Asthma, allergic rhinitis, gastroesophageal reflux disease (GERD), and antibody deficiency were risk factors for the presence of chronic rhinosinusitis among patients with bronchiectasis, according to study results published in the International Forum of Allergy & Rhinology.

Investigators obtained medical records from patients with bronchiectasis confirmed by chest computed tomography scans from a large database at a tertiary care center. Patients were grouped according to whether or not they also had concurrent chronic rhinosinusitis and potential risk factors were retroactively compared between groups. The following potential risk factors were examined: asthma, allergic rhinitis, GERD, chronic obstructive pulmonary disease, peripheral eosinophil counts, autoimmune disease, antibody deficiency, age, sex, race, ethnicity, body mass index, smoking status, and pulmonary function.

Among the 900 medical records examined, 45% of patients with bronchiectasis confirmed by chest computed tomography scans had concurrent chronic rhinosinusitis. Sex, race, smoking status, and body mass index did not significantly differ between patients with bronchiectasis with and without chronic rhinosinusitis; however, asthma, allergic rhinitis, GERD, and antibody deficiency were each independently associated with the presence of chronic rhinosinusitis in patients with bronchiectasis.

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The study investigators wrote, “Asthma, allergic rhinitis, GERD, and antibody deficiency were significantly associated with the presence of chronic rhinosinusitis in patients with bronchiectasis.”

They added, “This finding is clinically relevant as past evidence suggests that chronic rhinosinusitis and other comorbidities contribute to increased exacerbation frequency and decreased quality of life in patients with bronchiectasis.”

Reference

Somani SN, Kwah JH, Yeh C, et al. Prevalence and characterization of chronic rhinosinusitis in patients with non-cystic fibrosis bronchiectasis at a tertiary care center in the United States [published online October 7, 2019]. Int Forum Allergy Rhinol. doi:10.1002/alr.22436