In May, the Food and Drug Administration posted a drug shortage alert, adding Mylan's EpiPen (epinephrine injection) to the drug shortage list.
The FDA designation was supported by data from 7 studies evaluating the safety and efficacy of Xolair against various food allergens (eg, peanut, milk, egg, others).
The recalled nasal decongestant has a Lot number of 173089J and an expiration date of 09/19; it is packaged in 0.5 fluid ounce bottles.
The Company is currently conducting a Phase 3 trial (APeX-2) and a long-term safety study (APeX-S) evaluating 2 doses of the treatment.
Patients with aspirin-exacerbated respiratory disease had significantly lower levels of depression symptoms and higher quality of life compared with patients with asthma only.
Physicians can help children and teens adhere to eczema treatment plants by simplifying treatment, creating reminders, and sharing success stories.
Oral administration of BCX7353 at dose of 125 mg resulted in lower rate of hereditary angioedema attacks vs placebo.
Grass, other weeds, and unclassified pollen were significantly associated with increased risk for asthma hospitalization in young children.
Sensitization to Aspergillus fumigatus increased the risk for severe asthma.
An increase in atheroma burden and plaques with less stable features demonstrated an association with immunoglobulin E to α-Gal.
Cytokines produced by mitogen-stimulated immune cells from pregnant women without asthma were shown to be associated with the development of asthma in their children.
Respiratory symptoms were more common in older children compared with infants who presented with food-induced anaphylaxis.
In addition to respiratory sensitivity to aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), patients with AERD oftentimes experience an additional allergic reaction when drinking alcohol.
Clinically meaningful benefits were seen in patients with chronic rhinosinusitis, but the treatment effect was imprecise.
Lone star tick is most common in the South, but may be spreading to new areas.
The eFlow® nebulizer delivered CDP7766 without evidence of degradation, loss of potency, aggregation, or formation of particulates in a model of asthma in cynomolgus macaques.
Many patients with moderate to severe atopic dermatitis have inadequate disease control.
Bronchiectasis-associated genera included Aspergillus, Cryptococcus, Clavispora, Botrytis, and Alternaria.
Children with the early-onset persistent bronchial hyperresponsiveness phenotype had the highest blood eosinophil count and total serum IgE levels as well as sensitization rates.
The approval was based on data from a randomized, single-blind, multicenter, dose-ranging, crossover study which evaluated the safety and efficacy of Cinryze in 12 pediatric patients (7 to 11 years old).
The mean rate of exacerbations declined significantly after 1 year of subcutaneous immunotherapy in children with moderate to severe allergic asthma exacerbations.
Allergic rhinitis also had a negative effect on daily functioning, sleep, school productivity, and academic performance.
Most adults (52%) reported that an EAI was not used during their most severe reaction, even though it would have been beneficial, 45% said they didn't have it with them at the time.
Because determining an appropriate treatment plan for a patient depends on the subtype of the disease, it is imperative for providers to know and understand the underlying mechanisms of CRS as well as the components included in a medical evaluation of a patient.
A nasal immune-response pattern characterized by lower non-interferon antiviral immune response mediators and higher type 2 and type 17 cytokines was significantly associated with recurrent wheeze at 1 year.
The pharmacokinetics trial, which included 60 participants with seasonal allergies, also demonstrated rapid drug absorption with the intranasal spray.
Adenoidectomy and tonsillectomy in children by age 9 were associated with higher long-term risks for respiratory, infectious, and allergic diseases.
Vitamin D supplementation appears to reduce the recurrent wheezing by 12 months of age in black infants born prematurely.
Researchers developed a predictive algorithm to identify individuals with a higher risk for severe reactions to the standardized peanut oral food challenge.
Fluticasone Propionate Nasal Spray is a corticosteroid indicated for the management of the nasal symptoms of perennial nonallergic rhinitis in adults and pediatric patients aged 4 years and older.
Montelukast improved symptoms in a significant proportion of individuals with angioedema-predominant chronic spontaneous urticaria.
Many parents feel additional food labeling, allergy education, and stocking of epinephrine are needed.
The pattern of laryngeal motor dysfunction and the prevalence and severity of laryngeal hypersensitivity in individuals with chronic cough were similar to that observed in individuals with vocal cord dysfunction and muscle tension dysphonia.
A strong dose-response relation was seen with atopic eczema severity.
Researchers have developed a novel algorithm to identify hypersensitivity pneumonitis.
Nasal beclomethasone dipropionate was more effective in improving nasal patency and cytology as well as quality of life compared with cetirizine in children with perennial allergic rhinitis.
Physiological lipids in the products restored skin barrier function and hydration.
Potential risk factors for eosinophilic esophagitis include antibiotic use in infancy and behaviors such as smoking and alcohol intake.
Intermittent supply constraints due to manufacturing delays from Mylan's manufacturing partner, Meridian Medical Technologies, have resulted in varying supply levels.
Patient-oriented eczema measures cores did not meet the minimal clinically important difference after adjustment for confounders.
