Tralokinumab did not have a significant effect on eosinophilic airway inflammation in moderate to severe asthma that was inadequately controlled on inhaled corticosteroids.
There was as significant change in Bristol COPD Knowledge Questionnaire scores in patients who received a brief education program at the time of an acute exacerbation of COPD.
Acute COPD exacerbations were associated with an increased risk for myocardial infarction and ischemic stroke.
Identified viral pathogens were not associated with asthma exacerbation severity, but were linked to increased treatment failure.
A nasal immune-response pattern characterized by lower non-interferon antiviral immune response mediators and higher type 2 and type 17 cytokines was significantly associated with recurrent wheeze at 1 year.
In patients with mild asthma, use of the inhaled combined corticosteroid and beta agonist budesonide-formoterol as needed was superior to terbutaline as needed with respect to electronically recorded weeks of well-controlled asthma.
Zephyr® Endobronchial Valve EBV® treatment improved FEV1 in patients with heterogeneous emphysema.
The inclusion of residual volume-to-total lung capacity ratio may add another dimension to COPD not routinely captured by standard airflow indices that could be predictive of lower maximum exercise capacity.
A direct de-escalation from triple therapy to indacaterol/glycopyrronium may be appropriate in patients with infrequent COPD exacerbations.
Ivacaftor decreased the risk for death, transplantation, hospitalization, and pulmonary exacerbation in patients with cystic fibrosis.
Women with a diagnosis of asthma may have a higher risk for preterm birth, and their infants may have an increased risk for perinatal mortality, low birth weight, fetal growth restriction, and asphyxia.
In patients with aspirin exacerbated respiratory disease, treatment with omalizumab resulted in "clinically silent" aspirin desensitization.
Budesonide-formoterol as needed was not inferior compared with budesonide maintenance therapy in terms of severe asthma exacerbation rates, but may be inferior for controlling symptoms.
E-cigarettes are the most commonly used product in middle and high school students with or without asthma.
There was a 60% lower rate of severe asthma exacerbations in individuals treated with budesonide-formoterol compared with individuals treated with terbutaline as needed.
Although clinical presentation was similar in both community-acquired pneumonia and non-pneumonia exacerbations, CRP, glucose, and leukocytes were higher in the former vs the latter.
A definition of a pulmonary vascular phenotype of chronic obstructive pulmonary disease has been proposed.
Chemicals linked with endocrine disruption and asthma identified in hair products used by black women and children.
Researchers evaluated barrier dysfunction by exposing viral models to budesonide, montelukast, formoterol, or a combination.
Inhaled interferon-beta 1 a did not significantly reduce acute asthma exacerbations during respiratory viral infections.
Using e-cigarettes every day or some days increased the likelihood of developing chronic obstructive pulmonary disease.
Longer stay and higher costs were associated with antibiotic administration in adults hospitalized for an asthma exacerbation without documented evidence of a lung infection.
In this study, researchers examined the appropriateness of diagnosis and treatment of chronic obstructive pulmonary disease in individuals with and without HIV.
Inhaled corticosteroids for asthma dosed once daily in the evening appeared to offer some benefit in trough FEV1 and morning peak expiratory flow.
Investigators conducted a prospective survey to examine the association between asthma symptom severity and symptoms of depression and anxiety.
Overweight or obese children are more likely to develop new onset asthma compared with normal weight controls.
Researchers examined the association of timing, frequency, and class of antibiotic use during pregnancy on the development of childhood asthma.
The pooled safety analysis included data from the TRILOGY, TRINITY, and TRIBUTE studies.
Sertraline does not prove to be beneficial for relief of chronic breathlessness.
Incident diuretic use was associated with increased rates of respiratory-related morbidity and mortality in older adults with chronic obstructive pulmonary disease.
Subcutaneous dupilumab significantly reduced the use of oral corticosteroids in patients with corticosteroid-dependent severe asthma.
Peak expiratory flow increases were greater with benralizumab than placebo in patients with severe eosinophilic asthma.
Oral contraceptive use in women of reproductive age may increase the risk for lifetime asthma.
In individuals with asthma and vitamin D deficiency, vitamin D supplementation improved asthma control.
While macrolides had no direct effect on lung function, their use significantly improved asthma control and quality of life in patients with asthma.
The study authors examined data obtained from the 2007-2008 National Survey of Children's Health (NSCH) to determine the prevalence, risk factors, as well as the severity of asthma phenotypes.
