Select therapeutic use:

Bacterial infections:

Indications for Vancomycin Injection:

Serious or severe infections due to susceptible methicillin-resistant (beta-lactam-resistant) staphylococci in penicillin-allergic patients; patients who cannot receive or have failed to respond to other drugs, including penicillins and cephalosporins; and for infections due to vancomycin-susceptible organisms resistant to other antimicrobials. Staphylococcal endocarditis, including septicemia, and infections of the lower respiratory tract, bone, and skin and skin structure. Streptococcal endocarditis due to S. viridans or S. bovis as monotherapy or in combination with an aminoglycoside. Enterococcal endocarditis due to E. faecalis in combination with an aminoglycoside. Diphtheroid endocarditis. Early-onset prosthetic valve endocarditis due to S. epidermidis or diphtheroids in combination with rifampin, or an aminoglycoside, or both.

Adult Dosage:

Give by intermittent IV infusion over at least 60mins or at a rate of 10mg/min or less, whichever is longer. 2g/day in divided doses (500mg every 6hrs or 1g every 12hrs). Renal impairment: adjust or reduce dose, obesity; see full labeling.

Children Dosage:

Give by intermittent IV infusion over at least 60mins. Neonates: ≤1month: initially 15mg/kg, then 10mg/kg every 12hrs (for neonates in the 1st week of life) and every 8hrs thereafter (up to 1month of age). >1month: 10mg/kg per dose every 6hrs. Renal impairment: adjust or reduce dose, obesity; see full labeling.

Vancomycin Injection Warnings/Precautions:

Not for prophylaxis of endophthalmitis. Renal insufficiency. Monitor hearing, blood, renal function. Discontinue at the 1st signs of severe dermatologic reactions (eg, TEN, SJS, DRESS, AGEP, LABD). Monitor vancomycin serum concentrations closely. Elderly. Debilitated. Pregnancy. Nursing mothers.

Vancomycin Injection Classification:

Antibiotic.

Vancomycin Injection Interactions:

Monitor with other ototoxic, nephrotoxic, neurotoxic drugs (eg, aminoglycosides, amphotericin B, bacitracin, polymyxin B, colistin, viomycin, cisplatin). Erythema, histamine-like flushing, anaphylactoid reactions may occur with concomitant anesthetic agents.

Adverse Reactions:

Infusion-related events, nausea, drug fever, rash (may be serious, eg, Stevens-Johnson syndrome), ototoxicity, nephrotoxicity, thrombophlebitis, blood dyscrasias; rare: interstitial nephritis, vertigo.

Note:

Formerly known under the brand name Vancocin.

How Supplied:

Contact supplier.

Diarrhea:

Indications for Vancomycin Injection:

Antibiotic-associated pseudomembranous colitis due to C. difficile.

Adult Dosage:

Dilute dose in 1oz of water and drink or give via nasogastric tube; 500mg–2g per day in 3–4 divided doses for 7–10 days. Renal impairment: adjust or reduce dose, obesity; see full labeling.

Children Dosage:

Dilute dose in 1 oz of water and drink or give via nasogastric tube; 40mg/kg per day in 3–4 divided doses for 7–10 days; max 2g/day. Renal impairment: adjust or reduce dose, obesity; see full labeling.

Vancomycin Injection Warnings/Precautions:

Not for prophylaxis of endophthalmitis. Renal insufficiency. Monitor hearing, blood, renal function. Discontinue at the 1st signs of severe dermatologic reactions (eg, TEN, SJS, DRESS, AGEP, LABD). Monitor vancomycin serum concentrations closely. Elderly. Debilitated. Pregnancy. Nursing mothers.

Vancomycin Injection Classification:

Antibiotic.

Vancomycin Injection Interactions:

Monitor with other ototoxic, nephrotoxic, neurotoxic drugs (eg, aminoglycosides, amphotericin B, bacitracin, polymyxin B, colistin, viomycin, cisplatin). Erythema, histamine-like flushing, anaphylactoid reactions may occur with concomitant anesthetic agents.

Adverse Reactions:

Nausea, drug fever, urticaria, ototoxicity, nephrotoxicity, blood dyscrasias; rare: interstitial nephritis, vertigo.

Note:

Formerly known under the brand name Vancocin.

How Supplied:

Contact supplier.