral corticosteroids did not reduce symptom severity or duration in patients with lower respiratory tract infections without asthma.

New Biomarker May Enable Selective Antibiotic Use for COPD Exacerbation

New Biomarker May Enable Selective Antibiotic Use for COPD Exacerbation

Researchers hypothosized that increased sputum Gammaproteobacteria:Firmicutes ratio may serve as a biomarker to guide antibiotic treatment in COPD.

Expert Panel Updates Recommendations for Endoscopic Lung Volume Reduction for Emphysema

Expert Panel Updates Recommendations for Endoscopic Lung Volume Reduction for Emphysema

Advanced emphysema may benefit from endoscopic lung reduction treatment.

Reduced Mortality Risk in COPD Linked to Statin Tx

Reduced Mortality Risk in COPD Linked to Statin Tx

People with COPD have been found to benefit from statin therapies, with reduced risk of all-cause and pulmonary-related mortality.

COPD Exacerbations May Be Reduced With Mucolytic Agents

COPD Exacerbations May Be Reduced With Mucolytic Agents

Patients with COPD treated with mucolytic agents for at least 1 year were better protected against exacerbations compared with patients treated with placebo.

Addressing Asthma Exacerbations Via Sputum Eosinophils vs Clinical Symptoms

Addressing Asthma Exacerbations Via Sputum Eosinophils vs Clinical Symptoms

Adults with asthma benefit from tailoring interventions based on sputum eosinophils vs clinical symptoms.

Inappropriate Use of Short Acting Beta Agonists Linked to Adverse Outcomes

Inappropriate Use of Short Acting Beta Agonists Linked to Adverse Outcomes

Researchers analyzed over 2.1 million patient-years' worth of data to determine the impact of short-acting beta agonist use in asthma.

Tezepelumab Tx in Asthma: Does Treatment Reduce Exacerbations?

Tezepelumab Tx in Asthma: Does Treatment Reduce Exacerbations?

Participants received 70 mg of tezepelumab every 4 weeks throughout the study.

Efficacy of Tiotropium in Mild to Moderate COPD Examined

Efficacy of Tiotropium in Mild to Moderate COPD Examined

FEV1 was higher in patients who received tiotropium therapy vs those in the placebo group.

Global Asthma Mortality Rate Reductions at Standstill

Global Asthma Mortality Rate Reductions at Standstill

International trends in asthma mortality are useful for assessing the effect of treatment strategies on the burden of asthma.

Asthma and COPD: Updates on Prevalence, Disability, and Mortality

Asthma and COPD: Updates on Prevalence, Disability, and Mortality

A 2015 update from the 1990 Global Burden of Disease study reveals current prevalence and mortality of asthma and chronic obstructive pulmonary disease.

Diagnostic Accuracy of NICE Asthma Algorithm Poor in Children

Diagnostic Accuracy of NICE Asthma Algorithm Poor in Children

A new algorithm developed by the National Institute for Health and Care Excellence was not useful for diagnosing asthma in children and adolescents.

Steroid-Resistant Asthma: Exploring New Therapeutic Possibilities

Steroid-Resistant Asthma: Exploring New Therapeutic Possibilities

The pathogeneses of steroid insensitivity in severe, steroid-resistant asthma may unlock new potential treatments.

Association Between Asthma and Inflammatory Bowel Disease Examined

Association Between Asthma and Inflammatory Bowel Disease Examined

Asthma is associated with development of inflammatory bowel disease.

Once-Daily Fluticasone Furoate/Vilanterol Reduces Nighttime Asthma Symptoms

Once-Daily Fluticasone Furoate/Vilanterol Reduces Nighttime Asthma Symptoms

Fluticasone furoate and vilanterol combination therapy reduced both daytime and nighttime symptoms in patients with persistent uncontrolled asthma.

Improving Lung Function, QoL in COP With Once-Daily Triple-Tx

Improving Lung Function, QoL in COP With Once-Daily Triple-Tx

Study results showed the benefit of single-inhaler triple therapy vs ICS/LABA therapy in COPD.

Pulmonary Rehabilitation Benefits in COPD, Lung Cancer, and Other Respiratory Conditions

Pulmonary Rehabilitation Benefits in COPD, Lung Cancer, and Other Respiratory Conditions

Recent research suggests that perioperative and postoperative pulmonary rehabilitation improves outcomes in patients undergoing thoracic surgery.

Fracture Risk in COPD Increases With Extended Duration of Corticosteroid Use

Fracture Risk in COPD Increases With Extended Duration of Corticosteroid Use

Inhaled corticosteroids for COPD does not increase the risk for fractures when used for short-term periods.

Sputum Eosinophil Levels Correlate With Asthma Severity

Sputum Eosinophil Levels Correlate With Asthma Severity

Elevated sputum eosinophil levels correlate with the severity of clinical outcomes in asthma.

Earlier Reduction of Allergic Response With Omalizumab in Moderate to Severe Allergic Asthma

Earlier Reduction of Allergic Response With Omalizumab in Moderate to Severe Allergic Asthma

A single-center study found that omalizumab led to reductions in allergic response much earlier than previously demonstrated.

Influenza Vaccine May Benefit Elderly Patients With Asthma

Influenza Vaccine May Benefit Elderly Patients With Asthma

Influenza vaccination provided a small protective effect in patients with asthma.

Respiratory Microbiome Changes May Affect Airway Inflammation in Cystic Fibrosis

Respiratory Microbiome Changes May Affect Airway Inflammation in Cystic Fibrosis

Lower microbial diversity in the respiratory tract in patients with cystic fibrosis was linked with prophylactic antibiotics and less airway inflammation.

Avoiding Pneumonia in Patients With COPD

Avoiding Pneumonia in Patients With COPD

Pneumonia primarily affects young children, smokers, adults 65 years and older, and people with COPD.

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