Osimertinib May Improve Outcomes in EGFR Mutation-Postive NSCLC

HealthDay News — For patients with previously untreated, epidermal growth factor receptor (EGFR) mutation-positive advanced non-small-cell lung cancer (NSCLC), treatment with osimertinib is associated with longer progression-free survival than a standard EGFR tyrosine kinase inhibitor (TKI), according to a study published in the New England Journal of Medicine to coincide with the European Society for Medical Oncology Asia 2017 Congress, held from November 17 to 19 in Singapore.

Jean-Charles Soria, MD, PhD, from the Gustave Roussy Cancer Campus and University Paris-Sud, and colleagues conducted a phase 3 trial involving 556 patients with previously untreated EGFR mutation-positive advanced NSCLC. Participants were randomized to receive osimertinib or standard EGFR-TKI.

The researchers found that median progression-free survival was significantly longer with osimertinib than EGFR-TKIs (18.9 months vs 10.2 months; hazard ratio for disease progression or death, 0.46 [95% confidence interval, 0.37 to 0.57; P <.001]). The 2 groups had a similar objective response rate (80% and 76%, respectively; odds ratio, 1.27 [95% confidence interval, 0.85 to 1.90; P =.24]). The median response duration was 17.2 months with osimertinib and 8.5 months with standard EGFR-TKIs. Grade 3 or higher adverse events were less frequent with osimertinib (34% vs 45%).

“Osimertinib showed efficacy superior to that of standard EGFR-TKIs in the first-line treatment of EGFR mutation-positive advanced NSCLC, with a similar safety profile and lower rates of serious adverse events,” the authors write.

The study was funded by AstraZeneca, the manufacturer of osimertinib.

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Soria JC, Ohe Y, Vansteenkiste, J, et al. Osimertinib in untreated EGFR-mutated advanced non-small-cell lung cancer [published online November 18, 2017.] NEJM. doi: 10.1056/NEJMoa1713137