Emphysema Archives

Which Drug Combination Works Best to Reduce Acute COPD Exacerbations?

Which Drug Combination Works Best to Reduce Acute COPD Exacerbations?

Compared with a combination treatment of LABA/LAMA, ICS/LABA/LAMA combination therapy was associated with a significantly greater pooled risk reduction in COPD exacerbation.

Patients Hospitalized for COPD Rarely Receive Pulmonary Rehab

Patients Hospitalized for COPD Rarely Receive Pulmonary Rehab

Few individuals hospitalized for COPD receive pulmonary rehabilitation.

3D Super Clusters in COPD Could Affect Adjacent Healthy Tissue

3D Super Clusters in COPD Could Affect Adjacent Healthy Tissue

Three-dimensional "super clusters" in patients with COPD could play a role in the progression of COPD to emphysema.

Elevated Tuberculosis Risk in Inhaled Corticosteroid Users

Elevated Tuberculosis Risk in Inhaled Corticosteroid Users

There may an increased risk for tuberculosis in patients with COPD within 3 years of inhaled corticosteroid use.

Once-Daily, Nebulized Bronchodilator Approved for COPD Treatment

Once-Daily, Nebulized Bronchodilator Approved for COPD Treatment

The FDA has approved Yupelri inhalation solution for the maintenance treatment of patients with COPD.

Asthma-COPD Overlap Prevalence, Severity in Low- and Middle-Income Countries

Asthma-COPD Overlap Prevalence, Severity in Low- and Middle-Income Countries

The overall rate of asthma-COPD overlap was 3.8%, with a maximum prevalence of 7.8% in Matlab, Bangladesh.

Theophylline Adjunct Therapy Fails to Reduce COPD Exacerbations

Theophylline Adjunct Therapy Fails to Reduce COPD Exacerbations

Adults with COPD treated with both inhaled corticosteroids and low-dose theophylline as adjunct therapy did not have fewer exacerbations compared with patients treated with inhaled corticosteroids only.

Half of COPD Inhaler Use Does Not Align With GOLD Recommendations

Half of COPD Inhaler Use Does Not Align With GOLD Recommendations

Half of patients with COPD report use of inhaler medications that are not in alignment with the current treatment recommendations.

Oxygen-Driven vs Air-Driven Nebulizers for COPD Exacerbations

Oxygen-Driven vs Air-Driven Nebulizers for COPD Exacerbations

Air-driven bronchodilator nebulization is preferable to oxygen-driven nebulization in patients experiencing acute COPD exacerbations.

COPD May Predict Complications in Percutaneous Coronary Interventions

COPD May Predict Complications in Percutaneous Coronary Interventions

The increased occurrence of periprocedural complications in patients with COPD was largely attributed to cardiac arrest, myocardial infarctions, and no-reflows.

Albuminuria Associated With Lung Function Decline in COPD

Albuminuria Associated With Lung Function Decline in COPD

Albuminuria was associated with greater lung function decline in patients with chronic obstructive pulmonary disease.

CFTR Dysfunction Likely Associated With Worsened Airway Disease in Smokers

CFTR Dysfunction Likely Associated With Worsened Airway Disease in Smokers

Cystic fibrosis transmembrane conductance regulator dysfunction is associated with worsened airway disease in patients with COPD.

COPD Mortality Does Not Increase From Long-Term Use of Benzodiazepines

COPD Mortality Does Not Increase From Long-Term Use of Benzodiazepines

No difference in mortality, but there may be an elevated risk for suicide with long-term benzodiazepine use in patients with COPD and comorbid PTSD.

Effects of Testosterone Replacement Therapy in Men With COPD

Effects of Testosterone Replacement Therapy in Men With COPD

Middle-aged testosterone replacement therapy users with COPD had a greater reduction in hospitalizations compared with nonusers.

