Critical Care

Women With H1N1 Influenza in ICU Have Higher Risk for Adverse Birth Outcomes

Women With H1N1 Influenza in ICU Have Higher Risk for Adverse Birth Outcomes

Pregnant women admitted to ICU with 2009 H1N1 influenza were more likely to deliver preterm and low birth-weight infants.

Glass Particulate Identified in Certain Vials of Vecuronium Bromide

Glass Particulate Identified in Certain Vials of Vecuronium Bromide

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Vecuronium Bromide, a neuromuscular blocker, is indicated as adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Malignant Pleural Effusion Interventions: What Matters Most to the Patient?

Malignant Pleural Effusion Interventions: What Matters Most to the Patient?

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Patients with malignant pleural effusion may care more about relieving symptoms such as dyspnea as opposed to achieving pleurodesis.

Clinical Tool Rapidly Assesses Post-Intensive Care Syndrome

Clinical Tool Rapidly Assesses Post-Intensive Care Syndrome

A 27-item questionnaire was a valid clinical tool for assessing post-intensive care syndrome.

Treatment for Acute Agitation Gets Fast Track Designation

Treatment for Acute Agitation Gets Fast Track Designation

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According to the Company, a Phase 1 placebo-controlled, dose-escalation study of BXCL501 is expected to enroll up to 60 healthy adults across various dosing groups; pharmacokinetics and safety will be evaluated as primary endpoints.

Most Nurses Unsatisfied With Hospitals' End-of-Life Care

Most Nurses Unsatisfied With Hospitals' End-of-Life Care

The nurse practice environment was the best predictor of poor-quality end-of-life care.

Hypercapnic COPD Survival, Clinical Outcomes With High-Intensity NIV

Hypercapnic COPD Survival, Clinical Outcomes With High-Intensity NIV

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Patients with comorbid stable COPD and chronic hypercapnic respiratory failure have improved symptoms and survival rates with high-intensity noninvasive ventilation.

Procalcitonin-Guided Antibiotic Treatment Lowered Antibiotic Exposure

Procalcitonin-Guided Antibiotic Treatment Lowered Antibiotic Exposure

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Procalcitonin-guided antibiotic management resulted in lower antibiotic exposure while maintaining similar mortality rates in patients with bacteremia.

Stethoscopes in ICU Show High Levels of Bacterial Contamination

Stethoscopes in ICU Show High Levels of Bacterial Contamination

Stethoscopes in the intensive care unit have high levels of bacterial contamination.

Low Tidal Volume Ventilation Trial in Acute Respiratory Failure Not Feasible

Low Tidal Volume Ventilation Trial in Acute Respiratory Failure Not Feasible

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A cluster-randomized clinical trial of low tidal volume ventilation vs usual care in patients with acute respiratory failure was determined to be unfeasible.

ICU Lab Value Evaluation: Personalized, Outcomes-Based Evaluation Beneficial

ICU Lab Value Evaluation: Personalized, Outcomes-Based Evaluation Beneficial

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The use of a more contextual, personalized, probabilistic, outcomes-based approach for interpretation of laboratory values in patients in an intensive care unit may be beneficial.

Pediatric ARDS Identification, Stratification With PALICC Definition

Pediatric ARDS Identification, Stratification With PALICC Definition

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Using the Pediatric Acute Lung Injury Consensus Conference definition of pediatric acute respiratory distress syndrome identifies more patients with the condition than the Berlin definition.

Corticosteroid Response in Septic Shock Predicted by Transcriptomic Profiles

Corticosteroid Response in Septic Shock Predicted by Transcriptomic Profiles

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Transcriptomic sepsis response signatures may be helpful to identify patient response to corticosteroids at the onset of septic shock.

Amount of Muscle Mass During ICU Admission May Be Linked to Survival

Amount of Muscle Mass During ICU Admission May Be Linked to Survival

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Larger pectoralis muscle area at intensive care unit admission was associated with significantly better outcomes, including higher rates of 6-month survival.

S<sup>3</sup>-NIV Questionnaire Helps Assess Home Noninvasive Ventilation

S3-NIV Questionnaire Helps Assess Home Noninvasive Ventilation

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Convergent validity was high between the "respiratory symptoms" subscale of the S3-NIV questionnaire and the St. George's Respiratory Questionnaire.

