Treatments

Paracetamol Overuse During Cold and Flu Season

Paracetamol Overuse During Cold and Flu Season

During the cold and flu season, the use and over-dosing of paracetamol is common, and may partially be driven by higher use of over-the-counter combination medications for the treatment of upper respiratory cold/flu symptoms.

Chest Tube Placement vs Needle Aspiration for Spontaneous Pneumothorax

Chest Tube Placement vs Needle Aspiration for Spontaneous Pneumothorax

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Both chest tube placement and needle aspiration were considered acceptable treatments for primary spontaneous pneumothorax.

Adjuvant Pembrolizumab Beneficial in Metastatic NSCLC

Adjuvant Pembrolizumab Beneficial in Metastatic NSCLC

Nivolumab plus ipilimumab linked to better survival in NSCLC with high tumor mutational burden.

No significant benefit of long-acting muscarinic antagonists over long-acting beta-agonists in reducing exacerbation risk in uncontrolled, persistent asthma

Adjunct long-acting muscarinic antagonist (LAMA) use with corticosteroids was associated with reduced exacerbation risk compared with placebo in patients with uncontrolled, persistent asthma. However, LAMA, long-acting beta-agonist (LABA), and inhaled corticosteroids (triple therapy) were not associated with lower risk for exacerbations compared with LABA and inhaled corticosteroids alone.

Balanced crystalloids decreases adverse kidney events compared to saline among critically ill patients: The SMART trial

Use of balanced crystalloids (lactated Ringers or Plasma-Lyte A) was associated with a significant reduction in acute kidney injury events compared with normal saline among intensive care unit (ICU) patients. Use of balanced crystalloids was also associated with lower though nonsignificant in-hospital mortality at 30-days after admission.

AASM: Medical Marijuana Should Not Be Used to Treat Sleep Apnea

AASM: Medical Marijuana Should Not Be Used to Treat Sleep Apnea

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Continuous positive airway pressure (CPAP) remains the mainstay of medical treatment for OSA.

Fixed-Dosed Dual Bronchodilators for COPD: Overview and Clinician Interview

Fixed-Dosed Dual Bronchodilators for COPD: Overview and Clinician Interview

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Treating chronic obstructive pulmonary disease remains challenging, particularly in terms of choosing the appropriate fixed-dose combination bronchodilator.

Bedaquiline and Delamanid Effective in Multidrug-Resistant Tuberculosis

Bedaquiline and Delamanid Effective in Multidrug-Resistant Tuberculosis

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Bedaquiline and delamanid were effective and well tolerated in patients with multidrug-resistant tuberculosis.

Oral Treprostinil Dosing Characteristics in Pulmonary Arterial Hypertension

Oral Treprostinil Dosing Characteristics in Pulmonary Arterial Hypertension

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Prescribers tend to favor a frequency of 3 times per day for oral treprostinil dosing in patients with pulmonary arterial hypertension.

Treatment for Idiopathic Pulmonary Fibrosis Gets Orphan Drug Designation

Treatment for Idiopathic Pulmonary Fibrosis Gets Orphan Drug Designation

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RP5063 is a new chemical entity with a novel mechanism of multimodal modulation of serotonin and dopamine signaling pathways.

Respiratory Muscle Training in Multiple Sclerosis: Assessing the Evidence

Respiratory Muscle Training in Multiple Sclerosis: Assessing the Evidence

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Early intervention in the case of respiratory compromise in patients with multiple sclerosis has the potential to prevent infection and maintain pulmonary function.

Asthma Exacerbation Risk Lower With SMART Therapy

Asthma Exacerbation Risk Lower With SMART Therapy

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In patients with persistent asthma, single maintenance and reliever therapy was associated with a lower risk for exacerbations compared with inhaled corticosteroids as controller therapy and short-acting beta-agonists as relief therapy.

Mortality in Mechanically Ventilated Community-Acquired Pneumonia With or Without ARDS

Mortality in Mechanically Ventilated Community-Acquired Pneumonia With or Without ARDS

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The risk for death in patients with community-acquired pneumonia who were given mechanical ventilation does not seem to be affected by the presence of acute respiratory distress syndrome.

Tai Chi Helps Improve Respiratory Function in COPD

Tai Chi Helps Improve Respiratory Function in COPD

Tai chi found to be as effective as pulmonary rehabilitation for patients with chronic obstructive pulmonary disease.

