Cockroach and mouse allergies were most often associated with poorly controlled asthma and exacerbations in urban adolescents.
Children of East Asian-born parents had an increased risk for allergic rhinitis and aeroallergen sensitization compared with children of Caucasian ancestry.
Total omega-3 and omega-6 plasma polyunsaturated fatty acids relative abundances were significantly inversely correlated with asthma/recurrent wheeze and allergic sensitization.
Although allergic sensitization and hay fever rates increased as children grew older, the rates of asthma dropped.
Results from the extension trial showed a similar safety and tolerability profile for Fasenra as that seen in SIROCCO and CALIMA.
An increase was seen in asthma hospital visits with increasing ambient particulate matter in San Luis Valley.
The SYGMA trials assessed the use of an as-needed combined corticosteroid/beta-agonist inhaler in patients with mild asthma.
Currently, 3 anti-interleukin (IL)5 pathway-directed treatments (benralizumab, mepolizumab, reslizumab) have been approved by the Food and Drug Administration for the treatment of severe asthma with an eosinophilic phenotype.
In a population of primarily Latino children from low-income households, a program of school-supervised use of once-daily inhaled corticosteroids failed to improve asthma control.
Overall, 5 phenotypes were identified and differentiated mainly by patterns of wheezing and aeroallergen sensitization: low wheeze-low atopy, low wheeze-high atopy, transient wheeze-low atopy, high wheeze-low atopy, and high wheeze-high atopy.
Nasal expression of interleukin-10 showed an association with perceived stress burden, while perceived stress burden was strongly associated with asthma control score.
The designation was based on data from the Phase 2b PATHWAY trial that evaluated 3 doses of tezepelumab as add-on therapy in patients with a history of asthma exacerbations and uncontrolled asthma receiving inhaled corticosteroids/long-acting β-agonist with or without oral corticosteroids and additional asthma controllers vs placebo.
Significant negative correlations were seen between visceral fat area and bronchial lumen diameter and lumen area, and significant positive correlations were seen between subcutaneous fat area and bronchial wall area and total area.
A total of 8% of patients with asthma exacerbations met the criteria for diagnosing anaphylaxis, with 3.4% having likely experienced anaphylaxis.
African-American adolescents with asthma who took appropriate therapies had both decreased lung function and elevated blood lipid levels when exposed to short-term low ozone levels.
The risk of a mixing-up the treatments is especially high for pregnant women, says the Food and Drug Administration (FDA), as losartan is indicated to treat high blood pressure and could harm or kill a fetus.
Comorbid chronic rhinitis is significantly associated with 30-day hospital readmissions related to asthma and chronic obstructive pulmonary disease.
There is a significant relationship between attention deficit hyperactivity disorder and asthma.
Low-income urban preschoolers with asthma may not meet home medication readiness criteria.
In children who were symptomatic, small conducting airways ventilation inhomogeneity and alveolar nitric oxide concentration were both significantly associated with asthma exacerbations.
Adolescents who have asthma or allergic rhinitis may be at higher risk for developing migraine.
Pooled estimates from cohort studies suggested there was no association between antenatal blood vitamin D levels or vitamin D intake and asthma in offspring.
Combined tele-case management and tele-consultation was the most effective form of telemedicine for improving asthma control.
Use of labetalol vs other antihypertensives is linked to increased risk of status asthmaticus.
A high blood eosinophil count may increase the risk for a second asthma-related hospitalization within 1 year following an initial hospitalization.
Through Bluetooth technology, clinicians and patients will be able to share and monitor inhaler usage.
The authors write that once severe asthma is diagnosed, clinicians should determine asthma endotype (Type2-high or Type2-low) to help choose the best therapy for the patient.
Patients with severe asthma who are glucocorticoid dependent and treated with dupilumab for 24 weeks used significantly lower doses of glucocorticoids while maintaining asthmatic control compared with patients treated with placebo.
Children with asthma and/or wheeze who have a basophil level above 0.18% of the circulating peripheral blood mononuclear cell population have a higher risk for future exacerbations.
Socioeconomic and lifestyle risk factors had a more significant role in the development of COPD and asthma overlap syndrome in women than air pollution.
Asthma was not associated with a risk for intestinal resection surgery in patients with Crohn disease.
Electronic asthma action plans supported by text messaging services may improve control and reduce exacerbations.
Patients with aspirin-exacerbated respiratory disease had significantly lower levels of depression symptoms and higher quality of life compared with patients with asthma only.
