Allergies

Best Practices for Penicillin Allergy Evaluation

Best Practices for Penicillin Allergy Evaluation

Verifying reported penicillin allergies are necessary to improve outcomes and prevent antibiotic resistance.

Symjepi Now Available for Emergency Treatment of Allergic Reactions

Symjepi Now Available for Emergency Treatment of Allergic Reactions

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The product will be made available first in institutions followed by a launch in the retail setting.

How Common Is Anaphylaxis Following Vaccination?

How Common Is Anaphylaxis Following Vaccination?

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To investigate the incidence of anaphylaxis after vaccination, study authors reviewed data submitted to the Vaccine Adverse Event Reporting System (VAERS) between 1990 and 2016.

Investigational Cream Promising for Atopic Dermatitis

Investigational Cream Promising for Atopic Dermatitis

In a phase 2b trial, success rates were higher with TRPV1 antagonist than with vehicle cream.

Nearly 11% of US Adults Have Food Allergy

Nearly 11% of US Adults Have Food Allergy

Nearly 20% of US adults think they are food-allergic; shellfish, milk, peanut are the most common allergies.

First-in-Class OTC Bioelectronic Device for Sinus Pain Gets FDA-Cleared

First-in-Class OTC Bioelectronic Device for Sinus Pain Gets FDA-Cleared

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Tivic Health Systems announced that ClearUP Sinus Pain Relief has been cleared by the Food and Drug Administration (FDA) for the treatment of sinus pain due to allergic rhinitis, or hay fever, in adults aged ≥18 years.

Exposure to Heat in Car May Decrease Epinephrine Concentration in Autoinjectors

Exposure to Heat in Car May Decrease Epinephrine Concentration in Autoinjectors

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In order to determine the effect of heat exposure on the concentration of adrenaline in EAIs, the study authors placed nine 0.3mg EpiPen Senior EAIs inside a parked car from 8:30 AM until 8:30 PM on a summer day.

Dapsone Efficacy Examined in Patients With Chronic Spontaneous Urticaria

Dapsone Efficacy Examined in Patients With Chronic Spontaneous Urticaria

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In order to assess the safety and efficacy of dapsone, a sulfone antibiotic, in the treatment of CSU, the study authors reviewed the medical records of 79 CSU patients treated with dapsone.

Common Ragweed Projected to Expand in Northeastern United States

Common Ragweed Projected to Expand in Northeastern United States

Based on global climate models, ragweed distribution may expand in the northeastern United States.

Eczema Mean Cumulative Lifetime Prevalence Is 9.9%

Eczema Mean Cumulative Lifetime Prevalence Is 9.9%

The highest rates of active disease were seen for children aged 0 to 17 years and older adults aged 75 to 99 years.

Limited Doses of FDA-Approved Epinephrine Generic Now Available

Limited Doses of FDA-Approved Epinephrine Generic Now Available

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The generic version of the EpiPen Jr (epinephrine injection, USP) 0.15mg as well as additional supply of the generic version of the EpiPen Auto-Injector 0.3mg will be made available in 2019.

Lanadelumab Reduces Attack Rate in Hereditary Angioedema

Lanadelumab Reduces Attack Rate in Hereditary Angioedema

Significant reduction in attack rate compared with placebo seen for 3 dose regimens of lanadelumab.

Telling Time by Asthma, Allergy Symptom Severity

Telling Time by Asthma, Allergy Symptom Severity

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Clinicians are gaining a better understanding of how asthma and allergies are regulated by the circadian clock, which will help patients better alleviate their symptoms.

Childhood Asthma, Wheezing Linked to Maternal Blood Pressure in Pregnancy

Childhood Asthma, Wheezing Linked to Maternal Blood Pressure in Pregnancy

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Consistent associations were observed per 5 mm Hg higher maternal blood pressures in early pregnancy with lower FEV1/FVC.

Food Allergy Prevalence Is 7.6% in US Children

Food Allergy Prevalence Is 7.6% in US Children

The most prevalent allergens are peanut, milk, shellfish, and tree nut.

Almost 2% of Children Have Milk Allergy

Almost 2% of Children Have Milk Allergy

Of the children with food allergy, 53% of infants have milk allergy vs 15% of teenagers.

