Pneumonia

Positive Results for Zerbaxa in Phase 3 Study of Ventilated HABP, VABP Patients

Positive Results for Zerbaxa in Phase 3 Study of Ventilated HABP, VABP Patients

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The full findings from the study will be presented at a future scientific conference; Merck plans to include the data in a supplemental New Drug Application for Zerbaxa which will be submitted to the Food and Drug Administration.

Coadjuvant Corticosteroids in Influenza Pneumonia Increases ICU Mortality

Coadjuvant Corticosteroids in Influenza Pneumonia Increases ICU Mortality

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Corticosteroids should not be used concomitantly with antiviral therapy in patients with influenza pneumonia.

Influenza an Independent Risk Factor for Invasive Pulmonary Aspergillosis

Influenza an Independent Risk Factor for Invasive Pulmonary Aspergillosis

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Influenza proved to be an independent risk factor for invasive pulmonary aspergillosis.

CURB-65 Tool in Community-Acquired Pneumonia Useful But Has Limitations

CURB-65 Tool in Community-Acquired Pneumonia Useful But Has Limitations

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The clinical prediction tool that uses confusion, uremia, elevated respiratory rate, and hypotension in community-acquired pneumonia demonstrated an association with ICU admittance.

Therapeutic Algorithm May Guide Empiric Therapy in Pneumonia

Therapeutic Algorithm May Guide Empiric Therapy in Pneumonia

An algorithm based on risk factors for resistant pathogens and illness severity can simplify pneumonia treatment, improve the accuracy of empiric therapy, reduce mortality, and help avoid overusing broad spectrum therapy in some patients.

Long-Term PPI Use Linked to Pneumonia Risk in Older Adults

Long-Term PPI Use Linked to Pneumonia Risk in Older Adults

Rate of incident pneumonia increased in second year after initiating treatment with proton pump inhibitors.

Coal Workers' Pneumoconiosis Deaths on the Decline

Coal Workers' Pneumoconiosis Deaths on the Decline

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Coal workers' pneumoconiosis deaths significantly decreased from 1999 to 2016 for residents ≥25 years.

Genome Sequencing Traces <i>K pneumoniae</i> Outbreak to Outpatient Clinic

Genome Sequencing Traces K pneumoniae Outbreak to Outpatient Clinic

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An investigation into an outbreak of NDM-producing Klebsiella pneumoniae across 2 Belgian hospitals identified an outpatient clinic as the likely common site of transfer and highlights the importance of infection control measures in outpatient settings.

Omadacycline Gets FDA Committee Nod for Skin Infections, Pneumonia

Omadacycline Gets FDA Committee Nod for Skin Infections, Pneumonia

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The Committee's recommendation was based on data from the omadacycline global development program that included nearly 2000 adults in three Phase 3 studies.

Inappropriate Antibiotic Prescriptions Highest Among Urgent Care Facilities

Inappropriate Antibiotic Prescriptions Highest Among Urgent Care Facilities

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Inappropriate antibiotic prescriptions were highest among urgent care facilities (45.7%), with emergency departments (24.6%), medical offices (17.0%), and retail clinics (14.4%) following.

Drop in Childhood Pneumococcal, Hib Deaths From 2000 to 2015

Drop in Childhood Pneumococcal, Hib Deaths From 2000 to 2015

Most children who died of pneumococcus and Haemophilus influenzae type b presented with pneumonia.

Viral Testing May Reduce Antibiotic Use in Severe Lower Respiratory Infection

Viral Testing May Reduce Antibiotic Use in Severe Lower Respiratory Infection

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Advanced diagnostic platforms to identify viruses can help patients with severe lower respiratory tract infections avoid unnecessary diagnostic testing, reduce antibiotic use, and initiate antiviral therapy.

Is Short-Course Antibiotic Treatment for CAP Effective?

Is Short-Course Antibiotic Treatment for CAP Effective?

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To investigate what impact antibiotic treatment duration has on CAP outcomes, researchers from the Warren Alpert Medical School of Brown University conducted a search of various databases for studies comparing the safety and efficacy of treatment regimens lasting ≤6 days (short) and ≥7 days (long).

Type 2 Diabetes Does Not Affect Pneumonia Incidence, Outcomes After Stroke

Type 2 Diabetes Does Not Affect Pneumonia Incidence, Outcomes After Stroke

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Investigators examined the incidence and outcomes of pneumonia in patients with acute ischemic stroke and type 2 diabetes.

Community-Acquired Pneumonia In-Hospital Deaths Are Not Indicative of Lapse in Care

Community-Acquired Pneumonia In-Hospital Deaths Are Not Indicative of Lapse in Care

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Most deaths related to community-acquired pneumonia that occurred at tertiary-case hospitals were not preventable.

