Better asthma control, as indicated by lower mean scores on the Asthma Control Questionnaire-5, were seen in both the dupilumab and placebo groups.
Several asthma and allergy groups expressed "deep concern" over the recent FDA approval of Primatene MIST.
The new inhalation delivery system no longer includes CFC. It contains hydrofluroalkane (HFA) propellants and also features a built-in spray indicator and metal canister, replacing the glass container seen with the original Primatene Mist.
Higher BMI in adults was related to an increase in moderate to severe upper respiratory infections.
The ACCI includes questions about changes in asthma status, perceptions of disease burden, emergency room visits and hospitalizations, steroid use, adherence to prescribed medications, and symptom frequency.
Paradoxical bronchoconstriction is an underrecognized adverse event that can occur with administration of β2-agonist-containing inhaler formulations.
The overall rate of asthma-COPD overlap was 3.8%, with a maximum prevalence of 7.8% in Matlab, Bangladesh.
The use of chest radiographs in children with asthma who complain of chest pain should be limited, according to a new study.
Children exposed to cats, dogs, goats, cockroaches, and rats while in utero were more likely to develop asthma.
Time-series analysis based on geographic location revealed positive significant associations between asthma and influenza hospitalizations in Brooklyn and Manhattan.
The majority of study participants had rhinitis at baseline, including perennial allergic rhinitis with seasonal exacerbations, which is the most severe phenotype.
Changing to bronchodilator treatment with a metered dose inhaler in patients with mild to moderate asthma resulted in lower hospitalization rates, shorter hospital stays, and a decrease in continuous use of albuterol.
The FDA has approved Dupixent as an add-on maintenance treatment in patients with moderate-to-severe asthma aged 12 years and older with an eosinophilic phenotype or with oral corticosteroid-dependent asthma.
Total serum bilirubin levels of 9 to 11.9 mg/dL, 12 to 14.9 mg/dL, and 15 to 17.9 mg/dL were associated with significantly greater risks for asthma in infants.
Childhood non-atopic rhinitis is associated with an increased risk for adult asthma.
Children with asthma had a 66% higher risk for incident obesity compared with children without asthma.
Bronchial thermoplasty reduced gas trapping in individuals with asthma, particularly in patients with severe disease.
Infants who presented with pulmonary symptoms when diagnosed with gastroesophageal reflux disease had a higher incidence of early onset asthma compared with infants who did not have pulmonary symptoms.
Adolescents with asthma treated with dupilumab experienced significant improvements in FEV1 compared with placebo.
Patients with moderate to severe persistent allergic asthma who were treated with omalizumab experienced greater improvements in lung function after 16 weeks compared with those treated with placebo.
Benralizumab was associated with a significant reduction in annual asthma exacerbation rates.
Montelukast plus levocetirizine demonstrated a significant reduction in mean daytime nasal symptom scores compared with montelukast monotherapy.
Disrupting regular combination inhaled corticosteroid therapy refills increased hospitalizations and exacerbations.
Black and Hispanic respondents with asthma were less likely to use complementary alternative medicine than their white counterparts.
Regardless of severity, when children's asthma was appropriately managed according to guidelines, they experienced significant improvements.
A higher number of acute respiratory infections before the age of 2 may increase the risk for asthma by age 7.
Lower exposure to Proteobacteria in umbilical cord serum was associated with an increased risk for childhood wheezing.
The most common error related to the use of metered dose inhalers was the failure to attach the inhaler to a spacer.
African-American adolescents with asthma had improved outcomes when they received a comprehensive treatment plan.
The PFS formulation eliminates the need to reconstitute the solution before administration.
For every 10-fold rise in methyl and propyl concentrations, there was a 2.61 and a 2.18 increased prevalence odds ratio, respectively, of reporting an emergency department visit in the last 12 months in boys with asthma.
Smoking cessation in patients with asthma is associated with reduced symptoms, improved lung function and quality of life, reduced use of rescue medications, improved airway hyperresponsiveness, and decreased hyperactivity.
PubMed was searched to obtain data on the relative efficacies of benralizumab, dupilumab, lebrikizumab, mepolizumab, reslizumab, and tralokinumab.
Cockroach and mouse allergies were most often associated with poorly controlled asthma and exacerbations in urban adolescents.
Children of East Asian-born parents had an increased risk for allergic rhinitis and aeroallergen sensitization compared with children of Caucasian ancestry.
