The real-world effectiveness of PCV13 vaccine in preventing hospitalization for vaccine-type community-acquired pneumonia was assessed.
Although clinical presentation was similar in both community-acquired pneumonia and non-pneumonia exacerbations, CRP, glucose, and leukocytes were higher in the former vs the latter.
Early clinical response rates were similar across PORT risk class subgroups in patients with community-acquired bacterial pneumonia when treated with omadacycline or moxifloxacin.
PCV13, marketed as Prevnar 13, was evaluated in a test-negative case-control study in real-world conditions where patients were administered pneumococcal vaccination as advised by their healthcare providers.
In the LEAP 2 study (N=738), patients with moderate CABP received either oral lefamulin 600mg every 12 hours for 5 days or oral moxifloxacin 400mg once daily for 7 days.
Clinicians should consider these findings when using atypical antipsychotics in patients at risk for pneumonia.
Researchers have developed a novel algorithm to identify hypersensitivity pneumonitis.
Lung ultrasound was more effective in diagnosing pediatric community-acquired pneumonia than chest radiography.
Clinical presentation and outcomes in HIV-infected patients with Legionella pneumonia did not differ from patients without HIV infection.
Low-dose computed tomography may assist clinicians in modifying diagnosis of elderly patients who are admitted with suspected pneumonia.
A higher proportion of patients with COPD and a blood eosinophil count of ≥0.34×109/L had elevated markers of low-grade systemic inflammation regardless of forced expiratory volume in 1 second.
The risk for death in patients with community-acquired pneumonia who were given mechanical ventilation does not seem to be affected by the presence of acute respiratory distress syndrome.
Researchers found increased myocardial infarction rates during the week after Streptococcus pneumoniae and influenza infections.
Differences in serum inflammatory markers may exist between patients with community-acquired pneumonia who present within the first 48 hours of symptom onset vs those who present later.
Use of prophylactic antimicrobial therapy was not associated with a reduction in mortality or transfer to critical care compared with patients managed with supportive care only.
Adults with community-acquired pneumonia that is visualized on CT scan but not on concurrent chest radiograph have similar pathogens, disease severity, and outcomes as patients who had pneumonia confirmed via chest radiograph.
Interventional reduction of the angiopoietin-1/angiopoietin-2 ratio may provide therapeutic perspective for prevention of acute lung injury in pneumonia.
Children with asthma who experience chronic oral glucocorticoid exposure may have significant morbidities, including adrenal suppression, recurrent pneumonia, and behavioral problems.
Researchers retrospectively analyzed data from patients hospitalized with pneumococcal community-acquired pneumonia to determine risk factors for pneumococcal bacteremia.
As a result of activating the inflammatory-immune system, pneumonia may trigger cardiovascular complications.
Researchers found the strongest link between prescription opioid use and the risk for invasive pneumococcal disease was present in individuals using long-acting, high-dose, or highly potent formulations.
Long-acting, high-potency, and high-dose opioids were associated with an increased risk for invasive pneumococcal disease.
Invasive mechanical ventilation in patients with severe community-acquired pneumonia appeared to increase their mortality risk.
Nasopharyngeal samples collected from young children with acute otitis media were analyzed for S pneumoniae, H influenzae, and Moraxella catarrhalis and compared before and after PCV13 introduction.
Patient, practice, and provider characteristics are associated with inappropriate antimicrobial prescribing in the outpatient setting.
The FDA approved the supplemental New Drug Application for Avycaz to treat adults with hospital-acquired or ventilator-associated bacterial pneumonia.
The preoperative physiotherapy intervention cut the incidence of postoperative pulmonary complications by 50%.
Procalcitonin may decrease mortality rates in patients with acute respiratory infections, including pneumonia.
Short-term incidence of leukemia, lymphoma, and brain cancer may be higher in children who were hospitalized with pneumonia.
Mortality from severe pneumonia may be significantly reduced with corticosteroids.