Air-driven bronchodilator nebulization is preferable to oxygen-driven nebulization in patients experiencing acute COPD exacerbations.
The increased occurrence of periprocedural complications in patients with COPD was largely attributed to cardiac arrest, myocardial infarctions, and no-reflows.
Children exposed to cats, dogs, goats, cockroaches, and rats while in utero were more likely to develop asthma.
Albuminuria was associated with greater lung function decline in patients with chronic obstructive pulmonary disease.
Time-series analysis based on geographic location revealed positive significant associations between asthma and influenza hospitalizations in Brooklyn and Manhattan.
The majority of study participants had rhinitis at baseline, including perennial allergic rhinitis with seasonal exacerbations, which is the most severe phenotype.
Changing to bronchodilator treatment with a metered dose inhaler in patients with mild to moderate asthma resulted in lower hospitalization rates, shorter hospital stays, and a decrease in continuous use of albuterol.
The FDA has approved Dupixent as an add-on maintenance treatment in patients with moderate-to-severe asthma aged 12 years and older with an eosinophilic phenotype or with oral corticosteroid-dependent asthma.
Cystic fibrosis transmembrane conductance regulator dysfunction is associated with worsened airway disease in patients with COPD.
Total serum bilirubin levels of 9 to 11.9 mg/dL, 12 to 14.9 mg/dL, and 15 to 17.9 mg/dL were associated with significantly greater risks for asthma in infants.
Childhood non-atopic rhinitis is associated with an increased risk for adult asthma.
No difference in mortality, but there may be an elevated risk for suicide with long-term benzodiazepine use in patients with COPD and comorbid PTSD.
Middle-aged testosterone replacement therapy users with COPD had a greater reduction in hospitalizations compared with nonusers.
The FDA has granted Orphan Drug Designation to a novel inhaled treatment that could potentially improve lung function in patients with cystic fibrosis.
The risk for obstructive lung disease was nearly 8 times greater in heavy stable smokers compared with never-smokers.
Children with asthma had a 66% higher risk for incident obesity compared with children without asthma.
Bronchial thermoplasty reduced gas trapping in individuals with asthma, particularly in patients with severe disease.
Early pulmonary rehabilitation after hospitalization for an acute exacerbation of COPD was an effective intervention for reducing mortality.
The FDA has approved updated labeling for Stiolto Respimat to include COPD exacerbation data and a revised indication.
Patients who received a discharge care bundle after being hospitalized for an acute exacerbation of COPD had a lower rate of readmission.
Infants who presented with pulmonary symptoms when diagnosed with gastroesophageal reflux disease had a higher incidence of early onset asthma compared with infants who did not have pulmonary symptoms.
Patients with chronic obstructive pulmonary disease who used opioids were more likely to be intubated during their hospitalization compared with nonopioid users
Adolescents with asthma treated with dupilumab experienced significant improvements in FEV1 compared with placebo.
Patients with moderate to severe persistent allergic asthma who were treated with omalizumab experienced greater improvements in lung function after 16 weeks compared with those treated with placebo.
Benralizumab was associated with a significant reduction in annual asthma exacerbation rates.
There was a trend toward a reduction in mortality in patients with COPD who received beta-blocker treatment compared with patients who did not.
Montelukast plus levocetirizine demonstrated a significant reduction in mean daytime nasal symptom scores compared with montelukast monotherapy.
Disrupting regular combination inhaled corticosteroid therapy refills increased hospitalizations and exacerbations.
Black and Hispanic respondents with asthma were less likely to use complementary alternative medicine than their white counterparts.
Major cardiovascular adverse events were more common in the previous event subgroup, with 5.5% occurring in the aclidinium group and 6.2% in the placebo group.
Regardless of severity, when children's asthma was appropriately managed according to guidelines, they experienced significant improvements.
A higher number of acute respiratory infections before the age of 2 may increase the risk for asthma by age 7.
Lower exposure to Proteobacteria in umbilical cord serum was associated with an increased risk for childhood wheezing.
The most common error related to the use of metered dose inhalers was the failure to attach the inhaler to a spacer.
African-American adolescents with asthma had improved outcomes when they received a comprehensive treatment plan.
Patients with severe COPD improved significantly in both endurance time and walking distance with the use of automatically titrated oxygen flow vs constant oxygen flow.
The PFS formulation eliminates the need to reconstitute the solution before administration.
