Chest Radiographic Screening in Active Uveitis to Diagnose Sarcoidosis

HealthDay News — Most patients with active uveitis of unknown origin with abnormal chest radiographs have findings consistent with sarcoidosis, according to a study published in the Annals of the American Thoracic Society.

Fahriye Groen, MD, from the Erasmus Medical Center in Rotterdam, Netherlands, and colleagues conducted a retrospective cross-sectional study by reviewing all chest imaging for adults with new-onset uveitis of unknown origin. The authors related radiographic findings to clinical and other imaging characteristics.

The researchers found that 15% of the 200 patients included in the study had abnormal screening chest radiographs. Twenty-two patients (11%) had biopsy-confirmed sarcoidosis; 12 additional patients were presumed to have sarcoidosis. For biopsy-confirmed sarcoidosis, the finding of chest radiographic abnormalities interpreted as typical of sarcoidosis was specific, but not sensitive (91% and 64%, respectively). The sensitivity was increased to 79% with the combination of elevated serum angiotensin-enzyme level and chest radiographic findings typical of sarcoidosis. Patients with panuveitis more often had biopsy-confirmed sarcoidosis than those with other anatomical locations of uveitis (20% versus 4%).

“Our study shows that an abnormal chest radiograph was observed for 15% of 200 patients with active uveitis of unknown origin and of less than one year in duration,” the authors wrote.

The study was partially funded by AbbVie.

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Groen F, van Laar J, Rothova A. Chest Radiographic Screening for Sarcoidosis in the Diagnosis of Patients with Active Uveitis. Ann Am Thorac Soc. 2017Jun;14(6):912-918. doi:10.1513/AnnalsATS.201611-888OC

This article originally appeared on Infectious Disease Advisor