Treatments

Omalizumab Inhibits Respiratory Reactions During Aspirin Desensitization

Omalizumab Inhibits Respiratory Reactions During Aspirin Desensitization

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In patients with aspirin exacerbated respiratory disease, treatment with omalizumab resulted in "clinically silent" aspirin desensitization.

Asthma Exacerbation Risk With As-Needed Budesonide-Formoterol vs Maintenance Budesonide

Asthma Exacerbation Risk With As-Needed Budesonide-Formoterol vs Maintenance Budesonide

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Budesonide-formoterol as needed was not inferior compared with budesonide maintenance therapy in terms of severe asthma exacerbation rates, but may be inferior for controlling symptoms.

Effectiveness of Budesonide-Formoterol vs Terbutaline in Asthma Symptom Control

Effectiveness of Budesonide-Formoterol vs Terbutaline in Asthma Symptom Control

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There was a 60% lower rate of severe asthma exacerbations in individuals treated with budesonide-formoterol compared with individuals treated with terbutaline as needed.

Early Clinical Response With Omadacycline vs Moxifloxacin in CABP

Early Clinical Response With Omadacycline vs Moxifloxacin in CABP

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Early clinical response rates were similar across PORT risk class subgroups in patients with community-acquired bacterial pneumonia when treated with omadacycline or moxifloxacin.

Prevnar 13 Linked to Reduced Risk of CAP Hospitalization in Older Patients

Prevnar 13 Linked to Reduced Risk of CAP Hospitalization in Older Patients

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PCV13, marketed as Prevnar 13, was evaluated in a test-negative case-control study in real-world conditions where patients were administered pneumococcal vaccination as advised by their healthcare providers.

High-Flow Nasal Cannula vs Conventional Oxygen Therapy for Acute Respiratory Failure

High-Flow Nasal Cannula vs Conventional Oxygen Therapy for Acute Respiratory Failure

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In patients with acute respiratory failure, high-flow nasal cannula and conventional oxygen therapy provided similar benefits.

Positive Results Announced for Pleuromutilin Antibiotic in CABP

Positive Results Announced for Pleuromutilin Antibiotic in CABP

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In the LEAP 2 study (N=738), patients with moderate CABP received either oral lefamulin 600mg every 12 hours for 5 days or oral moxifloxacin 400mg once daily for 7 days.

Mortality Increased With Liberal Oxygen Therapy in Acutely Ill Patients

Mortality Increased With Liberal Oxygen Therapy in Acutely Ill Patients

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Liberal supplemental oxygen therapy in acutely ill patients increased mortality during hospitalization, at 30 days, and at longest follow-up.

Tiotropium/Olodaterol Combination vs Tiotropium Alone for Severe COPD Exacerbations

Tiotropium/Olodaterol Combination vs Tiotropium Alone for Severe COPD Exacerbations

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Tiotropium may be more effective in reducing the rate of moderate and severe chronic obstructive pulmonary disorder exacerbations when used in combination with olodaterol vs tiotropium alone.

Budesonide Improved Epithelial Barrier Function in Asthma

Budesonide Improved Epithelial Barrier Function in Asthma

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Researchers evaluated barrier dysfunction by exposing viral models to budesonide, montelukast, formoterol, or a combination.

Inhaled Interferon-Beta 1a Does Not Reduce Severe Asthma Exacerbations

Inhaled Interferon-Beta 1a Does Not Reduce Severe Asthma Exacerbations

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Inhaled interferon-beta 1 a did not significantly reduce acute asthma exacerbations during respiratory viral infections.

COPD Frequently Misdiagnosed, Undiagnosed in Individuals With or Without HIV

COPD Frequently Misdiagnosed, Undiagnosed in Individuals With or Without HIV

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In this study, researchers examined the appropriateness of diagnosis and treatment of chronic obstructive pulmonary disease in individuals with and without HIV.

Steroid Dosing, Glucose Levels Do Not Increase Likelihood of COPD Readmissions

Steroid Dosing, Glucose Levels Do Not Increase Likelihood of COPD Readmissions

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Steroid dosing and glucose levels were not associated with an increase in hospital readmissions related to COPD exacerbations.

Morning vs Evening ICS Dosing in Asthma: Efficacies Compared

Morning vs Evening ICS Dosing in Asthma: Efficacies Compared

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Inhaled corticosteroids for asthma dosed once daily in the evening appeared to offer some benefit in trough FEV1 and morning peak expiratory flow.

