Chronic Obstructive Pulmonary Disease (COPD)

3D Super Clusters in COPD Could Affect Adjacent Healthy Tissue

3D Super Clusters in COPD Could Affect Adjacent Healthy Tissue

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Three-dimensional "super clusters" in patients with COPD could play a role in the progression of COPD to emphysema.

Once-Daily, Nebulized Bronchodilator Approved for COPD Treatment

Once-Daily, Nebulized Bronchodilator Approved for COPD Treatment

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The FDA has approved Yupelri inhalation solution for the maintenance treatment of patients with COPD.

Elevated Tuberculosis Risk in Inhaled Corticosteroid Users

Elevated Tuberculosis Risk in Inhaled Corticosteroid Users

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There may an increased risk for tuberculosis in patients with COPD within 3 years of inhaled corticosteroid use.

Asthma-COPD Overlap Prevalence, Severity in Low- and Middle-Income Countries

Asthma-COPD Overlap Prevalence, Severity in Low- and Middle-Income Countries

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The overall rate of asthma-COPD overlap was 3.8%, with a maximum prevalence of 7.8% in Matlab, Bangladesh.

Half of COPD Inhaler Use Does Not Align With GOLD Recommendations

Half of COPD Inhaler Use Does Not Align With GOLD Recommendations

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Half of patients with COPD report use of inhaler medications that are not in alignment with the current treatment recommendations.

Oxygen-Driven vs Air-Driven Nebulizers for COPD Exacerbations

Oxygen-Driven vs Air-Driven Nebulizers for COPD Exacerbations

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Air-driven bronchodilator nebulization is preferable to oxygen-driven nebulization in patients experiencing acute COPD exacerbations.

COPD May Predict Complications in Percutaneous Coronary Interventions

COPD May Predict Complications in Percutaneous Coronary Interventions

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The increased occurrence of periprocedural complications in patients with COPD was largely attributed to cardiac arrest, myocardial infarctions, and no-reflows.

Albuminuria Associated With Lung Function Decline in COPD

Albuminuria Associated With Lung Function Decline in COPD

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Albuminuria was associated with greater lung function decline in patients with chronic obstructive pulmonary disease.

CFTR Dysfunction Likely Associated With Worsened Airway Disease in Smokers

CFTR Dysfunction Likely Associated With Worsened Airway Disease in Smokers

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Cystic fibrosis transmembrane conductance regulator dysfunction is associated with worsened airway disease in patients with COPD.

COPD Mortality Does Not Increase From Long-Term Use of Benzodiazepines

COPD Mortality Does Not Increase From Long-Term Use of Benzodiazepines

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No difference in mortality, but there may be an elevated risk for suicide with long-term benzodiazepine use in patients with COPD and comorbid PTSD.

Effects of Testosterone Replacement Therapy in Men With COPD

Effects of Testosterone Replacement Therapy in Men With COPD

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Middle-aged testosterone replacement therapy users with COPD had a greater reduction in hospitalizations compared with nonusers.

Early Pulmonary Rehabilitation Lowers Mortality After COPD Exacerbation

Early Pulmonary Rehabilitation Lowers Mortality After COPD Exacerbation

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Early pulmonary rehabilitation after hospitalization for an acute exacerbation of COPD was an effective intervention for reducing mortality.

Tiotropium Bromide and Olodaterol Labeling Updated With Revised Indication

Tiotropium Bromide and Olodaterol Labeling Updated With Revised Indication

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The FDA has approved updated labeling for Stiolto Respimat to include COPD exacerbation data and a revised indication.

Hospital Readmissions Reduced for COPD With Discharge Care Bundle

Hospital Readmissions Reduced for COPD With Discharge Care Bundle

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Patients who received a discharge care bundle after being hospitalized for an acute exacerbation of COPD had a lower rate of readmission.

Opioid Use Increases Likelihood of Intubation in COPD

Opioid Use Increases Likelihood of Intubation in COPD

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Patients with chronic obstructive pulmonary disease who used opioids were more likely to be intubated during their hospitalization compared with nonopioid users

Beta-Blockers Safe in COPD With Cardiovascular Comorbidities

Beta-Blockers Safe in COPD With Cardiovascular Comorbidities

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There was a trend toward a reduction in mortality in patients with COPD who received beta-blocker treatment compared with patients who did not.

