This article is part of Pulmonology Advisor‘s coverage of the ACAAI 2019 meeting, taking place in Houston, TX. Our staff will report on medical research related to allergies, asthma, and more conducted by experts in the field. Check back regularly for more news from ACAAI 2019.
HOUSTON — Gamma aminobutyric acid (GABA) agonists for chronic pain, such as gabapentin and pregabalin, were not associated with higher prevalence of allergic rhinoconjunctivitis and asthma, according to research presented at the 2019 Annual Scientific Meeting of the American College of Allergy, Asthma & Immunology held November 7-11 in Houston, Texas.
Researchers previously established an association between prescription opioid analgesics for chronic pain and the incidence of allergic rhinoconjunctivitis and asthma. To investigate whether the use of GABA agonists (eg, gabapentin, pregabalin) increased the prevalence of allergic rhinoconjunctivitis and asthma, the researchers conducted a retrospective chart review of data from 2951 patients who were hospitalized or who visited the emergency department or ambulatory surgery setting from 2013 through 2017. The percentage of these patients having asthma and allergic rhinoconjunctivitis as well as the percentage who had a prescription for gabapentin or pregabalin, were determined.
Results demonstrated that the use of GABA agonists was not associated with the prevalence of allergic rhinoconjunctivitis and asthma. In 124 patients with a diagnosis of allergic rhinoconjunctivitis, only 15 had a prescription for a GABA agonist (3.6%; P =.690). Of the 84 patients with an asthma diagnosis, only 9 had a prescription for a GABA agonist (2.2%; P =.521).
“Although we have previously determined that opioid prescription for chronic pain is associated with higher prevalence of allergic rhinoconjunctivitis and asthma, this study showed no association of use of GABA agonists such as gabapentin and pregabalin,” the researchers concluded.
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Khan S, Naik R, Mohiuddin A, Smerling J, Joks R. Association of use of GABA agonist prescription with asthma and allergic rhinoconjunctivitis. Presented at: 2019 Annual Scientific Meeting of the American College of Allergy, Asthma, & Immunology; November 7-11, 2019; Houston, TX. Abstract P355.