Select therapeutic use:

Asthma/COPD:

Indications for: NUCALA

Add-on maintenance treatment of severe asthma with an eosinophilic phenotype.

Limitations of Use:

Not for relief of acute bronchospasm or status asthmaticus.

Adults and Children:

<6yrs: not established. Give by SC inj into upper arm, thigh, or abdomen. 6–11yrs (use vials or 40mg/0.4mL prefilled syringes): 40mg once every 4 weeks. ≥12yrs: 100mg once every 4 weeks.

NUCALA Warnings/Precautions:

Not for treating acute asthma symptoms or exacerbations. Opportunistic infections (eg, herpes zoster); consider vaccination if appropriate. Treat pre-existing helminth infections prior to initiation; if infection develops and unresponsive to antihelmintics, discontinue Nucala until resolves. Avoid abrupt discontinuation of any corticosteroids upon Nucala initiation; reduce gradually if appropriate. Elderly. Pregnancy. Nursing mothers.

NUCALA Classification:

Interleukin-5 antagonist.

Adverse Reactions:

Headache, inj site reactions, back pain, fatigue, oropharyngeal pain, arthralgia; infections, hypersensitivity reactions (discontinue if occur); possible antibody formation.

Generic Drug Availability:

NO

How Supplied:

Single-dose vial (100mg)—1; Single-dose autoinjector (100mg/mL)—1 (w. needle); Single-dose prefilled syringe (100mg/mL, 40mg/0.4mL)—1 (w. needle)

Pricing for NUCALA

100mg/ml autoinjector (Qty: 1)
Appx. price $3401
GoodRx

Miscellaneous immune disorders:

Indications for: NUCALA

Eosinophilic granulomatosis with polyangiitis (EGPA) in adults. Treatment of patients with hypereosinophilic syndrome (HES) for ≥6 months without an identifiable non-hematologic secondary cause.

Adult Dosage:

Give by SC inj into upper arm, thigh, or abdomen. 300mg (as three separate 100mg inj) once every 4 weeks; inject at least 2 inches apart if at the same site.

Children Dosage:

EGPA (<18yrs): not established. HES (<12yrs): not established.

NUCALA Warnings/Precautions:

Not for treating acute asthma symptoms or exacerbations. Opportunistic infections (eg, herpes zoster); consider vaccination if appropriate. Treat pre-existing helminth infections prior to initiation; if infection develops and unresponsive to antihelmintics, discontinue Nucala until resolves. Avoid abrupt discontinuation of any corticosteroids upon Nucala initiation; reduce gradually if appropriate. Elderly. Pregnancy. Nursing mothers.

NUCALA Classification:

Interleukin-5 antagonist.

Adverse Reactions:

Headache, inj site reactions, back pain, fatigue, oropharyngeal pain, arthralgia; infections, hypersensitivity reactions (discontinue if occur); possible antibody formation.

Generic Drug Availability:

NO

How Supplied:

Single-dose vial (100mg)—1; Single-dose autoinjector (100mg/mL)—1 (w. needle); Single-dose prefilled syringe (100mg/mL, 40mg/0.4mL)—1 (w. needle)

Pricing for NUCALA

100mg/ml autoinjector (Qty: 1)
Appx. price $3401
GoodRx

Miscellaneous respiratory disorders:

Indications for: NUCALA

Add-on maintenance treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) in adults with inadequate response to nasal corticosteroids.

Adult Dosage:

Give by SC inj into upper arm, thigh, or abdomen. ≥18yrs: 100mg once every 4 weeks.

Children Dosage:

<18yrs: not established.

NUCALA Warnings/Precautions:

Not for treating acute asthma symptoms or exacerbations. Opportunistic infections (eg, herpes zoster); consider vaccination if appropriate. Treat pre-existing helminth infections prior to initiation; if infection develops and unresponsive to antihelmintics, discontinue Nucala until resolves. Avoid abrupt discontinuation of any corticosteroids upon Nucala initiation; reduce gradually if appropriate. Elderly. Pregnancy. Nursing mothers.

NUCALA Classification:

Interleukin-5 antagonist.

Adverse Reactions:

Headache, inj site reactions, back pain, fatigue, oropharyngeal pain, arthralgia; infections, hypersensitivity reactions (discontinue if occur); possible antibody formation.

Generic Drug Availability:

NO

How Supplied:

Single-dose vial (100mg)—1; Single-dose autoinjector (100mg/mL)—1 (w. needle); Single-dose prefilled syringe (100mg/mL, 40mg/0.4mL)—1 (w. needle)

Pricing for NUCALA

100mg/ml autoinjector (Qty: 1)
Appx. price $3401
GoodRx