Incident Diuretic Use May Increase Adverse Events in COPD

Incident Diuretic Use May Increase Adverse Events in COPD

Incident diuretic use was associated with increased rates of respiratory-related morbidity and mortality in older adults with chronic obstructive pulmonary disease.

Mortality Rates in Extrafine ICS-Containing vs ICS-Free Medications in COPD

Mortality Rates in Extrafine ICS-Containing vs ICS-Free Medications in COPD

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The pooled safety analysis included data from the TRILOGY, TRINITY, and TRIBUTE studies.

Efficacy, Safety of Dupilumab in Corticosteroid-Dependent Severe Asthma

Efficacy, Safety of Dupilumab in Corticosteroid-Dependent Severe Asthma

Subcutaneous dupilumab significantly reduced the use of oral corticosteroids in patients with corticosteroid-dependent severe asthma.

Lung Function in Severe Asthma Improved With Benralizumab

Lung Function in Severe Asthma Improved With Benralizumab

Peak expiratory flow increases were greater with benralizumab than placebo in patients with severe eosinophilic asthma.

Vitamin D Supplementation Improves Asthma Control

Vitamin D Supplementation Improves Asthma Control

In individuals with asthma and vitamin D deficiency, vitamin D supplementation improved asthma control.

Effect of Combination vs Triple Therapy on COPD Exacerbations

Effect of Combination vs Triple Therapy on COPD Exacerbations

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Combination therapy with LABA and LAMA yielded a lower annualized rate of COPD exacerbations compared with triple therapy.

Macrolides for Asthma Management: An Updated Review

Macrolides for Asthma Management: An Updated Review

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While macrolides had no direct effect on lung function, their use significantly improved asthma control and quality of life in patients with asthma.

Fixed vs Auto-Adjusting CPAP for Prevention of eGFR Decline in OSA

Fixed vs Auto-Adjusting CPAP for Prevention of eGFR Decline in OSA

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Fixed continuous positive airway pressure for the treatment of obstructive sleep apnea was associated with preventing a time-dependent decline in estimated glomerular filtration rate.

Beclomethasone Dipropionate vs Cetirizine in Children With Perennial Allergic Rhinitis

Beclomethasone Dipropionate vs Cetirizine in Children With Perennial Allergic Rhinitis

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Nasal beclomethasone dipropionate was more effective in improving nasal patency and cytology as well as quality of life compared with cetirizine in children with perennial allergic rhinitis.

Initiative Cuts Overuse of Tests, Treatments for Bronchiolitis

Initiative Cuts Overuse of Tests, Treatments for Bronchiolitis

The initiative helped reduce the ordering of chest radiographs, respiratory viral testing, and bronchodilators.

Most Concerning Med Issues Explored Among Youth With Asthma

Most Concerning Med Issues Explored Among Youth With Asthma

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The study authors reported, "The most commonly reported problems by youth were: (a) hard to remember when to take the asthma medication (54%) and (b) hard to use asthma medication at school (34%)."

Oral Anticoagulant Effective in Recurrent VTE Prevention in Cancer Patients

Oral Anticoagulant Effective in Recurrent VTE Prevention in Cancer Patients

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At the end of 6 months, the rate of VTE recurrence was 4% among rivaroxaban patients vs 11% in the dalteparin arm (hazard ratio [HR] 0.43, 95% CI: 0.19 to 0.99).

ICS Therapy May Not Be Enough for Asthma Patients With Elevated Eosinophils

ICS Therapy May Not Be Enough for Asthma Patients With Elevated Eosinophils

The study aimed to determine the association between ICS therapy adherence and the occurrence of asthma exacerbations in patients with high blood eosinophil levels.

Feasibility of At-Home Use Injectable Tx for Severe Asthma Assessed

Feasibility of At-Home Use Injectable Tx for Severe Asthma Assessed

Of the total 573 APFS dispensed, 1 malfunctioned and 1 was considered nonfunctional because it was not returned. The study authors also reported that patient-use error only led to 2 unsuccessful at-home administrations.

Copeptin May Serve as Prognostic Biomarker for Pulmonary Embolism

Copeptin May Serve as Prognostic Biomarker for Pulmonary Embolism

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Copeptin may be useful for identifying normotensive patients with pulmonary embolism who have a higher risk for an adverse outcome.

Assessing Depression Following Inpatient COPD Rehabilitation

Assessing Depression Following Inpatient COPD Rehabilitation

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PHQ-9 and PHQ-2 show factorial validity, invariance, and reliability for measuring depression in patients with chronic obstructive pulmonary disease.

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