Lung Cancer Archives

Tobacco Use Remains Leading Modifiable Cause of Cancer

Tobacco Use Remains Leading Modifiable Cause of Cancer

Tobacco control could prevent more cancer deaths than any other strategy.

Atezolizumab Combo Improved PFS, OS in Stage IV Non-Small Cell Lung Cancer

Atezolizumab Combo Improved PFS, OS in Stage IV Non-Small Cell Lung Cancer

Significant improvements were seen with the addition of atezolizumab to CnP in stage IV non-squamous non-small cell lung cancer, regardless of patient PD-L1 status.

Metastatic NSCLC Treatment Aided by Plasma-Based Genotyping

Metastatic NSCLC Treatment Aided by Plasma-Based Genotyping

Most patients with metastatic non-small cell lung cancer who received targeted therapy based on plasma result achieved clinical response.

Lung Cancer Deaths 28% Lower in California Than Rest of US

Lung Cancer Deaths 28% Lower in California Than Rest of US

In individuals aged 18 to 35, California has had larger drops in smoking initiation, intensity, and higher rates of quitting.

Immune-Related Adverse Events Due to Checkpoint Inhibition Are More Common in Melanoma Than in NSCLC

Immune-Related Adverse Events Due to Checkpoint Inhibition Are More Common in Melanoma Than in NSCLC

Researchers investigated whether the rates of immune-related adverse events linked to treatment with nivolumab or pembrolizumab were similar across 2 different cancer types.

Longer Survival in NSCLC With Brigatinib vs Crizotinib

Longer Survival in NSCLC With Brigatinib vs Crizotinib

Longer progression-free survival was significantly longer in patients with ALK-positive disease who did not previously take an ALK inhibitor.

Integrated Classifier Identifies Benign Lung Nodules

Integrated Classifier Identifies Benign Lung Nodules

Classifier integrates relative abundance of 2 plasma proteins with clinical risk prediction model for lung nodules.

Vizimpro Approved as First-Line Treatment for EGFR-Mutated Metastatic NSCLC

Vizimpro Approved as First-Line Treatment for EGFR-Mutated Metastatic NSCLC

The approval was based on data from the ARCHER 1050 open-label, active controlled study which randomized patients with unresectable, metastatic NSCLC to treatment with either dacomitinib (N=227) or gefitinib (N=225).

Salvage Therapy for Recurrent SABR-Treated Early-Stage NSCLC Increases Survival

Salvage Therapy for Recurrent SABR-Treated Early-Stage NSCLC Increases Survival

Salvage treatment for recurrence of early-stage non-small cell lung cancer after initial treatment with stereotactic ablative radiotherapy improved patient survival.

RET Inhibitor Gets Breakthrough Tx Status for NSCLC, Medullary Thyroid Cancer

RET Inhibitor Gets Breakthrough Tx Status for NSCLC, Medullary Thyroid Cancer

LOXO-292 is being evaluated in the ongoing Phase 1/2 LIBRETTO-001 clinical trial.

Poor, Non-English Speaking Cancer Patients Need Support

Poor, Non-English Speaking Cancer Patients Need Support

Serving patients' specific needs, such as referral to socioeconomic support, can improve care.

High-Quality Diet Linked to Lower Mortality in Cancer Survivors

High-Quality Diet Linked to Lower Mortality in Cancer Survivors

High-quality diet linked to reduced risk of overall and cancer-specific mortality vs poor-quality diet.

Poor Shared Decision Making for Lung Cancer Screening

Poor Shared Decision Making for Lung Cancer Screening

Physicians universally recommended lung cancer screening and rarely discuss harms.

Early CT Detection of Small Cell Lung Cancer Does Not Improve Survival Rates

Early CT Detection of Small Cell Lung Cancer Does Not Improve Survival Rates

Screening for small cell lung cancer using low-dose computed tomography had no effect on outcomes for patients.

Lung Cancer Imaging in Asymptomatic Patients: To Screen or Not to Screen?

Lung Cancer Imaging in Asymptomatic Patients: To Screen or Not to Screen?

Although screening for lung cancer with low-dose computed tomography has demonstrated a reduction in mortality, some experts say the benefits do not outweigh the potential harms.

