Association Between Asthma and Inflammatory Bowel Disease Examined

HealthDay News — Asthma is associated with subsequent development of inflammatory bowel disease (IBD), according to a study published in Clinical Gastroenterology and Hepatology.

M. Ellen Kuenzig, PhD, from University of Calgary in Canada, and colleagues used health administrative data to examine the association between a diagnosis of asthma and Crohn’s disease (3087 patients) or ulcerative colitis (2377 patients) compared to a diagnosis of asthma among persons without IBD (402,800 patients).

The researchers found that a diagnosis of asthma was associated with increased odds of incident Crohn’s disease (adjusted odds ratio [OR], 1.45; 95% CI, 1.31-1.60). Age at diagnosis did not change the effect for Crohn’s disease (P >.42). 

However, age at diagnosis did modify the effect for ulcerative colitis (P =.0103), with an adjusted OR of 1.49 (95% CI, 1.08-2.07) for individuals diagnosed at ≤16 years and an adjusted OR of 1.57 (95% CI, 1.31-1.89) among individuals diagnosed at >40 years. Among individuals diagnosed between ages 17 and 40 years, there was no association between asthma and ulcerative colitis (adjusted OR, 1.05; 95% CI, 0.86-1.26).

“In a population-based case-control study, we associated asthma with Crohn’s disease, and with early- and late-onset ulcerative colitis,” the authors write.

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Kuenzig ME, Barnabe C, Seow CH, et al. Asthma is associated with subsequent development of inflammatory bowel disease: A population-based case–control study. Clin Gastroenterol Hepatol. 2017;15(9):1405-1412.e3.