Eosinophilic Asthma Treatment: Biologic Agents Compared

Eosinophilic Asthma Treatment: Biologic Agents Compared

PubMed was searched to obtain data on the relative efficacies of benralizumab, dupilumab, lebrikizumab, mepolizumab, reslizumab, and tralokinumab.

Climate Change: Dire Implications for Respiratory Conditions

Climate Change: Dire Implications for Respiratory Conditions

Changing pollination patterns, extreme weather events, rising sea levels, air pollution, and extreme temperatures all negatively affect respiratory conditions.

Pest Allergies in Urban Adolescents Exacerbate Poorly Controlled Asthma

Pest Allergies in Urban Adolescents Exacerbate Poorly Controlled Asthma

Cockroach and mouse allergies were most often associated with poorly controlled asthma and exacerbations in urban adolescents.

Allergy, But Not Asthma, Risk Increased in Children of East Asian Descent

Allergy, But Not Asthma, Risk Increased in Children of East Asian Descent

Children of East Asian-born parents had an increased risk for allergic rhinitis and aeroallergen sensitization compared with children of Caucasian ancestry.

PUFAs Inversely Associated With Asthma in Preschool Children

PUFAs Inversely Associated With Asthma in Preschool Children

Total omega-3 and omega-6 plasma polyunsaturated fatty acids relative abundances were significantly inversely correlated with asthma/recurrent wheeze and allergic sensitization.

ICS/LABA Combined in One Inhaler vs LAMA Compared for Efficacy, Safety in COPD

ICS/LABA Combined in One Inhaler vs LAMA Compared for Efficacy, Safety in COPD

There were no statistically significant differences in mortality rates, rates of COPD exacerbations, lung inflammation, or serious adverse events between a once-daily combined inhaled corticosteroid/LABA and LAMA.

Relationship Between Atopic Disorders May Be Age Dependent

Relationship Between Atopic Disorders May Be Age Dependent

Although allergic sensitization and hay fever rates increased as children grew older, the rates of asthma dropped.

Revefenacin Cuts COPD Exacerbation Rates in Phase 3 Studies

Revefenacin Cuts COPD Exacerbation Rates in Phase 3 Studies

Pooled data from two identical 12-week pivotal Phase 3 trials (N=1229) in patients with moderate to very severe COPD showed that the mean annualized rate of all COPD exacerbations was 0.47, 0.45, and 0.55 for revefenacin 175mcg/day, 88mcg/day, and placebo, respectively.

Benralizumab Efficacy Maintained in Long-Term Severe Eosinophilic Asthma Study

Benralizumab Efficacy Maintained in Long-Term Severe Eosinophilic Asthma Study

Results from the extension trial showed a similar safety and tolerability profile for Fasenra as that seen in SIROCCO and CALIMA.

Does Monotherapy With Correctors Have Clinical Benefit in Cystic Fibrosis?

Does Monotherapy With Correctors Have Clinical Benefit in Cystic Fibrosis?

Evidence is lacking that demonstrates that monotherapy with correctors has a clinically important effect on individuals with cystic fibrosis who have 2 copies of the F508del mutation.

Ambient Particulate Matter Linked to Emergency Asthma Care

Ambient Particulate Matter Linked to Emergency Asthma Care

An increase was seen in asthma hospital visits with increasing ambient particulate matter in San Luis Valley.

Small Reduction in Lung Function With Treatment De-Escalation in COPD

Small Reduction in Lung Function With Treatment De-Escalation in COPD

No difference in exacerbations with indacaterol/glycopyrronium for non-frequently exacerbating COPD.

Budesonide/Formoterol for the Prevention of Serious Asthma Exacerbations

Budesonide/Formoterol for the Prevention of Serious Asthma Exacerbations

The SYGMA trials assessed the use of an as-needed combined corticosteroid/beta-agonist inhaler in patients with mild asthma.

