Periprocedural complications of percutaneous coronary interventions (PCIs) may occur more often in patients with chronic obstructive pulmonary disease (COPD), which may be an autonomous positive forecaster of no-reflow and a negative forecaster of periprocedural allergic response, according to a study published in PLOS One.

Researchers analyzed 221,187 patients who had undergone PCIs in Poland between January 2015 and December 2016. Of these patients, 5594 had COPD. The goal was to study the relationship between COPD, its complications, and statistics in patients undergoing PCI.

The results showed that patients with COPD were older compared with those who did not have COPD (70.3±9.9 vs 67±10.8 years; P <.05). There were 145 (2.6%) periprocedural complications in the COPD group and 4121 (1.9%) in the non-COPD group (P <.001). The increased occurrence of periprocedural complications in patients with COPD was largely attributed to cardiac arrest (P =.001), myocardial infarctions (P =.002), and no-reflows (P <.001). COPD was not the independent forecaster of all periprocedural complications. However, COPD was found to be a lone predictor of increased no-reflow risk (odds ratio [OR] 1.447; 95% CI, 1.085-1.929; P =.01), and indicative of a decreased risk for periprocedural allergic reactions (OR 0.117; 95% CI, 0.016-0.837; P =.03).

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 “In the patients undergoing PCI, the periprocedural complication rate is higher in those from the COPD group than the non-COPD group,” The researchers wrote. However, they noted, that COPD may not be an independent forecaster of periprocedural complications in patients undergoing PCI.


Januszek R, Dziewierz A, Siudak Z, Rakowski T, Dudek D, Bartuś S. Chronic obstructive pulmonary disease and periprocedural complications in patients undergoing percutaneous coronary interventions [published online October 1, 2018]. PLoS One. doi: 10.1371/journal.pone.0204257