Select therapeutic use:

Edema:

Indications for: Chlorothiazide

Edema.

Adult Dosage:

Initially 0.5g–1g once or twice daily; may give on intermittent schedule (every other day or 3–5 days/wk).

Children Dosage:

<6mos: up to 30mg/kg/day in 2 divided doses. ≥6mos: 10–20mg/kg/day in 1–2 divided doses. Max (<2yrs): 375mg/day; (2–12yrs): 1g/day.

Chlorothiazide Contraindications:

Anuria. Sulfonamide allergy.

Chlorothiazide Warnings/Precautions:

Renal or hepatic impairment. Arrhythmias. Diabetes. Gout. Asthma. SLE. Postsympathectomy. Excessive fluid loss. Monitor electrolytes, BUN (if high). Potassium supplements or K+-sparing diuretics may be needed. Discontinue if electrolyte disorders develop rapidly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Chlorothiazide Classification:

Diuretic (thiazide).

Chlorothiazide Interactions:

Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. Antagonized by NSAIDs. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Hyperglycemia, hyperuricemia more likely with diazoxide. NSAIDs may cause renal failure. May potentiate nondepolarizing muscle relaxants, other antihypertensives. Hypotension with CNS depressants. May interfere with parathyroid tests.

Adverse Reactions:

Electrolyte disorders (esp. hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, adverse lipid values.

Note:

Formerly known under the brand name Diuril.

How Supplied:

Tabs—100

Pricing for Chlorothiazide

500mg tablet (Qty: 90)
Appx. price $15
GoodRx

Hypertension:

Indications for: Chlorothiazide

Hypertension.

Adult Dosage:

0.5–1g/day as single or divided doses; max 2g/day.

Children Dosage:

<6mos: up to 30mg/kg/day in 2 divided doses. ≥6mos: 10–20mg/kg/day in 1–2 divided doses. Max (<2yrs): 375mg/day; (2–12yrs): 1g/day.

Chlorothiazide Contraindications:

Anuria. Sulfonamide allergy.

Chlorothiazide Warnings/Precautions:

Renal or hepatic impairment. Arrhythmias. Diabetes. Gout. Asthma. SLE. Postsympathectomy. Excessive fluid loss. Monitor electrolytes, BUN (if high). Potassium supplements or K+-sparing diuretics may be needed. Discontinue if electrolyte disorders develop rapidly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Chlorothiazide Classification:

Diuretic (thiazide).

Chlorothiazide Interactions:

Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. Antagonized by NSAIDs. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Hyperglycemia, hyperuricemia more likely with diazoxide. NSAIDs may cause renal failure. May potentiate nondepolarizing muscle relaxants, other antihypertensives. Hypotension with CNS depressants. May interfere with parathyroid tests.

Adverse Reactions:

Electrolyte disorders (esp. hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, adverse lipid values.

Note:

Formerly known under the brand name Diuril.

How Supplied:

Tabs—100

Pricing for Chlorothiazide

500mg tablet (Qty: 90)
Appx. price $15
GoodRx