For every 10-fold rise in methyl and propyl concentrations, there was a 2.61 and a 2.18 increased prevalence odds ratio, respectively, of reporting an emergency department visit in the last 12 months in boys with asthma.
Treatment with prophylactic antibiotics was associated with a reduction in the frequency of COPD exacerbations and improved quality of life.
Smoking cessation in patients with asthma is associated with reduced symptoms, improved lung function and quality of life, reduced use of rescue medications, improved airway hyperresponsiveness, and decreased hyperactivity.
No meaningful associations were detected in procedural listing preferences and survival outcomes in patients with COPD or interstitial lung disease awaiting lung transplant.
Clinicians are eager for new therapies to address the damage to airways and lung parenchyma because no current therapy can completely reverse COPD damage.
Forskolin-induced swelling in intestinal organoids is a clinically relevant biomarker of disease severity in infants diagnosed with cystic fibrosis.
After 12 months, patients in the Urban Training™ group had increased their number of daily steps by 816 compared with 64 steps in the usual care group.
Additional bronchodilation and hyperinflation reduction occurred in COPD when RPL554, an inhaled PDE 3 and 4 inhibitor, was combined with standard bronchodilators.
PubMed was searched to obtain data on the relative efficacies of benralizumab, dupilumab, lebrikizumab, mepolizumab, reslizumab, and tralokinumab.
Changing pollination patterns, extreme weather events, rising sea levels, air pollution, and extreme temperatures all negatively affect respiratory conditions.
Cockroach and mouse allergies were most often associated with poorly controlled asthma and exacerbations in urban adolescents.
Children of East Asian-born parents had an increased risk for allergic rhinitis and aeroallergen sensitization compared with children of Caucasian ancestry.
Total omega-3 and omega-6 plasma polyunsaturated fatty acids relative abundances were significantly inversely correlated with asthma/recurrent wheeze and allergic sensitization.
There were no statistically significant differences in mortality rates, rates of COPD exacerbations, lung inflammation, or serious adverse events between a once-daily combined inhaled corticosteroid/LABA and LAMA.
A total of 35% of heroin smokers screened positive for COPD.
Although allergic sensitization and hay fever rates increased as children grew older, the rates of asthma dropped.
Pooled data from two identical 12-week pivotal Phase 3 trials (N=1229) in patients with moderate to very severe COPD showed that the mean annualized rate of all COPD exacerbations was 0.47, 0.45, and 0.55 for revefenacin 175mcg/day, 88mcg/day, and placebo, respectively.
Results from the extension trial showed a similar safety and tolerability profile for Fasenra as that seen in SIROCCO and CALIMA.
Evidence is lacking that demonstrates that monotherapy with correctors has a clinically important effect on individuals with cystic fibrosis who have 2 copies of the F508del mutation.
An increase was seen in asthma hospital visits with increasing ambient particulate matter in San Luis Valley.
No difference in exacerbations with indacaterol/glycopyrronium for non-frequently exacerbating COPD.
The SYGMA trials assessed the use of an as-needed combined corticosteroid/beta-agonist inhaler in patients with mild asthma.
First-phase and glucose-potentiation of arginine-induced insulin secretion as assessed by acute C-peptide responses improved after the initiation of ivacaftor in children with cystic fibrosis.
Currently, 3 anti-interleukin (IL)5 pathway-directed treatments (benralizumab, mepolizumab, reslizumab) have been approved by the Food and Drug Administration for the treatment of severe asthma with an eosinophilic phenotype.
First bronchoscopic lung volume reduction using endobronchial valve performed at Temple University in Philadelphia, PA.
In a population of primarily Latino children from low-income households, a program of school-supervised use of once-daily inhaled corticosteroids failed to improve asthma control.
In their Complete Response Letter, the FDA stated that they require more clinical data to support approval.
Overall, 5 phenotypes were identified and differentiated mainly by patterns of wheezing and aeroallergen sensitization: low wheeze-low atopy, low wheeze-high atopy, transient wheeze-low atopy, high wheeze-low atopy, and high wheeze-high atopy.
Nasal expression of interleukin-10 showed an association with perceived stress burden, while perceived stress burden was strongly associated with asthma control score.
The designation was based on data from the Phase 2b PATHWAY trial that evaluated 3 doses of tezepelumab as add-on therapy in patients with a history of asthma exacerbations and uncontrolled asthma receiving inhaled corticosteroids/long-acting β-agonist with or without oral corticosteroids and additional asthma controllers vs placebo.