Ivacaftor Improves Insulin Secretion in Children With Cystic Fibrosis

Ivacaftor Improves Insulin Secretion in Children With Cystic Fibrosis

First-phase and glucose-potentiation of arginine-induced insulin secretion as assessed by acute C-peptide responses improved after the initiation of ivacaftor in children with cystic fibrosis.

Anti-IL5 Treatments Compared in Patients With Severe Eosinophilic Asthma

Anti-IL5 Treatments Compared in Patients With Severe Eosinophilic Asthma

Currently, 3 anti-interleukin (IL)5 pathway-directed treatments (benralizumab, mepolizumab, reslizumab) have been approved by the Food and Drug Administration for the treatment of severe asthma with an eosinophilic phenotype.

New Bronchoscopic Option Used for Severe Emphysema

New Bronchoscopic Option Used for Severe Emphysema

First bronchoscopic lung volume reduction using endobronchial valve performed at Temple University in Philadelphia, PA.

Asthma Control Not Improved With School-Supervised Inhaled Corticosteroid Use

Asthma Control Not Improved With School-Supervised Inhaled Corticosteroid Use

In a population of primarily Latino children from low-income households, a program of school-supervised use of once-daily inhaled corticosteroids failed to improve asthma control.

FDA: More Data Required to Support Mepolizumab Approval for COPD

FDA: More Data Required to Support Mepolizumab Approval for COPD

In their Complete Response Letter, the FDA stated that they require more clinical data to support approval.

Childhood Asthma Risk Assessed Using Respiratory Phenotypes

Childhood Asthma Risk Assessed Using Respiratory Phenotypes

Overall, 5 phenotypes were identified and differentiated mainly by patterns of wheezing and aeroallergen sensitization: low wheeze-low atopy, low wheeze-high atopy, transient wheeze-low atopy, high wheeze-low atopy, and high wheeze-high atopy.

IL-24 Shows Correlation Between Lower, Upper Airways in Allergic Asthma

IL-24 Shows Correlation Between Lower, Upper Airways in Allergic Asthma

Nasal expression of interleukin-10 showed an association with perceived stress burden, while perceived stress burden was strongly associated with asthma control score.

Tezepelumab Gets Breakthrough Therapy Designation for Severe Asthma

Tezepelumab Gets Breakthrough Therapy Designation for Severe Asthma

The designation was based on data from the Phase 2b PATHWAY trial that evaluated 3 doses of tezepelumab as add-on therapy in patients with a history of asthma exacerbations and uncontrolled asthma receiving inhaled corticosteroids/long-acting β-agonist with or without oral corticosteroids and additional asthma controllers vs placebo.

Asthma Affected Differently by Subcutaneous and Visceral Abdominal Fat

Asthma Affected Differently by Subcutaneous and Visceral Abdominal Fat

Significant negative correlations were seen between visceral fat area and bronchial lumen diameter and lumen area, and significant positive correlations were seen between subcutaneous fat area and bronchial wall area and total area.

Tiotropium Associated With Increased Cardiovascular Risk in COPD

Tiotropium Associated With Increased Cardiovascular Risk in COPD

Cardiovascular risk within 30 days of therapy start was approximately 2-fold higher with the incident use of tiotropium in COPD.

COPD Has Altered Deposition of Inhaled Nanoparticles

COPD Has Altered Deposition of Inhaled Nanoparticles

In patients with emphysema, deposition fraction was significantly lower than in other individuals, but no significant differences were found between healthy never smokers and current or former smokers.

Skeletal Muscle Mass in COPD Improved With Bimagrumab

Skeletal Muscle Mass in COPD Improved With Bimagrumab

Thigh muscle volume showed significant improvements in patients with COPD who were treated with bimagrumab vs placebo.

Prevalence of Asthma Exacerbations That Also Meet Anaphylaxis Criteria

Prevalence of Asthma Exacerbations That Also Meet Anaphylaxis Criteria

A total of 8% of patients with asthma exacerbations met the criteria for diagnosing anaphylaxis, with 3.4% having likely experienced anaphylaxis.