PCV13 Reduces Hospitalization for Vaccine-Type Community-Acquired Pneumonia

PCV13 Reduces Hospitalization for Vaccine-Type Community-Acquired Pneumonia

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The real-world effectiveness of PCV13 vaccine in preventing hospitalization for vaccine-type community-acquired pneumonia was assessed.

C-Reactive Protein as a Biomarker for CAP in Bronchiectasis

C-Reactive Protein as a Biomarker for CAP in Bronchiectasis

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Although clinical presentation was similar in both community-acquired pneumonia and non-pneumonia exacerbations, CRP, glucose, and leukocytes were higher in the former vs the latter.

Early Clinical Response With Omadacycline vs Moxifloxacin in CABP

Early Clinical Response With Omadacycline vs Moxifloxacin in CABP

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Early clinical response rates were similar across PORT risk class subgroups in patients with community-acquired bacterial pneumonia when treated with omadacycline or moxifloxacin.

Prevnar 13 Linked to Reduced Risk of CAP Hospitalization in Older Patients

Prevnar 13 Linked to Reduced Risk of CAP Hospitalization in Older Patients

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PCV13, marketed as Prevnar 13, was evaluated in a test-negative case-control study in real-world conditions where patients were administered pneumococcal vaccination as advised by their healthcare providers.

Positive Results Announced for Pleuromutilin Antibiotic in CABP

Positive Results Announced for Pleuromutilin Antibiotic in CABP

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In the LEAP 2 study (N=738), patients with moderate CABP received either oral lefamulin 600mg every 12 hours for 5 days or oral moxifloxacin 400mg once daily for 7 days.

Prior Atypical Antipsychotic Use May Increase Mortality Risk in Pneumonia

Prior Atypical Antipsychotic Use May Increase Mortality Risk in Pneumonia

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Clinicians should consider these findings when using atypical antipsychotics in patients at risk for pneumonia.

Hypersensitivity Pneumonitis Prevalence in an Insured US Population

Hypersensitivity Pneumonitis Prevalence in an Insured US Population

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Researchers have developed a novel algorithm to identify hypersensitivity pneumonitis.

Pediatric Pneumonia: Sensitivity of Lung Ultrasound vs Chest Radiography

Pediatric Pneumonia: Sensitivity of Lung Ultrasound vs Chest Radiography

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Lung ultrasound was more effective in diagnosing pediatric community-acquired pneumonia than chest radiography.

<i>Legionella</i> Pneumonia Outcomes Similar in Adults With/Without HIV

Legionella Pneumonia Outcomes Similar in Adults With/Without HIV

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Clinical presentation and outcomes in HIV-infected patients with Legionella pneumonia did not differ from patients without HIV infection.

Low-Dose CT May Modify Pneumonia Diagnosis in Elderly Patients

Low-Dose CT May Modify Pneumonia Diagnosis in Elderly Patients

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Low-dose computed tomography may assist clinicians in modifying diagnosis of elderly patients who are admitted with suspected pneumonia.

Pneumonia Risk in Severe COPD Linked to Elevated Eosinophil Count

Pneumonia Risk in Severe COPD Linked to Elevated Eosinophil Count

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A higher proportion of patients with COPD and a blood eosinophil count of ≥0.34×109/L had elevated markers of low-grade systemic inflammation regardless of forced expiratory volume in 1 second.

Mortality in Mechanically Ventilated Community-Acquired Pneumonia With or Without ARDS

Mortality in Mechanically Ventilated Community-Acquired Pneumonia With or Without ARDS

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The risk for death in patients with community-acquired pneumonia who were given mechanical ventilation does not seem to be affected by the presence of acute respiratory distress syndrome.

Pneumonia and Influenza May Trigger Acute MI, Stroke

Pneumonia and Influenza May Trigger Acute MI, Stroke

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Researchers found increased myocardial infarction rates during the week after Streptococcus pneumoniae and influenza infections.

Inflammatory Markers in CAP Influenced by Time From Symptom Onset to Presentation

Inflammatory Markers in CAP Influenced by Time From Symptom Onset to Presentation

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Differences in serum inflammatory markers may exist between patients with community-acquired pneumonia who present within the first 48 hours of symptom onset vs those who present later.

No Benefit From Prophylactic Antimicrobials in Aspiration Pneumonitis

No Benefit From Prophylactic Antimicrobials in Aspiration Pneumonitis

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Use of prophylactic antimicrobial therapy was not associated with a reduction in mortality or transfer to critical care compared with patients managed with supportive care only.

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