COPD

The Road to Precision Medicine in COPD Is Paved With Phenotypes

The Road to Precision Medicine in COPD Is Paved With Phenotypes

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Although emerging data offer valuable clues, the pathophysiological distinctions between different phenotypes of chronic obstructive pulmonary disease are still poorly understood.

Increased Mortality Rates Observed in Patients With Rheumatoid Arthritis, COPD

Increased Mortality Rates Observed in Patients With Rheumatoid Arthritis, COPD

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Mortality was significantly increased among patients with rheumatoid arthritis and COPD.

Illicit Drug Use in Asthma: Heroin, Cocaine, and Marijuana Worsen Symptoms

Illicit Drug Use in Asthma: Heroin, Cocaine, and Marijuana Worsen Symptoms

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Inhaling and smoking heroin and cocaine increase the risk for asthma exacerbations and decreased pulmonary function; marijuana is associated with wheezing, cough, and sputum production.

Effect of Antibiotic Duration in Acute COPD Exacerbations

Effect of Antibiotic Duration in Acute COPD Exacerbations

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Patients who were hospitalized for non-severe acute exacerbations of COPD did not experience improved outcomes when antibiotics were administered for longer than 24 hours.

High NT-proBNP in COPD May Predict Respiratory Exacerbations

High NT-proBNP in COPD May Predict Respiratory Exacerbations

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NT-proBNP may be an independent predictor of respiratory exacerbations in patients with COPD even without overt cardiovascular disease.

Pulmonary Embolism Prevalence in Acute COPD Exacerbations

Pulmonary Embolism Prevalence in Acute COPD Exacerbations

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Rates of pulmonary embolism ranged from 3.3% to 29.1% in patients with a clinical diagnosis of an acute exacerbation of COPD.

Variations in Practice Patterns Seen in Patients Treated for COPD

Variations in Practice Patterns Seen in Patients Treated for COPD

There were differences in use of steroids and antibiotics noted between teaching and non-teaching hospital staff.

Whole-Genome Sequencing Proves Valuable in Severe COPD

Whole-Genome Sequencing Proves Valuable in Severe COPD

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Whole-genome sequencing was valuable in identifying a large number of potentially significant functional variants in severe COPD.

Unraveling the Relationship Between COPD and Stroke

Unraveling the Relationship Between COPD and Stroke

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Although COPD has been identified as a risk factor for cardiovascular disease, researchers are less certain about the relationship between COPD and stroke.

Childhood Respiratory Risk Factor Profiles Predict Lung Function, COPD

Childhood Respiratory Risk Factor Profiles Predict Lung Function, COPD

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Frequent asthma, bronchitis, allergy demonstrated the strongest association with , lower FEV1, lower FEV1/forced vital capacity, and increased risk for COPD.

Tiotropim/Olodaterol Safe, Tolerable in COPD Regardless of Renal Impairment

Tiotropim/Olodaterol Safe, Tolerable in COPD Regardless of Renal Impairment

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Regardless of renal impairment, combination therapy with tiotropium/olodaterol was safe and tolerable in patients with moderate to very severe COPD.

Patient With COPD, Smoking History Presents to ED With Sensory Loss

Patient With COPD, Smoking History Presents to ED With Sensory Loss

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A 72-year-old man with a 50 pack-year smoking history and multiple comorbidities, including COPD, presents to the emergency department with left-sided hemiparesis and sensory loss.

Tiotropium/Olodaterol Combination vs Tiotropium Alone for Severe COPD Exacerbations

Tiotropium/Olodaterol Combination vs Tiotropium Alone for Severe COPD Exacerbations

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Tiotropium may be more effective in reducing the rate of moderate and severe chronic obstructive pulmonary disorder exacerbations when used in combination with olodaterol vs tiotropium alone.

COPD May Increase the Risk for Atrial Fibrillation

COPD May Increase the Risk for Atrial Fibrillation

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Patients with COPD had a nearly 2-fold increased risk for developing atrial fibrillation compared with patients without COPD.

Steroid Dosing, Glucose Levels Do Not Increase Likelihood of COPD Readmissions

Steroid Dosing, Glucose Levels Do Not Increase Likelihood of COPD Readmissions

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Steroid dosing and glucose levels were not associated with an increase in hospital readmissions related to COPD exacerbations.

