Prostate and other male cancers:

Indications for XOFIGO:

Treatment of patients with castration-resistant prostate cancer, symptomatic bone metastases and no known visceral metastatic disease.

Adult Dosage:

See full labeling. Administer by slow IV over 1 min. 50kBq (1.35 microcurie) per kg given at 4 week intervals for 6 injections.

Children Dosage:

<18yrs: not established.

XOFIGO Warnings/Precautions:

Not for use in females. Bone marrow suppression. Perform hematologic evaluation at baseline and prior to every dose. Before 1st dose, the ANC should be ≥1.5×109/L, platelets ≥100×109/L and hemoglobin ≥10g/dL. Before subsequent doses, the ANC should be ≥1×109/L and platelets ≥50×109/L; discontinue if no recovery within 6–8 weeks after last dose despite receiving supportive care. Monitor closely if evidence of compromised bone marrow reserve. Discontinue if life-threatening complications occur despite supportive care for bone marrow failure. Monitor oral intake and fluid status carefully. Embryo-fetal toxicity. Advise males (use condoms) and female partners of reproductive potential to use effective contraception during and 6 months after completion. Pregnancy. Nursing mothers: not studied.

XOFIGO Classification:

Alpha particle-emitting radioactive therapeutic agent.

XOFIGO Interactions:

Concomitant chemotherapy: not established. Discontinue if concomitant with chemotherapy, other systemic radioisotopes or hemibody external radiotherapy.

Adverse Reactions:

Nausea, diarrhea, vomiting, peripheral edema, anemia, lymphocytopenia, leukopenia, thrombocytopenia, neutropenia.

Generic Drug Availability:

NO

How Supplied:

Single-dose vials (6mL)—1