In the LEAP 2 study (N=738), patients with moderate CABP received either oral lefamulin 600mg every 12 hours for 5 days or oral moxifloxacin 400mg once daily for 7 days.
Clinicians should consider these findings when using atypical antipsychotics in patients at risk for pneumonia.
Researchers have developed a novel algorithm to identify hypersensitivity pneumonitis.
Lung ultrasound was more effective in diagnosing pediatric community-acquired pneumonia than chest radiography.
Clinical presentation and outcomes in HIV-infected patients with Legionella pneumonia did not differ from patients without HIV infection.
Low-dose computed tomography may assist clinicians in modifying diagnosis of elderly patients who are admitted with suspected pneumonia.
A high impact was seen, especially when the vaccine uptake was optimally distributed across age groups.
A higher proportion of patients with COPD and a blood eosinophil count of ≥0.34×109/L had elevated markers of low-grade systemic inflammation regardless of forced expiratory volume in 1 second.
This updated Committee Opinion includes more recent data on the safety and efficacy of influenza vaccination during pregnancy, as well as recommendations for treatment and postexposure chemoprophylaxis.
Adult caretaker influenza vaccination cocooning programs can prove beneficial and financially successful in private practice models where external funding is limited or not available.
During the cold and flu season, the use and over-dosing of paracetamol is common, and may partially be driven by higher use of over-the-counter combination medications for the treatment of upper respiratory cold/flu symptoms.
Among children there was an increased risk for acute respiratory illness caused by noninfluenza respiratory pathogens following influenza vaccination compared to unvaccinated children during the same period.
The risk for death in patients with community-acquired pneumonia who were given mechanical ventilation does not seem to be affected by the presence of acute respiratory distress syndrome.
Researchers found increased myocardial infarction rates during the week after Streptococcus pneumoniae and influenza infections.
Researchers assessed the relationship between prevention of RSV in preterm infants and the frequency of subsequent wheeze in childhood.
Higher serum bactericidal activity following immunization with PRP-CRM197 reflected superior short-term and long-term seroprotective effects compared with immunization with PRP-T.
Immunogenicity of RIV4 similar to that of inactivated vaccine, although responses to B Victoria were low with both.
Differences in serum inflammatory markers may exist between patients with community-acquired pneumonia who present within the first 48 hours of symptom onset vs those who present later.
Use of prophylactic antimicrobial therapy was not associated with a reduction in mortality or transfer to critical care compared with patients managed with supportive care only.
Further research on rapid tests is warranted, as industry-sponsored research tends to favor the industry's product and affects how physicians practice medicine.
Adults with community-acquired pneumonia that is visualized on CT scan but not on concurrent chest radiograph have similar pathogens, disease severity, and outcomes as patients who had pneumonia confirmed via chest radiograph.
Despite 8 of the 10 flights taking place during influenza season, results of quantitative polymerase chain reaction assays for 18 common respiratory viruses were all negative.
Interventional reduction of the angiopoietin-1/angiopoietin-2 ratio may provide therapeutic perspective for prevention of acute lung injury in pneumonia.
There was no significant correlation with suicide for oseltamavir exposure or for influenza diagnosis alone.
Acetaminophen use and overdosing increases during cold and flu season.
Children with asthma who experience chronic oral glucocorticoid exposure may have significant morbidities, including adrenal suppression, recurrent pneumonia, and behavioral problems.
The CDC's ACIP has voted in favor of renewing the recommendation for the use of live attenuated influenza vaccine.
Researchers retrospectively analyzed data from patients hospitalized with pneumococcal community-acquired pneumonia to determine risk factors for pneumococcal bacteremia.
Cardiac surgery during influenza season is an independent risk factor for acute respiratory distress syndrome.
Investigators sought to determine the association between maternal vaccination and infant mortality.
As a result of activating the inflammatory-immune system, pneumonia may trigger cardiovascular complications.
Researchers found the strongest link between prescription opioid use and the risk for invasive pneumococcal disease was present in individuals using long-acting, high-dose, or highly potent formulations.
Influenza A viruses have predominated the 2017 to 2018 season with a vaccine effectiveness between 25% and 67%.
Airborne influenza viruses may be safely and effectively eradicated with continuous low doses of far ultraviolet C light.
Long-acting, high-potency, and high-dose opioids were associated with an increased risk for invasive pneumococcal disease.
The recommended childhood and adolescent immunization schedule for the United States has been issued for 2018.
Invasive mechanical ventilation in patients with severe community-acquired pneumonia appeared to increase their mortality risk.
Nasopharyngeal samples collected from young children with acute otitis media were analyzed for S pneumoniae, H influenzae, and Moraxella catarrhalis and compared before and after PCV13 introduction.
Patient, practice, and provider characteristics are associated with inappropriate antimicrobial prescribing in the outpatient setting.
The FDA approved the supplemental New Drug Application for Avycaz to treat adults with hospital-acquired or ventilator-associated bacterial pneumonia.
The preoperative physiotherapy intervention cut the incidence of postoperative pulmonary complications by 50%.
Procalcitonin may decrease mortality rates in patients with acute respiratory infections, including pneumonia.
Patients who received provider-ordered influenza testing were more likely to be younger and present with fever and "influenza-like illness."
Influenza increased the risk for acute myocardial infarction within 1 year before and 1 year after the infection.
Short-term incidence of leukemia, lymphoma, and brain cancer may be higher in children who were hospitalized with pneumonia.
Patient reminder and recall systems seem to be effective for improving receipt of immunizations.
For febrile infants, human rhinovirus is common, and detection does not alter risk of concomitant urinary tract infection or invasive bacterial infection.