Smoking of Any Amount Is Proportionally Linked With Lung Disease

Smoking of Any Amount Is Proportionally Linked With Lung Disease

The risk for obstructive lung disease was nearly 8 times greater in heavy stable smokers compared with never-smokers.

Early Pulmonary Rehabilitation Lowers Mortality After COPD Exacerbation

Early Pulmonary Rehabilitation Lowers Mortality After COPD Exacerbation

Early pulmonary rehabilitation after hospitalization for an acute exacerbation of COPD was an effective intervention for reducing mortality.

Tiotropium Bromide and Olodaterol Labeling Updated With Revised Indication

Tiotropium Bromide and Olodaterol Labeling Updated With Revised Indication

The FDA has approved updated labeling for Stiolto Respimat to include COPD exacerbation data and a revised indication.

Hospital Readmissions Reduced for COPD With Discharge Care Bundle

Hospital Readmissions Reduced for COPD With Discharge Care Bundle

Patients who received a discharge care bundle after being hospitalized for an acute exacerbation of COPD had a lower rate of readmission.

Opioid Use Increases Likelihood of Intubation in COPD

Opioid Use Increases Likelihood of Intubation in COPD

Patients with chronic obstructive pulmonary disease who used opioids were more likely to be intubated during their hospitalization compared with nonopioid users

COPD Treatment With Revefenacin Offers Acceptable Cardiovascular Safety

COPD Treatment With Revefenacin Offers Acceptable Cardiovascular Safety

No changes were observed in 12-lead electrocardiographic recordings associated with daily doses of revefenacin 88 μg and 175 μg in patients with COPD.

Triple vs Dual Therapy Outcomes in Reversible, Nonreversible COPD

Triple vs Dual Therapy Outcomes in Reversible, Nonreversible COPD

Regardless of reversibility status, patients with COPD experienced significant improvements with triple vs dual therapy.

Beta-Blockers Safe in COPD With Cardiovascular Comorbidities

Beta-Blockers Safe in COPD With Cardiovascular Comorbidities

There was a trend toward a reduction in mortality in patients with COPD who received beta-blocker treatment compared with patients who did not.

Inhaled Corticosteroid Therapy Refill Disruption Leads to Exacerbations

Inhaled Corticosteroid Therapy Refill Disruption Leads to Exacerbations

Disrupting regular combination inhaled corticosteroid therapy refills increased hospitalizations and exacerbations.

Aclidinium Reduced Rate of COPD Exacerbations Regardless of CV Risk

Aclidinium Reduced Rate of COPD Exacerbations Regardless of CV Risk

Major cardiovascular adverse events were more common in the previous event subgroup, with 5.5% occurring in the aclidinium group and 6.2% in the placebo group.

Invasive Ventilation Risk in COPD Exacerbation

Invasive Ventilation Risk in COPD Exacerbation

Alcohol abuse, fluid and electrolyte abnormalities, and pulmonary circulation disorders increased the risk for noninvasive ventilation in a COPD exacerbation.

Metered Dose Inhaler Errors Affect Many With COPD and Asthma

Metered Dose Inhaler Errors Affect Many With COPD and Asthma

The most common error related to the use of metered dose inhalers was the failure to attach the inhaler to a spacer.

Improved Exercise Capacity in COPD With Automatic Oxygen Titration

Improved Exercise Capacity in COPD With Automatic Oxygen Titration

Patients with severe COPD improved significantly in both endurance time and walking distance with the use of automatically titrated oxygen flow vs constant oxygen flow.

Prophylactic Antibiotics Reduce COPD Exacerbations in Stable Disease

Prophylactic Antibiotics Reduce COPD Exacerbations in Stable Disease

Treatment with prophylactic antibiotics was associated with a reduction in the frequency of COPD exacerbations and improved quality of life.

Sleep Disturbances in COPD Linked to Airway Constriction Heterogeneity

Sleep Disturbances in COPD Linked to Airway Constriction Heterogeneity

Sleep disturbances caused by the symptoms of COPD are associated with airway constriction heterogeneity, which could be reflective of peripheral airway dysfunction.

