Tuberculosis

Diagnostic Accuracy: A Point-of-Care Tuberculosis Test for Those With HIV

By

Infectious Disease Advisor Contributing Writer

The novel Fujifilm SILVAMP TB LAM assay offers superior diagnostic sensitivity while also maintaining specificity, compared with standard assay.

Fourth Generation QuantiFERON-TB Gold Noninferior to Previous in Immunocompromised

By

Natasha Priya Dyal, MD

In patients who are immunocompromised, such as people living with HIV, the new fourth-generation QuantiFERON-TB Gold Plus assay demonstrated similar sensitivity to the third-generation interferon-gamma release assay for the diagnosis of latent tuberculosis.

PPD Shortage Prompts CDC to Issue New Recommendations for TB Testing

By

Diana Ernst, RPh

The CDC announced an expected 3 to 10 month shortage of Aplisol used as an aid in the diagnosis of tuberculosis.

FDA Panel Votes on Treatment for Extensively Drug-Resistant, Multidrug-Resistant TB

By

Diana Ernst, RPh

The FDA’s Antimicrobial Drugs Advisory Committee voted in favor of pretomanid, as part of a combination regimen with bedaquiline and linezolid, for the treatment of pulmonary extensively drug resistant, treatment intolerant, or nonresponsive multidrug resistant tuberculosis.

Low-Level Delamanid and Bedaquiline Resistance in Extremely Drug-Resistant TB

By

Sweta Gupta

Researchers reported a case of drug resistance against 2 recently approved antitubercular medications: delamanid and bedaquiline.

Rifapentine Plus Isoniazid Noninferior to Isoniazid in HIV-Related TB

By

Bradley van Paridon

For prevention of TB in people with HIV, a single month regimen of rifapentine plus isoniazid was noninferior to 9 months of isoniazid alone.

CDC: Tuberculosis Incidence Declined in United States in 2017

Number of tuberculosis cases and incidence decreased globally, but more progress is needed to meet targets.

QuantiFERON-TB Gold-Plus Performance in Children With Confirmed Tuberculosis

By

Pulmonology Advisor Contributing Writer

The new interferon-gamma release assay QuantiFERON-TB Gold Plus had good sensitivity in children with pulmonary tuberculosis.