Aclidinium Reduced Rate of COPD Exacerbations Regardless of CV Risk

Aclidinium Reduced Rate of COPD Exacerbations Regardless of CV Risk

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Major cardiovascular adverse events were more common in the previous event subgroup, with 5.5% occurring in the aclidinium group and 6.2% in the placebo group.

Improved Exercise Capacity in COPD With Automatic Oxygen Titration

Improved Exercise Capacity in COPD With Automatic Oxygen Titration

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Patients with severe COPD improved significantly in both endurance time and walking distance with the use of automatically titrated oxygen flow vs constant oxygen flow.

Prophylactic Antibiotics Reduce COPD Exacerbations in Stable Disease

Prophylactic Antibiotics Reduce COPD Exacerbations in Stable Disease

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Treatment with prophylactic antibiotics was associated with a reduction in the frequency of COPD exacerbations and improved quality of life.

COPD, ILD Do Not Benefit More From Bilateral Transplantation Only Listing

COPD, ILD Do Not Benefit More From Bilateral Transplantation Only Listing

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No meaningful associations were detected in procedural listing preferences and survival outcomes in patients with COPD or interstitial lung disease awaiting lung transplant.

Adipose Tissue Transfer, Lung Scaffolds: The Future of Stem Cells in COPD

Adipose Tissue Transfer, Lung Scaffolds: The Future of Stem Cells in COPD

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Clinicians are eager for new therapies to address the damage to airways and lung parenchyma because no current therapy can completely reverse COPD damage.

Urban Training™ Efficacious in Increasing Physical Activity in COPD

Urban Training™ Efficacious in Increasing Physical Activity in COPD

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After 12 months, patients in the Urban Training™ group had increased their number of daily steps by 816 compared with 64 steps in the usual care group.

RPL554 Combined With LABAs or LAMAs Increases Bronchodilation in COPD

RPL554 Combined With LABAs or LAMAs Increases Bronchodilation in COPD

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Additional bronchodilation and hyperinflation reduction occurred in COPD when RPL554, an inhaled PDE 3 and 4 inhibitor, was combined with standard bronchodilators.

Climate Change: Dire Implications for Respiratory Conditions

Climate Change: Dire Implications for Respiratory Conditions

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Changing pollination patterns, extreme weather events, rising sea levels, air pollution, and extreme temperatures all negatively affect respiratory conditions.

ICS/LABA Combined in One Inhaler vs LAMA Compared for Efficacy, Safety in COPD

ICS/LABA Combined in One Inhaler vs LAMA Compared for Efficacy, Safety in COPD

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There were no statistically significant differences in mortality rates, rates of COPD exacerbations, lung inflammation, or serious adverse events between a once-daily combined inhaled corticosteroid/LABA and LAMA.

Combining COPD Screening and Community Drug Services Benefits Heroin Smokers

Combining COPD Screening and Community Drug Services Benefits Heroin Smokers

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A total of 35% of heroin smokers screened positive for COPD.

Revefenacin Cuts COPD Exacerbation Rates in Phase 3 Studies

Revefenacin Cuts COPD Exacerbation Rates in Phase 3 Studies

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Pooled data from two identical 12-week pivotal Phase 3 trials (N=1229) in patients with moderate to very severe COPD showed that the mean annualized rate of all COPD exacerbations was 0.47, 0.45, and 0.55 for revefenacin 175mcg/day, 88mcg/day, and placebo, respectively.

Small Reduction in Lung Function With Treatment De-Escalation in COPD

Small Reduction in Lung Function With Treatment De-Escalation in COPD

No difference in exacerbations with indacaterol/glycopyrronium for non-frequently exacerbating COPD.

New Bronchoscopic Option Used for Severe Emphysema

New Bronchoscopic Option Used for Severe Emphysema

First bronchoscopic lung volume reduction using endobronchial valve performed at Temple University in Philadelphia, PA.

FDA: More Data Required to Support Mepolizumab Approval for COPD

FDA: More Data Required to Support Mepolizumab Approval for COPD

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In their Complete Response Letter, the FDA stated that they require more clinical data to support approval.

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