COPD, ILD Do Not Benefit More From Bilateral Transplantation Only Listing

COPD, ILD Do Not Benefit More From Bilateral Transplantation Only Listing

No meaningful associations were detected in procedural listing preferences and survival outcomes in patients with COPD or interstitial lung disease awaiting lung transplant.

Adipose Tissue Transfer, Lung Scaffolds: The Future of Stem Cells in COPD

Adipose Tissue Transfer, Lung Scaffolds: The Future of Stem Cells in COPD

Clinicians are eager for new therapies to address the damage to airways and lung parenchyma because no current therapy can completely reverse COPD damage.

Urban Training™ Efficacious in Increasing Physical Activity in COPD

Urban Training™ Efficacious in Increasing Physical Activity in COPD

After 12 months, patients in the Urban Training™ group had increased their number of daily steps by 816 compared with 64 steps in the usual care group.

RPL554 Combined With LABAs or LAMAs Increases Bronchodilation in COPD

RPL554 Combined With LABAs or LAMAs Increases Bronchodilation in COPD

Additional bronchodilation and hyperinflation reduction occurred in COPD when RPL554, an inhaled PDE 3 and 4 inhibitor, was combined with standard bronchodilators.

Climate Change: Dire Implications for Respiratory Conditions

Climate Change: Dire Implications for Respiratory Conditions

Changing pollination patterns, extreme weather events, rising sea levels, air pollution, and extreme temperatures all negatively affect respiratory conditions.

ICS/LABA Combined in One Inhaler vs LAMA Compared for Efficacy, Safety in COPD

ICS/LABA Combined in One Inhaler vs LAMA Compared for Efficacy, Safety in COPD

There were no statistically significant differences in mortality rates, rates of COPD exacerbations, lung inflammation, or serious adverse events between a once-daily combined inhaled corticosteroid/LABA and LAMA.

Revefenacin Cuts COPD Exacerbation Rates in Phase 3 Studies

Revefenacin Cuts COPD Exacerbation Rates in Phase 3 Studies

Pooled data from two identical 12-week pivotal Phase 3 trials (N=1229) in patients with moderate to very severe COPD showed that the mean annualized rate of all COPD exacerbations was 0.47, 0.45, and 0.55 for revefenacin 175mcg/day, 88mcg/day, and placebo, respectively.

Small Reduction in Lung Function With Treatment De-Escalation in COPD

Small Reduction in Lung Function With Treatment De-Escalation in COPD

No difference in exacerbations with indacaterol/glycopyrronium for non-frequently exacerbating COPD.

New Bronchoscopic Option Used for Severe Emphysema

New Bronchoscopic Option Used for Severe Emphysema

First bronchoscopic lung volume reduction using endobronchial valve performed at Temple University in Philadelphia, PA.

FDA: More Data Required to Support Mepolizumab Approval for COPD

FDA: More Data Required to Support Mepolizumab Approval for COPD

In their Complete Response Letter, the FDA stated that they require more clinical data to support approval.

Tiotropium Associated With Increased Cardiovascular Risk in COPD

Tiotropium Associated With Increased Cardiovascular Risk in COPD

Cardiovascular risk within 30 days of therapy start was approximately 2-fold higher with the incident use of tiotropium in COPD.

COPD Has Altered Deposition of Inhaled Nanoparticles

COPD Has Altered Deposition of Inhaled Nanoparticles

In patients with emphysema, deposition fraction was significantly lower than in other individuals, but no significant differences were found between healthy never smokers and current or former smokers.

Skeletal Muscle Mass in COPD Improved With Bimagrumab

Skeletal Muscle Mass in COPD Improved With Bimagrumab

Thigh muscle volume showed significant improvements in patients with COPD who were treated with bimagrumab vs placebo.