Low Ozone Levels Negatively Affect Subsets of Adolescents With Asthma

Low Ozone Levels Negatively Affect Subsets of Adolescents With Asthma

African-American adolescents with asthma who took appropriate therapies had both decreased lung function and elevated blood lipid levels when exposed to short-term low ozone levels.

Asthma Medicine Recalled Due to Tablet Mix-Up That May Pose Safety Risk

Asthma Medicine Recalled Due to Tablet Mix-Up That May Pose Safety Risk

The risk of a mixing-up the treatments is especially high for pregnant women, says the Food and Drug Administration (FDA), as losartan is indicated to treat high blood pressure and could harm or kill a fetus.

Comorbidities Affect Treatment for COPD Exacerbations

Comorbidities Affect Treatment for COPD Exacerbations

Patients with COPD who have comorbidities are less likely to receive beneficial treatment for exacerbations.

COPD Screening Should Not Be Limited to Symptomatic Patients

COPD Screening Should Not Be Limited to Symptomatic Patients

The incidence of undiagnosed COPD was 26%, and based on the GOLD spirometry grading system, 95% had mild to moderate disease.

Emphysema Associated With Worse Outcomes in Heart Failure

Emphysema Associated With Worse Outcomes in Heart Failure

After 2.1 years of follow-up, 49% of patients who had emphysema on chest CT were readmitted for heart failure and 24% had died.

COPD Exacerbation Rates May Worsen During Colder Seasonal Temperatures

COPD Exacerbation Rates May Worsen During Colder Seasonal Temperatures

Although the summer season yielded the lowest overall COPD exacerbation rate, 43% of exacerbations during summer were moderate to very severe.

Bronchiectasis Prevalence on the Rise in COPD

Bronchiectasis Prevalence on the Rise in COPD

The average annual prevalence of bronchiectasis from 2012 to 2014 was 701 cases per 100,000 individuals.

Species-Specific Interactions of Common Bacteria in COPD

Species-Specific Interactions of Common Bacteria in COPD

S pneumoniae colonization was positively associated with H influenza colonization, whereas negative associations were reported between P aeruginosa and H influenzae and between P aeruginosa and M catarrhalis.

Is There an "Ideal" Cystic Fibrosis Candidate for Lung Transplantation?

Is There an "Ideal" Cystic Fibrosis Candidate for Lung Transplantation?

Lung transplantation can extend survival in patients with cystic fibrosis who have compromised lung function and increasing exacerbations.

Asthma, COPD Readmissions Independently Predicted by Chronic Rhinitis

Asthma, COPD Readmissions Independently Predicted by Chronic Rhinitis

Comorbid chronic rhinitis is significantly associated with 30-day hospital readmissions related to asthma and chronic obstructive pulmonary disease.

Asthma and ADHD: What's the Link?

Asthma and ADHD: What's the Link?

There is a significant relationship between attention deficit hyperactivity disorder and asthma.

Many Children With Asthma Do Not Have Medications Ready

Many Children With Asthma Do Not Have Medications Ready

Low-income urban preschoolers with asthma may not meet home medication readiness criteria.

Lung Function in Primary Ciliary Dyskinesia Affected at Early Age

Lung Function in Primary Ciliary Dyskinesia Affected at Early Age

Lung function in patients with primary ciliary dyskinesia was reduced compared with reference values from patients with cystic fibrosis in both sexes and in all age groups.

Small Airway Function in Children With Mild to Moderate Asthma

Small Airway Function in Children With Mild to Moderate Asthma

In children who were symptomatic, small conducting airways ventilation inhomogeneity and alveolar nitric oxide concentration were both significantly associated with asthma exacerbations.