Racial Disparities in Surgical Treatment of Lung Cancer

Racial Disparities in Surgical Treatment of Lung Cancer

As lung cancer screening disseminates into clinical practice, efforts designed to target black men should be prioritized.

Keytruda With Pemetrexed + Platinum Chemotherapy OK'd for Nonsquamous NSCLC

Keytruda With Pemetrexed + Platinum Chemotherapy OK'd for Nonsquamous NSCLC

The median OS was not reached at the time of the data cut-off in the pembrolizumab plus chemotherapy arm and was 11.3 months for those in the chemotherapy arm.

Opdivo Approved to Treat Metastatic Small Cell Lung Cancer

Opdivo Approved to Treat Metastatic Small Cell Lung Cancer

Data showed that 12% responded to treatment based on assessment by a Blinded Independent Central Review, regardless of PD-L1 expression; 11% had a partial response, and 1 patient had a complete response (0.9%).

Broad Genetic Testing for NSCLC May Not Improve Survival

Broad Genetic Testing for NSCLC May Not Improve Survival

Compared with routine genetic testing, there was no improvement in unadjusted mortality rate in non-small cell lung cancer.

Disparities Remain in Prevalence of Cancer Screening Tests

Disparities Remain in Prevalence of Cancer Screening Tests

From 2000 to 2015, individuals without insurance or usual care were less likely to have undergone cancer screening.

Biomarker Panel May Improve Lung Cancer Risk Assessment

Biomarker Panel May Improve Lung Cancer Risk Assessment

Risk score based on panel of four circulating protein biomarkers.

Lurbinectedin Gains Orphan Drug Status for Small Cell Lung Cancer

Lurbinectedin Gains Orphan Drug Status for Small Cell Lung Cancer

A Phase 2 multicenter trial examined the safety and efficacy of lurbinectedin in several types of advanced solid tumors, including SCLC.

Nurse Navigators Can Help to Improve Oncology Care

Nurse Navigators Can Help to Improve Oncology Care

Nurse navigators include registered nurses and licensed practical nurses who work together in pairs

Lay Health Workers Can Improve End-of-Life Cancer Care

Lay Health Workers Can Improve End-of-Life Cancer Care

Incorporating lay health workers into cancer care increases goals-of-care documentation and patient satisfaction.

Aldehydes Dominant Carcinogen in Tobacco Smoke

Aldehydes Dominant Carcinogen in Tobacco Smoke

Aldehydes act by inducing DNA damage and inhibiting DNA repair.

Lung Cancer Incidence in HIV Remains High Years After Smoking Cessation

Lung Cancer Incidence in HIV Remains High Years After Smoking Cessation

The incidence of lung cancer remains increased 5 years after smoking cessation.

Initial Outcomes No Worse for Surgical ICU Patients With Cancer

Initial Outcomes No Worse for Surgical ICU Patients With Cancer

ICU and hospital mortality were lower for patients with cancer vs those without cancer.

Exploring Overdiagnosis in Cancer Screening

Exploring Overdiagnosis in Cancer Screening

Standardized definition and guidance on estimation may facilitate understanding of cancer overdiagnosis.

In Cancer, PTSD May Increase Symptom Burden

In Cancer, PTSD May Increase Symptom Burden

Post-traumatic stress symptoms were also linked to lower risk of readmission in hospitalized patients with cancer.

Awake Video-Assisted Thoracoscopic Surgery Safe Option in Lung Cancer

Awake Video-Assisted Thoracoscopic Surgery Safe Option in Lung Cancer

Awake video-assisted thoracoscopic surgery was safe and feasible in some patients with poor lung function and lung cancer.

Non-Small Cell Lung Cancer Risk Increases With Chronic Inflammatory Lung Disease

Non-Small Cell Lung Cancer Risk Increases With Chronic Inflammatory Lung Disease

A history of chronic inflammatory lung disease appears to increase the risk of developing non-small cell lung cancer.

New Assays May Detect Early Lung Cancer in Blood

New Assays May Detect Early Lung Cancer in Blood

Targeted sequencing, whole-genome sequencing, and whole-genome bisulfite sequencing showed potential for detecting lung cancer.

Pembrolizumab Superior for Initial Treatment of Advanced NSCLC

Pembrolizumab Superior for Initial Treatment of Advanced NSCLC

Pembrolizumab improved overall survival vs chemotherapy regardless of the programmed death ligand 1 tumor proportion score.

