Treatment reinitiation after a short interruption was well tolerated in patients taking standardized quality house mite sublingual immunotherapy tablets.
Significantly greater reductions in the mean esophageal eosinophil counts occurred in patients who received the humanized anti-interleukin 13 antibody, RPC4046.
The prevalence of depression in patients with atopic dermatitis was higher than in those without atopic dermatitis.
Upadacitinib, a selective janus kinase-1 inhibitor, was associated with early improvements in pruritus in patients with moderate to severe atopic dermatitis.
GSP301 treatment was associated with a significant improvement in reflective and instantaneous Total Nasal Symptom Scores compared with placebo.
Patients who received a fixed-dose combination nasal spray showed significantly improved Physician-assessed Nasal Symptom Scores compared with those who received placebo.
The FDA has approved the use of Oralair for the treatment of grass pollen-induced allergic rhinitis in pediatric patients aged 5-9.
Adverse drug reactions from the 300IR 5-grass pollen tablet occurred in approximately half of patients but typically resolved within a week of treatment.
Patients with hereditary angioedema who received lanadelumab exhibited few cases of hypersensitivity and had low immunogenicity.
Despite many pediatric patients receiving higher than recommended doses of epinephrine for their weight, they did not present with epinephrine-related symptoms.
The change from baseline in 2-hour pruritus score was shown to be statistically noninferior from IV cetirizine to IV diphenhydramine, in favor of IV cetirizine.
Several asthma and allergy groups expressed "deep concern" over the recent FDA approval of Primatene MIST.
Patients with atopic dermatitis and more severe disease have higher scores on dermatology life quality index.
The FDA has issued a safety communication alerting patients and healthcare providers that for some EpiPen and EpiPen Jr auto-injectors, and their authorized generics, the device label may become stuck to the inside of the carrier tube and potentially delay administration.
The expiration dates for certain lots of epinephrine injection, USP auto-injector 0.15mg and 0.3mg have been extended by 2 month.
Class 1 was defined as minimal sensitization, class 2 was defined as sensitization with indoor pet exposure, class 3 was defined as sensitization with tobacco smoke exposure, and class 4 was defined as multiple sensitization and eczema.
The majority of study participants had rhinitis at baseline, including perennial allergic rhinitis with seasonal exacerbations, which is the most severe phenotype.
Childhood non-atopic rhinitis is associated with an increased risk for adult asthma.
In both studies, at 24 weeks, patients treated with dupilumab plus corticosteroid nasal spray experienced a 51% and 57% improvement in nasal congestion/obstruction severity vs 15% and 19% improvement with nasal spray alone.
Lower exposure to Proteobacteria in umbilical cord serum was associated with an increased risk for childhood wheezing.
Changes in allergy records were suggested by the allergy service consult for 62% of the patients.
Both doses will be supplied in single-dose, prefilled syringes for manual injection.
Cockroach and mouse allergies were most often associated with poorly controlled asthma and exacerbations in urban adolescents.
Children of East Asian-born parents had an increased risk for allergic rhinitis and aeroallergen sensitization compared with children of Caucasian ancestry.
Total omega-3 and omega-6 plasma polyunsaturated fatty acids relative abundances were significantly inversely correlated with asthma/recurrent wheeze and allergic sensitization.
Although allergic sensitization and hay fever rates increased as children grew older, the rates of asthma dropped.
According to the report, the patient complained of a non-productive cough, accumulation of mucus, and post-nasal drip and requested a thorough assessment of her medical conditions.
In a population of primarily Latino children from low-income households, a program of school-supervised use of once-daily inhaled corticosteroids failed to improve asthma control.
The Smart Case includes electronics and sensors to monitor the proximity, temperature, presence and removal, and expiration of auto-injectors.
This effort is in response to epinephrine auto-injector supply issues reported by manufacturers to the Food and Drug Administration (FDA).
A total of 8% of patients with asthma exacerbations met the criteria for diagnosing anaphylaxis, with 3.4% having likely experienced anaphylaxis.
The risk of a mixing-up the treatments is especially high for pregnant women, says the Food and Drug Administration (FDA), as losartan is indicated to treat high blood pressure and could harm or kill a fetus.