Significant negative correlations were seen between visceral fat area and bronchial lumen diameter and lumen area, and significant positive correlations were seen between subcutaneous fat area and bronchial wall area and total area.
Cardiovascular risk within 30 days of therapy start was approximately 2-fold higher with the incident use of tiotropium in COPD.
In patients with emphysema, deposition fraction was significantly lower than in other individuals, but no significant differences were found between healthy never smokers and current or former smokers.
Thigh muscle volume showed significant improvements in patients with COPD who were treated with bimagrumab vs placebo.
A total of 8% of patients with asthma exacerbations met the criteria for diagnosing anaphylaxis, with 3.4% having likely experienced anaphylaxis.
African-American adolescents with asthma who took appropriate therapies had both decreased lung function and elevated blood lipid levels when exposed to short-term low ozone levels.
The risk of a mixing-up the treatments is especially high for pregnant women, says the Food and Drug Administration (FDA), as losartan is indicated to treat high blood pressure and could harm or kill a fetus.
Patients with COPD who have comorbidities are less likely to receive beneficial treatment for exacerbations.
The incidence of undiagnosed COPD was 26%, and based on the GOLD spirometry grading system, 95% had mild to moderate disease.
After 2.1 years of follow-up, 49% of patients who had emphysema on chest CT were readmitted for heart failure and 24% had died.
Although the summer season yielded the lowest overall COPD exacerbation rate, 43% of exacerbations during summer were moderate to very severe.
The average annual prevalence of bronchiectasis from 2012 to 2014 was 701 cases per 100,000 individuals.
S pneumoniae colonization was positively associated with H influenza colonization, whereas negative associations were reported between P aeruginosa and H influenzae and between P aeruginosa and M catarrhalis.
Lung transplantation can extend survival in patients with cystic fibrosis who have compromised lung function and increasing exacerbations.
Comorbid chronic rhinitis is significantly associated with 30-day hospital readmissions related to asthma and chronic obstructive pulmonary disease.
There is a significant relationship between attention deficit hyperactivity disorder and asthma.
Low-income urban preschoolers with asthma may not meet home medication readiness criteria.
Lung function in patients with primary ciliary dyskinesia was reduced compared with reference values from patients with cystic fibrosis in both sexes and in all age groups.
In children who were symptomatic, small conducting airways ventilation inhomogeneity and alveolar nitric oxide concentration were both significantly associated with asthma exacerbations.
Adolescents who have asthma or allergic rhinitis may be at higher risk for developing migraine.
Pooled estimates from cohort studies suggested there was no association between antenatal blood vitamin D levels or vitamin D intake and asthma in offspring.
The approval was supported by data from ARRIVAL (N=25), an ongoing Phase 3 open-label safety study in children with CF aged 12 to <24 months with 1 of 10 CFTR gene mutations (G551D, G178R, S549N, S549R, G551S, G1244E, S1251N, S1255P, G1349D or R117H).
Combined tele-case management and tele-consultation was the most effective form of telemedicine for improving asthma control.
Prior use of systemic corticosteroids and prior isolation of Pseudomonas aeruginosa were risk factors associated with the presence of Pseudomonas aeruginosa in COPD.
Use of labetalol vs other antihypertensives is linked to increased risk of status asthmaticus.
A high blood eosinophil count may increase the risk for a second asthma-related hospitalization within 1 year following an initial hospitalization.
Through Bluetooth technology, clinicians and patients will be able to share and monitor inhaler usage.
The authors write that once severe asthma is diagnosed, clinicians should determine asthma endotype (Type2-high or Type2-low) to help choose the best therapy for the patient.
Short-term corticosteroids may be sufficient for treating patients with acute COPD exacerbations.
Patients with COPD who had a relative lymphocyte count ≤20% had a higher risk for mortality.
Patients with severe asthma who are glucocorticoid dependent and treated with dupilumab for 24 weeks used significantly lower doses of glucocorticoids while maintaining asthmatic control compared with patients treated with placebo.
In adult-diagnosed cystic fibrosis, diabetes, lung function, and age at diagnosis may predict patient survival.
Children with asthma and/or wheeze who have a basophil level above 0.18% of the circulating peripheral blood mononuclear cell population have a higher risk for future exacerbations.