AR101 May Protect Against Accidental Peanut Exposure

AR101 May Protect Against Accidental Peanut Exposure

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More than 67% of patients who received AR101 were able to ingest a dose of 600 mg or more of peanut protein at the exit food challenge, without dose-limiting symptoms

Increased Medication Burden for Patients With Both Asthma and Allergies

Increased Medication Burden for Patients With Both Asthma and Allergies

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Patients with both asthma and allergies had a significant increase in the number of prescriptions dispensed for controller medications.

Olopatadine/Mometasone Nasal Spray Reduces Seasonal Allergy Symptoms

Olopatadine/Mometasone Nasal Spray Reduces Seasonal Allergy Symptoms

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Patients who received olopatadine/mometasone either once or twice daily experienced significant improvements in their instantaneous Total Nasal Symptom Scores compared with placebo.

Short Interruption of House Dust Mite Immunotherapy Well Tolerated

Short Interruption of House Dust Mite Immunotherapy Well Tolerated

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Treatment reinitiation after a short interruption was well tolerated in patients taking standardized quality house mite sublingual immunotherapy tablets.

Eosinophilic Esophagitis Symptoms Reduced With Anti-Interleukin 13 Antibody

Eosinophilic Esophagitis Symptoms Reduced With Anti-Interleukin 13 Antibody

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Significantly greater reductions in the mean esophageal eosinophil counts occurred in patients who received the humanized anti-interleukin 13 antibody, RPC4046.

Increased Risk of Depression, Suicide in Atopic Dermatitis

Increased Risk of Depression, Suicide in Atopic Dermatitis

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The prevalence of depression in patients with atopic dermatitis was higher than in those without atopic dermatitis.

Upadacitinib Improves Pruritus in Moderate to Severe Atopic Dermatitis

Upadacitinib Improves Pruritus in Moderate to Severe Atopic Dermatitis

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Upadacitinib, a selective janus kinase-1 inhibitor, was associated with early improvements in pruritus in patients with moderate to severe atopic dermatitis.

Olopatadine/Mometasone Nasal Spray Effective for Perennial Allergic Rhinitis

Olopatadine/Mometasone Nasal Spray Effective for Perennial Allergic Rhinitis

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GSP301 treatment was associated with a significant improvement in reflective and instantaneous Total Nasal Symptom Scores compared with placebo.

GSP301 Nasal Spray Improves QoL Seasonal Allergic Rhinitis

GSP301 Nasal Spray Improves QoL Seasonal Allergic Rhinitis

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Patients who received a fixed-dose combination nasal spray showed significantly improved Physician-assessed Nasal Symptom Scores compared with those who received placebo.

Lanadelumab Well-Tolerated in Hereditary Angioedema

Lanadelumab Well-Tolerated in Hereditary Angioedema

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Patients with hereditary angioedema who received lanadelumab exhibited few cases of hypersensitivity and had low immunogenicity.

Grass Pollen Tablet AEs Spontaneously Resolve in Pediatric Allergic Rhinitis

Grass Pollen Tablet AEs Spontaneously Resolve in Pediatric Allergic Rhinitis

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Adverse drug reactions from the 300IR 5-grass pollen tablet occurred in approximately half of patients but typically resolved within a week of treatment.

Grass Pollen Tablet Approved for Younger Patients With Grass Pollen Allergy

Grass Pollen Tablet Approved for Younger Patients With Grass Pollen Allergy

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The FDA has approved the use of Oralair for the treatment of grass pollen-induced allergic rhinitis in pediatric patients aged 5-9.

Cetirizine Provides More Benefits for Acute Urticaria Than Diphenhydramine

Cetirizine Provides More Benefits for Acute Urticaria Than Diphenhydramine

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The change from baseline in 2-hour pruritus score was shown to be statistically noninferior from IV cetirizine to IV diphenhydramine, in favor of IV cetirizine.

Does Prearrival Epinephrine Adversely Affect Pediatric Anaphylaxis Patients?

Does Prearrival Epinephrine Adversely Affect Pediatric Anaphylaxis Patients?

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Despite many pediatric patients receiving higher than recommended doses of epinephrine for their weight, they did not present with epinephrine-related symptoms.

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