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Treatment for Bronchiolitis Obliterans Gains Orphan Drug Status

Treatment for Bronchiolitis Obliterans Gains Orphan Drug Status

Bronchiolitis obliterans is the leading cause of morbidity and mortality in the pulmonary transplant population with ≥50% of patients who receive a lung transplant developing the condition within 5 years.

Omadacycline Gets FDA Committee Nod for Skin Infections, Pneumonia

Omadacycline Gets FDA Committee Nod for Skin Infections, Pneumonia

The Committee's recommendation was based on data from the omadacycline global development program that included nearly 2000 adults in three Phase 3 studies.

FDA Panel Votes on Therapy for Nontuberculous Mycobacterial Lung Disease

FDA Panel Votes on Therapy for Nontuberculous Mycobacterial Lung Disease

The recommendation was supported by materials developed from the ALIS New Drug Application (NDA), which included data from the CONVERT study.

Flu Vaccine Reduces Mortality in Rheumatoid Arthritis

Flu Vaccine Reduces Mortality in Rheumatoid Arthritis

Hospitalization risk was also reduced for RA patients who received influenza vaccination.

Inappropriate Antibiotic Prescriptions Highest Among Urgent Care Facilities

Inappropriate Antibiotic Prescriptions Highest Among Urgent Care Facilities

Inappropriate antibiotic prescriptions were highest among urgent care facilities (45.7%), with emergency departments (24.6%), medical offices (17.0%), and retail clinics (14.4%) following.

H1N1 Immune Priming and Egg-Adaptation Affect Antibody Responses After Vaccination

H1N1 Immune Priming and Egg-Adaptation Affect Antibody Responses After Vaccination

Immune priming with seasonal H1N1 viruses earlier in life and egg-adaptation in vaccines can impact antibody responses following influenza vaccination.

Drop in Childhood Pneumococcal, Hib Deaths From 2000 to 2015

Drop in Childhood Pneumococcal, Hib Deaths From 2000 to 2015

Most children who died of pneumococcus and Haemophilus influenzae type b presented with pneumonia.

Viral Testing May Reduce Antibiotic Use in Severe Lower Respiratory Infection

Viral Testing May Reduce Antibiotic Use in Severe Lower Respiratory Infection

Advanced diagnostic platforms to identify viruses can help patients with severe lower respiratory tract infections avoid unnecessary diagnostic testing, reduce antibiotic use, and initiate antiviral therapy.

Is Short-Course Antibiotic Treatment for CAP Effective?

Is Short-Course Antibiotic Treatment for CAP Effective?

To investigate what impact antibiotic treatment duration has on CAP outcomes, researchers from the Warren Alpert Medical School of Brown University conducted a search of various databases for studies comparing the safety and efficacy of treatment regimens lasting ≤6 days (short) and ≥7 days (long).

Type 2 Diabetes Does Not Affect Pneumonia Incidence, Outcomes After Stroke

Type 2 Diabetes Does Not Affect Pneumonia Incidence, Outcomes After Stroke

Investigators examined the incidence and outcomes of pneumonia in patients with acute ischemic stroke and type 2 diabetes.

Priority Review Granted to Novel Oral Influenza Treatment

Priority Review Granted to Novel Oral Influenza Treatment

The New Drug Application for baloxavir marboxil is supported by results from the Phase 3 CAPSTONE-1 study (N=1436) which examined the effects of a single dose of baloxavir marboxil vs placebo or oseltamivir 75mg twice daily for 5 days.

Community-Acquired Pneumonia In-Hospital Deaths Are Not Indicative of Lapse in Care

Community-Acquired Pneumonia In-Hospital Deaths Are Not Indicative of Lapse in Care

Most deaths related to community-acquired pneumonia that occurred at tertiary-case hospitals were not preventable.

Respiratory Viruses Linked to Treatment Failure in Asthma Exacerbations

Respiratory Viruses Linked to Treatment Failure in Asthma Exacerbations

Respiratory pathogens were associated with an increased risk for treatment failure in children with asthma exacerbations.

Misuse of Antibiotics Common in Outpatient Acute Respiratory Infections

Misuse of Antibiotics Common in Outpatient Acute Respiratory Infections

The researchers argued that outpatient antibiotic stewardship efforts must be strengthened to eliminate antibiotic treatment for viral upper respiratory infections and acute bronchitis.

PCV13 Reduces Hospitalization for Vaccine-Type Community-Acquired Pneumonia

PCV13 Reduces Hospitalization for Vaccine-Type Community-Acquired Pneumonia

The real-world effectiveness of PCV13 vaccine in preventing hospitalization for vaccine-type community-acquired pneumonia was assessed.

C-Reactive Protein as a Biomarker for CAP in Bronchiectasis

C-Reactive Protein as a Biomarker for CAP in Bronchiectasis

Although clinical presentation was similar in both community-acquired pneumonia and non-pneumonia exacerbations, CRP, glucose, and leukocytes were higher in the former vs the latter.

Early Clinical Response With Omadacycline vs Moxifloxacin in CABP

Early Clinical Response With Omadacycline vs Moxifloxacin in CABP

Early clinical response rates were similar across PORT risk class subgroups in patients with community-acquired bacterial pneumonia when treated with omadacycline or moxifloxacin.

Prevnar 13 Linked to Reduced Risk of CAP Hospitalization in Older Patients

Prevnar 13 Linked to Reduced Risk of CAP Hospitalization in Older Patients

PCV13, marketed as Prevnar 13, was evaluated in a test-negative case-control study in real-world conditions where patients were administered pneumococcal vaccination as advised by their healthcare providers.

AAP Recommends Shot Over Nasal Spray for 2018-2019 Flu Season

AAP Recommends Shot Over Nasal Spray for 2018-2019 Flu Season

The advisory comes early as physicians are currently placing vaccine orders.

Positive Results Announced for Pleuromutilin Antibiotic in CABP

Positive Results Announced for Pleuromutilin Antibiotic in CABP

In the LEAP 2 study (N=738), patients with moderate CABP received either oral lefamulin 600mg every 12 hours for 5 days or oral moxifloxacin 400mg once daily for 7 days.

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