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Cytokine Profiles of Pregnant Women Predict Asthma in Children

Cytokine Profiles of Pregnant Women Predict Asthma in Children

Cytokines produced by mitogen-stimulated immune cells from pregnant women without asthma were shown to be associated with the development of asthma in their children.

Dexamethasone Ineffective for Prevention of Acute Mountain Sickness in COPD

Dexamethasone Ineffective for Prevention of Acute Mountain Sickness in COPD

Dexamethasone was not effective in reducing the incidence of acute mountain sickness and altitude-related adverse health effects in individuals with mild to moderate COPD.

CDC: Wildfire Smoke Poses Health Risks

CDC: Wildfire Smoke Poses Health Risks

The US Centers for Disease Control offers steps to minimize exposure to wildfire smoke, particularly for those with chronic conditions.

Free Vitamin D3 Inferior to Total Concentrations in Predicting Asthma Response

Free Vitamin D3 Inferior to Total Concentrations in Predicting Asthma Response

No associations were found between free concentration vitamin D3 levels and treatment failure or exacerbation rates in adults with asthma

Inhaled IL-13 Monoclonal Antibody Inhibits IL-13 in Animal Asthma Model

Inhaled IL-13 Monoclonal Antibody Inhibits IL-13 in Animal Asthma Model

The eFlow® nebulizer delivered CDP7766 without evidence of degradation, loss of potency, aggregation, or formation of particulates in a model of asthma in cynomolgus macaques.

Umeclidinium/Vilanterol Efficacy Assessed in Elderly COPD Patients

Umeclidinium/Vilanterol Efficacy Assessed in Elderly COPD Patients

Study authors performed a post hoc pooled analysis of data from 10 trials to assess the safety and efficacy of umeclidinium/vilanterol in elderly symptomatic patients with COPD.

Anti-IL-5 Therapy Eligibility Characteristics Examined in Adult-Onset Asthma

Anti-IL-5 Therapy Eligibility Characteristics Examined in Adult-Onset Asthma

Patients with severe asthma were more often current smokers at diagnosis and had higher body mass index at follow-up compared with patients with nonsevere asthma and anti-IL-5 therapy-eligible asthma.

GERD and Nasal Symptoms Affect Bronchitis Symptom Severity in COPD

GERD and Nasal Symptoms Affect Bronchitis Symptom Severity in COPD

Gastroesophageal reflux disease is associated with an increase in bronchitis symptoms in patients with COPD.

Prolonged Leisure-Time Sitting Tied to Increased COPD Mortality Risk

Prolonged Leisure-Time Sitting Tied to Increased COPD Mortality Risk

Increase in all-cause, cardiovascular disease, cancer, diabetes, kidney disease, suicide, and COPD mortality.

FDA Approves Zephyr Endobronchial Valve for Treating Severe Emphysema

FDA Approves Zephyr Endobronchial Valve for Treating Severe Emphysema

The approval was based on results from a multicenter study (LIBERATE) of 190 patients with severe emphysema.

Use of Palliative Care, Oxygen Therapy Increasing for COPD

Use of Palliative Care, Oxygen Therapy Increasing for COPD

For patients with advanced COPD, the use of formal palliative care services and long-term oxygen therapy has increased but remains low.

Patient Engagement in Asthma Treatment Plans May Improve Quality of Life

Patient Engagement in Asthma Treatment Plans May Improve Quality of Life

Older adults with asthma and a greater desire for involvement in decision making have higher asthma-related quality of life.

Azithromycin Reduced Pulmonary Exacerbation Risk in Cystic Fibrosis

Azithromycin Reduced Pulmonary Exacerbation Risk in Cystic Fibrosis

Compared with placebo, the risk for a pulmonary exacerbation was reduced by 44% in participants with cystic fibrosis who received azithromycin.

Aspergillus Common in Bronchiectasis Pulmonary Mycobiome, Associated With Exacerbations

Aspergillus Common in Bronchiectasis Pulmonary Mycobiome, Associated With Exacerbations

Bronchiectasis-associated genera included Aspergillus, Cryptococcus, Clavispora, Botrytis, and Alternaria.

Obstructive Sleep Apnea in Asthma: Gaining Control by Losing Weight

Obstructive Sleep Apnea in Asthma: Gaining Control by Losing Weight

Poor control of asthma and obstructive sleep apnea can feed off one another, according to Michelle Zeidler, MD, pulmonologist at the University of California, Los Angeles, and director of the UCLA Sleep Fellowship Program.

Clinical Effect of Emphysema in Individuals With HIV

Clinical Effect of Emphysema in Individuals With HIV

The clinical significance of emphysema was greater in people living with HIV vs those without HIV.

COPD End-of-Life Management Strategies: Use Could Be Expanded

COPD End-of-Life Management Strategies: Use Could Be Expanded

The use of formal palliative care services among patients with chronic obstructive pulmonary disease increased by 1% per year, going from 5.3% in 2004 to 14.3% in 2014.

Asthma Risk Increased With Early-Onset Persistent Bronchial Hyperresponsiveness

Asthma Risk Increased With Early-Onset Persistent Bronchial Hyperresponsiveness

Children with the early-onset persistent bronchial hyperresponsiveness phenotype had the highest blood eosinophil count and total serum IgE levels as well as sensitization rates.

Subcutaneous Immunotherapy Shows Promise for Allergic Asthma Exacerbations

Subcutaneous Immunotherapy Shows Promise for Allergic Asthma Exacerbations

The mean rate of exacerbations declined significantly after 1 year of subcutaneous immunotherapy in children with moderate to severe allergic asthma exacerbations.

Asthma Exacerbation, Treatment Failure Prevention During Step-Down Therapy

Asthma Exacerbation, Treatment Failure Prevention During Step-Down Therapy

A hospital emergency department visit in the prior year was associated with subsequent asthma treatment failure.

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