Comorbidities Affect Treatment for COPD Exacerbations

Comorbidities Affect Treatment for COPD Exacerbations

Patients with COPD who have comorbidities are less likely to receive beneficial treatment for exacerbations.

COPD Screening Should Not Be Limited to Symptomatic Patients

COPD Screening Should Not Be Limited to Symptomatic Patients

The incidence of undiagnosed COPD was 26%, and based on the GOLD spirometry grading system, 95% had mild to moderate disease.

Emphysema Associated With Worse Outcomes in Heart Failure

Emphysema Associated With Worse Outcomes in Heart Failure

After 2.1 years of follow-up, 49% of patients who had emphysema on chest CT were readmitted for heart failure and 24% had died.

COPD Exacerbation Rates May Worsen During Colder Seasonal Temperatures

COPD Exacerbation Rates May Worsen During Colder Seasonal Temperatures

Although the summer season yielded the lowest overall COPD exacerbation rate, 43% of exacerbations during summer were moderate to very severe.

Bronchiectasis Prevalence on the Rise in COPD

Bronchiectasis Prevalence on the Rise in COPD

The average annual prevalence of bronchiectasis from 2012 to 2014 was 701 cases per 100,000 individuals.

Species-Specific Interactions of Common Bacteria in COPD

Species-Specific Interactions of Common Bacteria in COPD

S pneumoniae colonization was positively associated with H influenza colonization, whereas negative associations were reported between P aeruginosa and H influenzae and between P aeruginosa and M catarrhalis.

Asthma, COPD Readmissions Independently Predicted by Chronic Rhinitis

Asthma, COPD Readmissions Independently Predicted by Chronic Rhinitis

Comorbid chronic rhinitis is significantly associated with 30-day hospital readmissions related to asthma and chronic obstructive pulmonary disease.

Pseudomonas Associated With Frequent Hospitalizations Due to COPD Exacerbations

Pseudomonas Associated With Frequent Hospitalizations Due to COPD Exacerbations

Prior use of systemic corticosteroids and prior isolation of Pseudomonas aeruginosa were risk factors associated with the presence of Pseudomonas aeruginosa in COPD.

Hailie Solution Now Available for Tracking Asthma, COPD Medication Use

Hailie Solution Now Available for Tracking Asthma, COPD Medication Use

Through Bluetooth technology, clinicians and patients will be able to share and monitor inhaler usage.

Short-Term Corticosteroids Sufficient in Acute COPD Exacerbations

Short-Term Corticosteroids Sufficient in Acute COPD Exacerbations

Short-term corticosteroids may be sufficient for treating patients with acute COPD exacerbations.

Low Relative Lymphocyte Count Associated With Higher Mortality in COPD

Low Relative Lymphocyte Count Associated With Higher Mortality in COPD

Patients with COPD who had a relative lymphocyte count ≤20% had a higher risk for mortality.

Vaporized Cannabis Has Lack of Effect on Airway Function in COPD

Vaporized Cannabis Has Lack of Effect on Airway Function in COPD

When compared with a placebo control cannabis, cannabis had no effect on breathlessness intensity ratings during exercise at isotime or on exercise endurance time.

COPD and Asthma Overlap: Individual vs Environmental Risk Factors in Women

COPD and Asthma Overlap: Individual vs Environmental Risk Factors in Women

Socioeconomic and lifestyle risk factors had a more significant role in the development of COPD and asthma overlap syndrome in women than air pollution.

Shorter Telomeres May Predict Poor Outcomes in COPD

Shorter Telomeres May Predict Poor Outcomes in COPD

Shorter telomere length was associated with worse health status in chronic obstructive pulmonary disease, as measured by St. George's Respiratory Questionnaire.

Anxiety Prevalence in COPD Determined by Screening Questionnaires vs DSM-V

Anxiety Prevalence in COPD Determined by Screening Questionnaires vs DSM-V

Anxiety symptoms are more common in patients with COPD as determined by the Generalized Anxiety Disorder, Hospital Anxiety and Depression scale, and Anxiety Inventory for Respiratory Disease screening questionnaires vs the DSM-V criteria.

