Self-Reported Lung-Related Comorbidities Have No Impact on LCS Outcomes

The future of chemotherapy-based options for patients with HER2-negative MBC is evolving, with emerg
The future of chemotherapy-based options for patients with HER2-negative MBC is evolving, with emerg
Researchers sought to determine if self-reported lung-related comorbidities was an indicator of poor outcomes on lung cancer screening.

Patients undergoing lung cancer screening (LCS) who self-reported lung-related comorbidities did not have differing outcomes compared with those not reporting conditions. These findings were published in JAMA Network Open.

Current guideline recommendations indicate people aged 50 to 80 years who had a 20 pack-year smoking history should undergo annual LCS. These recommendations do not specify whether those with comorbidities should be evaluated.

This study sought to assess whether self-reported lung-related comorbidities may be a marker for poorer LCS outcomes. Data for this study were sourced from the North Carolina Lung Screening Registry. For this study, 611 patients who underwent LCS at 5 centers between 2014 and 2020 were evaluated for characteristics and outcomes on the basis of self-reported comorbidities.

Patients with and without (335 and 276, respectively) self-reported comorbidities comprised 53.7% and 44.6% women (P =.02), 84.4% and 71.0% were White (P <.001), and 46.7% and 30.8% had high school or less education (P =.001), respectively. No significant differences in nonlung comorbidities were observed between cohorts.

Among all examinations, 13.8% were positive at baseline, 11.6% were positive at follow-up, the cancer detection rate was 1.8 per 100 persons, and the false positive rate was 11.2 per 100 persons. No significant differences in LCS outcomes were observed on the basis of self-reported lung-related comorbidity (all P ≥.14).

Among the 17 participants found to have lung cancer, 82.4% had non-small cell lung cancer, 81.3% had stage I disease, and 64.7% had adenocarcinoma histology.

The major limitation of this study was that some patients may have sought medical care outside the network for lung cancer.

These data indicated that White women with lower educational attainment were more likely to self-report lung-related comorbidities, but that self-reporting had little correlation with LCS outcomes.


Metwally EM, Rivera MP, Durham DD, et al. Lung cancer screening in individuals with and without lung-related comorbidities. JAMA Netw Open. 2022;5(9):e2230146. doi:10.1001/jamanetworkopen.2022.30146

This article originally appeared on Oncology Nurse Advisor