Major cardiovascular adverse events were more common in the previous event subgroup, with 5.5% occurring in the aclidinium group and 6.2% in the placebo group.
Regardless of severity, when children's asthma was appropriately managed according to guidelines, they experienced significant improvements.
A higher number of acute respiratory infections before the age of 2 may increase the risk for asthma by age 7.
Lower exposure to Proteobacteria in umbilical cord serum was associated with an increased risk for childhood wheezing.
The most common error related to the use of metered dose inhalers was the failure to attach the inhaler to a spacer.
African-American adolescents with asthma had improved outcomes when they received a comprehensive treatment plan.
Patients with severe COPD improved significantly in both endurance time and walking distance with the use of automatically titrated oxygen flow vs constant oxygen flow.
The PFS formulation eliminates the need to reconstitute the solution before administration.
For every 10-fold rise in methyl and propyl concentrations, there was a 2.61 and a 2.18 increased prevalence odds ratio, respectively, of reporting an emergency department visit in the last 12 months in boys with asthma.
Treatment with prophylactic antibiotics was associated with a reduction in the frequency of COPD exacerbations and improved quality of life.
Smoking cessation in patients with asthma is associated with reduced symptoms, improved lung function and quality of life, reduced use of rescue medications, improved airway hyperresponsiveness, and decreased hyperactivity.
No meaningful associations were detected in procedural listing preferences and survival outcomes in patients with COPD or interstitial lung disease awaiting lung transplant.
Clinicians are eager for new therapies to address the damage to airways and lung parenchyma because no current therapy can completely reverse COPD damage.
Forskolin-induced swelling in intestinal organoids is a clinically relevant biomarker of disease severity in infants diagnosed with cystic fibrosis.
After 12 months, patients in the Urban Training™ group had increased their number of daily steps by 816 compared with 64 steps in the usual care group.
Additional bronchodilation and hyperinflation reduction occurred in COPD when RPL554, an inhaled PDE 3 and 4 inhibitor, was combined with standard bronchodilators.
PubMed was searched to obtain data on the relative efficacies of benralizumab, dupilumab, lebrikizumab, mepolizumab, reslizumab, and tralokinumab.
Changing pollination patterns, extreme weather events, rising sea levels, air pollution, and extreme temperatures all negatively affect respiratory conditions.
Cockroach and mouse allergies were most often associated with poorly controlled asthma and exacerbations in urban adolescents.
Children of East Asian-born parents had an increased risk for allergic rhinitis and aeroallergen sensitization compared with children of Caucasian ancestry.
Total omega-3 and omega-6 plasma polyunsaturated fatty acids relative abundances were significantly inversely correlated with asthma/recurrent wheeze and allergic sensitization.
There were no statistically significant differences in mortality rates, rates of COPD exacerbations, lung inflammation, or serious adverse events between a once-daily combined inhaled corticosteroid/LABA and LAMA.
A total of 35% of heroin smokers screened positive for COPD.
Although allergic sensitization and hay fever rates increased as children grew older, the rates of asthma dropped.
Pooled data from two identical 12-week pivotal Phase 3 trials (N=1229) in patients with moderate to very severe COPD showed that the mean annualized rate of all COPD exacerbations was 0.47, 0.45, and 0.55 for revefenacin 175mcg/day, 88mcg/day, and placebo, respectively.
Results from the extension trial showed a similar safety and tolerability profile for Fasenra as that seen in SIROCCO and CALIMA.
Evidence is lacking that demonstrates that monotherapy with correctors has a clinically important effect on individuals with cystic fibrosis who have 2 copies of the F508del mutation.
An increase was seen in asthma hospital visits with increasing ambient particulate matter in San Luis Valley.
No difference in exacerbations with indacaterol/glycopyrronium for non-frequently exacerbating COPD.
The SYGMA trials assessed the use of an as-needed combined corticosteroid/beta-agonist inhaler in patients with mild asthma.
First-phase and glucose-potentiation of arginine-induced insulin secretion as assessed by acute C-peptide responses improved after the initiation of ivacaftor in children with cystic fibrosis.
Currently, 3 anti-interleukin (IL)5 pathway-directed treatments (benralizumab, mepolizumab, reslizumab) have been approved by the Food and Drug Administration for the treatment of severe asthma with an eosinophilic phenotype.
First bronchoscopic lung volume reduction using endobronchial valve performed at Temple University in Philadelphia, PA.