The study authors reported, "The most commonly reported problems by youth were: (a) hard to remember when to take the asthma medication (54%) and (b) hard to use asthma medication at school (34%)."
Of the total 573 APFS dispensed, 1 malfunctioned and 1 was considered nonfunctional because it was not returned. The study authors also reported that patient-use error only led to 2 unsuccessful at-home administrations.
The study aimed to determine the association between ICS therapy adherence and the occurrence of asthma exacerbations in patients with high blood eosinophil levels.
The positive association between type 2 biomarkers and severe exacerbations in severe refractory asthma may not extend to mild to moderate asthma.
PHQ-9 and PHQ-2 show factorial validity, invariance, and reliability for measuring depression in patients with chronic obstructive pulmonary disease.
Children living in neighborhoods with low walkability are at increased risk of asthma.
Emerging guidelines for diagnosing and treating asthma COPD overlap syndrome will help clinicians better manage patients and prevent serious adverse effects.
Palliative care consultation was linked to a reduction in hospital costs for hospitalized adults with serious illness, such as COPD.
Physician asthma care education Plus training resulted in improvements in provider confidence, perceived skill in communicating cross culturally, and short-term asthma-specific outcomes.
An asthma care program improved implementation of guidelines as well as provider documentation in 65 community centers in 4 states that serve patients with asthma.
Survival at 6 months was significantly associated with acute respiratory failure and history of COPD.
Patients with severe asthma who were current smokers were distinguishable from ex-smokers based on their sputum proteomic level of colony stimulating factor 2.
A higher proportion of patients with COPD and a blood eosinophil count of ≥0.34×109/L had elevated markers of low-grade systemic inflammation regardless of forced expiratory volume in 1 second.
Children with status asthmaticus who received magnesium sulfate therapy were on continuous albuterol for a longer duration.
Readmission rates were highest during the first 72 hours after admission for an acute exacerbation of chronic obstructive pulmonary disease.
Adding olodaterol to tiotropium did not significantly reduce exacerbations in patients with chronic obstructive pulmonary disease as much as researchers had anticipated.
Asthma and COPD overlap linked to higher prevalence of sleep-related symptoms, including difficulty falling asleep and maintaining sleep, early-morning awakening, and excessive daytime sleepiness.
The drug consists of fluticasone furoate, an inhaled corticosteroid (ICS), umeclidinium, a long-acting muscarinic antagonist, and vilanterol, a long-acting beta2-adrenergic agonist (LABA), delivered via an Ellipta dry powder inhaler.
Early child care attendance increased the risk for wheeze in children ≤2 years of age but decreased the risk for asthma in children 3 to 5 years of age.
In patients with COPD, transcatheter aortic valve replacement was associated with fewer respiratory-related complications than surgical aortic valve replacement.
Statins have anti-inflammatory and anti-oxidative effects, which could reduce exacerbations of both asthma and chronic obstructive pulmonary disease.
Triple therapy with fluticasone furoate, umeclidinium, and vilanterol was associated with a lower rate of exacerbations in chronic obstructive pulmonary disease.
A childhood measles infection may increase the risk for post-bronchodilator airflow obstruction in middle-age adults via its interaction with asthma and smoking.
A 55-year-old man with chronic obstructive pulmonary disease reports having some mild chest pain.
Preterm-born children had significantly more frequent preschool wheeze compared with children born at term.
No significant benefit of long-acting muscarinic antagonists over long-acting beta-agonists in reducing exacerbation risk in uncontrolled, persistent asthma
Adjunct long-acting muscarinic antagonist (LAMA) use with corticosteroids was associated with reduced exacerbation risk compared with placebo in patients with uncontrolled, persistent asthma. However, LAMA, long-acting beta-agonist (LABA), and inhaled corticosteroids (triple therapy) were not associated with lower risk for exacerbations compared with LABA and inhaled corticosteroids alone.
A 64-year-old man with chronic obstructive pulmonary disease, diabetes, chronic kidney disease, and morbid obesity seeks preoperative approval for femoral popliteal bypass surgery.
Treating chronic obstructive pulmonary disease remains challenging, particularly in terms of choosing the appropriate fixed-dose combination bronchodilator.
Greater Pi10 was associated with incident spirometry-defined chronic obstructive pulmonary disease in a general population-based sample without clinical lung disease.