Indeterminate Pulmonary Nodules Characterized by CT-Based Radiomic Classifier

Indeterminate Pulmonary Nodules Characterized by CT-Based Radiomic Classifier

A total of 8 quantitative radiologic features were used to characterize indeterminate screen-detected lung nodules.

Alimta Labeling Updated to Include Combo Treatment for NSCLC

Alimta Labeling Updated to Include Combo Treatment for NSCLC

Merck initially gained accelerated approval for Keytruda with Alimta and carboplatin in May 2017.

Prediction Tool Helps Tailor Lung Cancer Screening to Patients

Prediction Tool Helps Tailor Lung Cancer Screening to Patients

Researchers created a web-based decision tool to facilitate personalized discussions regarding lung cancer screening.

Lung Cancer Incidence Higher in Young Women Than Young Men

Lung Cancer Incidence Higher in Young Women Than Young Men

Researchers examined nationwide population-based incidence of lung cancer according to sex, race or ethnic group, age group, birth year, and calendar period of diagnosis.

Bioengineering Feasible for Airway Reconstruction

Bioengineering Feasible for Airway Reconstruction

Bioengineered tracheal and bronchial reconstruction was conducted using stented aortic matrices.

Few Eligible Smokers Had Lung Cancer Screening in 2016

Few Eligible Smokers Had Lung Cancer Screening in 2016

The most eligible smokers were populated in South, which had most screening sites but the low screening rates

Risk Models Help Select Ever Smokers for Lung Cancer Screening

Risk Models Help Select Ever Smokers for Lung Cancer Screening

Four models were well-calibrated and had higher areas under the curve than 5 models that overestimated lung cancer risk.

CKAP4 Is Novel Serodiagnostic Marker for Lung Cancer

CKAP4 Is Novel Serodiagnostic Marker for Lung Cancer

Serum CKAP4 levels of lung cancer patients were significantly higher than those of healthy controls.

Cancer Incidences and Burden Expected to Shift in HIV-Positive

Cancer Incidences and Burden Expected to Shift in HIV-Positive

Prostate and lung cancer expected to emerge as the most common types by 2030.

Clinical Upstaging of NSCLC Seen With Each Progressive Week

Clinical Upstaging of NSCLC Seen With Each Progressive Week

For clinical stage 1 non-small-cell lung cancer, 21.7% of patients upstaged after 1 week and 31.5% after 8 weeks.

Polypharmacy More Likely for Cancer Survivors

Polypharmacy More Likely for Cancer Survivors

More cancer survivors prescribed 5 or more unique medications, including medications with abuse potential.

A Potential Algorithm for Diagnosing Cavitary Lung Diseases

A Potential Algorithm for Diagnosing Cavitary Lung Diseases

Researchers developed an algorithmic approach to diagnosing lung cavitary diseases.

Adjuvant Pembrolizumab Beneficial in Metastatic NSCLC

Adjuvant Pembrolizumab Beneficial in Metastatic NSCLC

Nivolumab plus ipilimumab linked to better survival in NSCLC with high tumor mutational burden.

Most Patients Are Unaware of Cancer Drug Shortages

Most Patients Are Unaware of Cancer Drug Shortages

Majority of patients say they want to know about even minor consequences of cancer drug substitutions.

Dacomitinib Granted Priority Review for NSCLC With EGFR-Activating Mutations

Dacomitinib Granted Priority Review for NSCLC With EGFR-Activating Mutations

Dacomitinib is a pan-human epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor.

Lag in Progress Against Lung Cancer Mortality in Midwest, Appalachia

Lag in Progress Against Lung Cancer Mortality in Midwest, Appalachia

Findings based on rates in women vs steady decline seen nationally.

Benign Lung Nodules Identified Using Proteomic Biomarker

Benign Lung Nodules Identified Using Proteomic Biomarker

An integrated proteomic classifier accurately identified benign lung nodules when used in patients with a pretest probability of malignancy ≤50%.

Lung Cancer Risk May Be Predicted by Frequency of COPD Exacerbations

Lung Cancer Risk May Be Predicted by Frequency of COPD Exacerbations

Independent predictive factors of lung cancer in chronic obstructive pulmonary disease may include frequency of exacerbations, in addition to airflow obstruction and visual emphysema.

