Constipation and bowel cleansers:
Indications for MOVIPREP:
Bowel cleansing before colonoscopy.
No solid food from start of prep. For both regimens start the evening before colonoscopy. Split-dose regimen: drink 240mL every 15mins over 1hr until 1L consumed, follow with 480mL of clear liquids; in the AM (start ≥3.5hrs before colonoscopy), drink 2nd liter over 1hr, then drink 480mL of clear liquids at least 2hrs before colonoscopy; or, Evening-only regimen: start at least 3.5hrs before bedtime; drink 240mL every 15mins over 1hr until 1L consumed, then drink 2nd liter 1.5hrs later over 1hr; in addition, drink 1L of clear liquids.
<18yrs: not established.
GI obstruction. Bowel perforation. Gastric retention. Ileus. Toxic colitis or megacolon.
Correct fluid/electrolyte abnormalities before use. Hyponatremia. History of prolonged QT, uncontrolled arrhythmias, recent MI, unstable angina, CHF, cardiomyopathy, or electrolyte imbalance: increased risk of arrhythmias; consider ECGs at pre-dose and post-colonoscopy. History or risk of seizures. Renal impairment; perform baseline and post-colonoscopy electrolytes, creatinine, BUN. Inflammatory bowel disease. Rule out suspected GI obstruction/perforation before administering. Severe ulcerative colitis. Impaired gag reflex. Risk of regurgitation or aspiration. G6PD deficiency. Phenylketonuria. Maintain adequate hydration. Pregnancy. Nursing mothers.
Caution with drugs that increase risk of fluid/electrolyte abnormalities, renal impairment, seizures, arrhythmias, or QT prolongation. Drugs that may lower the seizure threshold (eg, tricyclic antidepressants), alcohol or benzodiazepine withdrawal, known or suspected hyponatremia: may increase risk of seizures. Concomitant diuretics, ACE inhibitors, ARBs, NSAIDs; may affect renal function. Concomitant stimulant laxatives: not recommended; may increase risk of mucosal ulceration, ischemic colitis. Oral drugs administered within 1hr of start of MoviPrep may not be absorbed.
Malaise, nausea, vomiting, abdominal distension and pain (give slowly or discontinue if occurs), anal discomfort, thirst, sleep disorder, rigors, hunger, dizziness; hypersensitivity reactions; rare: arrhythmias, seizures.
Generic Drug Availability:
Carton—1 (disposable container w. 4 pouches)