Asthma and Allergic Rhinitis May Be Risk Factors for Migraine in Adolescents

Asthma and Allergic Rhinitis May Be Risk Factors for Migraine in Adolescents

Adolescents who have asthma or allergic rhinitis may be at higher risk for developing migraine.

Does Early Life Vitamin D Status Affect Asthma, Wheeze in Later Life?

Does Early Life Vitamin D Status Affect Asthma, Wheeze in Later Life?

Pooled estimates from cohort studies suggested there was no association between antenatal blood vitamin D levels or vitamin D intake and asthma in offspring.

Kalydeco Approved to Treat Cystic Fibrosis in Children 12 to <24 Months

Kalydeco Approved to Treat Cystic Fibrosis in Children 12 to <24 Months

The approval was supported by data from ARRIVAL (N=25), an ongoing Phase 3 open-label safety study in children with CF aged 12 to <24 months with 1 of 10 CFTR gene mutations (G551D, G178R, S549N, S549R, G551S, G1244E, S1251N, S1255P, G1349D or R117H).

Telemedicine Interventions Can Improve Asthma Control, Quality of Life

Telemedicine Interventions Can Improve Asthma Control, Quality of Life

Combined tele-case management and tele-consultation was the most effective form of telemedicine for improving asthma control.

Pseudomonas Associated With Frequent Hospitalizations Due to COPD Exacerbations

Pseudomonas Associated With Frequent Hospitalizations Due to COPD Exacerbations

Prior use of systemic corticosteroids and prior isolation of Pseudomonas aeruginosa were risk factors associated with the presence of Pseudomonas aeruginosa in COPD.

Labetalol Use Higher in Patients With Asthma and Preeclampsia

Labetalol Use Higher in Patients With Asthma and Preeclampsia

Use of labetalol vs other antihypertensives is linked to increased risk of status asthmaticus.

High Blood Eosinophil Count Linked to Asthma-Related Hospital Readmission

High Blood Eosinophil Count Linked to Asthma-Related Hospital Readmission

A high blood eosinophil count may increase the risk for a second asthma-related hospitalization within 1 year following an initial hospitalization.

Hailie Solution Now Available for Tracking Asthma, COPD Medication Use

Hailie Solution Now Available for Tracking Asthma, COPD Medication Use

Through Bluetooth technology, clinicians and patients will be able to share and monitor inhaler usage.

Biologic Therapy Selection for Severe Asthma: Factors to Consider

Biologic Therapy Selection for Severe Asthma: Factors to Consider

The authors write that once severe asthma is diagnosed, clinicians should determine asthma endotype (Type2-high or Type2-low) to help choose the best therapy for the patient.

Short-Term Corticosteroids Sufficient in Acute COPD Exacerbations

Short-Term Corticosteroids Sufficient in Acute COPD Exacerbations

Short-term corticosteroids may be sufficient for treating patients with acute COPD exacerbations.

Low Relative Lymphocyte Count Associated With Higher Mortality in COPD

Low Relative Lymphocyte Count Associated With Higher Mortality in COPD

Patients with COPD who had a relative lymphocyte count ≤20% had a higher risk for mortality.

Dupilumab reduces systemic glucocorticoid use in severe asthmatics

Patients with severe asthma who are glucocorticoid dependent and treated with dupilumab for 24 weeks used significantly lower doses of glucocorticoids while maintaining asthmatic control compared with patients treated with placebo.

Predictors for Survival Rates for Adult-Diagnosed Cystic Fibrosis

Predictors for Survival Rates for Adult-Diagnosed Cystic Fibrosis

In adult-diagnosed cystic fibrosis, diabetes, lung function, and age at diagnosis may predict patient survival.

Basophil Levels in Childhood Asthma May Indicate Risk for Future Exacerbations

Basophil Levels in Childhood Asthma May Indicate Risk for Future Exacerbations

Children with asthma and/or wheeze who have a basophil level above 0.18% of the circulating peripheral blood mononuclear cell population have a higher risk for future exacerbations.