Individuals with clinician-diagnosed asthma were at an estimated 38% higher risk for atrial fibrillation.
The Hailie sensor attaches to the asthma or chronic obstructive pulmonary disease (COPD) inhaler to monitor and help patient adherence.
Grass, other weeds, and unclassified pollen were significantly associated with increased risk for asthma hospitalization in young children.
Inhaling and smoking heroin and cocaine increase the risk for asthma exacerbations and decreased pulmonary function; marijuana is associated with wheezing, cough, and sputum production.
Sensitization to Aspergillus fumigatus increased the risk for severe asthma.
Combination therapy with a long-acting β2-agonist plus an inhaled glucocorticoid for asthma was not associated with a significantly higher risk for serious asthma-related events compared with an inhaled glucocorticoid alone.
Frequent asthma, bronchitis, allergy demonstrated the strongest association with , lower FEV1, lower FEV1/forced vital capacity, and increased risk for COPD.
Cytokines produced by mitogen-stimulated immune cells from pregnant women without asthma were shown to be associated with the development of asthma in their children.
The US Centers for Disease Control offers steps to minimize exposure to wildfire smoke, particularly for those with chronic conditions.
No associations were found between free concentration vitamin D3 levels and treatment failure or exacerbation rates in adults with asthma
The eFlow® nebulizer delivered CDP7766 without evidence of degradation, loss of potency, aggregation, or formation of particulates in a model of asthma in cynomolgus macaques.
Patients with severe asthma were more often current smokers at diagnosis and had higher body mass index at follow-up compared with patients with nonsevere asthma and anti-IL-5 therapy-eligible asthma.
Older adults with asthma and a greater desire for involvement in decision making have higher asthma-related quality of life.
Poor control of asthma and obstructive sleep apnea can feed off one another, according to Michelle Zeidler, MD, pulmonologist at the University of California, Los Angeles, and director of the UCLA Sleep Fellowship Program.
Children with the early-onset persistent bronchial hyperresponsiveness phenotype had the highest blood eosinophil count and total serum IgE levels as well as sensitization rates.
The mean rate of exacerbations declined significantly after 1 year of subcutaneous immunotherapy in children with moderate to severe allergic asthma exacerbations.
A hospital emergency department visit in the prior year was associated with subsequent asthma treatment failure.
Respiratory pathogens were associated with an increased risk for treatment failure in children with asthma exacerbations.
Tralokinumab did not have a significant effect on eosinophilic airway inflammation in moderate to severe asthma that was inadequately controlled on inhaled corticosteroids.
Identified viral pathogens were not associated with asthma exacerbation severity, but were linked to increased treatment failure.
A nasal immune-response pattern characterized by lower non-interferon antiviral immune response mediators and higher type 2 and type 17 cytokines was significantly associated with recurrent wheeze at 1 year.
In patients with mild asthma, use of the inhaled combined corticosteroid and beta agonist budesonide-formoterol as needed was superior to terbutaline as needed with respect to electronically recorded weeks of well-controlled asthma.
Women with a diagnosis of asthma may have a higher risk for preterm birth, and their infants may have an increased risk for perinatal mortality, low birth weight, fetal growth restriction, and asphyxia.
In patients with aspirin exacerbated respiratory disease, treatment with omalizumab resulted in "clinically silent" aspirin desensitization.
Budesonide-formoterol as needed was not inferior compared with budesonide maintenance therapy in terms of severe asthma exacerbation rates, but may be inferior for controlling symptoms.
E-cigarettes are the most commonly used product in middle and high school students with or without asthma.
There was a 60% lower rate of severe asthma exacerbations in individuals treated with budesonide-formoterol compared with individuals treated with terbutaline as needed.
Chemicals linked with endocrine disruption and asthma identified in hair products used by black women and children.
Researchers evaluated barrier dysfunction by exposing viral models to budesonide, montelukast, formoterol, or a combination.
Inhaled interferon-beta 1 a did not significantly reduce acute asthma exacerbations during respiratory viral infections.
Longer stay and higher costs were associated with antibiotic administration in adults hospitalized for an asthma exacerbation without documented evidence of a lung infection.
Inhaled corticosteroids for asthma dosed once daily in the evening appeared to offer some benefit in trough FEV1 and morning peak expiratory flow.
Investigators conducted a prospective survey to examine the association between asthma symptom severity and symptoms of depression and anxiety.
Overweight or obese children are more likely to develop new onset asthma compared with normal weight controls.
