Indications for FORANE:

Induction and maintenance of general anesthesia.

Adults and Children:

See full labeling. Individualize. Induction: inspired concentrations of 1.5–3% isoflurane usually produce surgical anesthesia in 7–10 minutes. Maintenance: surgical levels of anesthesia may be sustained with a 1–2.5% concentration when nitrous oxide is used concomitantly. An additional 0.5–1% may be required when isoflurane is given using oxygen alone. If added relaxation is required, supplemental doses of muscle relaxants may be used.

FORANE Contraindications:

Hypersensitivity to halogenated agents. Susceptibility to malignant hyperthermia.

FORANE Warnings/Precautions:

To be administered only by those experienced in general anesthesia. Have intubation, artificial ventilation, oxygen and circulatory resuscitation available. Monitor for perioperative hyperkalemia esp. in pediatric patients during post-op period and those with latent or overt neuromuscular disease (eg, Duchenne muscular dystrophy); cardiac arrhythmias and death may occur. Pediatric neurotoxicity risk with repeated or prolonged use. Pregnancy. Nursing mothers.

FORANE Classification:

Inhalation anesthetic.

FORANE Interactions:

Caution with desiccated CO2 absorbents; replace before administration. Hyperkalemia with succinylcholine. Potentiates effects of muscle relaxants, esp. nondepolarizing muscle relaxants. MAC reduced by concomitant nitrous oxide.

Adverse Reactions:

Respiratory depression, hypotension, arrhythmias, shivering, nausea, vomiting, ileus, transient elevations in CSF pressure, blood glucose, creatinine, cholesterol, ALK, WBC; perioperative hyperkalemia, malignant hyperthermia.

How Supplied:

Bottles (100mL, 250mL)—1