The eFlow® nebulizer delivered CDP7766 without evidence of degradation, loss of potency, aggregation, or formation of particulates in a model of asthma in cynomolgus macaques.
Patients with severe asthma were more often current smokers at diagnosis and had higher body mass index at follow-up compared with patients with nonsevere asthma and anti-IL-5 therapy-eligible asthma.
Older adults with asthma and a greater desire for involvement in decision making have higher asthma-related quality of life.
Poor control of asthma and obstructive sleep apnea can feed off one another, according to Michelle Zeidler, MD, pulmonologist at the University of California, Los Angeles, and director of the UCLA Sleep Fellowship Program.
Children with the early-onset persistent bronchial hyperresponsiveness phenotype had the highest blood eosinophil count and total serum IgE levels as well as sensitization rates.
The mean rate of exacerbations declined significantly after 1 year of subcutaneous immunotherapy in children with moderate to severe allergic asthma exacerbations.
A hospital emergency department visit in the prior year was associated with subsequent asthma treatment failure.
Respiratory pathogens were associated with an increased risk for treatment failure in children with asthma exacerbations.
Tralokinumab did not have a significant effect on eosinophilic airway inflammation in moderate to severe asthma that was inadequately controlled on inhaled corticosteroids.
Identified viral pathogens were not associated with asthma exacerbation severity, but were linked to increased treatment failure.
A nasal immune-response pattern characterized by lower non-interferon antiviral immune response mediators and higher type 2 and type 17 cytokines was significantly associated with recurrent wheeze at 1 year.
In patients with mild asthma, use of the inhaled combined corticosteroid and beta agonist budesonide-formoterol as needed was superior to terbutaline as needed with respect to electronically recorded weeks of well-controlled asthma.
Women with a diagnosis of asthma may have a higher risk for preterm birth, and their infants may have an increased risk for perinatal mortality, low birth weight, fetal growth restriction, and asphyxia.
In patients with aspirin exacerbated respiratory disease, treatment with omalizumab resulted in "clinically silent" aspirin desensitization.
Budesonide-formoterol as needed was not inferior compared with budesonide maintenance therapy in terms of severe asthma exacerbation rates, but may be inferior for controlling symptoms.
E-cigarettes are the most commonly used product in middle and high school students with or without asthma.
There was a 60% lower rate of severe asthma exacerbations in individuals treated with budesonide-formoterol compared with individuals treated with terbutaline as needed.
Chemicals linked with endocrine disruption and asthma identified in hair products used by black women and children.
Researchers evaluated barrier dysfunction by exposing viral models to budesonide, montelukast, formoterol, or a combination.
Inhaled interferon-beta 1 a did not significantly reduce acute asthma exacerbations during respiratory viral infections.
Longer stay and higher costs were associated with antibiotic administration in adults hospitalized for an asthma exacerbation without documented evidence of a lung infection.
Inhaled corticosteroids for asthma dosed once daily in the evening appeared to offer some benefit in trough FEV1 and morning peak expiratory flow.
Investigators conducted a prospective survey to examine the association between asthma symptom severity and symptoms of depression and anxiety.
Overweight or obese children are more likely to develop new onset asthma compared with normal weight controls.
Researchers examined the association of timing, frequency, and class of antibiotic use during pregnancy on the development of childhood asthma.
Sertraline does not prove to be beneficial for relief of chronic breathlessness.
Subcutaneous dupilumab significantly reduced the use of oral corticosteroids in patients with corticosteroid-dependent severe asthma.
Peak expiratory flow increases were greater with benralizumab than placebo in patients with severe eosinophilic asthma.
Oral contraceptive use in women of reproductive age may increase the risk for lifetime asthma.
In individuals with asthma and vitamin D deficiency, vitamin D supplementation improved asthma control.
While macrolides had no direct effect on lung function, their use significantly improved asthma control and quality of life in patients with asthma.
The study authors examined data obtained from the 2007-2008 National Survey of Children's Health (NSCH) to determine the prevalence, risk factors, as well as the severity of asthma phenotypes.
The study authors reported, "The most commonly reported problems by youth were: (a) hard to remember when to take the asthma medication (54%) and (b) hard to use asthma medication at school (34%)."
Of the total 573 APFS dispensed, 1 malfunctioned and 1 was considered nonfunctional because it was not returned. The study authors also reported that patient-use error only led to 2 unsuccessful at-home administrations.