The Road to Precision Medicine in COPD Is Paved With Phenotypes

The Road to Precision Medicine in COPD Is Paved With Phenotypes

Although emerging data offer valuable clues, the pathophysiological distinctions between different phenotypes of chronic obstructive pulmonary disease are still poorly understood.

Increased Mortality Rates Observed in Patients With Rheumatoid Arthritis, COPD

Increased Mortality Rates Observed in Patients With Rheumatoid Arthritis, COPD

Mortality was significantly increased among patients with rheumatoid arthritis and COPD.

Illicit Drug Use in Asthma: Heroin, Cocaine, and Marijuana Worsen Symptoms

Illicit Drug Use in Asthma: Heroin, Cocaine, and Marijuana Worsen Symptoms

Inhaling and smoking heroin and cocaine increase the risk for asthma exacerbations and decreased pulmonary function; marijuana is associated with wheezing, cough, and sputum production.

Effect of Antibiotic Duration in Acute COPD Exacerbations

Effect of Antibiotic Duration in Acute COPD Exacerbations

Patients who were hospitalized for non-severe acute exacerbations of COPD did not experience improved outcomes when antibiotics were administered for longer than 24 hours.

High NT-proBNP in COPD May Predict Respiratory Exacerbations

High NT-proBNP in COPD May Predict Respiratory Exacerbations

NT-proBNP may be an independent predictor of respiratory exacerbations in patients with COPD even without overt cardiovascular disease.

COPD Severity May Be Affected by Collagen Biomarker Remodeling

COPD Severity May Be Affected by Collagen Biomarker Remodeling

Collagen biomarkers were significantly higher at extreme exacerbations, and were also associated with circulating adrenomedullin.

Pulmonary Embolism Prevalence in Acute COPD Exacerbations

Pulmonary Embolism Prevalence in Acute COPD Exacerbations

Rates of pulmonary embolism ranged from 3.3% to 29.1% in patients with a clinical diagnosis of an acute exacerbation of COPD.

Variations in Practice Patterns Seen in Patients Treated for COPD

Variations in Practice Patterns Seen in Patients Treated for COPD

There were differences in use of steroids and antibiotics noted between teaching and non-teaching hospital staff.

Whole-Genome Sequencing Proves Valuable in Severe COPD

Whole-Genome Sequencing Proves Valuable in Severe COPD

Whole-genome sequencing was valuable in identifying a large number of potentially significant functional variants in severe COPD.

Unraveling the Relationship Between COPD and Stroke

Unraveling the Relationship Between COPD and Stroke

Although COPD has been identified as a risk factor for cardiovascular disease, researchers are less certain about the relationship between COPD and stroke.

Childhood Respiratory Risk Factor Profiles Predict Lung Function, COPD

Childhood Respiratory Risk Factor Profiles Predict Lung Function, COPD

Frequent asthma, bronchitis, allergy demonstrated the strongest association with , lower FEV1, lower FEV1/forced vital capacity, and increased risk for COPD.

Dexamethasone Ineffective for Prevention of Acute Mountain Sickness in COPD

Dexamethasone Ineffective for Prevention of Acute Mountain Sickness in COPD

Dexamethasone was not effective in reducing the incidence of acute mountain sickness and altitude-related adverse health effects in individuals with mild to moderate COPD.

Tiotropim/Olodaterol Safe, Tolerable in COPD Regardless of Renal Impairment

Tiotropim/Olodaterol Safe, Tolerable in COPD Regardless of Renal Impairment

Regardless of renal impairment, combination therapy with tiotropium/olodaterol was safe and tolerable in patients with moderate to very severe COPD.

Umeclidinium/Vilanterol Efficacy Assessed in Elderly COPD Patients

Umeclidinium/Vilanterol Efficacy Assessed in Elderly COPD Patients

Study authors performed a post hoc pooled analysis of data from 10 trials to assess the safety and efficacy of umeclidinium/vilanterol in elderly symptomatic patients with COPD.