The bioavailability of the novel epinephrine nasal spray also proved similar to that of intramuscular injection with EpiPen 0.3mg injection.
ADVM-053 is being developed as a single‑administration treatment that could potentially provide sustained levels of the C1 esterase inhibitor protein, which may prevent breakthrough angioedema attacks.
The approval was based on data from 4 clinical trials, including the 26-week Phase 3 HELP (Hereditary Angioedema Long-Term Prophylaxis) study that enrolled 125 patients with HAE aged ≥12 years.
Haemophilus influenzae, Staphylococcus aureus, and Streptococcus pyogenes were found in approximately one-fifth of isolated IgE antibodies via plasmablasts residing in nasal polyps.
This date modification beyond the approved 20-month shelf life was based an FDA review of product stability data submitted by Mylan.
Adolescents who have asthma or allergic rhinitis may be at higher risk for developing migraine.
Unlike other generic approvals, epinephrine auto-injectors are considered "combination products" because they consist of both a drug and a device, making the approval process more challenging.
In May, the Food and Drug Administration posted a drug shortage alert, adding Mylan's EpiPen (epinephrine injection) to the drug shortage list.
The FDA designation was supported by data from 7 studies evaluating the safety and efficacy of Xolair against various food allergens (eg, peanut, milk, egg, others).
The recalled nasal decongestant has a Lot number of 173089J and an expiration date of 09/19; it is packaged in 0.5 fluid ounce bottles.
The Company is currently conducting a Phase 3 trial (APeX-2) and a long-term safety study (APeX-S) evaluating 2 doses of the treatment.
Patients with aspirin-exacerbated respiratory disease had significantly lower levels of depression symptoms and higher quality of life compared with patients with asthma only.
Physicians can help children and teens adhere to eczema treatment plants by simplifying treatment, creating reminders, and sharing success stories.
Oral administration of BCX7353 at dose of 125 mg resulted in lower rate of hereditary angioedema attacks vs placebo.
Grass, other weeds, and unclassified pollen were significantly associated with increased risk for asthma hospitalization in young children.
Sensitization to Aspergillus fumigatus increased the risk for severe asthma.
An increase in atheroma burden and plaques with less stable features demonstrated an association with immunoglobulin E to α-Gal.
Cytokines produced by mitogen-stimulated immune cells from pregnant women without asthma were shown to be associated with the development of asthma in their children.
Respiratory symptoms were more common in older children compared with infants who presented with food-induced anaphylaxis.
In addition to respiratory sensitivity to aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), patients with AERD oftentimes experience an additional allergic reaction when drinking alcohol.
Clinically meaningful benefits were seen in patients with chronic rhinosinusitis, but the treatment effect was imprecise.
Lone star tick is most common in the South, but may be spreading to new areas.
The eFlow® nebulizer delivered CDP7766 without evidence of degradation, loss of potency, aggregation, or formation of particulates in a model of asthma in cynomolgus macaques.
Many patients with moderate to severe atopic dermatitis have inadequate disease control.
Bronchiectasis-associated genera included Aspergillus, Cryptococcus, Clavispora, Botrytis, and Alternaria.
Children with the early-onset persistent bronchial hyperresponsiveness phenotype had the highest blood eosinophil count and total serum IgE levels as well as sensitization rates.
The approval was based on data from a randomized, single-blind, multicenter, dose-ranging, crossover study which evaluated the safety and efficacy of Cinryze in 12 pediatric patients (7 to 11 years old).
The mean rate of exacerbations declined significantly after 1 year of subcutaneous immunotherapy in children with moderate to severe allergic asthma exacerbations.
Allergic rhinitis also had a negative effect on daily functioning, sleep, school productivity, and academic performance.
Most adults (52%) reported that an EAI was not used during their most severe reaction, even though it would have been beneficial, 45% said they didn't have it with them at the time.
Because determining an appropriate treatment plan for a patient depends on the subtype of the disease, it is imperative for providers to know and understand the underlying mechanisms of CRS as well as the components included in a medical evaluation of a patient.
A nasal immune-response pattern characterized by lower non-interferon antiviral immune response mediators and higher type 2 and type 17 cytokines was significantly associated with recurrent wheeze at 1 year.
