Survival at 6 months was significantly associated with acute respiratory failure and history of COPD.
Patients with severe asthma who were current smokers were distinguishable from ex-smokers based on their sputum proteomic level of colony stimulating factor 2.
A higher proportion of patients with COPD and a blood eosinophil count of ≥0.34×109/L had elevated markers of low-grade systemic inflammation regardless of forced expiratory volume in 1 second.
Children with status asthmaticus who received magnesium sulfate therapy were on continuous albuterol for a longer duration.
Readmission rates were highest during the first 72 hours after admission for an acute exacerbation of chronic obstructive pulmonary disease.
Adding olodaterol to tiotropium did not significantly reduce exacerbations in patients with chronic obstructive pulmonary disease as much as researchers had anticipated.
Asthma and COPD overlap linked to higher prevalence of sleep-related symptoms, including difficulty falling asleep and maintaining sleep, early-morning awakening, and excessive daytime sleepiness.
The drug consists of fluticasone furoate, an inhaled corticosteroid (ICS), umeclidinium, a long-acting muscarinic antagonist, and vilanterol, a long-acting beta2-adrenergic agonist (LABA), delivered via an Ellipta dry powder inhaler.
Early child care attendance increased the risk for wheeze in children ≤2 years of age but decreased the risk for asthma in children 3 to 5 years of age.
In patients with COPD, transcatheter aortic valve replacement was associated with fewer respiratory-related complications than surgical aortic valve replacement.
Statins have anti-inflammatory and anti-oxidative effects, which could reduce exacerbations of both asthma and chronic obstructive pulmonary disease.
Triple therapy with fluticasone furoate, umeclidinium, and vilanterol was associated with a lower rate of exacerbations in chronic obstructive pulmonary disease.
A childhood measles infection may increase the risk for post-bronchodilator airflow obstruction in middle-age adults via its interaction with asthma and smoking.
A 55-year-old man with chronic obstructive pulmonary disease reports having some mild chest pain.
Preterm-born children had significantly more frequent preschool wheeze compared with children born at term.
No significant benefit of long-acting muscarinic antagonists over long-acting beta-agonists in reducing exacerbation risk in uncontrolled, persistent asthma
Adjunct long-acting muscarinic antagonist (LAMA) use with corticosteroids was associated with reduced exacerbation risk compared with placebo in patients with uncontrolled, persistent asthma. However, LAMA, long-acting beta-agonist (LABA), and inhaled corticosteroids (triple therapy) were not associated with lower risk for exacerbations compared with LABA and inhaled corticosteroids alone.
A 64-year-old man with chronic obstructive pulmonary disease, diabetes, chronic kidney disease, and morbid obesity seeks preoperative approval for femoral popliteal bypass surgery.
Treating chronic obstructive pulmonary disease remains challenging, particularly in terms of choosing the appropriate fixed-dose combination bronchodilator.
Greater Pi10 was associated with incident spirometry-defined chronic obstructive pulmonary disease in a general population-based sample without clinical lung disease.
Sputum viscoelastic properties were associated with lung function and disease status in patients with cystic fibrosis.
In patients with persistent asthma, single maintenance and reliever therapy was associated with a lower risk for exacerbations compared with inhaled corticosteroids as controller therapy and short-acting beta-agonists as relief therapy.
Tai chi found to be as effective as pulmonary rehabilitation for patients with chronic obstructive pulmonary disease.
It is still not known whether differences in mortality rates between patients who receive noninvasive vs invasive ventilation for acute exacerbations of COPD can be attributed to less severe disease or other factors.
Regardless of blood eosinophil count, omalizumab was an effective treatment in adult and pediatric patients with severe allergic asthma.
Researchers identified 6 distinct FEV1 lung function trajectories, 3 of which were responsible for 75% of the COPD burden.
Proteostasis Therapeutics is developing the combination treatment which includes a novel transmembrane conductance regulator (CFTR) amplifier (PTI-428), a third generation corrector (PTI-801) and a potentiator (PTI-808).
Findings for subsequent allergic disease following infant exposure in the first six months of life.
Lonhala Magnair is available as a 25mcg strength inhalation solution per 1mL vial.
Peak flow meter, microspirometry are optimal, with full spirometry for positive results.
Sleep quality in patients with chronic obstructive pulmonary disease may be a significant predictor of multiple metrics of quality of life.
Study authors concluded, "Combining tiotropium and olodaterol did not reduce exacerbation rate as much as expected compared with tiotropium alone."