COPD, Respiratory Symptoms Associated With "Western" Diet

COPD, Respiratory Symptoms Associated With "Western" Diet

Researchers used data from the Atherosclerosis Risk in Communities Study to assess associations between dietary pattern and pulmonary assessments.

Infused Chemotherapy Trends During 10-Year Period

Infused Chemotherapy Trends During 10-Year Period

During a 10-year period, there was an increase in the rate of commercially insured patients receiving infused chemotherapy in hospital outpatient departments.

Exercise May Improve Quality of Life in Lung Cancer

Exercise May Improve Quality of Life in Lung Cancer

Study examines increased physical activity may lower the risk for several cancers and may be beneficial for improving quality of life.

Lung Cancer Screening: Updated Guidelines From CHEST

Lung Cancer Screening: Updated Guidelines From CHEST

A CHEST expert panel has released updated guidelines for lung cancer screening.

Lung Cancer Postoperative Complications Reduced With Preoperative Exercise

Lung Cancer Postoperative Complications Reduced With Preoperative Exercise

Patients who underwent lung resections had reduced postoperative complication rates when they participated in preoperative exercise.

Early-Stage Non-Small Cell Lung Cancer Mortality With Surgery vs Radiotherapy

Early-Stage Non-Small Cell Lung Cancer Mortality With Surgery vs Radiotherapy

Mortality rates are higher after surgery vs stereotactic body radiotherapy for patients with early non-small-cell lung cancer.

Lung Cancer Screening Requires Effective Risk Stratification

Lung Cancer Screening Requires Effective Risk Stratification

Lung cancer screening is more effective and efficient for high-risk individuals.

Lung Cancer Survival May Be Predicted by BMI and Age

Lung Cancer Survival May Be Predicted by BMI and Age

Younger age and higher body mass index may be positive predictors of progression-free survival in patients with squamous cell carcinoma of the lung.

Small Cell Lung Cancer: Barriers to Chemotherapy, Radiation

Small Cell Lung Cancer: Barriers to Chemotherapy, Radiation

Lack of insurance correlated with a reduced likelihood of chemotherapy and radiation therapy for small cell lung cancer.

Lack of Communication Regarding Malignancy Risk in Indeterminate Pulmonary Nodules

Lack of Communication Regarding Malignancy Risk in Indeterminate Pulmonary Nodules

Qualitative risk statements of malignancy for indeterminate pulmonary nodules are imprecise, highly variable, and should be replaced by a standard scale.

Current Cancer Death Rates in the United States

Current Cancer Death Rates in the United States

The cancer death rate declined by 1.5% annually from 2006 to 2015 in the United States.

Lung Cancer Screening by CT Scan: Risk-Based vs USPSTF Criteria

Lung Cancer Screening by CT Scan: Risk-Based vs USPSTF Criteria

Lung cancer screening based on USPSTF criteria decreased from 2010 to 2015 while risk-targeted screening is associated with modest gains in terms of early lung cancer mortality per person screened.

Measuring Immuno-Oncology Agents Against Cancer Care Framework

Measuring Immuno-Oncology Agents Against Cancer Care Framework

Few modern, US FDA-approved immuno-oncology agents have durable survival and response rates that are deemed significant by the ASCO value framework.

Treatment Disparities in Elderly Patients With Non-Small Cell Lung Cancer

Treatment Disparities in Elderly Patients With Non-Small Cell Lung Cancer

Many octogenarians and nonagenarians with non-small cell lung cancer do not receive cancer-directed care.

Thromboembolic Event Risk With Cisplatin vs Carboplatin in Lung Cancer

Thromboembolic Event Risk With Cisplatin vs Carboplatin in Lung Cancer

Platinum-based chemotherapy agents for lung cancer may increase the risk for thromboembolism.

Chemotherapy Followed by Radiotherapy Improves Survival in NSCLC

Chemotherapy Followed by Radiotherapy Improves Survival in NSCLC

Adjuvant chemotherapy administered prior to, rather than concurrently with, radiotherapy improves survival outcomes among patients with NSCLC.