The pharmacokinetics trial, which included 60 participants with seasonal allergies, also demonstrated rapid drug absorption with the intranasal spray.
Adenoidectomy and tonsillectomy in children by age 9 were associated with higher long-term risks for respiratory, infectious, and allergic diseases.
Vitamin D supplementation appears to reduce the recurrent wheezing by 12 months of age in black infants born prematurely.
Researchers developed a predictive algorithm to identify individuals with a higher risk for severe reactions to the standardized peanut oral food challenge.
Fluticasone Propionate Nasal Spray is a corticosteroid indicated for the management of the nasal symptoms of perennial nonallergic rhinitis in adults and pediatric patients aged 4 years and older.
Montelukast improved symptoms in a significant proportion of individuals with angioedema-predominant chronic spontaneous urticaria.
Many parents feel additional food labeling, allergy education, and stocking of epinephrine are needed.
The pattern of laryngeal motor dysfunction and the prevalence and severity of laryngeal hypersensitivity in individuals with chronic cough were similar to that observed in individuals with vocal cord dysfunction and muscle tension dysphonia.
A strong dose-response relation was seen with atopic eczema severity.
Researchers have developed a novel algorithm to identify hypersensitivity pneumonitis.
Nasal beclomethasone dipropionate was more effective in improving nasal patency and cytology as well as quality of life compared with cetirizine in children with perennial allergic rhinitis.
Physiological lipids in the products restored skin barrier function and hydration.
Potential risk factors for eosinophilic esophagitis include antibiotic use in infancy and behaviors such as smoking and alcohol intake.
Intermittent supply constraints due to manufacturing delays from Mylan's manufacturing partner, Meridian Medical Technologies, have resulted in varying supply levels.
Patient-oriented eczema measures cores did not meet the minimal clinically important difference after adjustment for confounders.
The supplemental New Drug Application (sNDA) for the 0.1mg strength was granted Priority Review by the Food and Drug Administration (FDA).
Intake of birch-pollen related foods may lead to aggravation of symptoms in patients with atopic dermatitis.
Higher parental income was the only significant positive predictor of willingness to enroll child in a clinical trial.
Only 16.5% of pharmacy customers with hay fever select optimal medications.
Findings for subsequent allergic disease following infant exposure in the first six months of life.
Sinuva can be implanted during a routine physician visit under local or topical anesthesia.
More than 90% of non-azithromycin antibiotic courses were 10 days or longer for acute sinusitis.
The majority of school nurses report staff training on anaphylaxis and epinephrine availability.
Adults with grass pollen rhinoconjunctivitis benefited from immunotherapy with peptide hydrolysates from Lolium perenne.
According to a systematic literature review, there was inconclusive evidence that single indoor allergen interventions were effective at improving asthma outcomes.
When patients visiting an allergy/immunology outpatient clinic had expectations met regarding diagnosis and testing, they were more likely to be satisfied with their visit.
Patients with chronic rhinosinusitis may experience decreases in health-related quality of life comparable to other serious chronic diseases.
Prenatal vitamin D is associated with an increased risk for allergic rhinitis in children born to African American women, but not white women.
In patients with food allergies but without a history of atopic dermatitis, there was an association of more antibiotic and gastroesophageal reflux medication use.
When testing for sensitivity to histamine, larger swelling sizes were recorded for infants with eczema and atopic dermatitis compared with infants without those conditions.
Researchers sought to assess the effect of seasonal dose adjustments on the rate of systemic reactions in pediatric patients receiving standardized allergen subcutaneous immunotherapy.
Higher levels of unmetabolized folic acid at birth may be associated with the development of food allergies.
Children who are exposed to antibiotics earlier in life may have an increased risk for allergic diseases, including asthma, atopic dermatitis, and allergic rhinitis.
Patients with hereditary angioedema experienced a significant reduction in attack rates when treated with lanadelumab.
Intranasal corticosteroids are the current guideline-preferred treatment recommendation for nasal congestion.
A first look at what will be presented at the 2018 Joint Congress of the American Academy of Allergy, Asthma & Immunology and the World Allergy Organization.