Lung Function Impairment Level in COPD Not Related to Cognitive Impairment

Lung Function Impairment Level in COPD Not Related to Cognitive Impairment

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No association was found between the degree of lung function impairment and the development of mild cognitive impairment in chronic obstructive pulmonary disease.

Effect of Combination vs Triple Therapy on COPD Exacerbations

Effect of Combination vs Triple Therapy on COPD Exacerbations

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Combination therapy with LABA and LAMA yielded a lower annualized rate of COPD exacerbations compared with triple therapy.

COPD Mortality Risk and Physical Activity Have Dose-Response Relationship

COPD Mortality Risk and Physical Activity Have Dose-Response Relationship

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Individuals with chronic obstructive pulmonary disease who met physical activity guidelines experienced the greatest reductions in all-cause, CVD, and respiratory mortality risk.

Lung Cancer Risk May Be Predicted by Frequency of COPD Exacerbations

Lung Cancer Risk May Be Predicted by Frequency of COPD Exacerbations

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Independent predictive factors of lung cancer in chronic obstructive pulmonary disease may include frequency of exacerbations, in addition to airflow obstruction and visual emphysema.

COPD, Respiratory Symptoms Associated With "Western" Diet

COPD, Respiratory Symptoms Associated With "Western" Diet

Researchers used data from the Atherosclerosis Risk in Communities Study to assess associations between dietary pattern and pulmonary assessments.

Predictors of Mortality After Hospitalization for COPD Exacerbation

Predictors of Mortality After Hospitalization for COPD Exacerbation

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One-year mortality after the initial hospitalization for chronic obstructive pulmonary disease exacerbation was related to clinical characteristics of the patient and of the index event.

Clinical Challenge: Elderly Man Presents With Dyspnea at Rest and Chronic Cough

Clinical Challenge: Elderly Man Presents With Dyspnea at Rest and Chronic Cough

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An 80-year-old man with a history of smoking, hypertension, diabetes, and COPD presents to the emergency department with dyspnea at rest and chest tightness.

Preventing COPD Exacerbations in Upper Respiratory Tract Infections

Preventing COPD Exacerbations in Upper Respiratory Tract Infections

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A significant reduction in severe COPD exacerbations was seen with intensified combination therapy at the onset of upper respiratory tract infections.

COPD Home-Based Coaching Intervention: Effects on Physical Activity, Healthcare Utilization

COPD Home-Based Coaching Intervention: Effects on Physical Activity, Healthcare Utilization

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Patients with COPD may increase their physical activity levels using a home-based coaching intervention.

COPD and Asthma Risk in Women With Rheumatoid Arthritis

COPD and Asthma Risk in Women With Rheumatoid Arthritis

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Women with rheumatoid arthritis had an increased risk for chronic obstructive pulmonary disease, but did not have an increased risk for asthma compared with women without RA.

Inhaled Long-Acting Bronchodilators for COPD: Potential Cardiovascular Risk

Inhaled Long-Acting Bronchodilators for COPD: Potential Cardiovascular Risk

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Within the first 30 days of therapy, patients with COPD who began using long-acting bronchodilators had a 1.5-fold increased risk for cardiovascular events.

Precision Medicine May Pave the Way for Better Treatment in Asthma, COPD

Precision Medicine May Pave the Way for Better Treatment in Asthma, COPD

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At a research seminar held by the European Respiratory Society in February 2017, a group of investigators discussed how precision medicine may improve treatment in asthma and COPD.

Predicting COPD Exacerbations Using Sputum vs Blood Eosinophils

Predicting COPD Exacerbations Using Sputum vs Blood Eosinophils

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Sputum eosinophil counts may be a better predictor of COPD exacerbations compared with serum blood eosinophil counts.

Biomarkers Useful for Differentiating Between Asthma and COPD

Biomarkers Useful for Differentiating Between Asthma and COPD

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Patients with asthma were found to have higher blood eosinophil counts, fractional exhaled nitric oxide levels, and total serum IgE concentrations compared with patients with COPD.

COPD Hospital Readmission, Mortality Risk Predicted by 3-Variable Score

COPD Hospital Readmission, Mortality Risk Predicted by 3-Variable Score

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A 3-variable score that encompasses dyspnea score, prednisone use, and prior hospitalization for COPD exacerbations can predict mortality and readmission risk.

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