PubMed was searched to obtain data on the relative efficacies of benralizumab, dupilumab, lebrikizumab, mepolizumab, reslizumab, and tralokinumab.
Changing pollination patterns, extreme weather events, rising sea levels, air pollution, and extreme temperatures all negatively affect respiratory conditions.
Cockroach and mouse allergies were most often associated with poorly controlled asthma and exacerbations in urban adolescents.
Children of East Asian-born parents had an increased risk for allergic rhinitis and aeroallergen sensitization compared with children of Caucasian ancestry.
Total omega-3 and omega-6 plasma polyunsaturated fatty acids relative abundances were significantly inversely correlated with asthma/recurrent wheeze and allergic sensitization.
There were no statistically significant differences in mortality rates, rates of COPD exacerbations, lung inflammation, or serious adverse events between a once-daily combined inhaled corticosteroid/LABA and LAMA.
A total of 35% of heroin smokers screened positive for COPD.
Although allergic sensitization and hay fever rates increased as children grew older, the rates of asthma dropped.
Pooled data from two identical 12-week pivotal Phase 3 trials (N=1229) in patients with moderate to very severe COPD showed that the mean annualized rate of all COPD exacerbations was 0.47, 0.45, and 0.55 for revefenacin 175mcg/day, 88mcg/day, and placebo, respectively.
Results from the extension trial showed a similar safety and tolerability profile for Fasenra as that seen in SIROCCO and CALIMA.
Evidence is lacking that demonstrates that monotherapy with correctors has a clinically important effect on individuals with cystic fibrosis who have 2 copies of the F508del mutation.
An increase was seen in asthma hospital visits with increasing ambient particulate matter in San Luis Valley.
No difference in exacerbations with indacaterol/glycopyrronium for non-frequently exacerbating COPD.
The SYGMA trials assessed the use of an as-needed combined corticosteroid/beta-agonist inhaler in patients with mild asthma.
First-phase and glucose-potentiation of arginine-induced insulin secretion as assessed by acute C-peptide responses improved after the initiation of ivacaftor in children with cystic fibrosis.
Currently, 3 anti-interleukin (IL)5 pathway-directed treatments (benralizumab, mepolizumab, reslizumab) have been approved by the Food and Drug Administration for the treatment of severe asthma with an eosinophilic phenotype.
First bronchoscopic lung volume reduction using endobronchial valve performed at Temple University in Philadelphia, PA.
In a population of primarily Latino children from low-income households, a program of school-supervised use of once-daily inhaled corticosteroids failed to improve asthma control.
In their Complete Response Letter, the FDA stated that they require more clinical data to support approval.
Overall, 5 phenotypes were identified and differentiated mainly by patterns of wheezing and aeroallergen sensitization: low wheeze-low atopy, low wheeze-high atopy, transient wheeze-low atopy, high wheeze-low atopy, and high wheeze-high atopy.
Nasal expression of interleukin-10 showed an association with perceived stress burden, while perceived stress burden was strongly associated with asthma control score.
The designation was based on data from the Phase 2b PATHWAY trial that evaluated 3 doses of tezepelumab as add-on therapy in patients with a history of asthma exacerbations and uncontrolled asthma receiving inhaled corticosteroids/long-acting β-agonist with or without oral corticosteroids and additional asthma controllers vs placebo.
Significant negative correlations were seen between visceral fat area and bronchial lumen diameter and lumen area, and significant positive correlations were seen between subcutaneous fat area and bronchial wall area and total area.
Cardiovascular risk within 30 days of therapy start was approximately 2-fold higher with the incident use of tiotropium in COPD.
In patients with emphysema, deposition fraction was significantly lower than in other individuals, but no significant differences were found between healthy never smokers and current or former smokers.
Thigh muscle volume showed significant improvements in patients with COPD who were treated with bimagrumab vs placebo.
A total of 8% of patients with asthma exacerbations met the criteria for diagnosing anaphylaxis, with 3.4% having likely experienced anaphylaxis.
African-American adolescents with asthma who took appropriate therapies had both decreased lung function and elevated blood lipid levels when exposed to short-term low ozone levels.
The risk of a mixing-up the treatments is especially high for pregnant women, says the Food and Drug Administration (FDA), as losartan is indicated to treat high blood pressure and could harm or kill a fetus.
Patients with COPD who have comorbidities are less likely to receive beneficial treatment for exacerbations.