Disease management added to recommended care in chronic obstructive pulmonary disease was not superior to recommended care alone.
Four different doses of glycopyrronium delivered via metered dose inhaler were compared for safety and efficacy in the treatment of chronic obstructive pulmonary disease.
Patients with asthma or chronic obstructive pulmonary disease have especially high rates of nonadherence, even in comparison with other chronic diseases.
In children with allergic asthma, SCIT may reduce long-term asthma medication use.
The Smartinhaler sensor is a device installed onto a patient's inhaler to monitor and promote asthma and COPD medication adherence.
Long-acting muscarinic antagonists or long-acting β-agonists plus inhaled corticosteroids lowered the risk for asthma exacerbations vs adjuvant placebo.
Prenatal and early life stress, including societal stress, have been implicated in the development of asthma and other allergic diseases in children.
In children aged 5 to 11 years with mild to moderate persistent asthma who were treated with daily inhaled glucocorticoids, quintupling the dose during the initial signs of worsening asthma control did not reduce the rate of severe exacerbations.
The Clinical COPD Questionnaire cutoff point of 1.4 demonstrated a better agreement with other COPD measures in patients with more symptomatic disease.
Patients with chronic obstructive pulmonary disease with 5% emphysema based on thoracic computed tomography (CT) imaging may be at a greater risk for poor outcomes.
Current tobacco smoke exposure is not associated with airflow obstruction in school-aged children, but prenatal smoking is associated with airflow obstruction in children with asthma.
Bronchial thermoplasty can treat severe asthmatic cough that is unresponsive to conventional therapies.
Patients with cystic fibrosis who took azithromycin had a significantly lower risk for detection of new nontuberculous mycobacteria, methicillin-resistant Staphylococcus aureus, and Burkholderia cepacia complex.
Combination treatment with indacaterol-glycopyrronium may improve cardiac function in patients with chronic obstructive pulmonary disease.
Intermittent use of high-dose glucocorticoids did not increase the risk for fracture in patients with COPD.
Independent predictive factors of lung cancer in chronic obstructive pulmonary disease may include frequency of exacerbations, in addition to airflow obstruction and visual emphysema.
Smokers and nonsmokers had similar symptoms and risk factors present for asthma, but differed in comorbidities.
Researchers used data from the Atherosclerosis Risk in Communities Study to assess associations between dietary pattern and pulmonary assessments.
Long-term continuous cyclic azithromycin therapy for severe chronic obstructive pulmonary disease was associated with reductions in exacerbations and hospitalizations.
According to a systematic literature review, there was inconclusive evidence that single indoor allergen interventions were effective at improving asthma outcomes.
Short-acting beta-agonists for asthma management may reduce fertility rates in women with asthma.
When patients visiting an allergy/immunology outpatient clinic had expectations met regarding diagnosis and testing, they were more likely to be satisfied with their visit.
Spirometry may be underused for the diagnosis and monitoring of asthma in the primary care setting.
Fractional exhaled nitric oxide, periostin, and eosinophils may help identify patients at increased risk for severe asthma exacerbations, according to a post hoc analysis of a phase 2b trial on dupilumab.
Children diagnosed with eczema before the age of 2 years may be at increased risk for early-onset asthma.
Sputum cultures could aid clinicians in choosing an appropriate antibiotic for patients with cystic fibrosis and avoiding allergies and antibiotic resistance.
Children with asthma who experience chronic oral glucocorticoid exposure may have significant morbidities, including adrenal suppression, recurrent pneumonia, and behavioral problems.
Patients with opioid dependence or abuse may exhibit a higher prevalence of asthma compared with the general population.
Tiotropium, when added to standard asthma maintenance therapy, improves lung function in adult patients with symptomatic asthma regardless of GINA asthma severity.
Researchers examined real-world characteristics of patients receiving albuterol multidose dry powder inhaler or short-acting β2 agonists with short-acting β2 agonists for asthma and chronic obstructive pulmonary disease.
Episodically treating children with recurrent wheezing with inhaled combined salmeterol/fluticasone propionate may be as effective as a daily inhaled fluticasone propionate regimen.
Mepolizumab may be effective in patients with asthma that does not respond to omalizumab.
Researchers investigated whether intravenous reslizumab, a humanized anti-interleukin-5 monoclonal antibody, could aid in the management of asthma and eosinophilia.
Researchers assessed pooled randomized clinical trial data (NAVIGATE I and II; N5641) to examine the change in SF-36v2 and SF-6D from baseline to the end of double blind and to the end of the studies.
