Non-Small Cell Lung Cancer

Longer Survival in NSCLC With Brigatinib vs Crizotinib

Longer Survival in NSCLC With Brigatinib vs Crizotinib

Longer progression-free survival was significantly longer in patients with ALK-positive disease who did not previously take an ALK inhibitor.

Broad Genetic Testing for NSCLC May Not Improve Survival

Broad Genetic Testing for NSCLC May Not Improve Survival

Compared with routine genetic testing, there was no improvement in unadjusted mortality rate in non-small cell lung cancer.

Pembrolizumab Superior for Initial Treatment of Advanced NSCLC

Pembrolizumab Superior for Initial Treatment of Advanced NSCLC

Pembrolizumab improved overall survival vs chemotherapy regardless of the programmed death ligand 1 tumor proportion score.

Clinical Upstaging of NSCLC Seen With Each Progressive Week

Clinical Upstaging of NSCLC Seen With Each Progressive Week

For clinical stage 1 non-small-cell lung cancer, 21.7% of patients upstaged after 1 week and 31.5% after 8 weeks.

Adjuvant Pembrolizumab Beneficial in Metastatic NSCLC

Adjuvant Pembrolizumab Beneficial in Metastatic NSCLC

Nivolumab plus ipilimumab linked to better survival in NSCLC with high tumor mutational burden.

Dacomitinib Granted Priority Review for NSCLC With EGFR-Activating Mutations

Dacomitinib Granted Priority Review for NSCLC With EGFR-Activating Mutations

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Dacomitinib is a pan-human epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor.

Treatment Disparities in Elderly Patients With Non-Small Cell Lung Cancer

Treatment Disparities in Elderly Patients With Non-Small Cell Lung Cancer

Many octogenarians and nonagenarians with non-small cell lung cancer do not receive cancer-directed care.

Chemotherapy Followed by Radiotherapy Improves Survival in NSCLC

Chemotherapy Followed by Radiotherapy Improves Survival in NSCLC

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Adjuvant chemotherapy administered prior to, rather than concurrently with, radiotherapy improves survival outcomes among patients with NSCLC.

Lobectomy vs Stereotactic Body Radiation Therapy in Non-Small Cell Lung Cancer

Lobectomy vs Stereotactic Body Radiation Therapy in Non-Small Cell Lung Cancer

Survival is better with lobectomy than SBRT in patients with NSCLC.

Osimertinib May Improve Outcomes in <i>EGFR</i> Mutation-Postive NSCLC

Osimertinib May Improve Outcomes in EGFR Mutation-Postive NSCLC

Treatment with osimertinib is associated with longer progression-free survival in patients with previously untreated EGFR mutation-positive advanced non-small-cell lung cancer.

Non-Small Cell Lung Cancer: Trends in Stage I Treatment

Non-Small Cell Lung Cancer: Trends in Stage I Treatment

Between 2000 and 2010, researchers identified a decline in the number of patients with stage I NSCLC who remained untreated.

Non-Small Cell Lung Cancer: Nivolumab vs Docetaxel for Long-Term Efficacy

Non-Small Cell Lung Cancer: Nivolumab vs Docetaxel for Long-Term Efficacy

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Results of two phase 3 studies found that nivolumab provided superior overall survival vs docetaxel in people with non-small cell lung cancer.

Quality of Life Benefits of Yoga in Non-Small Cell Lung Cancer

Quality of Life Benefits of Yoga in Non-Small Cell Lung Cancer

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Patients with NSCLC experienced improvements in both function and quality of life with yoga therapy.

Potential Delays in Non-Small Cell Lung Cancer Therapy

Potential Delays in Non-Small Cell Lung Cancer Therapy

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Study results stress the importance of a multiethnic support system for patients needing to overcome communication barriers.

Gefitinib Treatment Should Be Avoided Prior to Chemotherapy in Non-small Cell Lung Cancer

Gefitinib Treatment Should Be Avoided Prior to Chemotherapy in Non-small Cell Lung Cancer

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First generation EGFR tyrosine kinase inhibitors should be used in combination with chemotherapy if a patient has progressive EGFR mutation-positive non-small cell lung cancer.