Polypharmacy Linked to Poorer Cognitive, Physical Capability

Polypharmacy Linked to Poorer Cognitive, Physical Capability

Researchers found stronger negative associations for participants with polypharmacy between the ages of 60 and 64 years and at 69 years.

Debating Noninvasive vs Invasive Ventilation in Acute Exacerbations of COPD

Debating Noninvasive vs Invasive Ventilation in Acute Exacerbations of COPD

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It is still not known whether differences in mortality rates between patients who receive noninvasive vs invasive ventilation for acute exacerbations of COPD can be attributed to less severe disease or other factors.

Omalizumab Effective in Severe Allergic Asthma, Regardless of Eosinophil Level

Omalizumab Effective in Severe Allergic Asthma, Regardless of Eosinophil Level

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Regardless of blood eosinophil count, omalizumab was an effective treatment in adult and pediatric patients with severe allergic asthma.

Dacomitinib Granted Priority Review for NSCLC With EGFR-Activating Mutations

Dacomitinib Granted Priority Review for NSCLC With EGFR-Activating Mutations

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Dacomitinib is a pan-human epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor.

Novel Cystic Fibrosis Treatment Granted Fast Track Status

Novel Cystic Fibrosis Treatment Granted Fast Track Status

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Proteostasis Therapeutics is developing the combination treatment which includes a novel transmembrane conductance regulator (CFTR) amplifier (PTI-428), a third generation corrector (PTI-801) and a potentiator (PTI-808).

Most Patients Select Suboptimal Medications for Allergic Rhinitis

Most Patients Select Suboptimal Medications for Allergic Rhinitis

Only 16.5% of pharmacy customers with hay fever select optimal medications.

Lonhala Magnair Now Available for Long-Term COPD Maintenance

Lonhala Magnair Now Available for Long-Term COPD Maintenance

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Lonhala Magnair is available as a 25mcg strength inhalation solution per 1mL vial.

Sinuva Sinus Implant Launched to Treat Recurrent Nasal Polyps

Sinuva Sinus Implant Launched to Treat Recurrent Nasal Polyps

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Sinuva can be implanted during a routine physician visit under local or topical anesthesia.

Duration of Antibiotics Often Exceeds Guidelines for Sinusitis

Duration of Antibiotics Often Exceeds Guidelines for Sinusitis

More than 90% of non-azithromycin antibiotic courses were 10 days or longer for acute sinusitis.

NDA for Novel Amikacin Inhalation Submitted for Rare Lung Infection

NDA for Novel Amikacin Inhalation Submitted for Rare Lung Infection

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ALIS has previously been designated orphan drug status, breakthrough therapy status and a Qualified Infectious Disease Product.

Two Inhalers Go Head-to-Head in COPD Exacerbation Study

Two Inhalers Go Head-to-Head in COPD Exacerbation Study

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Study authors concluded, "Combining tiotropium and olodaterol did not reduce exacerbation rate as much as expected compared with tiotropium alone."

COPD: Disease Management Care vs Recommended Care Alone

COPD: Disease Management Care vs Recommended Care Alone

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Disease management added to recommended care in chronic obstructive pulmonary disease was not superior to recommended care alone.

Efficacy of Different Doses of Glycopyrronium Via a Metered Dose Inhaler in COPD

Efficacy of Different Doses of Glycopyrronium Via a Metered Dose Inhaler in COPD

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Four different doses of glycopyrronium delivered via metered dose inhaler were compared for safety and efficacy in the treatment of chronic obstructive pulmonary disease.

Prevent Treatment Nonadherence in Asthma, COPD: Build Strong Patient Relationships

Prevent Treatment Nonadherence in Asthma, COPD: Build Strong Patient Relationships

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Patients with asthma or chronic obstructive pulmonary disease have especially high rates of nonadherence, even in comparison with other chronic diseases.

Smartinhaler Sensor for Symbicort Will Be Available Over-the-Counter

Smartinhaler Sensor for Symbicort Will Be Available Over-the-Counter

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The Smartinhaler sensor is a device installed onto a patient's inhaler to monitor and promote asthma and COPD medication adherence.

Delirium in ICU Prevented With Nocturnal Administration of Dexmedetomidine

Delirium in ICU Prevented With Nocturnal Administration of Dexmedetomidine

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A higher percentage of critically ill patients in the intensive care unit who were given nocturnal dexmedetomidine remained delirium free compared with placebo.

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