Dupilumab significantly reduced severe asthma exacerbations in patients with oral corticosteroid-dependent severe asthma with and without early improvements in lung function.
Irrespective of the type and number of background controller therapies, mepolizumab consistently reduced the annual rate of exacerbations in severe eosinophilic asthma compared with placebo.
Better asthma control in children can be achieved by either increasing inhaled corticosteroid dose or by switching to a combination of inhaled corticosteroid plus long-acting beta agonist with similar treatment outcomes.