The study aimed to determine the association between ICS therapy adherence and the occurrence of asthma exacerbations in patients with high blood eosinophil levels.
The positive association between type 2 biomarkers and severe exacerbations in severe refractory asthma may not extend to mild to moderate asthma.
Children living in neighborhoods with low walkability are at increased risk of asthma.
Emerging guidelines for diagnosing and treating asthma COPD overlap syndrome will help clinicians better manage patients and prevent serious adverse effects.
Physician asthma care education Plus training resulted in improvements in provider confidence, perceived skill in communicating cross culturally, and short-term asthma-specific outcomes.
An asthma care program improved implementation of guidelines as well as provider documentation in 65 community centers in 4 states that serve patients with asthma.
Patients with severe asthma who were current smokers were distinguishable from ex-smokers based on their sputum proteomic level of colony stimulating factor 2.
Children with status asthmaticus who received magnesium sulfate therapy were on continuous albuterol for a longer duration.
Asthma and COPD overlap linked to higher prevalence of sleep-related symptoms, including difficulty falling asleep and maintaining sleep, early-morning awakening, and excessive daytime sleepiness.
Early child care attendance increased the risk for wheeze in children ≤2 years of age but decreased the risk for asthma in children 3 to 5 years of age.
Statins have anti-inflammatory and anti-oxidative effects, which could reduce exacerbations of both asthma and chronic obstructive pulmonary disease.
A childhood measles infection may increase the risk for post-bronchodilator airflow obstruction in middle-age adults via its interaction with asthma and smoking.
Preterm-born children had significantly more frequent preschool wheeze compared with children born at term.
No significant benefit of long-acting muscarinic antagonists over long-acting beta-agonists in reducing exacerbation risk in uncontrolled, persistent asthma
Adjunct long-acting muscarinic antagonist (LAMA) use with corticosteroids was associated with reduced exacerbation risk compared with placebo in patients with uncontrolled, persistent asthma. However, LAMA, long-acting beta-agonist (LABA), and inhaled corticosteroids (triple therapy) were not associated with lower risk for exacerbations compared with LABA and inhaled corticosteroids alone.
In patients with persistent asthma, single maintenance and reliever therapy was associated with a lower risk for exacerbations compared with inhaled corticosteroids as controller therapy and short-acting beta-agonists as relief therapy.
Regardless of blood eosinophil count, omalizumab was an effective treatment in adult and pediatric patients with severe allergic asthma.
Researchers identified 6 distinct FEV1 lung function trajectories, 3 of which were responsible for 75% of the COPD burden.
Findings for subsequent allergic disease following infant exposure in the first six months of life.
Patients with asthma or chronic obstructive pulmonary disease have especially high rates of nonadherence, even in comparison with other chronic diseases.
In children with allergic asthma, SCIT may reduce long-term asthma medication use.
The Smartinhaler sensor is a device installed onto a patient's inhaler to monitor and promote asthma and COPD medication adherence.
Long-acting muscarinic antagonists or long-acting β-agonists plus inhaled corticosteroids lowered the risk for asthma exacerbations vs adjuvant placebo.
Prenatal and early life stress, including societal stress, have been implicated in the development of asthma and other allergic diseases in children.
In children aged 5 to 11 years with mild to moderate persistent asthma who were treated with daily inhaled glucocorticoids, quintupling the dose during the initial signs of worsening asthma control did not reduce the rate of severe exacerbations.
Current tobacco smoke exposure is not associated with airflow obstruction in school-aged children, but prenatal smoking is associated with airflow obstruction in children with asthma.
Bronchial thermoplasty can treat severe asthmatic cough that is unresponsive to conventional therapies.
Smokers and nonsmokers had similar symptoms and risk factors present for asthma, but differed in comorbidities.
According to a systematic literature review, there was inconclusive evidence that single indoor allergen interventions were effective at improving asthma outcomes.
Short-acting beta-agonists for asthma management may reduce fertility rates in women with asthma.
When patients visiting an allergy/immunology outpatient clinic had expectations met regarding diagnosis and testing, they were more likely to be satisfied with their visit.
Spirometry may be underused for the diagnosis and monitoring of asthma in the primary care setting.