Researchers assessed whether the administration of dupilumab improves signs and symptoms of atopic dermatitis in patients with or without comorbid asthma.
A meta-analysis sought to determine whether prebiotics and probiotics improved the immunogenicity of the flu vaccine in adults.
Children who had both parental and sibling asthma in their families had an increased risk for asthma.
Reslizumab reduced the risk for exacerbations and improved lung function in patients with severe eosinophilic asthma.
Children who had both parental and sibling asthma in their families had an increased risk for asthma.
Children with mild to moderate persistent asthma were not more effectively treated with a quintupled dose of inhaled glucocorticoids.
Children who are exposed to antibiotics earlier in life may have an increased risk for allergic diseases, including asthma, atopic dermatitis, and allergic rhinitis.
Tezepelumab improved asthma control in patients with severe or uncontrolled asthma.
A post-hoc pooled analysis of phase 3 SIROCCO and CALIMA trials demonstrated benralizumab to be effective in the treatment of individuals with severe, uncontrolled eosinophilic asthma and nasal polyps.
Researchers assessed the use of dupilumab in adults with chronic rhinosinusitis and nasal polyps who did not respond to treatment with intranasal corticosteroids.
Intranasal corticosteroids are the current guideline-preferred treatment recommendation for nasal congestion.
Data from the Isle of Wight birth cohort study and the Kuwait University Allergy cross-sectional study were used to assess self-reported acetaminophen use and asthma diagnosis.
A cohort from the CANDLE study was assessed to determine if race plays a role in the protective effect of maternal vitamin D levels on childhood asthma.
Rural areas have a significantly higher prevalence of chronic obstructive pulmonary disease.
Researchers performed a literature review and summarized the evidence regarding adverse events associated with the use of inhaled corticosteroids in individuals with asthma.
In an attempt to determine if the presence of S aureus could be used as a marker for more severe disease, investigators assessed the relationship between S aureus-positive bronchiectasis infection and pulmonary function, frequency of exacerbations, and hospital admissions.
The TRIBUTE study was the first long-term trial that specifically compared the effects of the extrafine inhaled corticosteroid-containing triple therapy regimen of beclomethasone dipropionate, formoterol fumarate, and glycopyrronium with the dual bronchodilator combination of indacaterol plus glycopyrronium for COPD.
Patients with COPD and heightened cardiovascular risk received respiratory benefits from long-acting beta-agonist therapy without increasing their cardiovascular risk, regardless of beta-blocker therapy.
A first look at what will be presented at the 2018 Joint Congress of the American Academy of Allergy, Asthma & Immunology and the World Allergy Organization.
The dietary inflammatory index was used to examine the risk for current wheeze with a proinflammatory diet in adults and children.
Researchers evaluated whether duration of breastfeeding was associated with a modified risk for asthma development in children.
Although adherence to asthma guidelines tended to be higher in specialists, both specialists and primary care physicians had low adherence to specific core recommendations.
While there is currently no cure for asthma, treatments are effective at providing symptom relief.
Patients with chronic obstructive pulmonary disease had a modest increased risk for hip and upper extremity fractures when taking long-term, high-dose inhaled corticosteroids.
Lung transplantation can improve survival in patients with chronic obstructive pulmonary disease, but several variables can affect the surgery's success.
A new cystic fibrosis transmembrane conductance regulator modulator treatment has been approved by the FDA for use in patients aged 12 years and older.
Maternal prenatal and early childhood intake of sugar-sweetened beverages and fructose is associated with current asthma in midchildhood.
CFTR modulator therapy recommended in certain patients with cystic fibrosis.
Researchers conducted an anonymous survey of medical trainees with a case vignette to determine attitudes regarding palliative care for chronic obstructive pulmonary disease.
Researchers compared the clinical cure and adverse effect rates of multiple antibiotics in the treatment of acute exacerbations in chronic obstructive pulmonary disease.
High levels of C-reactive protein and neutrophils as well as low eosinophil count predicted a poor prognosis in COPD.
Respiratory symptoms that develop between the ages of 18 and 30 may hold prognostic value for later decline in lung function.
Researchers examined variation in airway branches to determine whether they have an effect on the course of chronic obstructive pulmonary disease.
Patients with COPD experienced a weighted mean increase in exercise endurance time following treatment with long-acting bronchodilators.
Children who received oral prednisolone vs placebo for virus-associated wheeze had a shorter length of hospital stay.