Lung Cancer Risk Reduced With Smoke-Free Ordinances

Lung Cancer Risk Reduced With Smoke-Free Ordinances

Few cases of lung cancer suspected in counties with smoke-free ordinances.

Cancer Survival Varies by Type of Health Insurance

Cancer Survival Varies by Type of Health Insurance

Improvements in cancer survival were limited to patients with private insurance, from 1997-2014.

Lung Cancer Has Highest Number of Preventable Cases, Deaths

Lung Cancer Has Highest Number of Preventable Cases, Deaths

An estimated 42.0% of all incident cancers and 45.1% of cancer deaths in the United States are attributed to potentially modifiable risk factors.

Lobectomy vs Stereotactic Body Radiation Therapy in Non-Small Cell Lung Cancer

Lobectomy vs Stereotactic Body Radiation Therapy in Non-Small Cell Lung Cancer

Survival is better with lobectomy than SBRT in patients with NSCLC.

Cancer-Related Fatigue May Benefit From Acupuncture

Cancer-Related Fatigue May Benefit From Acupuncture

More than 50% of patients report experiencing cancer-related fatigue throughout the disease process.

Traits for High-Value Oncology Practices Identified

Traits for High-Value Oncology Practices Identified

Three of 13 attributes identified had the highest potential for reduced spending without compromising care.

Liquid Biopsy May Be a Noninvasive Measure for Treatment Response in NSCLC

Liquid Biopsy May Be a Noninvasive Measure for Treatment Response in NSCLC

Patients with PD-L1-positive malignancies have shown higher response rates to immune checkpoint inhibition and consequently prolonged progression-free/overall survival compared with others.

Osimertinib May Improve Outcomes in EGFR Mutation-Postive NSCLC

Osimertinib May Improve Outcomes in EGFR Mutation-Postive NSCLC

Treatment with osimertinib is associated with longer progression-free survival in patients with previously untreated EGFR mutation-positive advanced non-small-cell lung cancer.

Non-Small Cell Lung Cancer: Trends in Stage I Treatment

Non-Small Cell Lung Cancer: Trends in Stage I Treatment

Between 2000 and 2010, researchers identified a decline in the number of patients with stage I NSCLC who remained untreated.

Non-Small Cell Lung Cancer: Nivolumab vs Docetaxel for Long-Term Efficacy

Non-Small Cell Lung Cancer: Nivolumab vs Docetaxel for Long-Term Efficacy

Results of two phase 3 studies found that nivolumab provided superior overall survival vs docetaxel in people with non-small cell lung cancer.

Small Cell Lung Cancer Survival With Anticoagulant Therapy

Small Cell Lung Cancer Survival With Anticoagulant Therapy

Trial results provided strong evidence against the use of anticoagulant low molecular weight heparin in SCLC.

Anti-Inflammatory Therapy With Canakinumab May Reduce Lung Cancer Rates

Anti-Inflammatory Therapy With Canakinumab May Reduce Lung Cancer Rates

Patients with lung cancer and atherosclerosis diagnosis may benefit from anti-inflammatory therapy with canakinumab.

Quality of Life Benefits of Yoga in Non-Small Cell Lung Cancer

Quality of Life Benefits of Yoga in Non-Small Cell Lung Cancer

Patients with NSCLC experienced improvements in both function and quality of life with yoga therapy.

Potential Delays in Non-Small Cell Lung Cancer Therapy

Potential Delays in Non-Small Cell Lung Cancer Therapy

Study results stress the importance of a multiethnic support system for patients needing to overcome communication barriers.

New "Pan-Can" Model More Accurately Predicts Lung Cancer Risk

New "Pan-Can" Model More Accurately Predicts Lung Cancer Risk

PanCan study effectively identified patients who eventually developed early-stage lung cancer, compared to other predictive models.

Updated Lung Cancer Screening Guidelines Released at CHEST

Updated Lung Cancer Screening Guidelines Released at CHEST

The ACCP just released new lung cancer screening guidelines.

Lung Cancer Screening Endorsed by Pulmonary and Primary Care Providers

Lung Cancer Screening Endorsed by Pulmonary and Primary Care Providers

Researchers surveyed knowledge, beliefs, attitudes, barriers, and facilitators related to screening patients for lung cancer.