Sputum viscoelastic properties were associated with lung function and disease status in patients with cystic fibrosis.
In patients with persistent asthma, single maintenance and reliever therapy was associated with a lower risk for exacerbations compared with inhaled corticosteroids as controller therapy and short-acting beta-agonists as relief therapy.
Tai chi found to be as effective as pulmonary rehabilitation for patients with chronic obstructive pulmonary disease.
It is still not known whether differences in mortality rates between patients who receive noninvasive vs invasive ventilation for acute exacerbations of COPD can be attributed to less severe disease or other factors.
Regardless of blood eosinophil count, omalizumab was an effective treatment in adult and pediatric patients with severe allergic asthma.
Researchers identified 6 distinct FEV1 lung function trajectories, 3 of which were responsible for 75% of the COPD burden.
Proteostasis Therapeutics is developing the combination treatment which includes a novel transmembrane conductance regulator (CFTR) amplifier (PTI-428), a third generation corrector (PTI-801) and a potentiator (PTI-808).
Findings for subsequent allergic disease following infant exposure in the first six months of life.
Lonhala Magnair is available as a 25mcg strength inhalation solution per 1mL vial.
Peak flow meter, microspirometry are optimal, with full spirometry for positive results.
Sleep quality in patients with chronic obstructive pulmonary disease may be a significant predictor of multiple metrics of quality of life.
Study authors concluded, "Combining tiotropium and olodaterol did not reduce exacerbation rate as much as expected compared with tiotropium alone."
Disease management added to recommended care in chronic obstructive pulmonary disease was not superior to recommended care alone.
Four different doses of glycopyrronium delivered via metered dose inhaler were compared for safety and efficacy in the treatment of chronic obstructive pulmonary disease.
Patients with asthma or chronic obstructive pulmonary disease have especially high rates of nonadherence, even in comparison with other chronic diseases.
In children with allergic asthma, SCIT may reduce long-term asthma medication use.
The Smartinhaler sensor is a device installed onto a patient's inhaler to monitor and promote asthma and COPD medication adherence.
Long-acting muscarinic antagonists or long-acting β-agonists plus inhaled corticosteroids lowered the risk for asthma exacerbations vs adjuvant placebo.
Prenatal and early life stress, including societal stress, have been implicated in the development of asthma and other allergic diseases in children.
In children aged 5 to 11 years with mild to moderate persistent asthma who were treated with daily inhaled glucocorticoids, quintupling the dose during the initial signs of worsening asthma control did not reduce the rate of severe exacerbations.
The Clinical COPD Questionnaire cutoff point of 1.4 demonstrated a better agreement with other COPD measures in patients with more symptomatic disease.
Patients with chronic obstructive pulmonary disease with 5% emphysema based on thoracic computed tomography (CT) imaging may be at a greater risk for poor outcomes.
Current tobacco smoke exposure is not associated with airflow obstruction in school-aged children, but prenatal smoking is associated with airflow obstruction in children with asthma.
Bronchial thermoplasty can treat severe asthmatic cough that is unresponsive to conventional therapies.
Patients with cystic fibrosis who took azithromycin had a significantly lower risk for detection of new nontuberculous mycobacteria, methicillin-resistant Staphylococcus aureus, and Burkholderia cepacia complex.
Combination treatment with indacaterol-glycopyrronium may improve cardiac function in patients with chronic obstructive pulmonary disease.
Intermittent use of high-dose glucocorticoids did not increase the risk for fracture in patients with COPD.
Independent predictive factors of lung cancer in chronic obstructive pulmonary disease may include frequency of exacerbations, in addition to airflow obstruction and visual emphysema.
Smokers and nonsmokers had similar symptoms and risk factors present for asthma, but differed in comorbidities.
Researchers used data from the Atherosclerosis Risk in Communities Study to assess associations between dietary pattern and pulmonary assessments.
Long-term continuous cyclic azithromycin therapy for severe chronic obstructive pulmonary disease was associated with reductions in exacerbations and hospitalizations.
According to a systematic literature review, there was inconclusive evidence that single indoor allergen interventions were effective at improving asthma outcomes.
Short-acting beta-agonists for asthma management may reduce fertility rates in women with asthma.
When patients visiting an allergy/immunology outpatient clinic had expectations met regarding diagnosis and testing, they were more likely to be satisfied with their visit.
Spirometry may be underused for the diagnosis and monitoring of asthma in the primary care setting.