Total omega-3 and omega-6 plasma polyunsaturated fatty acids relative abundances were significantly inversely correlated with asthma/recurrent wheeze and allergic sensitization.
Although allergic sensitization and hay fever rates increased as children grew older, the rates of asthma dropped.
Results from the extension trial showed a similar safety and tolerability profile for Fasenra as that seen in SIROCCO and CALIMA.
An increase was seen in asthma hospital visits with increasing ambient particulate matter in San Luis Valley.
The SYGMA trials assessed the use of an as-needed combined corticosteroid/beta-agonist inhaler in patients with mild asthma.
Currently, 3 anti-interleukin (IL)5 pathway-directed treatments (benralizumab, mepolizumab, reslizumab) have been approved by the Food and Drug Administration for the treatment of severe asthma with an eosinophilic phenotype.
In a population of primarily Latino children from low-income households, a program of school-supervised use of once-daily inhaled corticosteroids failed to improve asthma control.
Overall, 5 phenotypes were identified and differentiated mainly by patterns of wheezing and aeroallergen sensitization: low wheeze-low atopy, low wheeze-high atopy, transient wheeze-low atopy, high wheeze-low atopy, and high wheeze-high atopy.
Nasal expression of interleukin-10 showed an association with perceived stress burden, while perceived stress burden was strongly associated with asthma control score.
The designation was based on data from the Phase 2b PATHWAY trial that evaluated 3 doses of tezepelumab as add-on therapy in patients with a history of asthma exacerbations and uncontrolled asthma receiving inhaled corticosteroids/long-acting β-agonist with or without oral corticosteroids and additional asthma controllers vs placebo.
Significant negative correlations were seen between visceral fat area and bronchial lumen diameter and lumen area, and significant positive correlations were seen between subcutaneous fat area and bronchial wall area and total area.
A total of 8% of patients with asthma exacerbations met the criteria for diagnosing anaphylaxis, with 3.4% having likely experienced anaphylaxis.
African-American adolescents with asthma who took appropriate therapies had both decreased lung function and elevated blood lipid levels when exposed to short-term low ozone levels.
The risk of a mixing-up the treatments is especially high for pregnant women, says the Food and Drug Administration (FDA), as losartan is indicated to treat high blood pressure and could harm or kill a fetus.
Comorbid chronic rhinitis is significantly associated with 30-day hospital readmissions related to asthma and chronic obstructive pulmonary disease.
There is a significant relationship between attention deficit hyperactivity disorder and asthma.
Low-income urban preschoolers with asthma may not meet home medication readiness criteria.
In children who were symptomatic, small conducting airways ventilation inhomogeneity and alveolar nitric oxide concentration were both significantly associated with asthma exacerbations.
Adolescents who have asthma or allergic rhinitis may be at higher risk for developing migraine.
Pooled estimates from cohort studies suggested there was no association between antenatal blood vitamin D levels or vitamin D intake and asthma in offspring.
Combined tele-case management and tele-consultation was the most effective form of telemedicine for improving asthma control.
Use of labetalol vs other antihypertensives is linked to increased risk of status asthmaticus.
A high blood eosinophil count may increase the risk for a second asthma-related hospitalization within 1 year following an initial hospitalization.
Through Bluetooth technology, clinicians and patients will be able to share and monitor inhaler usage.
The authors write that once severe asthma is diagnosed, clinicians should determine asthma endotype (Type2-high or Type2-low) to help choose the best therapy for the patient.
Patients with severe asthma who are glucocorticoid dependent and treated with dupilumab for 24 weeks used significantly lower doses of glucocorticoids while maintaining asthmatic control compared with patients treated with placebo.
Children with asthma and/or wheeze who have a basophil level above 0.18% of the circulating peripheral blood mononuclear cell population have a higher risk for future exacerbations.
Socioeconomic and lifestyle risk factors had a more significant role in the development of COPD and asthma overlap syndrome in women than air pollution.
Asthma was not associated with a risk for intestinal resection surgery in patients with Crohn disease.
Electronic asthma action plans supported by text messaging services may improve control and reduce exacerbations.
Patients with aspirin-exacerbated respiratory disease had significantly lower levels of depression symptoms and higher quality of life compared with patients with asthma only.
Individuals with clinician-diagnosed asthma were at an estimated 38% higher risk for atrial fibrillation.