Vaporized Cannabis Has Lack of Effect on Airway Function in COPD

Vaporized Cannabis Has Lack of Effect on Airway Function in COPD

When compared with a placebo control cannabis, cannabis had no effect on breathlessness intensity ratings during exercise at isotime or on exercise endurance time.

COPD and Asthma Overlap: Individual vs Environmental Risk Factors in Women

COPD and Asthma Overlap: Individual vs Environmental Risk Factors in Women

Socioeconomic and lifestyle risk factors had a more significant role in the development of COPD and asthma overlap syndrome in women than air pollution.

Comorbid Asthma Not Associated With Need for Surgery in Crohn Disease

Comorbid Asthma Not Associated With Need for Surgery in Crohn Disease

Asthma was not associated with a risk for intestinal resection surgery in patients with Crohn disease.

Electronic Asthma Action Plans Help Reduce Exacerbations

Electronic Asthma Action Plans Help Reduce Exacerbations

Electronic asthma action plans supported by text messaging services may improve control and reduce exacerbations.

Orkambi Approved to Treat Younger Cystic Fibrosis Patients

Orkambi Approved to Treat Younger Cystic Fibrosis Patients

The approval was based on data from a 24-week, open-label, Phase 3 study in patients aged 2 to 5 years.

Quality of Life in Aspirin-Exacerbated Respiratory Disease vs Asthma Only

Quality of Life in Aspirin-Exacerbated Respiratory Disease vs Asthma Only

Patients with aspirin-exacerbated respiratory disease had significantly lower levels of depression symptoms and higher quality of life compared with patients with asthma only.

Anaerobic Bacteria in Cystic Fibrosis Airways Associated With Milder Disease

Anaerobic Bacteria in Cystic Fibrosis Airways Associated With Milder Disease

A higher prevalence of anaerobic bacteria in cystic fibrosis was associated with higher lung function, less use of antibiotics, increased BMI, pancreatic sufficiency, and no requirement for insulin.

Shorter Telomeres May Predict Poor Outcomes in COPD

Shorter Telomeres May Predict Poor Outcomes in COPD

Shorter telomere length was associated with worse health status in chronic obstructive pulmonary disease, as measured by St. George's Respiratory Questionnaire.

Anxiety Prevalence in COPD Determined by Screening Questionnaires vs DSM-V

Anxiety Prevalence in COPD Determined by Screening Questionnaires vs DSM-V

Anxiety symptoms are more common in patients with COPD as determined by the Generalized Anxiety Disorder, Hospital Anxiety and Depression scale, and Anxiety Inventory for Respiratory Disease screening questionnaires vs the DSM-V criteria.

Asthma and Poorly Controlled Asthma May Increase Atrial Fibrillation Risk

Asthma and Poorly Controlled Asthma May Increase Atrial Fibrillation Risk

Individuals with clinician-diagnosed asthma were at an estimated 38% higher risk for atrial fibrillation.

Hailie Sensor Gets FDA Clearance for Additional Asthma Inhalers

Hailie Sensor Gets FDA Clearance for Additional Asthma Inhalers

The Hailie sensor attaches to the asthma or chronic obstructive pulmonary disease (COPD) inhaler to monitor and help patient adherence.

The Road to Precision Medicine in COPD Is Paved With Phenotypes

The Road to Precision Medicine in COPD Is Paved With Phenotypes

Although emerging data offer valuable clues, the pathophysiological distinctions between different phenotypes of chronic obstructive pulmonary disease are still poorly understood.

Asthma Hospitalization Risk in Children From Grass, Weed, and Other Pollens

Asthma Hospitalization Risk in Children From Grass, Weed, and Other Pollens

Grass, other weeds, and unclassified pollen were significantly associated with increased risk for asthma hospitalization in young children.

