Pulmonary Hypertension

Pulmonary Arterial Stiffness Related to mPAP and Heart Rate in Idiopathic PAH

Pulmonary Arterial Stiffness Related to mPAP and Heart Rate in Idiopathic PAH

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Pulmonary arterial stiffness was related to mean pulmonary arterial pressure and heart rate in patients with untreated idiopathic pulmonary arterial hypertension.

Prognostic Model for Mortality in Pediatric Pulmonary Hypertension

Prognostic Model for Mortality in Pediatric Pulmonary Hypertension

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The Pediatric Index Pulmonary Hypertension Intensive Care Mortality model was compared with the Pediatric Risk of Mortality 2 and 3 models to determine the best model for predicting mortality.

RV Trabecular Complexity Fractal Analysis: Measuring Remodeling in PH

RV Trabecular Complexity Fractal Analysis: Measuring Remodeling in PH

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The fractal dimension of right ventricular trabecular complexity was a good reproducible marker of remodeling in pulmonary hypertension.

RV Base/Apex Ratio May Help Diagnose Pulmonary Arterial Hypertension in Children

RV Base/Apex Ratio May Help Diagnose Pulmonary Arterial Hypertension in Children

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Right ventricular base/apex ratio reference values may help clinicians diagnose children with pulmonary arterial hypertension.

Pregnancy in Pulmonary Arterial Hypertension: Improved Patient Counseling Needed

Pregnancy in Pulmonary Arterial Hypertension: Improved Patient Counseling Needed

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Many healthcare providers reported that they often do not have the time to counsel their patients with pulmonary arterial hypertension on pregnancy risks.

PAH in Congenital Heart Disease: Challenges and Advances

PAH in Congenital Heart Disease: Challenges and Advances

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Management strategies were discussed for subtypes of PAH-congenital heart disease including Eisenmenger syndrome, PAH with persistent systemic to pulmonary shunts, and PAH with small or coincidental defect or PAH after defect closure.

Worsening Shortness of Breath in Patient With Hypertension, Afib

Worsening Shortness of Breath in Patient With Hypertension, Afib

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A 72-year-old man with hypertension and paroxysmal atrial fibrillation presents to the emergency department because he has been experiencing worsening shortness of breath.

Cyanosis From PH or Congenital Heart Disease Responds Well to IV Ferrous Carboxymaltose

Cyanosis From PH or Congenital Heart Disease Responds Well to IV Ferrous Carboxymaltose

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After iron supplementation, patients with cyanosis experienced significant improvements in hemoglobin concentration, hematocrit, mean corpuscular volume, ferritin, and transferrin saturation.

Venoarterial ECMO Improves Survival to Transplant in Interstitial Lung Disease

Venoarterial ECMO Improves Survival to Transplant in Interstitial Lung Disease

In patients with end-stage interstitial lung disease, there was a higher rate of survival to transplantation with venoarterial extracorporeal membrane oxygenation.

Oxygen Therapy Affects Health-Related QoL in Pulmonary Hypertension

Oxygen Therapy Affects Health-Related QoL in Pulmonary Hypertension

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Strong relationships were observed between health-related quality-of-life scores and factors such as breathlessness, fatigue, depression, anxiety, and sleep in pulmonary hypertension.

Double Lung Transplantation Improves Survival in Interstitial Pulmonary Fibrosis

Double Lung Transplantation Improves Survival in Interstitial Pulmonary Fibrosis

Double lung transplantation appears to offer superior survival outcomes to single lung transplantation in patients with interstitial pulmonary fibrosis who are younger than 70 years.

Age-Obesity Interaction in Pulmonary Arterial Hypertension

Age-Obesity Interaction in Pulmonary Arterial Hypertension

The interaction of age and obesity with respect to survival in pulmonary arterial hypertension showed an increased risk for mortality in young adults who were morbidly obese.

PAH in Systemic Sclerosis Increases Risk for Early Mortality

PAH in Systemic Sclerosis Increases Risk for Early Mortality

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The majority of deaths in patients with systemic sclerosis-associated pulmonary arterial hypertension occurred within 4 years of diagnosis.

CTEPH Increases Risk for Sleep Disordered Breathing

CTEPH Increases Risk for Sleep Disordered Breathing

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Precapillary pulmonary hypertension and obstructive sleep apnea may be causative factors for central sleep apnea and pulmonary hypertension, respectively.

Sildenafil, Bosentan Combination vs Sildenafil Monotherapy in SSc-Associated PAH

Sildenafil, Bosentan Combination vs Sildenafil Monotherapy in SSc-Associated PAH

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There was no significant difference in efficacy between sildenafil and bosentan initial combination therapy and sildenafil monotherapy in patients with systemic sclerosis-related pulmonary arterial hypertension.

