Lung Cancer

Broad Genetic Testing for NSCLC May Not Improve Survival

Broad Genetic Testing for NSCLC May Not Improve Survival

Compared with routine genetic testing, there was no improvement in unadjusted mortality rate in non-small cell lung cancer.

Disparities Remain in Prevalence of Cancer Screening Tests

Disparities Remain in Prevalence of Cancer Screening Tests

From 2000 to 2015, individuals without insurance or usual care were less likely to have undergone cancer screening.

Biomarker Panel May Improve Lung Cancer Risk Assessment

Biomarker Panel May Improve Lung Cancer Risk Assessment

Risk score based on panel of four circulating protein biomarkers.

Lurbinectedin Gains Orphan Drug Status for Small Cell Lung Cancer

Lurbinectedin Gains Orphan Drug Status for Small Cell Lung Cancer

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A Phase 2 multicenter trial examined the safety and efficacy of lurbinectedin in several types of advanced solid tumors, including SCLC.

Nurse Navigators Can Help to Improve Oncology Care

Nurse Navigators Can Help to Improve Oncology Care

Nurse navigators include registered nurses and licensed practical nurses who work together in pairs

Lay Health Workers Can Improve End-of-Life Cancer Care

Lay Health Workers Can Improve End-of-Life Cancer Care

Incorporating lay health workers into cancer care increases goals-of-care documentation and patient satisfaction.

Aldehydes Dominant Carcinogen in Tobacco Smoke

Aldehydes Dominant Carcinogen in Tobacco Smoke

Aldehydes act by inducing DNA damage and inhibiting DNA repair.

Lung Cancer Incidence in HIV Remains High Years After Smoking Cessation

Lung Cancer Incidence in HIV Remains High Years After Smoking Cessation

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The incidence of lung cancer remains increased 5 years after smoking cessation.

Initial Outcomes No Worse for Surgical ICU Patients With Cancer

Initial Outcomes No Worse for Surgical ICU Patients With Cancer

ICU and hospital mortality were lower for patients with cancer vs those without cancer.

Exploring Overdiagnosis in Cancer Screening

Exploring Overdiagnosis in Cancer Screening

Standardized definition and guidance on estimation may facilitate understanding of cancer overdiagnosis.

In Cancer, PTSD May Increase Symptom Burden

In Cancer, PTSD May Increase Symptom Burden

Post-traumatic stress symptoms were also linked to lower risk of readmission in hospitalized patients with cancer.

Awake Video-Assisted Thoracoscopic Surgery Safe Option in Lung Cancer

Awake Video-Assisted Thoracoscopic Surgery Safe Option in Lung Cancer

Awake video-assisted thoracoscopic surgery was safe and feasible in some patients with poor lung function and lung cancer.

New Assays May Detect Early Lung Cancer in Blood

New Assays May Detect Early Lung Cancer in Blood

Targeted sequencing, whole-genome sequencing, and whole-genome bisulfite sequencing showed potential for detecting lung cancer.

Pembrolizumab Superior for Initial Treatment of Advanced NSCLC

Pembrolizumab Superior for Initial Treatment of Advanced NSCLC

Pembrolizumab improved overall survival vs chemotherapy regardless of the programmed death ligand 1 tumor proportion score.

Indeterminate Pulmonary Nodules Characterized by CT-Based Radiomic Classifier

Indeterminate Pulmonary Nodules Characterized by CT-Based Radiomic Classifier

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A total of 8 quantitative radiologic features were used to characterize indeterminate screen-detected lung nodules.

Alimta Labeling Updated to Include Combo Treatment for NSCLC

Alimta Labeling Updated to Include Combo Treatment for NSCLC

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Merck initially gained accelerated approval for Keytruda with Alimta and carboplatin in May 2017.

Prediction Tool Helps Tailor Lung Cancer Screening to Patients

Prediction Tool Helps Tailor Lung Cancer Screening to Patients

Researchers created a web-based decision tool to facilitate personalized discussions regarding lung cancer screening.

Lung Cancer Incidence Higher in Young Women Than Young Men

Lung Cancer Incidence Higher in Young Women Than Young Men

Researchers examined nationwide population-based incidence of lung cancer according to sex, race or ethnic group, age group, birth year, and calendar period of diagnosis.

Bioengineering Feasible for Airway Reconstruction

Bioengineering Feasible for Airway Reconstruction

Bioengineered tracheal and bronchial reconstruction was conducted using stented aortic matrices.

Few Eligible Smokers Had Lung Cancer Screening in 2016

Few Eligible Smokers Had Lung Cancer Screening in 2016

The most eligible smokers were populated in South, which had most screening sites but the low screening rates

Risk Models Help Select Ever Smokers for Lung Cancer Screening

Risk Models Help Select Ever Smokers for Lung Cancer Screening

Four models were well-calibrated and had higher areas under the curve than 5 models that overestimated lung cancer risk.

CKAP4 Is Novel Serodiagnostic Marker for Lung Cancer

CKAP4 Is Novel Serodiagnostic Marker for Lung Cancer

Serum CKAP4 levels of lung cancer patients were significantly higher than those of healthy controls.

Cancer Incidences and Burden Expected to Shift in HIV-Positive

Cancer Incidences and Burden Expected to Shift in HIV-Positive

Prostate and lung cancer expected to emerge as the most common types by 2030.

Clinical Upstaging of NSCLC Seen With Each Progressive Week

Clinical Upstaging of NSCLC Seen With Each Progressive Week

For clinical stage 1 non-small-cell lung cancer, 21.7% of patients upstaged after 1 week and 31.5% after 8 weeks.

Polypharmacy More Likely for Cancer Survivors

Polypharmacy More Likely for Cancer Survivors

More cancer survivors prescribed 5 or more unique medications, including medications with abuse potential.

A Potential Algorithm for Diagnosing Cavitary Lung Diseases

A Potential Algorithm for Diagnosing Cavitary Lung Diseases

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Researchers developed an algorithmic approach to diagnosing lung cavitary diseases.

Adjuvant Pembrolizumab Beneficial in Metastatic NSCLC

Adjuvant Pembrolizumab Beneficial in Metastatic NSCLC

Nivolumab plus ipilimumab linked to better survival in NSCLC with high tumor mutational burden.

Most Patients Are Unaware of Cancer Drug Shortages

Most Patients Are Unaware of Cancer Drug Shortages

Majority of patients say they want to know about even minor consequences of cancer drug substitutions.

Dacomitinib Granted Priority Review for NSCLC With EGFR-Activating Mutations

Dacomitinib Granted Priority Review for NSCLC With EGFR-Activating Mutations

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Dacomitinib is a pan-human epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor.

Lag in Progress Against Lung Cancer Mortality in Midwest, Appalachia

Lag in Progress Against Lung Cancer Mortality in Midwest, Appalachia

Findings based on rates in women vs steady decline seen nationally.

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