The incidence of undiagnosed COPD was 26%, and based on the GOLD spirometry grading system, 95% had mild to moderate disease.
After 2.1 years of follow-up, 49% of patients who had emphysema on chest CT were readmitted for heart failure and 24% had died.
Although the summer season yielded the lowest overall COPD exacerbation rate, 43% of exacerbations during summer were moderate to very severe.
The average annual prevalence of bronchiectasis from 2012 to 2014 was 701 cases per 100,000 individuals.
S pneumoniae colonization was positively associated with H influenza colonization, whereas negative associations were reported between P aeruginosa and H influenzae and between P aeruginosa and M catarrhalis.
Lung transplantation can extend survival in patients with cystic fibrosis who have compromised lung function and increasing exacerbations.
Comorbid chronic rhinitis is significantly associated with 30-day hospital readmissions related to asthma and chronic obstructive pulmonary disease.
There is a significant relationship between attention deficit hyperactivity disorder and asthma.
Low-income urban preschoolers with asthma may not meet home medication readiness criteria.
Lung function in patients with primary ciliary dyskinesia was reduced compared with reference values from patients with cystic fibrosis in both sexes and in all age groups.
In children who were symptomatic, small conducting airways ventilation inhomogeneity and alveolar nitric oxide concentration were both significantly associated with asthma exacerbations.
Adolescents who have asthma or allergic rhinitis may be at higher risk for developing migraine.
Pooled estimates from cohort studies suggested there was no association between antenatal blood vitamin D levels or vitamin D intake and asthma in offspring.
The approval was supported by data from ARRIVAL (N=25), an ongoing Phase 3 open-label safety study in children with CF aged 12 to <24 months with 1 of 10 CFTR gene mutations (G551D, G178R, S549N, S549R, G551S, G1244E, S1251N, S1255P, G1349D or R117H).
Combined tele-case management and tele-consultation was the most effective form of telemedicine for improving asthma control.
Prior use of systemic corticosteroids and prior isolation of Pseudomonas aeruginosa were risk factors associated with the presence of Pseudomonas aeruginosa in COPD.
Use of labetalol vs other antihypertensives is linked to increased risk of status asthmaticus.
A high blood eosinophil count may increase the risk for a second asthma-related hospitalization within 1 year following an initial hospitalization.
Through Bluetooth technology, clinicians and patients will be able to share and monitor inhaler usage.
The authors write that once severe asthma is diagnosed, clinicians should determine asthma endotype (Type2-high or Type2-low) to help choose the best therapy for the patient.
Short-term corticosteroids may be sufficient for treating patients with acute COPD exacerbations.
Patients with COPD who had a relative lymphocyte count ≤20% had a higher risk for mortality.
Patients with severe asthma who are glucocorticoid dependent and treated with dupilumab for 24 weeks used significantly lower doses of glucocorticoids while maintaining asthmatic control compared with patients treated with placebo.
In adult-diagnosed cystic fibrosis, diabetes, lung function, and age at diagnosis may predict patient survival.
Children with asthma and/or wheeze who have a basophil level above 0.18% of the circulating peripheral blood mononuclear cell population have a higher risk for future exacerbations.
When compared with a placebo control cannabis, cannabis had no effect on breathlessness intensity ratings during exercise at isotime or on exercise endurance time.
Socioeconomic and lifestyle risk factors had a more significant role in the development of COPD and asthma overlap syndrome in women than air pollution.
Asthma was not associated with a risk for intestinal resection surgery in patients with Crohn disease.
Electronic asthma action plans supported by text messaging services may improve control and reduce exacerbations.
The approval was based on data from a 24-week, open-label, Phase 3 study in patients aged 2 to 5 years.
Patients with aspirin-exacerbated respiratory disease had significantly lower levels of depression symptoms and higher quality of life compared with patients with asthma only.
A higher prevalence of anaerobic bacteria in cystic fibrosis was associated with higher lung function, less use of antibiotics, increased BMI, pancreatic sufficiency, and no requirement for insulin.
Shorter telomere length was associated with worse health status in chronic obstructive pulmonary disease, as measured by St. George's Respiratory Questionnaire.
Anxiety symptoms are more common in patients with COPD as determined by the Generalized Anxiety Disorder, Hospital Anxiety and Depression scale, and Anxiety Inventory for Respiratory Disease screening questionnaires vs the DSM-V criteria.
Individuals with clinician-diagnosed asthma were at an estimated 38% higher risk for atrial fibrillation.
