Pharmacological Effects of Alcohol with Medications

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PHARMACOLOGICAL EFFECTS OF ALCOHOL WITH MEDICATIONS
Generic Brand Potential Reactions
ALLERGIES/COLD/FLU
brompheniramine Dimetapp Cold & Allergy Drowsiness, dizziness, increased risk for overdose
cetirizine Zyrtec
chlorpheniramine Sudafed Sinus & Allergy, Triaminic Cold & Allergy, Tylenol Allergy Sinus, Tylenol Cold & Flu
desloratadine Clarinex
diphenhydramine Benadryl
hydroxyzine
loratadine Alavert, Claritin, Claritin‑D
ANGINA
isosorbide Isordil Rapid heartbeat, sudden changes in blood pressure, dizziness, fainting
nitroglycerin Nitrostat, Nitro‑Bid
ANXIETY/EPILEPSY
alprazolam Xanax Drowsiness, dizziness, increased risk for overdose, slowed or difficulty breathing, impaired motor control, unusual behavior, memory problems
buspirone
clonazepam Klonopin
chlordiazepoxide Librium
diazepam Valium
lorazepam Ativan
paroxetine Paxil
herbal
preparations
Kava Kava Liver damage, drowsiness
ARTHRITIS
celecoxib Celebrex Ulcers, stomach bleeding, liver damage
diclofenac Voltaren
naproxen Naprosyn
ATTENTION AND CONCENTRATION (ADHD)
amphetamine/dextroamphetamine Adderall XR Dizziness, drowsiness, impaired concentration (methylphenidate, dexmethylphenidate); possible increased risk for heart problems (amphetamine, dextroamphetamine, lisdexamfetamine); liver damage (atomoxetine)
atomoxetine Strattera
dexmethylphenidate Focalin
dextroamphetamine Dexedrine
lisdexamfetamine Vyvanse
methylphenidate Concerta, Ritalin
Benign Prostatic Hyperplasia (BPH)
doxazosin Cardura Dizziness, light headedness, fainting
tamsulosin Flomax
terazosin
BLOOD CLOT
warfarin Coumadin Occasional drinking may lead to internal bleeding; heavier drinking also may cause bleeding or may have the opposite effect, resulting in possible blood clots, strokes, or heart attacks
COUGH
dextromethorpan Delsym,Robitussin Cough Drowsiness, dizziness, increased risk for overdose
guaifenesin + codeine
DEPRESSION
amitriptyline Drowsiness, dizziness, increased risk for overdose, increased feelings of depression or hopelessness (all medications); impaired motor control (mirtazapine); increased alcohol effect (bupropion); liver damage (duloxetine); serious cardiac effects, increased risk of hypertensive crisis (phenelzine, tranylcypromine)
bupropion Wellbutrin
citalopram Celexa
clomipramine Anafranil
desipramine Norpramin
desvenlafaxine Pristiq
duloxetine Cymbalta
escitalopram Lexapro
fluoxetine Prozac
fluoxetine/olanzapine Symbyax
fluvoxamine
mirtazapine Remeron
nefazodone
paroxetine Paxil
phenelzine Nardil
sertraline Zoloft
tranylcypromine Parnate
trazodone
venlafaxine Effexor XR
herbal
preparations
St. John's Wort
DIABETES
chlorpropamide Diabinese Hypoglycemia, flushing reaction (nausea, vomiting, headache, tachycardia, sudden changes in BP); nausea and weakness (metformin)
glipizide Glucotrol
glyburide Diabeta, Glynase
metformin Glucophage
HEARTBURN/GERD
cimetidine Tagamet Rapid heartbeat, sudden changes in blood pressure (metoclopramide), increased alcohol effect
metoclopramide Reglan
nizatidine Axid
ranitidine Zantac
 
Generic Brand Potential Reactions
HYPERLIPIDEMIA
atorvastatin Lipitor Liver damage (all medications); increased flushing and itching (niacin)
ezetimibe + simvastatin Vytorin
lovastatin Altoprev
niacin Niaspan
pravastatin Pravachol
rosuvastatin Crestor
simvastatin Zocor
HYPERTENSION
amlodipine Norvasc Dizziness, fainting, drowsiness, cardiac effects (eg, arrhythmia)
benzapril Lotensin
clonidine Catapres
enalapril Vaseretic
hydrochloro-
thiazide
lisinopril Prinivil, Zestril
losartan Cozaar
prazosin Minipress
quinapril Accupril
verapamil Calan
INFECTION
azithromycin Zithromax Fast heartbeat, sudden changes in blood pressure, stomach pain, upset stomach, vomiting, headache, or flushing or redness of the face; liver damage (isoniazid, ketoconazole)
cycloserine Seromycin
griseofulvin
isoniazid
ketoconazole Nizoral
metronidazole Flagyl
nitrofurantoin Macrobid, Macrodantin
tinidazole Tindamax
INSOMNIA
diphenhydramine Sominex Drowsiness, sleepiness, dizziness, slowed or difficulty breathing, impaired motor control, unusual behavior, memory problems
doxylamine Unisom
estazolam
eszopiclone Lunesta
temazepam Restoril
zolpidem Ambien
herbal
preparations
Chamomile, Valerian, Lavender Increased drowsiness
MUSCLE PAIN
carisoprodol Soma Drowsiness, dizziness, increased risk of seizures, increased risk for overdose, slowed or difficulty breathing, impaired motor control, unusual behavior, memory problems
cyclobenzaprine
NAUSEA
dimenhydrinate Dramamine Drowsiness, dizziness, increased risk for overdose
meclizine
promethazine
PAIN/FEVER/INFLAMMATION/MIGRAINE
acetaminophen Tylenol Upset stomach, bleeding, ulcers, rapid heartbeat; liver damage (acetaminophen)
acetaminophen + 
aspirin
Excedrin
ibuprofen Advil, Motrin
naproxen Aleve
butalbital + codeine Fiorinal with Codeine Drowsiness, dizziness, increased risk for overdose, slowed or difficulty breathing, impaired motor control, unusual behavior, memory problems
hydrocodone
meperidine Demerol
oxycodone Percocet
PSYCHOSIS/MOOD DISORDERS
aripiprazole Abilify Drowsiness, dizziness, increased risk for overdose, increased feelings of depression or hopelessness (all medications); impaired motor control (quetiapine)
clozapine Clozaril
olanzapine Zyprexa
paliperidone Invega
quetiapine Seroquel
risperidone Risperdal
ziprasidone Geodon
lithium Lithobid Drowsiness, dizziness, tremors, increased risk for restlessness/impaired motor control, loss of appetite, stomach upset, irregular bowel movement, joint or muscle pain, depression; liver damage (valproic acid)
valproic acid Depakene, Depakote
SEIZURE
carbamazepine Tegretol Drowsiness, dizziness (all medications); increased risk of seizures (levetiracetam, phenytoin); unusual behavior, mental health changes, suicidal thoughts (topiramate)
clonazepam Klonopin
gabapentin Horizant, Neurontin
lamotrigine Lamictal
levetiracetam Keppra
oxcarbazepine Trileptal
phenobarbital
phenytoin Dilantin
pregabalin Lyrica
topiramate Topamax
REFERENCES

National Institute on Alcohol Abuse and Alcoholism. Harmful Interactions: Mixing Alcohol with Medicines. NIH Publication No. 13-5329. https://pubs.niaaa.nih.gov/publications/medicine/Harmful_Interactions.pdf. Published 2003. Revised 2014. Accessed March 13, 2018.

Not an inclusive list of medications that may interact with alcohol. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling.

(Rev. 4/2018)

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