Bradley van Paridon

Researchers examined duration of viral RNA shedding and viable virus shedding of SARS-CoV-2 in body fluids and compared SARS-CoV-2, SARS-CoV, and MERS-CoV viral dynamics.

Investigators assessed whether interleukin-6 inhibitors reduced the odds of in-hospital COVID-related mortality.

Investigators examined whether brensocatib reduces incidence of exacerbations of bronchiectasis, reduces rate of exacerbations, or changes the concentration of active neutrophil in the sputum from baseline.

Intensive health surveillance of close contracts of patients with COVID-19 provided a rare opportunity to determine asymptomatic attack rates and SARS-CoV-2 transmission risk factors.

One reason for the lack of antiviral therapies for COVID-19 is the paucity of knowledge about the β-Coronavirus-host cell interface, until now.

This detailed description of an institutional response to the COVID-19 pandemic in NYC highlights approaches that can be applied to help other hospitals plan for surges.

Study authors evaluated the performance of symptom-based definitions to detect influenza in a cohort of pregnant women in India, Peru, and Thailand.

Study authors analyzed microbiological data on COVID-19 patients to assess for bacterial co-infections associated with antimicrobial therapy.

Study authors assessed the association of piperacillin/tazobactam MIC, meropenem MIC, and beta-lactam resistance genes with mortality in the MERINO trial.

Study authors evaluated whether use of aspirin in hospitalized patients with COVID-19 was associated with reduced risk of mechanical ventilation, reduced risk for intensive care unit admission, and in-hospital mortality.

To facilitate harmonized evaluation and comparison of the efficacy of COVID-19 vaccines, study authors proposed a general set of clinical endpoints, along with considerations to guide the selection of primary endpoints.

Study authors assessed the effectiveness of high-dose influenza vaccines in patients with HIV during the 2017-2018 influenza season.

Study authors described the prescribing patterns in children with community-acquired pneumonia, and assessed the relationship between narrow-spectrum antibiotics, broad-spectrum antibiotics, and macrolides with clinical outcomes.

Investigators compared the clinical course, risk factors, and outcomes of cancer patients with COVID-19 with non-cancer patients with COVID-19.

Study authors assessed the specificity and positive predictive value of a customized, institutional, early warning score for predicting decompensation in COVID-19 patients.

Study authors conducted a multinational meta-analysis in SARS-CoV-2 patients to assess the risk of stroke relative to the general population and to identify risk factors of stroke.

The effect of therapeutic anticoagulation with enoxaparin vs prophylactic anticoagulation with unfractionated heparin was assessed in severe COVID-19 patients.

SARS-CoV-2 isolates from patients in Los Angeles, California, to isolates that originated from Europe and compared Los Angeles strains with strain distributions found in New York City, Washington state, and China were compared.

Study authors assessed the relationship between children living in contact with sputum smear-positive tuberculosis patients on DOTS and children getting infected with tuberculosis or tubercular infection.

Researchers evaluated prevalence of and sociodemographic disparities in influenza vaccination among individuals with ASCVD.

Researchers identified a prognostic BAS2IC score to assist physicians in identifying patients at high-risk of developing early severe COVID-19.

Levels of immunoglobulin G antibodies against nucleocapsid, the spike protein, and the receptor binding domain were related to viral clearance.

Neutrophil-to-lymphocyte ratio may be a valuable biomarker to help clinicians recognize severe COVID-19 infection with moderate to severe ARDS.

At a skilled nursing facility in Massachusetts, researchers found an 85% prevalence of the SARS-CoV-2 virus among asymptomatic facility residents.

Study results may provide guidance for healthcare policy and pandemic management at a selective, local level.

New clinical practice guidelines for the treatment of nontuberculous mycobacterial pulmonary disease were published by leading respiratory medicine and infectious disease societies.

Despite treatment with antiretroviral therapies, people with HIV may be more likely to experience severe manifestations of COVID-19.

A team of investigators assessed clinical outcomes among patients with COVID-19 receiving ibuprofen for fever reduction.

A team of investigators report on the findings from a randomized controlled trial of 3 enhanced influenza vaccines and a standard-dose vaccine in older adults.

As heart transplant recipients may be at increased risk for infection with COVID-19, investigators sought to identify characteristics, treatment, and outcomes of this patient population.