In a population of primarily Latino children from low-income households, a program of school-supervised use of once-daily inhaled corticosteroids failed to improve asthma control.
In their Complete Response Letter, the FDA stated that they require more clinical data to support approval.
Overall, 5 phenotypes were identified and differentiated mainly by patterns of wheezing and aeroallergen sensitization: low wheeze-low atopy, low wheeze-high atopy, transient wheeze-low atopy, high wheeze-low atopy, and high wheeze-high atopy.
Nasal expression of interleukin-10 showed an association with perceived stress burden, while perceived stress burden was strongly associated with asthma control score.
The designation was based on data from the Phase 2b PATHWAY trial that evaluated 3 doses of tezepelumab as add-on therapy in patients with a history of asthma exacerbations and uncontrolled asthma receiving inhaled corticosteroids/long-acting β-agonist with or without oral corticosteroids and additional asthma controllers vs placebo.
Significant negative correlations were seen between visceral fat area and bronchial lumen diameter and lumen area, and significant positive correlations were seen between subcutaneous fat area and bronchial wall area and total area.
Cardiovascular risk within 30 days of therapy start was approximately 2-fold higher with the incident use of tiotropium in COPD.
In patients with emphysema, deposition fraction was significantly lower than in other individuals, but no significant differences were found between healthy never smokers and current or former smokers.
Thigh muscle volume showed significant improvements in patients with COPD who were treated with bimagrumab vs placebo.
A total of 8% of patients with asthma exacerbations met the criteria for diagnosing anaphylaxis, with 3.4% having likely experienced anaphylaxis.
African-American adolescents with asthma who took appropriate therapies had both decreased lung function and elevated blood lipid levels when exposed to short-term low ozone levels.
The risk of a mixing-up the treatments is especially high for pregnant women, says the Food and Drug Administration (FDA), as losartan is indicated to treat high blood pressure and could harm or kill a fetus.
Patients with COPD who have comorbidities are less likely to receive beneficial treatment for exacerbations.
The incidence of undiagnosed COPD was 26%, and based on the GOLD spirometry grading system, 95% had mild to moderate disease.
After 2.1 years of follow-up, 49% of patients who had emphysema on chest CT were readmitted for heart failure and 24% had died.
Although the summer season yielded the lowest overall COPD exacerbation rate, 43% of exacerbations during summer were moderate to very severe.
The average annual prevalence of bronchiectasis from 2012 to 2014 was 701 cases per 100,000 individuals.
S pneumoniae colonization was positively associated with H influenza colonization, whereas negative associations were reported between P aeruginosa and H influenzae and between P aeruginosa and M catarrhalis.
Lung transplantation can extend survival in patients with cystic fibrosis who have compromised lung function and increasing exacerbations.
Comorbid chronic rhinitis is significantly associated with 30-day hospital readmissions related to asthma and chronic obstructive pulmonary disease.
There is a significant relationship between attention deficit hyperactivity disorder and asthma.
Low-income urban preschoolers with asthma may not meet home medication readiness criteria.
Lung function in patients with primary ciliary dyskinesia was reduced compared with reference values from patients with cystic fibrosis in both sexes and in all age groups.
In children who were symptomatic, small conducting airways ventilation inhomogeneity and alveolar nitric oxide concentration were both significantly associated with asthma exacerbations.
Adolescents who have asthma or allergic rhinitis may be at higher risk for developing migraine.
Pooled estimates from cohort studies suggested there was no association between antenatal blood vitamin D levels or vitamin D intake and asthma in offspring.
The approval was supported by data from ARRIVAL (N=25), an ongoing Phase 3 open-label safety study in children with CF aged 12 to <24 months with 1 of 10 CFTR gene mutations (G551D, G178R, S549N, S549R, G551S, G1244E, S1251N, S1255P, G1349D or R117H).
Combined tele-case management and tele-consultation was the most effective form of telemedicine for improving asthma control.
Prior use of systemic corticosteroids and prior isolation of Pseudomonas aeruginosa were risk factors associated with the presence of Pseudomonas aeruginosa in COPD.
Use of labetalol vs other antihypertensives is linked to increased risk of status asthmaticus.
A high blood eosinophil count may increase the risk for a second asthma-related hospitalization within 1 year following an initial hospitalization.
Through Bluetooth technology, clinicians and patients will be able to share and monitor inhaler usage.
The authors write that once severe asthma is diagnosed, clinicians should determine asthma endotype (Type2-high or Type2-low) to help choose the best therapy for the patient.
