Patients with severe obstructive sleep apnea had higher blood pressure values than those with mild-to-moderate OSA or individuals without OSA.
Continuous positive airway pressure may be a preferred alternative to noninvasive ventilation as first-line therapy in stable ambulatory patients with obesity hypoventilation syndrome and concurrent severe obstructive sleep apnea.
Treatment response was more likely with favorable nonpharyngeal traits, moderate pharyngeal collapsibility, and weaker muscle compensation.
Interventions producing sustained weight loss of 25% to 30% of body weight recommended.
Individuals with obstructive sleep apnea who breathed through their mouths >25% of the time failed to achieve stable breathing during oronasal CPAP therapy.