Small-cell Lung Cancer Benefits From Maintenance Therapy With Pazopanib

Small-cell Lung Cancer Benefits From Maintenance Therapy With Pazopanib

Pazopanib improves progression-free survival in patients with small-cell lung cancer.

Gefitinib Treatment Should Be Avoided Prior to Chemotherapy in Non-small Cell Lung Cancer

Gefitinib Treatment Should Be Avoided Prior to Chemotherapy in Non-small Cell Lung Cancer

First generation EGFR tyrosine kinase inhibitors should be used in combination with chemotherapy if a patient has progressive EGFR mutation-positive non-small cell lung cancer.

Dacomitinib vs Gefitinib for Progression-Free Survival in Non-small Cell Lung Cancer

Dacomitinib vs Gefitinib for Progression-Free Survival in Non-small Cell Lung Cancer

Dacomitinib improved progression-free survival in patients with non-small cell lung cancer.

Case Report: Small Cell Lung Cancer Case With Tumor Lysis Syndrome

Case Report: Small Cell Lung Cancer Case With Tumor Lysis Syndrome

Tumor lysis syndrome can occur even in the absence of chemotherapy, and clinicians should remain suspicious when patients demonstrate laboratory abnormalities.

Greater Depth of Response to Therapy Improves Survival in Non-small Cell Lung Cancer

Greater Depth of Response to Therapy Improves Survival in Non-small Cell Lung Cancer

Overall and progression-free survival were improved with greater depth of response to therapy in non-small cell lung cancer.

Thoracic Radiotherapy Does Not Increase Risk for Immune-Related AEs in Lung Cancer

Thoracic Radiotherapy Does Not Increase Risk for Immune-Related AEs in Lung Cancer

Patients with metastatic lung cancer who receive both both immune checkpoint inhibitors and thoracic radiotherapy.do not have a greater risk for immune-related adverse events.

Non-small Cell Lung Cancer Survival Improved With Adoptive Cellular Immunotherapy

Non-small Cell Lung Cancer Survival Improved With Adoptive Cellular Immunotherapy

Adjuvant adoptive cellular immunotherapy plus chemotherapy improved survival in patients with resected non-small cell lung caner.

Non-small Cell Lung Cancer Staging Accuracy Tied to Nodal Examination

Non-small Cell Lung Cancer Staging Accuracy Tied to Nodal Examination

Thoroughness of nodal examination determines prognostic value of non-small cell lung cancer staging.

Non-small Cell Lung Cancer Metastasis at Diagnosis May Be Predicted by Genetic Mutations

Non-small Cell Lung Cancer Metastasis at Diagnosis May Be Predicted by Genetic Mutations

ROS1 and ALK rearrangements in patients with non-small cell lung cancer may predict different metastasis distributions at diagnosis.

Diagnostic Test Can Identify Biomarkers to Detect Lung Cancer

Diagnostic Test Can Identify Biomarkers to Detect Lung Cancer

A new diagnostic test and algorithm may be able to diagnose lung cancer from tumor-educated platelets.

Lung Cancer Is a Significant Cause of Death in Smokers Living With HIV

Lung Cancer Is a Significant Cause of Death in Smokers Living With HIV

Smokers with HIV who are adherent to antiretroviral therapy are still likely to die from lung cancer.

Standard vs High-Dose Chemoradiation in Stage 3 Non-Small Cell Lung Cancer

Standard vs High-Dose Chemoradiation in Stage 3 Non-Small Cell Lung Cancer

Higher doses of chemoradiation in stage 3 non-small cell lung cancer did not improve overall survival rates.

Impact of Canakinumab on Mortality, Incidence of Lung Cancer

Impact of Canakinumab on Mortality, Incidence of Lung Cancer

There may be a decreased rate of lung cancer for patients who receive anti-inflammatory therapy with canakinumab.

Durvalumab Linked to Longer Progression-Free Survival in NSCLC

Durvalumab Linked to Longer Progression-Free Survival in NSCLC

Fewer than 30% of patients undergoing durvalumab therapy experienced either grade 3 or 4 adverse events.

Does CT Scan at Follow-up Improve Resected NSCLC Survival?

Does CT Scan at Follow-up Improve Resected NSCLC Survival?

Recommendations to include CT scans as standard follow-up procedure is based on poor evidence.

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