Elizabeth M. Van Cott

All articles by Elizabeth M. Van Cott

Factor XIII Deficiency – Acquired

At a Glance Severe acquired factor XIII deficiency is very rare and can be caused by a factor XIII auto-antibody (inhibitor). There have been at least 36 cases of factor XIII inhibitors reported, with additional cases that have not been published. A factor XIII inhibitor can be considered in a patient who develops a severe,…

Factor XIII Deficiency – Congenital

At a Glance Hereditary factor XIII deficiency can be considered in a patient with delayed bleeding after minor trauma in whom more common etiologies have been excluded. Hereditary factor XIII deficiency is rare, affecting 1 in 2-5 million persons. Umbilical stump bleeding as a newborn is a characteristic feature. The risk for spontaneous intracranial hemorrhage…

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