Clinical Trials in PAH: Interpreting Risk Reduction With Caution

Clinical Trials in PAH: Interpreting Risk Reduction With Caution

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Researchers raise issues regarding interpretation of clinical trial results in the field of pulmonary arterial hypertension.

PAH Pulmonary Hemodynamics Improved With Optimized Iloprost Delivery

PAH Pulmonary Hemodynamics Improved With Optimized Iloprost Delivery

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Researchers modified the inhalation technique of iloprost in a patient with pulmonary arterial hypertension by attaching a nasal cannula to the inhalator's inlet port, shortening the administration duration.

Improved Pulmonary Arterial Hypertension Risk Prediction Tools Needed

Improved Pulmonary Arterial Hypertension Risk Prediction Tools Needed

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The use of a risk calculator aimed at achieving a low-risk profile in PAH trials is discussed.

Arrhythmia Associated With Higher Mortality in Congenitial Heart Disease-Related PAH

Arrhythmia Associated With Higher Mortality in Congenitial Heart Disease-Related PAH

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Arrhythmia was a significant predictor of mortality in adult patients with congenital heart disease and pulmonary arterial hypertension.

Right Ventricular Stroke Work Effective Biomarker in Pediatric PAH

Right Ventricular Stroke Work Effective Biomarker in Pediatric PAH

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Clinical worsening in pediatric pulmonary arterial hypertension may be predicted using right ventricular stroke work indexed by ejection fraction.

Composite Echo Score Predicts PH in Interstitial Lung Disease

Composite Echo Score Predicts PH in Interstitial Lung Disease

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The variables for the stepwise echocardiographic score included right ventricular systolic pressure, early pulmonary regurgitation gradient, right atrial area size, tricuspid regurgitation velocity, left ventricle eccentricity index, and right ventricle fractional area change.

Potential COPD Pulmonary Vascular Phenotype Associated With Poor Outcomes

Potential COPD Pulmonary Vascular Phenotype Associated With Poor Outcomes

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A definition of a pulmonary vascular phenotype of chronic obstructive pulmonary disease has been proposed.

Brain Natriuretic Peptide Shows Promise as Biomarker in Group 1 PAH

Brain Natriuretic Peptide Shows Promise as Biomarker in Group 1 PAH

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There was a significant relationship between brain natriuretic peptide levels and mortality in patients with group 1 pulmonary arterial hypertension.

Poor Subpleural Perfusion May Predict Balloon Pulmonary Angioplasty Failure

Poor Subpleural Perfusion May Predict Balloon Pulmonary Angioplasty Failure

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Poor subpleural perfusion in patients with nonoperable chronic thromboembolic pulmonary hypertension may predict balloon pulmonary angioplasty failure.

Metformin May Benefit Pulmonary Hypertension Associated With HFpEF, But Not PAH

Metformin May Benefit Pulmonary Hypertension Associated With HFpEF, But Not PAH

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Although metformin prevented the development of PAH in hypoxia and monocrotalinerat models and reversed PAH in SU5416/hypoxia rats, it failed to reverse pulmonary pressures and vascular remodeling in mice with SU5416/hypoxia-induced PAH.

PAH-Associated Connective Tissue Diseases: A Case for Separating SSc, SLE

PAH-Associated Connective Tissue Diseases: A Case for Separating SSc, SLE

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Recent evidence suggests that systemic sclerosis and systemic lupus erythematosus in pulmonary arterial hypertension should be considered separate diseases.

Pulmonary Hypertension Has Adverse Effect on Post-Lung Transplant Survival

Pulmonary Hypertension Has Adverse Effect on Post-Lung Transplant Survival

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The 1-year survival rate after lung transplantation in patients with a mean pulmonary arterial pressure ≥25 mm Hg was lower than the survival rate of those with a mean pulmonary arterial pressure <25 mm Hg.

PAH-SYMPACT<sup>®</sup>: A Reliable Instrument for PAH Symptom Assessment

PAH-SYMPACT®: A Reliable Instrument for PAH Symptom Assessment

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The Pulmonary Arterial Hypertension-Symptoms and Impact questionnaire has good psychometric properties and can be administered in clinical practice.

Egg-and-Banana Sign Has High Specificity for Pulmonary Hypertension Diagnosis

Egg-and-Banana Sign Has High Specificity for Pulmonary Hypertension Diagnosis

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The "egg-and-banana" sign is a valid computed tomography marker of pulmonary hypertension.

Oral Anticoagulant Effective in Recurrent VTE Prevention in Cancer Patients

Oral Anticoagulant Effective in Recurrent VTE Prevention in Cancer Patients

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At the end of 6 months, the rate of VTE recurrence was 4% among rivaroxaban patients vs 11% in the dalteparin arm (hazard ratio [HR] 0.43, 95% CI: 0.19 to 0.99).

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