The Hailie sensor attaches to the asthma or chronic obstructive pulmonary disease (COPD) inhaler to monitor and help patient adherence.
Grass, other weeds, and unclassified pollen were significantly associated with increased risk for asthma hospitalization in young children.
Inhaling and smoking heroin and cocaine increase the risk for asthma exacerbations and decreased pulmonary function; marijuana is associated with wheezing, cough, and sputum production.
Sensitization to Aspergillus fumigatus increased the risk for severe asthma.
Combination therapy with a long-acting β2-agonist plus an inhaled glucocorticoid for asthma was not associated with a significantly higher risk for serious asthma-related events compared with an inhaled glucocorticoid alone.
Frequent asthma, bronchitis, allergy demonstrated the strongest association with , lower FEV1, lower FEV1/forced vital capacity, and increased risk for COPD.
Cytokines produced by mitogen-stimulated immune cells from pregnant women without asthma were shown to be associated with the development of asthma in their children.
The US Centers for Disease Control offers steps to minimize exposure to wildfire smoke, particularly for those with chronic conditions.
No associations were found between free concentration vitamin D3 levels and treatment failure or exacerbation rates in adults with asthma
The eFlow® nebulizer delivered CDP7766 without evidence of degradation, loss of potency, aggregation, or formation of particulates in a model of asthma in cynomolgus macaques.
Patients with severe asthma were more often current smokers at diagnosis and had higher body mass index at follow-up compared with patients with nonsevere asthma and anti-IL-5 therapy-eligible asthma.
Older adults with asthma and a greater desire for involvement in decision making have higher asthma-related quality of life.
Poor control of asthma and obstructive sleep apnea can feed off one another, according to Michelle Zeidler, MD, pulmonologist at the University of California, Los Angeles, and director of the UCLA Sleep Fellowship Program.
Children with the early-onset persistent bronchial hyperresponsiveness phenotype had the highest blood eosinophil count and total serum IgE levels as well as sensitization rates.
The mean rate of exacerbations declined significantly after 1 year of subcutaneous immunotherapy in children with moderate to severe allergic asthma exacerbations.
A hospital emergency department visit in the prior year was associated with subsequent asthma treatment failure.
Respiratory pathogens were associated with an increased risk for treatment failure in children with asthma exacerbations.
Tralokinumab did not have a significant effect on eosinophilic airway inflammation in moderate to severe asthma that was inadequately controlled on inhaled corticosteroids.
Identified viral pathogens were not associated with asthma exacerbation severity, but were linked to increased treatment failure.
A nasal immune-response pattern characterized by lower non-interferon antiviral immune response mediators and higher type 2 and type 17 cytokines was significantly associated with recurrent wheeze at 1 year.
In patients with mild asthma, use of the inhaled combined corticosteroid and beta agonist budesonide-formoterol as needed was superior to terbutaline as needed with respect to electronically recorded weeks of well-controlled asthma.
Women with a diagnosis of asthma may have a higher risk for preterm birth, and their infants may have an increased risk for perinatal mortality, low birth weight, fetal growth restriction, and asphyxia.
In patients with aspirin exacerbated respiratory disease, treatment with omalizumab resulted in "clinically silent" aspirin desensitization.
Budesonide-formoterol as needed was not inferior compared with budesonide maintenance therapy in terms of severe asthma exacerbation rates, but may be inferior for controlling symptoms.
E-cigarettes are the most commonly used product in middle and high school students with or without asthma.
There was a 60% lower rate of severe asthma exacerbations in individuals treated with budesonide-formoterol compared with individuals treated with terbutaline as needed.
Chemicals linked with endocrine disruption and asthma identified in hair products used by black women and children.
Researchers evaluated barrier dysfunction by exposing viral models to budesonide, montelukast, formoterol, or a combination.
Inhaled interferon-beta 1 a did not significantly reduce acute asthma exacerbations during respiratory viral infections.
Longer stay and higher costs were associated with antibiotic administration in adults hospitalized for an asthma exacerbation without documented evidence of a lung infection.
Inhaled corticosteroids for asthma dosed once daily in the evening appeared to offer some benefit in trough FEV1 and morning peak expiratory flow.
Investigators conducted a prospective survey to examine the association between asthma symptom severity and symptoms of depression and anxiety.
Overweight or obese children are more likely to develop new onset asthma compared with normal weight controls.