Dacomitinib vs Gefitinib for Progression-Free Survival in Non-small Cell Lung Cancer

Dacomitinib vs Gefitinib for Progression-Free Survival in Non-small Cell Lung Cancer

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Dacomitinib improved progression-free survival in patients with non-small cell lung cancer.

Durvalumab Linked to Longer Progression-Free Survival in NSCLC

Durvalumab Linked to Longer Progression-Free Survival in NSCLC

Fewer than 30% of patients undergoing durvalumab therapy experienced either grade 3 or 4 adverse events.

Does CT Scan at Follow-up Improve Resected NSCLC Survival?

Does CT Scan at Follow-up Improve Resected NSCLC Survival?

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Recommendations to include CT scans as standard follow-up procedure is based on poor evidence.

Improving Anorexia-Cachexia in Non-small Cell Lung Cancer

Improving Anorexia-Cachexia in Non-small Cell Lung Cancer

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Data from 5 phase 2/3 studies demonstrate improved weight and body mass in patients with NSCLC receiving anamorelin.

Improving Survival in Resected NSCLC With Adoptive Cellular Immunotherapy

Improving Survival in Resected NSCLC With Adoptive Cellular Immunotherapy

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A phase 3 trial examined the efficacy of chemoimunnotherapy vs chemotherapy alone in postsurgical patients with non-small cell lung cancer.

FDA: Priority Review for Alectinib for ALK-positive NSCLC

FDA: Priority Review for Alectinib for ALK-positive NSCLC

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Priority review for alectinib was granted based on evidence from the phase 3 ALEX and J-ALEX clinical trials.

FDA: Durvalumab Granted Breakthrough Therapy Designation for NSCLC

FDA: Durvalumab Granted Breakthrough Therapy Designation for NSCLC

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Durvalumab can be used to treat patients with locally advanced, unrescetable NSCLC, who do not relapse after platinum-based chemoradiation.

Predicting Overall Survival With Neutrophil-Lymphocyte Ratio in NSCLC

Predicting Overall Survival With Neutrophil-Lymphocyte Ratio in NSCLC

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Valuable information regarding patients' life expectancy can be collected through neutrophil-lymphocyte ratio biomarkers.

Efficacy of Neoadjuvant Nivolumab in NSCLC

Efficacy of Neoadjuvant Nivolumab in NSCLC

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Researchers considered the response rate "encouraging" and comparable to cisplatin-based neoadjuvant therapy outcomes.

Survival Outcomes With Nivolumab vs Chemotherapy for Stage IV, Recurrent NSCLC

Survival Outcomes With Nivolumab vs Chemotherapy for Stage IV, Recurrent NSCLC

Findings in patients with previously untreated disease with PD-L1 expression level of 5%.

Improving NSCLC Outcomes With Midtreatment FDG-PET-Driven Radiation Tx

Improving NSCLC Outcomes With Midtreatment FDG-PET-Driven Radiation Tx

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Increased radiation therapy based on midtreatment residual tumor FDG-PET may improve local control among patients with advanced NSCLC.

Survival Rate Increases With Adjuvant Gefitinib in NSCLC

Survival Rate Increases With Adjuvant Gefitinib in NSCLC

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Adjuvant gefitnib increases disease-free survival for patients with stage II to III non-small lung cancer.

Glucose Dependency in Squamous Cell vs Adenocarcinoma NSCLC Tumors

Glucose Dependency in Squamous Cell vs Adenocarcinoma NSCLC Tumors

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Data can be used to target the development of new drugs for treating squamous cell carcinomas.

Does Docetaxel Plus Selumetinib in NSCLC Increase Progression-Free Survival?

Does Docetaxel Plus Selumetinib in NSCLC Increase Progression-Free Survival?

The added combination of selumetinib with docetaxel did not improve progression-free survival among patients previously treated for advanced NSCLC.

Vaccine Therapies Show Promise As Lung Cancer Tx

Vaccine Therapies Show Promise As Lung Cancer Tx

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Developed in Cuba, the TG4010 and CIMAvax-EGF vaccines are undergoing clinical study in the US.

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