The Hailie sensor attaches to the asthma or chronic obstructive pulmonary disease (COPD) inhaler to monitor and help patient adherence.
Although emerging data offer valuable clues, the pathophysiological distinctions between different phenotypes of chronic obstructive pulmonary disease are still poorly understood.
Grass, other weeds, and unclassified pollen were significantly associated with increased risk for asthma hospitalization in young children.
Mortality was significantly increased among patients with rheumatoid arthritis and COPD.
Inhaling and smoking heroin and cocaine increase the risk for asthma exacerbations and decreased pulmonary function; marijuana is associated with wheezing, cough, and sputum production.
Patients who were hospitalized for non-severe acute exacerbations of COPD did not experience improved outcomes when antibiotics were administered for longer than 24 hours.
NT-proBNP may be an independent predictor of respiratory exacerbations in patients with COPD even without overt cardiovascular disease.
Sensitization to Aspergillus fumigatus increased the risk for severe asthma.
Collagen biomarkers were significantly higher at extreme exacerbations, and were also associated with circulating adrenomedullin.
Rates of pulmonary embolism ranged from 3.3% to 29.1% in patients with a clinical diagnosis of an acute exacerbation of COPD.
There were differences in use of steroids and antibiotics noted between teaching and non-teaching hospital staff.
Whole-genome sequencing was valuable in identifying a large number of potentially significant functional variants in severe COPD.
Although COPD has been identified as a risk factor for cardiovascular disease, researchers are less certain about the relationship between COPD and stroke.
Combination therapy with a long-acting β2-agonist plus an inhaled glucocorticoid for asthma was not associated with a significantly higher risk for serious asthma-related events compared with an inhaled glucocorticoid alone.
Frequent asthma, bronchitis, allergy demonstrated the strongest association with , lower FEV1, lower FEV1/forced vital capacity, and increased risk for COPD.
Cytokines produced by mitogen-stimulated immune cells from pregnant women without asthma were shown to be associated with the development of asthma in their children.
Dexamethasone was not effective in reducing the incidence of acute mountain sickness and altitude-related adverse health effects in individuals with mild to moderate COPD.
The US Centers for Disease Control offers steps to minimize exposure to wildfire smoke, particularly for those with chronic conditions.
Regardless of renal impairment, combination therapy with tiotropium/olodaterol was safe and tolerable in patients with moderate to very severe COPD.
No associations were found between free concentration vitamin D3 levels and treatment failure or exacerbation rates in adults with asthma
The eFlow® nebulizer delivered CDP7766 without evidence of degradation, loss of potency, aggregation, or formation of particulates in a model of asthma in cynomolgus macaques.
Study authors performed a post hoc pooled analysis of data from 10 trials to assess the safety and efficacy of umeclidinium/vilanterol in elderly symptomatic patients with COPD.
Patients with severe asthma were more often current smokers at diagnosis and had higher body mass index at follow-up compared with patients with nonsevere asthma and anti-IL-5 therapy-eligible asthma.
Gastroesophageal reflux disease is associated with an increase in bronchitis symptoms in patients with COPD.
Increase in all-cause, cardiovascular disease, cancer, diabetes, kidney disease, suicide, and COPD mortality.
The approval was based on results from a multicenter study (LIBERATE) of 190 patients with severe emphysema.
For patients with advanced COPD, the use of formal palliative care services and long-term oxygen therapy has increased but remains low.
Older adults with asthma and a greater desire for involvement in decision making have higher asthma-related quality of life.
Compared with placebo, the risk for a pulmonary exacerbation was reduced by 44% in participants with cystic fibrosis who received azithromycin.
Bronchiectasis-associated genera included Aspergillus, Cryptococcus, Clavispora, Botrytis, and Alternaria.
Poor control of asthma and obstructive sleep apnea can feed off one another, according to Michelle Zeidler, MD, pulmonologist at the University of California, Los Angeles, and director of the UCLA Sleep Fellowship Program.
The clinical significance of emphysema was greater in people living with HIV vs those without HIV.
The use of formal palliative care services among patients with chronic obstructive pulmonary disease increased by 1% per year, going from 5.3% in 2004 to 14.3% in 2014.
Children with the early-onset persistent bronchial hyperresponsiveness phenotype had the highest blood eosinophil count and total serum IgE levels as well as sensitization rates.
The mean rate of exacerbations declined significantly after 1 year of subcutaneous immunotherapy in children with moderate to severe allergic asthma exacerbations.