Fractional exhaled nitric oxide, periostin, and eosinophils may help identify patients at increased risk for severe asthma exacerbations, according to a post hoc analysis of a phase 2b trial on dupilumab.
Children diagnosed with eczema before the age of 2 years may be at increased risk for early-onset asthma.
Children with asthma who experience chronic oral glucocorticoid exposure may have significant morbidities, including adrenal suppression, recurrent pneumonia, and behavioral problems.
Patients with opioid dependence or abuse may exhibit a higher prevalence of asthma compared with the general population.
Tiotropium, when added to standard asthma maintenance therapy, improves lung function in adult patients with symptomatic asthma regardless of GINA asthma severity.
Researchers examined real-world characteristics of patients receiving albuterol multidose dry powder inhaler or short-acting β2 agonists with short-acting β2 agonists for asthma and chronic obstructive pulmonary disease.
Episodically treating children with recurrent wheezing with inhaled combined salmeterol/fluticasone propionate may be as effective as a daily inhaled fluticasone propionate regimen.
Mepolizumab may be effective in patients with asthma that does not respond to omalizumab.
Researchers investigated whether intravenous reslizumab, a humanized anti-interleukin-5 monoclonal antibody, could aid in the management of asthma and eosinophilia.
Researchers assessed pooled randomized clinical trial data (NAVIGATE I and II; N5641) to examine the change in SF-36v2 and SF-6D from baseline to the end of double blind and to the end of the studies.
Researchers assessed whether the administration of dupilumab improves signs and symptoms of atopic dermatitis in patients with or without comorbid asthma.
A meta-analysis sought to determine whether prebiotics and probiotics improved the immunogenicity of the flu vaccine in adults.
Children who had both parental and sibling asthma in their families had an increased risk for asthma.
Reslizumab reduced the risk for exacerbations and improved lung function in patients with severe eosinophilic asthma.
Children who had both parental and sibling asthma in their families had an increased risk for asthma.
Children with mild to moderate persistent asthma were not more effectively treated with a quintupled dose of inhaled glucocorticoids.
Children who are exposed to antibiotics earlier in life may have an increased risk for allergic diseases, including asthma, atopic dermatitis, and allergic rhinitis.
Tezepelumab improved asthma control in patients with severe or uncontrolled asthma.
A post-hoc pooled analysis of phase 3 SIROCCO and CALIMA trials demonstrated benralizumab to be effective in the treatment of individuals with severe, uncontrolled eosinophilic asthma and nasal polyps.
Researchers assessed the use of dupilumab in adults with chronic rhinosinusitis and nasal polyps who did not respond to treatment with intranasal corticosteroids.
Intranasal corticosteroids are the current guideline-preferred treatment recommendation for nasal congestion.
Data from the Isle of Wight birth cohort study and the Kuwait University Allergy cross-sectional study were used to assess self-reported acetaminophen use and asthma diagnosis.
A cohort from the CANDLE study was assessed to determine if race plays a role in the protective effect of maternal vitamin D levels on childhood asthma.
Researchers performed a literature review and summarized the evidence regarding adverse events associated with the use of inhaled corticosteroids in individuals with asthma.
A first look at what will be presented at the 2018 Joint Congress of the American Academy of Allergy, Asthma & Immunology and the World Allergy Organization.
The dietary inflammatory index was used to examine the risk for current wheeze with a proinflammatory diet in adults and children.
Researchers evaluated whether duration of breastfeeding was associated with a modified risk for asthma development in children.
Although adherence to asthma guidelines tended to be higher in specialists, both specialists and primary care physicians had low adherence to specific core recommendations.
While there is currently no cure for asthma, treatments are effective at providing symptom relief.
Maternal prenatal and early childhood intake of sugar-sweetened beverages and fructose is associated with current asthma in midchildhood.
Children who received oral prednisolone vs placebo for virus-associated wheeze had a shorter length of hospital stay.
Prednisolone may be a more effective treatment in individuals with acute allergic bronchopulmonary aspergillosis complicated asthma, but with more adverse effects compared with itraconazole.
Researchers found that tiotropium was safe and may reduce the risk for exacerbations in young children with asthma.
A 55-year-old man with asthma presents to the emergency department with dyspnea at rest and electrocardiogram findings suggest a prior myocardial infarction.
Timing of birth may increase risk for asthma or atopic dermatitis.