GERD and Nasal Symptoms Affect Bronchitis Symptom Severity in COPD

GERD and Nasal Symptoms Affect Bronchitis Symptom Severity in COPD

Gastroesophageal reflux disease is associated with an increase in bronchitis symptoms in patients with COPD.

Prolonged Leisure-Time Sitting Tied to Increased COPD Mortality Risk

Prolonged Leisure-Time Sitting Tied to Increased COPD Mortality Risk

Increase in all-cause, cardiovascular disease, cancer, diabetes, kidney disease, suicide, and COPD mortality.

FDA Approves Zephyr Endobronchial Valve for Treating Severe Emphysema

FDA Approves Zephyr Endobronchial Valve for Treating Severe Emphysema

The approval was based on results from a multicenter study (LIBERATE) of 190 patients with severe emphysema.

Use of Palliative Care, Oxygen Therapy Increasing for COPD

Use of Palliative Care, Oxygen Therapy Increasing for COPD

For patients with advanced COPD, the use of formal palliative care services and long-term oxygen therapy has increased but remains low.

Clinical Effect of Emphysema in Individuals With HIV

Clinical Effect of Emphysema in Individuals With HIV

The clinical significance of emphysema was greater in people living with HIV vs those without HIV.

COPD End-of-Life Management Strategies: Use Could Be Expanded

COPD End-of-Life Management Strategies: Use Could Be Expanded

The use of formal palliative care services among patients with chronic obstructive pulmonary disease increased by 1% per year, going from 5.3% in 2004 to 14.3% in 2014.

Patient With COPD, Smoking History Presents to ED With Sensory Loss

Patient With COPD, Smoking History Presents to ED With Sensory Loss

A 72-year-old man with a 50 pack-year smoking history and multiple comorbidities, including COPD, presents to the emergency department with left-sided hemiparesis and sensory loss.

COPD Education Program Improved Patient Knowledge of Disease

COPD Education Program Improved Patient Knowledge of Disease

There was as significant change in Bristol COPD Knowledge Questionnaire scores in patients who received a brief education program at the time of an acute exacerbation of COPD.

Stroke, MI Risk Increased After Severe COPD Exacerbations

Stroke, MI Risk Increased After Severe COPD Exacerbations

Acute COPD exacerbations were associated with an increased risk for myocardial infarction and ischemic stroke.

Severe Emphysema Benefits From Zephyr® Endobronchial Valve Treatment

Severe Emphysema Benefits From Zephyr® Endobronchial Valve Treatment

Zephyr® Endobronchial Valve EBV® treatment improved FEV1 in patients with heterogeneous emphysema.

COPD Risk From Secondhand Smoke May Be Linked With Lung Volume Variations

COPD Risk From Secondhand Smoke May Be Linked With Lung Volume Variations

The inclusion of residual volume-to-total lung capacity ratio may add another dimension to COPD not routinely captured by standard airflow indices that could be predictive of lower maximum exercise capacity.

COPD Triple Therapy Switch to LABA/LAMA May Be Appropriate in Some Patients

COPD Triple Therapy Switch to LABA/LAMA May Be Appropriate in Some Patients

A direct de-escalation from triple therapy to indacaterol/glycopyrronium may be appropriate in patients with infrequent COPD exacerbations.

Potential COPD Pulmonary Vascular Phenotype Associated With Poor Outcomes

Potential COPD Pulmonary Vascular Phenotype Associated With Poor Outcomes

A definition of a pulmonary vascular phenotype of chronic obstructive pulmonary disease has been proposed.

COPD and the "Obesity Paradox:" Is a Higher BMI Protective?

COPD and the "Obesity Paradox:" Is a Higher BMI Protective?

Recent research suggests that increasing obesity class is independently associated with worse respiratory-specific and general quality of life outcomes in COPD.

