Although emerging data offer valuable clues, the pathophysiological distinctions between different phenotypes of chronic obstructive pulmonary disease are still poorly understood.
Mortality was significantly increased among patients with rheumatoid arthritis and COPD.
Inhaling and smoking heroin and cocaine increase the risk for asthma exacerbations and decreased pulmonary function; marijuana is associated with wheezing, cough, and sputum production.
Patients who were hospitalized for non-severe acute exacerbations of COPD did not experience improved outcomes when antibiotics were administered for longer than 24 hours.
NT-proBNP may be an independent predictor of respiratory exacerbations in patients with COPD even without overt cardiovascular disease.
Rates of pulmonary embolism ranged from 3.3% to 29.1% in patients with a clinical diagnosis of an acute exacerbation of COPD.
There were differences in use of steroids and antibiotics noted between teaching and non-teaching hospital staff.
Whole-genome sequencing was valuable in identifying a large number of potentially significant functional variants in severe COPD.
Although COPD has been identified as a risk factor for cardiovascular disease, researchers are less certain about the relationship between COPD and stroke.
Frequent asthma, bronchitis, allergy demonstrated the strongest association with , lower FEV1, lower FEV1/forced vital capacity, and increased risk for COPD.
Regardless of renal impairment, combination therapy with tiotropium/olodaterol was safe and tolerable in patients with moderate to very severe COPD.
A 72-year-old man with a 50 pack-year smoking history and multiple comorbidities, including COPD, presents to the emergency department with left-sided hemiparesis and sensory loss.
Tiotropium may be more effective in reducing the rate of moderate and severe chronic obstructive pulmonary disorder exacerbations when used in combination with olodaterol vs tiotropium alone.
Patients with COPD had a nearly 2-fold increased risk for developing atrial fibrillation compared with patients without COPD.
Steroid dosing and glucose levels were not associated with an increase in hospital readmissions related to COPD exacerbations.
No association was found between the degree of lung function impairment and the development of mild cognitive impairment in chronic obstructive pulmonary disease.
Combination therapy with LABA and LAMA yielded a lower annualized rate of COPD exacerbations compared with triple therapy.
Individuals with chronic obstructive pulmonary disease who met physical activity guidelines experienced the greatest reductions in all-cause, CVD, and respiratory mortality risk.
Independent predictive factors of lung cancer in chronic obstructive pulmonary disease may include frequency of exacerbations, in addition to airflow obstruction and visual emphysema.
Researchers used data from the Atherosclerosis Risk in Communities Study to assess associations between dietary pattern and pulmonary assessments.
One-year mortality after the initial hospitalization for chronic obstructive pulmonary disease exacerbation was related to clinical characteristics of the patient and of the index event.
An 80-year-old man with a history of smoking, hypertension, diabetes, and COPD presents to the emergency department with dyspnea at rest and chest tightness.
A significant reduction in severe COPD exacerbations was seen with intensified combination therapy at the onset of upper respiratory tract infections.
Patients with COPD may increase their physical activity levels using a home-based coaching intervention.
Women with rheumatoid arthritis had an increased risk for chronic obstructive pulmonary disease, but did not have an increased risk for asthma compared with women without RA.
Within the first 30 days of therapy, patients with COPD who began using long-acting bronchodilators had a 1.5-fold increased risk for cardiovascular events.
At a research seminar held by the European Respiratory Society in February 2017, a group of investigators discussed how precision medicine may improve treatment in asthma and COPD.
Sputum eosinophil counts may be a better predictor of COPD exacerbations compared with serum blood eosinophil counts.
Patients with asthma were found to have higher blood eosinophil counts, fractional exhaled nitric oxide levels, and total serum IgE concentrations compared with patients with COPD.
A 3-variable score that encompasses dyspnea score, prednisone use, and prior hospitalization for COPD exacerbations can predict mortality and readmission risk.