Patients treated for acute pulmonary embolism with direct oral anticoagulants at doses against manufacturer recommendations had a higher rate of major bleeding events.
At the end of 6 months, the rate of VTE recurrence was 4% among rivaroxaban patients vs 11% in the dalteparin arm (hazard ratio [HR] 0.43, 95% CI: 0.19 to 0.99).
D-dimer test adjustment based on pretest probability results may be a safe option to reduce the need for imaging during evaluation for pulmonary embolism.
Copeptin may be useful for identifying normotensive patients with pulmonary embolism who have a higher risk for an adverse outcome.
Varicose veins may increase the risk for pulmonary embolism and peripheral artery disease.
Observation in the emergency department followed by outpatient management with anticoagulation may be appropriate treatment for some patients with low-risk pulmonary embolism.
Pulmonary Embolism Rule-out Criteria non-inferior to usual care for patients at low-risk for pulmonary embolismFebruary 19, 2018
In this multicenter, randomized controlled study, the Pulmonary Embolism Rule-out Criteria (PERC) strategy resulted in significantly fewer uses of CT pulmonary angiography, reduced ED length of stay, and fewer hospital admissions.
Based on this retrospective cohort study from multiple countries, the prevalence of pulmonary embolism in patients presenting to the emergency department with syncope was low.
Although the Wells and revised Geneva scores are used in the general population to predict pulmonary embolism, researchers found they were not reliable in pregnant and postpartum women.
A clinical trial is underway to assess the safety and efficacy of dabigatran in intermediate-risk pulmonary embolism after completing 72 hours of heparin therapy.
Prospective validation research is needed before these clinical predictors of pediatric PE can become guidelines.
A systematic review evaluated whether catheter-directed thrombolysis improved outcomes in patients with intermediate-risk pulmonary emboli.
The use of veno-arterial extracorporeal membrane oxygenation as bridge therapy for massive pulmonary embolism may allow clinicians to better triage patients to appropriate destination therapy.
Influenza vaccination does not increase the risk for venous thromboembolism in patients older than 50 years of age.
Similar short-term outcomes were seen in patients with saddle and nonsaddle pulmonary embolism.
Charleston comorbidity index is an independent predictor of mortality in patients with hemodynamically stable pulmonary embolism.
Patients with either central or peripheral pulmonary embolism had positive outcomes with surgical pulmonary embolectomy for peripheral distribution of thrombus.
Obstructive sleep apnea increases patients' risk for recurrent pulmonary embolism following cessation of oral anticoagulation therapy.