Researchers examined the association of timing, frequency, and class of antibiotic use during pregnancy on the development of childhood asthma.
Sertraline does not prove to be beneficial for relief of chronic breathlessness.
Subcutaneous dupilumab significantly reduced the use of oral corticosteroids in patients with corticosteroid-dependent severe asthma.
Peak expiratory flow increases were greater with benralizumab than placebo in patients with severe eosinophilic asthma.
Oral contraceptive use in women of reproductive age may increase the risk for lifetime asthma.
In individuals with asthma and vitamin D deficiency, vitamin D supplementation improved asthma control.
While macrolides had no direct effect on lung function, their use significantly improved asthma control and quality of life in patients with asthma.
The study authors examined data obtained from the 2007-2008 National Survey of Children's Health (NSCH) to determine the prevalence, risk factors, as well as the severity of asthma phenotypes.
The study authors reported, "The most commonly reported problems by youth were: (a) hard to remember when to take the asthma medication (54%) and (b) hard to use asthma medication at school (34%)."
Of the total 573 APFS dispensed, 1 malfunctioned and 1 was considered nonfunctional because it was not returned. The study authors also reported that patient-use error only led to 2 unsuccessful at-home administrations.
The study aimed to determine the association between ICS therapy adherence and the occurrence of asthma exacerbations in patients with high blood eosinophil levels.
The positive association between type 2 biomarkers and severe exacerbations in severe refractory asthma may not extend to mild to moderate asthma.
Children living in neighborhoods with low walkability are at increased risk of asthma.
Emerging guidelines for diagnosing and treating asthma COPD overlap syndrome will help clinicians better manage patients and prevent serious adverse effects.
Physician asthma care education Plus training resulted in improvements in provider confidence, perceived skill in communicating cross culturally, and short-term asthma-specific outcomes.
An asthma care program improved implementation of guidelines as well as provider documentation in 65 community centers in 4 states that serve patients with asthma.
Patients with severe asthma who were current smokers were distinguishable from ex-smokers based on their sputum proteomic level of colony stimulating factor 2.
Children with status asthmaticus who received magnesium sulfate therapy were on continuous albuterol for a longer duration.
Asthma and COPD overlap linked to higher prevalence of sleep-related symptoms, including difficulty falling asleep and maintaining sleep, early-morning awakening, and excessive daytime sleepiness.
Early child care attendance increased the risk for wheeze in children ≤2 years of age but decreased the risk for asthma in children 3 to 5 years of age.
Statins have anti-inflammatory and anti-oxidative effects, which could reduce exacerbations of both asthma and chronic obstructive pulmonary disease.
A childhood measles infection may increase the risk for post-bronchodilator airflow obstruction in middle-age adults via its interaction with asthma and smoking.
Preterm-born children had significantly more frequent preschool wheeze compared with children born at term.
No significant benefit of long-acting muscarinic antagonists over long-acting beta-agonists in reducing exacerbation risk in uncontrolled, persistent asthma
Adjunct long-acting muscarinic antagonist (LAMA) use with corticosteroids was associated with reduced exacerbation risk compared with placebo in patients with uncontrolled, persistent asthma. However, LAMA, long-acting beta-agonist (LABA), and inhaled corticosteroids (triple therapy) were not associated with lower risk for exacerbations compared with LABA and inhaled corticosteroids alone.
In patients with persistent asthma, single maintenance and reliever therapy was associated with a lower risk for exacerbations compared with inhaled corticosteroids as controller therapy and short-acting beta-agonists as relief therapy.
Regardless of blood eosinophil count, omalizumab was an effective treatment in adult and pediatric patients with severe allergic asthma.
Researchers identified 6 distinct FEV1 lung function trajectories, 3 of which were responsible for 75% of the COPD burden.
Findings for subsequent allergic disease following infant exposure in the first six months of life.
Patients with asthma or chronic obstructive pulmonary disease have especially high rates of nonadherence, even in comparison with other chronic diseases.
In children with allergic asthma, SCIT may reduce long-term asthma medication use.
The Smartinhaler sensor is a device installed onto a patient's inhaler to monitor and promote asthma and COPD medication adherence.
Long-acting muscarinic antagonists or long-acting β-agonists plus inhaled corticosteroids lowered the risk for asthma exacerbations vs adjuvant placebo.
Prenatal and early life stress, including societal stress, have been implicated in the development of asthma and other allergic diseases in children.