NEW ORLEANS — Asthma appeared to be associated with lower mortality in patients admitted to the hospital with myocardial infarction (MI), according to the results of a large propensity-matched cohort study presented at the CHEST 2019 Annual Meeting held October 19 to 23, in New Orleans, Louisiana.

Researchers hypothesized that the immunopathology profile associated with asthma might confer protection after MI. All hospital admissions with a primary diagnosis of MI (both ST-elevation MI and non-ST-elevation MI) were examined using the 2016 National Inpatient Sample. International Statistical Classification of Diseases and Related Health Problems-10 codes were used to identify patients with a history of asthma. The designated outcome was inpatient mortality.

A total of 12,926 patients were included in the analysis (6463 with asthma and 6463 without asthma). Patients with asthma were more likely to be men, to have ST-elevation MI, and to undergo percutaneous coronary intervention compared with patients without asthma. They also tended to have a lower prevalence of cancer, lower Elixhauser scores, and lower Charlson Comorbidity indices. No other notable demographic differences were recorded.


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Inpatient mortality was lower in patients with asthma vs patients without asthma (odds ratio, 0.74; 95% CI, 0.62-0.89; P =.001), which remained the same after adjusting for sex, type of MI, percutaneous coronary intervention, cancer, and Charlson and Elixhauser indices (odds ratio, 0.80; 95% CI, 0.66-0.97; P =.025).

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The researchers noted there was no interaction between asthma and sex or type of MI with respect to mortality. In addition, there were no major differences in lengths of stay or total inpatient charges between patients with and without asthma.

“Understanding the immunopathology of asthma may provide mechanistic clues to improve outcomes in patients with [MI],” the researchers wrote.

Disclosure: Several study authors declared affiliations with the pharmaceutical industry. Please see the original reference for a full list of authors’ disclosures.

Reference

Tashtish N, Al-Kindi S, Yaqoob Z, Khayata M, Zidar D, Zein J. Asthma is associated with lower risk of mortality in patients admitted with acute myocardial infarction. Presented at: CHEST 2019 Annual Meeting; October 19-23, 2019; New Orleans, LA. Abstract 37.