The supplemental New Drug Application (sNDA) for the 0.1mg strength was granted Priority Review by the Food and Drug Administration (FDA).
Intake of birch-pollen related foods may lead to aggravation of symptoms in patients with atopic dermatitis.
Higher parental income was the only significant positive predictor of willingness to enroll child in a clinical trial.
Only 16.5% of pharmacy customers with hay fever select optimal medications.
Findings for subsequent allergic disease following infant exposure in the first six months of life.
Sinuva can be implanted during a routine physician visit under local or topical anesthesia.
More than 90% of non-azithromycin antibiotic courses were 10 days or longer for acute sinusitis.
The majority of school nurses report staff training on anaphylaxis and epinephrine availability.
Adults with grass pollen rhinoconjunctivitis benefited from immunotherapy with peptide hydrolysates from Lolium perenne.
According to a systematic literature review, there was inconclusive evidence that single indoor allergen interventions were effective at improving asthma outcomes.
Patients with chronic rhinosinusitis may experience decreases in health-related quality of life comparable to other serious chronic diseases.
Researchers sought to assess the effect of seasonal dose adjustments on the rate of systemic reactions in pediatric patients receiving standardized allergen subcutaneous immunotherapy.
Higher levels of unmetabolized folic acid at birth may be associated with the development of food allergies.
Children who are exposed to antibiotics earlier in life may have an increased risk for allergic diseases, including asthma, atopic dermatitis, and allergic rhinitis.
Patients with hereditary angioedema experienced a significant reduction in attack rates when treated with lanadelumab.
Intranasal corticosteroids are the current guideline-preferred treatment recommendation for nasal congestion.
A first look at what will be presented at the 2018 Joint Congress of the American Academy of Allergy, Asthma & Immunology and the World Allergy Organization.
The dietary inflammatory index was used to examine the risk for current wheeze with a proinflammatory diet in adults and children.
Children who received oral prednisolone vs placebo for virus-associated wheeze had a shorter length of hospital stay.
Timing of birth may increase risk for asthma or atopic dermatitis.
Indoor allergens are much higher in day-care centers than in homes.
A prospective study evaluated whether chronic exposure to air pollution increased risk for pregnancy loss.
Investigators sought to determine the association between food allergies and the development of asthma.
Atopic dermatitis without concomitant allergic sensitization in children is not associated an increased risk for asthma.
FlutiCare OTC can relieve both indoor and outdoor allergy symptoms caused by pollen, dust, and animal dander.
The 2006 CHEST management algorithms for acute, subacute, and chronic cough appear to be useful in treating adults globally.
Exclusive breastfeeding may have a protective effect against flexural dermatitis development in infants, but appears to have no long-term effect on measures of asthma.
The American College of Allergy, Asthma, and Immunology has issued updated guidelines on seasonal allergic rhinitis treatment.
Further research is needed, but the position statement authors support the use of telemedicine as a method of health care delivery.
Over 10 years, patients with local allergic rhinitis show worsening of rhinitis, development of asthma, and poor quality of life.
Clinical symptoms of pneumonia should be identified quickly in pediatric patients to prevent inappropriate therapy.
A systematic review examined the safety and cost-effectiveness of allergen immunotherapy for allergic rhinitis, allergic asthma, food allergy, and venom allergy.
Cyproheptadine is used to treat various allergic reactions.
Nasal hyperreactivity was predictive of treatment success.
Allergic and nonallergic rhinitis guidelines include the latest updates from BSACI for diagnosing and managing children and adults.
A study of 65 patients examined the efficacy of using serum periostin as a biomarker for asthma with comorbid upper airway disease.
BMI is causally related to higher prevalence of asthma, but not hay fever or allergy.
Following multiple tick and mosquito bites, a male patient experienced severe anaphylaxis and hypotention following the ingestion of mammalian meat or dairy products.
Rules integrating signs, symptoms, CRP can diagnose acute rhinosinusitis, bacterial rhinosinusitis
Smokers had worse rhinosinusitis symptoms and used more antibiotics and oral corticosteroids to treat sinus infections.
Patients with recurrent grass pollen-induced allergic rhinitis benefit from ultra-short courses of booster immunotherapy.
AllerVarx is a bilayer tablet that allows for controlled release of ingredients like quercetin and vitamin D3.
A combination of several factors -- including electrical activity, high humidity, and rainfall -- can lead to asthma outbreaks in conjunction with thunderstorms.
NasalCom nasal spray has been recalled due to possible microbial contamination in the water used to manufacture the product.
The rise in asthma and allergy symptoms may be due to climate change which heightens the damage of airway cells by outdoor fungus.
Sublingual immunotherapy is associated with slower AR progression and less frequent asthma onset in patients with allergic rhinitis.
Allergen immunotherapy (AIT) was shown to reduce short-term symptoms and medication scores.
Over 8 years follow-up, researchers identified cholestatoma in 209 patients with chronic rhinosinusitis.
Two years is insufficient for sublingual immunotherapy to induce long-term clinical efficacy in allergic rhinitis.
Researchers examined the impact of uncontrolled allergic rhinitis on work productivity.