Mortality from severe pneumonia may be significantly reduced with corticosteroids.
A gas-capillary column ion mobility spectrometer may be a feasible and noninvasive tool for clinicians to diagnose respiratory tract infections in hospitalized patients.
Non-ventilator hospital-acquired pneumonia is a significant burden in US acute care hospitals and poses a risk to nonelderly, non-intensive unit patients.
Researchers from the National Institute of Allergy and Infectious Diseases are working to develop a universal influenza vaccine.
AuroMedics Pharma announced a voluntary recall of 1 lot of Linezolid injection after a batch found contained mold.
Vaccination for influenza for multiple seasons is twice as effective in preventing severe influenza.
Researchers identified 4 specific symptoms that could be the basis for a pneumonia diagnosis.
A middle-aged man with no significant medical history presents to his local urgent care with flu-like symptoms but sees no improvement after starting antibiotics.
Patients with an egg allergy do not need to avoid or take special precautions when receiving the influenza vaccine.
Educational campaigns regarding the value of vaccines should integrate social psychological considerations with health communication principles.
Midturbinate swabs for influenza detection provided a more comfortable experience for patients compared with traditional nasopharyngeal swabs.
Since the start of November 2017, influenza activity has increased in the United States.
The ability of machine learning programs to diagnose medical conditions and predict outcomes is discussed in an opinion article.
A glycoprotein mutation in fertilized chicken eggs may be the cause of the limited effectiveness of the 2016-2017 flu vaccine.
About 50 employees have been fired from Essentia Health, a Duluth, Minnesota-based hospital chain, for refusing to receive the flu vaccination.
No single finding appears to reliably predict a pneumonia diagnosis in pediatric patients younger than 5 years of age.
The 2006 CHEST management algorithms for acute, subacute, and chronic cough appear to be useful in treating adults globally.
Interventions to target healthcare professional-associated influenza transmission, intervention may be necessary to prevent transmission.
Antipyretic administration for fever in young children is not associated with any significant blunting of immune response to inactivated influenza vaccination.
Text messaging may be an effective way to increase the rate of influenza vaccination.
Influenza vaccination in the pediatric emergency department setting appears to be a cost-effective strategy.
Temporary discontinuation of methotrexate after influenza vaccination is associated with improved immunogenicity of vaccination in RA.
A highly pathogenic variant of H7N9 avian influenza has evolved and is now capable of causing a pandemic, according to recent research.
Rapivab is now indicated for use in pediatric patients ≥2 years with acute uncomplicated influenza.
Clustering patients with interstitial lung disease independently predicted progression-free and transplant-free survival.
Prophylactic antibiotics administered to patients who were mechanically ventilated reduced the rate of ventilator-associated pneumonia.
In contrast to previous study findings, inhaled corticosteroids do not appear to increase risk for pneumonia in patients with COPD with moderate airflow limitation.
Strictly following empirical antimicrobial treatment guidelines in patients with hospital-acquired or ventilator-associated pneumonia may result in overtreatment with antibiotics.
Patients who underwent open lung resections had a significantly higher incidence of postoperative pneumonia vs minimally invasive surgery.
Study results indicate that delafloxacin has potent in-vitro activity against most common pathogens seen in community-acquired pneumonia.
Combination antibiotic therapy with a macrolide improves hospital length of stay in patients with severe community-acquired pneumonia.
Researchers developed a clinical tool to predict prolonged hospital stays in patients with pediatric community-acquired complicated pneumonia.
Low education and low income are linked to lower uptakes of PCV13 in minorities 65 years and older.
Investigators found that macrolides correlated with lower odds of treatment failure in patients younger than 5 with CAP.
Using serum procalcitonin levels to diagnose and manage bacterial pneumonia decreases length of hospital stay.
Despite the loss of the live attenuated influenza vaccine, overall immunization rates in children 2-17 remained steady.
The majority of healthcare workers receive an influenza vaccination, but more pregnant women should be vaccinated.
The CDC continues to urge pregnant women to receive influenza vaccinations.
Influenza vaccination does not increase the risk for venous thromboembolism in patients older than 50 years of age.
Fewer than half of patients with asthma have received a pneumococcal vaccination.
While the newest high-valent PCV10 and PCV13 vaccines are effective in preventing IPD caused by the serotypes within the vaccines, breakthrough patterns of conversion to non-PCV13 serotypes are emerging.
Underlying cystic fibrosis may be a risk factor for the prediction of delayed gastric emptying in patients who undergo lung transplantation.
Early time to positivity of blood culture in patients with bacteremic pneumococcal pneumonia predicted the risk for invasive mechanical ventilation.
Gastroesophageal reflux disease (GERD) is associated with long-term risk of pneumonia, especially in the younger population and in patients who have been treated with proton pump inhibitors.
The correlation between patient race and ethnicity and administration of antibiotic treatment for viral acute respiratory tract infections was examined.
The American Academy of Pediatrics recommends against the use of the quadrivalent live attenuated influenza vaccine (LAIV4).
Three cases of community-acquired pneumonia were reported in otherwise healthy adults.
Patients with chronic obstructive pulmonary disease, particularly with exacerbations, have an increased risk for diabetes development.
Respiratory infection frequency during the first 2 years of life is tied to celiac disease risk in high-risk children.
Researchers examined the efficacy of digital immunoassays vs rapid influenza diagnostic tests for diagnosing influenza.
Men have an increased risk of cardiovascular disease for more than 5 years following either sepsis or pneumonia.
Fewer children were immunized against influenza once the CDC ruled out use of the nasal spray.
Hospitalization risk was increased in infants of vaccinated vs nonvaccinated mothers only during the first 90 days of life.