Increased Mortality Rates Observed in Patients With Rheumatoid Arthritis, COPD

Increased Mortality Rates Observed in Patients With Rheumatoid Arthritis, COPD

Mortality was significantly increased among patients with rheumatoid arthritis and COPD.

Illicit Drug Use in Asthma: Heroin, Cocaine, and Marijuana Worsen Symptoms

Illicit Drug Use in Asthma: Heroin, Cocaine, and Marijuana Worsen Symptoms

Inhaling and smoking heroin and cocaine increase the risk for asthma exacerbations and decreased pulmonary function; marijuana is associated with wheezing, cough, and sputum production.

Effect of Antibiotic Duration in Acute COPD Exacerbations

Effect of Antibiotic Duration in Acute COPD Exacerbations

Patients who were hospitalized for non-severe acute exacerbations of COPD did not experience improved outcomes when antibiotics were administered for longer than 24 hours.

High NT-proBNP in COPD May Predict Respiratory Exacerbations

High NT-proBNP in COPD May Predict Respiratory Exacerbations

NT-proBNP may be an independent predictor of respiratory exacerbations in patients with COPD even without overt cardiovascular disease.

Severe Asthma Risk Increased From Aspergillus fumigatus Sensitization

Severe Asthma Risk Increased From Aspergillus fumigatus Sensitization

Sensitization to Aspergillus fumigatus increased the risk for severe asthma.

COPD Severity May Be Affected by Collagen Biomarker Remodeling

COPD Severity May Be Affected by Collagen Biomarker Remodeling

Collagen biomarkers were significantly higher at extreme exacerbations, and were also associated with circulating adrenomedullin.

Pulmonary Embolism Prevalence in Acute COPD Exacerbations

Pulmonary Embolism Prevalence in Acute COPD Exacerbations

Rates of pulmonary embolism ranged from 3.3% to 29.1% in patients with a clinical diagnosis of an acute exacerbation of COPD.

Variations in Practice Patterns Seen in Patients Treated for COPD

Variations in Practice Patterns Seen in Patients Treated for COPD

There were differences in use of steroids and antibiotics noted between teaching and non-teaching hospital staff.

Whole-Genome Sequencing Proves Valuable in Severe COPD

Whole-Genome Sequencing Proves Valuable in Severe COPD

Whole-genome sequencing was valuable in identifying a large number of potentially significant functional variants in severe COPD.

Unraveling the Relationship Between COPD and Stroke

Unraveling the Relationship Between COPD and Stroke

Although COPD has been identified as a risk factor for cardiovascular disease, researchers are less certain about the relationship between COPD and stroke.

Fewer Asthma Exacerbations With LABA Plus Inhaled Glucocorticoid

Fewer Asthma Exacerbations With LABA Plus Inhaled Glucocorticoid

Combination therapy with a long-acting β2-agonist plus an inhaled glucocorticoid for asthma was not associated with a significantly higher risk for serious asthma-related events compared with an inhaled glucocorticoid alone.

Childhood Respiratory Risk Factor Profiles Predict Lung Function, COPD

Childhood Respiratory Risk Factor Profiles Predict Lung Function, COPD

Frequent asthma, bronchitis, allergy demonstrated the strongest association with , lower FEV1, lower FEV1/forced vital capacity, and increased risk for COPD.

Cytokine Profiles of Pregnant Women Predict Asthma in Children

Cytokine Profiles of Pregnant Women Predict Asthma in Children

Cytokines produced by mitogen-stimulated immune cells from pregnant women without asthma were shown to be associated with the development of asthma in their children.

Dexamethasone Ineffective for Prevention of Acute Mountain Sickness in COPD

Dexamethasone Ineffective for Prevention of Acute Mountain Sickness in COPD

Dexamethasone was not effective in reducing the incidence of acute mountain sickness and altitude-related adverse health effects in individuals with mild to moderate COPD.