Short-term corticosteroids may be sufficient for treating patients with acute COPD exacerbations.
Patients with COPD who had a relative lymphocyte count ≤20% had a higher risk for mortality.
Patients with severe asthma who are glucocorticoid dependent and treated with dupilumab for 24 weeks used significantly lower doses of glucocorticoids while maintaining asthmatic control compared with patients treated with placebo.
In adult-diagnosed cystic fibrosis, diabetes, lung function, and age at diagnosis may predict patient survival.
Children with asthma and/or wheeze who have a basophil level above 0.18% of the circulating peripheral blood mononuclear cell population have a higher risk for future exacerbations.
When compared with a placebo control cannabis, cannabis had no effect on breathlessness intensity ratings during exercise at isotime or on exercise endurance time.
Socioeconomic and lifestyle risk factors had a more significant role in the development of COPD and asthma overlap syndrome in women than air pollution.
Asthma was not associated with a risk for intestinal resection surgery in patients with Crohn disease.
Electronic asthma action plans supported by text messaging services may improve control and reduce exacerbations.
The approval was based on data from a 24-week, open-label, Phase 3 study in patients aged 2 to 5 years.
Patients with aspirin-exacerbated respiratory disease had significantly lower levels of depression symptoms and higher quality of life compared with patients with asthma only.
A higher prevalence of anaerobic bacteria in cystic fibrosis was associated with higher lung function, less use of antibiotics, increased BMI, pancreatic sufficiency, and no requirement for insulin.
Shorter telomere length was associated with worse health status in chronic obstructive pulmonary disease, as measured by St. George's Respiratory Questionnaire.
Anxiety symptoms are more common in patients with COPD as determined by the Generalized Anxiety Disorder, Hospital Anxiety and Depression scale, and Anxiety Inventory for Respiratory Disease screening questionnaires vs the DSM-V criteria.
Individuals with clinician-diagnosed asthma were at an estimated 38% higher risk for atrial fibrillation.
The Hailie sensor attaches to the asthma or chronic obstructive pulmonary disease (COPD) inhaler to monitor and help patient adherence.
Grass, other weeds, and unclassified pollen were significantly associated with increased risk for asthma hospitalization in young children.
Inhaling and smoking heroin and cocaine increase the risk for asthma exacerbations and decreased pulmonary function; marijuana is associated with wheezing, cough, and sputum production.
Sensitization to Aspergillus fumigatus increased the risk for severe asthma.
Collagen biomarkers were significantly higher at extreme exacerbations, and were also associated with circulating adrenomedullin.
Combination therapy with a long-acting β2-agonist plus an inhaled glucocorticoid for asthma was not associated with a significantly higher risk for serious asthma-related events compared with an inhaled glucocorticoid alone.
Frequent asthma, bronchitis, allergy demonstrated the strongest association with , lower FEV1, lower FEV1/forced vital capacity, and increased risk for COPD.
Cytokines produced by mitogen-stimulated immune cells from pregnant women without asthma were shown to be associated with the development of asthma in their children.
Dexamethasone was not effective in reducing the incidence of acute mountain sickness and altitude-related adverse health effects in individuals with mild to moderate COPD.
The US Centers for Disease Control offers steps to minimize exposure to wildfire smoke, particularly for those with chronic conditions.
No associations were found between free concentration vitamin D3 levels and treatment failure or exacerbation rates in adults with asthma
The eFlow® nebulizer delivered CDP7766 without evidence of degradation, loss of potency, aggregation, or formation of particulates in a model of asthma in cynomolgus macaques.
Study authors performed a post hoc pooled analysis of data from 10 trials to assess the safety and efficacy of umeclidinium/vilanterol in elderly symptomatic patients with COPD.
Patients with severe asthma were more often current smokers at diagnosis and had higher body mass index at follow-up compared with patients with nonsevere asthma and anti-IL-5 therapy-eligible asthma.
Gastroesophageal reflux disease is associated with an increase in bronchitis symptoms in patients with COPD.
Increase in all-cause, cardiovascular disease, cancer, diabetes, kidney disease, suicide, and COPD mortality.
The approval was based on results from a multicenter study (LIBERATE) of 190 patients with severe emphysema.
For patients with advanced COPD, the use of formal palliative care services and long-term oxygen therapy has increased but remains low.
Older adults with asthma and a greater desire for involvement in decision making have higher asthma-related quality of life.