QuantiFERON-TB Gold Plus was comparable to other interferon gamma release assays for predicting tuberculosis in adults with recent contacts.
Preventive therapy was effective in most children with tuberculosis if given before development of active disease.
The National Tuberculosis Controllers Association and the Centers for Disease Control and Prevention have released updated guidelines for the treatment of latent tuberculosis infection.
A short, 9-month regimen of normal dose moxifloxacin maintained good effectiveness up to 24 months after therapy cessation in patients with rifampicin-resistant tuberculosis.
Daily doses of 10 to 15 mg/kg isoniazid demonstrated similar activity against tuberculosis (TB) strains with inhA mutations as 5 mg/kg doses against drug-sensitive strains.
In patients without a contraindication, rifampicin may be the safest treatment option for latent tuberculosis (TB) infection.
Treatment with 4 months of rifampin for latent tuberculosis infection was associated with higher adherence, lower costs, and lower risk for severe hepatoxicity compared with 9 months of isoniazid.
Post-tuberculosis lung disease is common in patients with HIV-associated tuberculosis at high risk for tuberculosis-associated immune reconstitution inflammatory syndrome.