Patients hospitalized with pneumonia often receive excess antibiotic therapy that may be associated with adverse events.
Understanding the pneumococcal population dynamics will drive an effective next-generation vaccine design.
The PCV-13 demonstrated an association with the detection of low-density colonization and resulted in vaccine efficacy against colonization acquisition.
In elderly patients who are admitted to the hospital with community-acquired pneumonia with sepsis and do not require critical care unit support, the use of high-dose simvastatin may improve clinical outcomes.
Despite national guideline recommendations and the high prevalence of viral etiology of CAP in children, the use of antibiotics remains high.