Tiotropium/Olodaterol Combination vs Tiotropium Alone for Severe COPD Exacerbations

Tiotropium/Olodaterol Combination vs Tiotropium Alone for Severe COPD Exacerbations

Tiotropium may be more effective in reducing the rate of moderate and severe chronic obstructive pulmonary disorder exacerbations when used in combination with olodaterol vs tiotropium alone.

COPD May Increase the Risk for Atrial Fibrillation

COPD May Increase the Risk for Atrial Fibrillation

Patients with COPD had a nearly 2-fold increased risk for developing atrial fibrillation compared with patients without COPD.

E-Cigarette Use Associated With Increased Risk for COPD

E-Cigarette Use Associated With Increased Risk for COPD

Using e-cigarettes every day or some days increased the likelihood of developing chronic obstructive pulmonary disease.

COPD Frequently Misdiagnosed, Undiagnosed in Individuals With or Without HIV

COPD Frequently Misdiagnosed, Undiagnosed in Individuals With or Without HIV

In this study, researchers examined the appropriateness of diagnosis and treatment of chronic obstructive pulmonary disease in individuals with and without HIV.

Steroid Dosing, Glucose Levels Do Not Increase Likelihood of COPD Readmissions

Steroid Dosing, Glucose Levels Do Not Increase Likelihood of COPD Readmissions

Steroid dosing and glucose levels were not associated with an increase in hospital readmissions related to COPD exacerbations.

Lung Function Impairment Level in COPD Not Related to Cognitive Impairment

Lung Function Impairment Level in COPD Not Related to Cognitive Impairment

No association was found between the degree of lung function impairment and the development of mild cognitive impairment in chronic obstructive pulmonary disease.

Mortality Rates in Extrafine ICS-Containing vs ICS-Free Medications in COPD

Mortality Rates in Extrafine ICS-Containing vs ICS-Free Medications in COPD

The pooled safety analysis included data from the TRILOGY, TRINITY, and TRIBUTE studies.

Incident Diuretic Use May Increase Adverse Events in COPD

Incident Diuretic Use May Increase Adverse Events in COPD

Incident diuretic use was associated with increased rates of respiratory-related morbidity and mortality in older adults with chronic obstructive pulmonary disease.

Effect of Combination vs Triple Therapy on COPD Exacerbations

Effect of Combination vs Triple Therapy on COPD Exacerbations

Combination therapy with LABA and LAMA yielded a lower annualized rate of COPD exacerbations compared with triple therapy.

Assessing Depression Following Inpatient COPD Rehabilitation

Assessing Depression Following Inpatient COPD Rehabilitation

PHQ-9 and PHQ-2 show factorial validity, invariance, and reliability for measuring depression in patients with chronic obstructive pulmonary disease.

COPD, Asthma, or Asthma COPD Overlap Syndrome: Diagnostic Challenges

COPD, Asthma, or Asthma COPD Overlap Syndrome: Diagnostic Challenges

Emerging guidelines for diagnosing and treating asthma COPD overlap syndrome will help clinicians better manage patients and prevent serious adverse effects.

Palliative Care Consult Can Cut Hospital Costs in Seriously Ill

Palliative Care Consult Can Cut Hospital Costs in Seriously Ill

Palliative care consultation was linked to a reduction in hospital costs for hospitalized adults with serious illness, such as COPD.

Survival Predictors When Life Support Is Withheld in ICU

Survival Predictors When Life Support Is Withheld in ICU

Survival at 6 months was significantly associated with acute respiratory failure and history of COPD.

Pneumonia Risk in Severe COPD Linked to Elevated Eosinophil Count

Pneumonia Risk in Severe COPD Linked to Elevated Eosinophil Count

A higher proportion of patients with COPD and a blood eosinophil count of ≥0.34×109/L had elevated markers of low-grade systemic inflammation regardless of forced expiratory volume in 1 second.

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