Lower and higher oxygen saturation targets result in equal but contrasting outcomes for extremely preterm infantsAugust 15, 2018
In this meta-analysis, there was no significant difference between lower and higher oxygen saturation targets on a primary composite of mortality or major disability at a corrected age of 18-24 months for infants born extremely preterm.
Lactate clearance improved in patients who presented with septic shock who were given thiamine within 24 hours of hospital admission.
Indwelling pleural catheters can be used safely but with caution as a bridge to transplant or as palliative care.
Overall outcomes of hospital mortality, unit mortality, and reintubation were similar between patients who were still on vasoactive infusions and those who were not.
Reducing the number of computers in surgical intensive care units reduced barriers to communication.
The Pediatric Index Pulmonary Hypertension Intensive Care Mortality model was compared with the Pediatric Risk of Mortality 2 and 3 models to determine the best model for predicting mortality.
ICU telemedicine was associated with a reduction in interhospital transfers in patients with respiratory and gastrointestinal diagnoses.
ICU and hospital mortality were lower for patients with cancer vs those without cancer.
In patients with end-stage interstitial lung disease, there was a higher rate of survival to transplantation with venoarterial extracorporeal membrane oxygenation.
Risk for death from sepsis was higher at hospitals with the lowest volume of immunosuppressed patients with sepsis.
Systematic early lactate measurements speed antibiotic administration and improve outcomes in patients with sepsis.
Increased circulating immature granulocytes at the acute phase of sepsis are linked to clinical worsening, especially when associated with T-cell lymphopenia.
In patients with very severe acute respiratory distress syndrome, 60-day mortality was not significantly lower with venovenous extracorporeal membrane oxygenation than with conventional treatment.
In patients with acute respiratory failure, high-flow nasal cannula and conventional oxygen therapy provided similar benefits.
Liberal supplemental oxygen therapy in acutely ill patients increased mortality during hospitalization, at 30 days, and at longest follow-up.
It may be more lung protective to use the lower of either measured or predicted body weight when targeting tidal volume for mechanically ventilated children.
A randomized clinical trial evaluated whether premedication with propofol reduced the frequency of prolonged desaturation during neonatal nasotracheal intubation compared with the combination of a rapid-onset short-acting opioid and a muscle relaxant.
The SeptiCyteTM LAB may be an effective complementary diagnostic tool to clinical assessment of critically ill adult patients in discriminating between sepsis and noninfectious systemic inflammation syndrome.
An indwelling pleural catheter and administration of talc may have a higher odds of achieving pleurodesis compared with an indwelling pleural catheter alone in individuals with malignant pleural effusions.
Palliative care consultation was linked to a reduction in hospital costs for hospitalized adults with serious illness, such as COPD.
Survival at 6 months was significantly associated with acute respiratory failure and history of COPD.
Balanced crystalloids decreases adverse kidney events compared to saline among critically ill patients: The SMART trialApril 18, 2018
Use of balanced crystalloids (lactated Ringers or Plasma-Lyte A) was associated with a significant reduction in acute kidney injury events compared with normal saline among intensive care unit (ICU) patients. Use of balanced crystalloids was also associated with lower though nonsignificant in-hospital mortality at 30-days after admission.
In patients with insulin-treated diabetes and sepsis, increased highest glucose levels and glycemic variability have a significant illness severity-adjusted association with decreasing in-hospital mortality.
The risk for death in patients with community-acquired pneumonia who were given mechanical ventilation does not seem to be affected by the presence of acute respiratory distress syndrome.
Sedative-associated, hypoxic, and septic delirium were predictive of long-term cognitive impairment in patients with a critical illness related to acute respiratory failure, shock, or both.
A higher percentage of critically ill patients in the intensive care unit who were given nocturnal dexmedetomidine remained delirium free compared with placebo.
High-flow oxygen therapy may be more effective in preventing care escalation in infants with bronchiolitis compared with standard oxygen therapy.
Prophylactic haloperidol did not reduce delirium incidence, delirium-free days, duration of mechanical ventilation, or hospital length of stay in patients in the intensive care unit.
Patients with septic shock in the intensive care unit undergoing mechanical ventilation and managed with adjunctive continuous hydrocortisone infusion did not have a lower 90-day mortality compared with placebo.
A routine chest radiograph after ultrasound-guided central venous catheter insertion is now considered costly and unnecessary.