This article is part of Pulmonology Advisor‘s coverage of the CHEST 2019 meeting, taking place in New Orleans, LA. Our staff will report on medical research related to asthma, COPD, critical care medicine, and more conducted by experts in the field. Check back regularly for more news from CHEST 2019.


NEW ORLEANS — Use of home oxygen (O2) is associated with reduced physical function in patients with either chronic obstructive pulmonary disease (COPD) or idiopathic pulmonary fibrosis (IPF), according to research presented at CHEST Annual Meeting 2019, held October 19 to 23, in New Orleans, Louisiana.

The study was a cross-sectional analysis of patients from the COPD Patient-Powered Research Network (PPRN) and PaTH Clinical Data Research Network (CDRN) IPF cohort. Individuals in this cohort reported a diagnosis of either COPD (n=5334) or IPF (n=154). Researchers assessed the prevalence of O2 use in this population and examined the associations between patient-reported O2 therapy and 7 Patient-Reported Outcomes Measurement Information System (PROMIS) domains. These domains included physical function, fatigue, anxiety, depression, sleep, satisfaction with participation in social roles, ability to participate in social roles, and pain interference.

Approximately 18% of patients with COPD and 34% of patients with IPF reported using O2 only with ambulation and/or during sleep. Continuous O2 use was reported in 32% of patients with COPD and 31% of patients with IPF. In patients with IPF, the use of O2 was more likely in patients aged ≥60 years (87 vs 77; P =.02), were men (57% vs 39%; P <.001), and were married or living with a partner (79% vs 55%; P <.001) vs patients with COPD.

Any O2 use correlated with a higher proportion of patients in both cohorts reporting worsened physical function compared with no O2 use (P <.001). In the IPF cohort, patients using O2 reported worse satisfaction with social roles compared with those not using O2 therapy (P <.001). A higher proportion of patients in the COPD cohort reported symptoms of anxiety, depression, fatigue, and less ability to participate in social roles if they used O2 (P <.001).

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“Future research is needed to understand factors contributing to poor [quality of life] in patients using supplemental oxygen, and to develop and evaluate interventions to support this patient population,” the researchers wrote.

Disclosure: Several study authors declared affiliations with the pharmaceutical industry. Please see the original reference for a full list of authors’ disclosures.

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Reference

Prieto-Centuron V, Dimmock A, Krishnan J, et al. The need for oxygen therapy is associated with worse patient-reported outcomes in patients with COPD and IPF. Presented at: CHEST Annual Meeting 2019; October 19-23, 2019; New Orleans, LA. Abstract 467.