Select therapeutic use:

Colorectal disorders:

Indications for: LINZESS

Irritable bowel syndrome with constipation (IBS-C).

Adult Dosage:

Swallow whole. Take on empty stomach, at least 30mins before first meal of the day. May open caps and mix contents in applesauce or with water if unable to swallow; or, may give with water via NG or gastrostomy tube. 290mcg once daily.

Children Dosage:

<2yrs: contraindicated. 2–<18yrs: not established.

LINZESS Contraindications:

Children <2yrs old. Known or suspected mechanical GI obstruction.

Boxed Warning:

Risk of serious dehydration in pediatric patients <2yrs of age.

LINZESS Warnings/Precautions:

Consider dose suspension and rehydration if severe diarrhea occurs. Pregnancy. Nursing mothers.

LINZESS Classification:

Guanylate cyclase-C agonist.

Adverse Reactions:

Diarrhea, abdominal pain, flatulence, abdominal distention.

Generic Drug Availability:

NO

How Supplied:

Caps—30

Pricing for LINZESS

145mcg capsule (Qty: 30)
Appx. price $486
GoodRx

Constipation and bowel cleansers:

Indications for: LINZESS

Chronic idiopathic constipation (CIC).

Adult Dosage:

Swallow whole. Take on empty stomach, at least 30mins before first meal of the day. May open caps and mix contents in applesauce or with water if unable to swallow; or, may give with water via NG or gastrostomy tube. 145mcg once daily. A dosage of 72mcg once daily may be used based on individual presentation or tolerability.

Children Dosage:

<2yrs: contraindicated. 2–<18yrs: not established.

LINZESS Contraindications:

Children <2yrs old. Known or suspected mechanical GI obstruction.

Boxed Warning:

Risk of serious dehydration in pediatric patients <2yrs of age.

LINZESS Warnings/Precautions:

Consider dose suspension and rehydration if severe diarrhea occurs. Pregnancy. Nursing mothers.

LINZESS Classification:

Guanylate cyclase-C agonist.

Adverse Reactions:

Diarrhea, abdominal pain, flatulence, abdominal distention.

Generic Drug Availability:

NO

How Supplied:

Caps—30

Pricing for LINZESS

145mcg capsule (Qty: 30)
Appx. price $486
GoodRx