Cholestenoic Acid: A Potential Biomarker for Acute Respiratory Distress Syndrome

Cholestenoic Acid: A Potential Biomarker for Acute Respiratory Distress Syndrome

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Cholestenoic acid may represent a unique and clinically important biomarker for acute respiratory distress syndrome.

Cancer Pain Severity May Be Reduced With Smartphone-Based App

Cancer Pain Severity May Be Reduced With Smartphone-Based App

The smartphone-based app can cut both the severity of advanced cancer patients' reported pain and hospital admissions.

Would A Change in Nomenclature for Intensive Care Units Promote Less Aggressive Care?

Would A Change in Nomenclature for Intensive Care Units Promote Less Aggressive Care?

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The term "intensive care unit" (ICU) was meant to refer to the intensity of the resources allocated to patient care.

Large Numbers of Negative Trial Results Impede Progress in Critical Care Medicine

Large Numbers of Negative Trial Results Impede Progress in Critical Care Medicine

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Excessive numbers of negative clinical trials — many of which may be false-negative trials — are a major impediment to the advancement of critical care medicine.

Case: Severe ARDS Following Hydrochlorothiazide Administration

Case: Severe ARDS Following Hydrochlorothiazide Administration

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A recent report published in The Journal of Emergency Medicine describes the case of a male patient who experienced HCTZ-induced pulmonary edema that was complicated by ARDS.

Thoracic US Score Predicts Pleurodesis Success in Malignant Pleural Effusion

Thoracic US Score Predicts Pleurodesis Success in Malignant Pleural Effusion

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A pleural adherence score derived from thoracic ultrasound at 24 hours post-talc administration is predictive of long-term pleurodesis success in patients with symptomatic malignant pleural effusion.

Spontaneous Pneumothorax Hospital Admissions Have Increased

Spontaneous Pneumothorax Hospital Admissions Have Increased

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Hospital readmission was also more likely in individuals whose first spontaneous pneumothorax occurred after 2008 compared with before 2008.

Neither Haloperidol, Ziprasidone Shortens Delirium in ICU

Neither Haloperidol, Ziprasidone Shortens Delirium in ICU

No decrease in duration vs placebo in patients with hypoactive or hyperactive delirium in ICU.

Remimazolam Safe, Effective for Sedation During Flexible Bronchoscopy

Remimazolam Safe, Effective for Sedation During Flexible Bronchoscopy

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Remimazolam was safe and effective for achieving moderate sedation in patients undergoing flexible bronchoscopy.

Prehospital Advanced Life Support Shortens Antibiotic Wait Times in Sepsis

Prehospital Advanced Life Support Shortens Antibiotic Wait Times in Sepsis

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Antibiotic treatment started sooner in individuals with sepsis treated with advanced life support who did not have hypotension.

High Flow Nasal Cannula Oxygen Therapy May Benefit Elderly Patients in ICU

High Flow Nasal Cannula Oxygen Therapy May Benefit Elderly Patients in ICU

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After high flow nasal cannula oxygen therapy, 15% of patients had to be intubated and mechanically ventilated, but the majority stepped down to regular oxygen therapy.

Factors Associated With Mechanical Ventilation Mortality in Pregnancy

Factors Associated With Mechanical Ventilation Mortality in Pregnancy

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Vasopressor requirement, transfusions, neurologic dysfunction, coagulopathy, and acute respiratory distress syndrome were related to higher mortality after multivariate analysis.

Vitamin C Treatment May Be Beneficial for Sepsis, But Duration and Dose Unclear

Vitamin C Treatment May Be Beneficial for Sepsis, But Duration and Dose Unclear

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Vitamin C was associated with lower mortality rates, shorter lengths of ICU stay, and shorter durations of vasopressor use in patients with sepsis.

Invasive Ventilation Risk in COPD Exacerbation

Invasive Ventilation Risk in COPD Exacerbation

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Alcohol abuse, fluid and electrolyte abnormalities, and pulmonary circulation disorders increased the risk for noninvasive ventilation in a COPD exacerbation.

Risk Factors for Multidrug-Resistant Pathogens in Pneumonia

Risk Factors for Multidrug-Resistant Pathogens in Pneumonia

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Previous antibiotic use and mechanical invasive ventilation were risk factors for multidrug-resistant pathogens in hospital-associated or ventilator-associated pneumonia.

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