Tracy Minichiello

Venous hypercoagulability I. Problem/Condition. A wide range of conditions can create a hypercoagulable environment that increases the likelihood of forming clinically significant venous thromboembolism (VTE). Risk increases in the setting of a variety of inherited and acquired conditions collectively referred to as thrombophilias, some of which increase the risk of both venous and arterial clotting.…

Antiphospholipid antibody syndrome (APS), also known as Hughes syndrome, is an acquired autoimmune thrombotic disorder characterized by venous and/or arterial thrombosis or obstetrical complications. Although the exact pathophysiology is not known, the antiphospholipid antibodies are thought to activate endothelial cells, monocytes and platelets resulting in increased synthesis of tissue factor and thromboxane A2 causing thrombosis…