CDC: Wildfire Smoke Poses Health Risks

CDC: Wildfire Smoke Poses Health Risks

The US Centers for Disease Control offers steps to minimize exposure to wildfire smoke, particularly for those with chronic conditions.

Tiotropim/Olodaterol Safe, Tolerable in COPD Regardless of Renal Impairment

Tiotropim/Olodaterol Safe, Tolerable in COPD Regardless of Renal Impairment

Regardless of renal impairment, combination therapy with tiotropium/olodaterol was safe and tolerable in patients with moderate to very severe COPD.

Free Vitamin D3 Inferior to Total Concentrations in Predicting Asthma Response

Free Vitamin D3 Inferior to Total Concentrations in Predicting Asthma Response

No associations were found between free concentration vitamin D3 levels and treatment failure or exacerbation rates in adults with asthma

Inhaled IL-13 Monoclonal Antibody Inhibits IL-13 in Animal Asthma Model

Inhaled IL-13 Monoclonal Antibody Inhibits IL-13 in Animal Asthma Model

The eFlow® nebulizer delivered CDP7766 without evidence of degradation, loss of potency, aggregation, or formation of particulates in a model of asthma in cynomolgus macaques.

Umeclidinium/Vilanterol Efficacy Assessed in Elderly COPD Patients

Umeclidinium/Vilanterol Efficacy Assessed in Elderly COPD Patients

Study authors performed a post hoc pooled analysis of data from 10 trials to assess the safety and efficacy of umeclidinium/vilanterol in elderly symptomatic patients with COPD.

Anti-IL-5 Therapy Eligibility Characteristics Examined in Adult-Onset Asthma

Anti-IL-5 Therapy Eligibility Characteristics Examined in Adult-Onset Asthma

Patients with severe asthma were more often current smokers at diagnosis and had higher body mass index at follow-up compared with patients with nonsevere asthma and anti-IL-5 therapy-eligible asthma.

GERD and Nasal Symptoms Affect Bronchitis Symptom Severity in COPD

GERD and Nasal Symptoms Affect Bronchitis Symptom Severity in COPD

Gastroesophageal reflux disease is associated with an increase in bronchitis symptoms in patients with COPD.

Prolonged Leisure-Time Sitting Tied to Increased COPD Mortality Risk

Prolonged Leisure-Time Sitting Tied to Increased COPD Mortality Risk

Increase in all-cause, cardiovascular disease, cancer, diabetes, kidney disease, suicide, and COPD mortality.

FDA Approves Zephyr Endobronchial Valve for Treating Severe Emphysema

FDA Approves Zephyr Endobronchial Valve for Treating Severe Emphysema

The approval was based on results from a multicenter study (LIBERATE) of 190 patients with severe emphysema.

Use of Palliative Care, Oxygen Therapy Increasing for COPD

Use of Palliative Care, Oxygen Therapy Increasing for COPD

For patients with advanced COPD, the use of formal palliative care services and long-term oxygen therapy has increased but remains low.

Patient Engagement in Asthma Treatment Plans May Improve Quality of Life

Patient Engagement in Asthma Treatment Plans May Improve Quality of Life

Older adults with asthma and a greater desire for involvement in decision making have higher asthma-related quality of life.

Azithromycin Reduced Pulmonary Exacerbation Risk in Cystic Fibrosis

Azithromycin Reduced Pulmonary Exacerbation Risk in Cystic Fibrosis

Compared with placebo, the risk for a pulmonary exacerbation was reduced by 44% in participants with cystic fibrosis who received azithromycin.

Aspergillus Common in Bronchiectasis Pulmonary Mycobiome, Associated With Exacerbations

Aspergillus Common in Bronchiectasis Pulmonary Mycobiome, Associated With Exacerbations

Bronchiectasis-associated genera included Aspergillus, Cryptococcus, Clavispora, Botrytis, and Alternaria.

Obstructive Sleep Apnea in Asthma: Gaining Control by Losing Weight

Obstructive Sleep Apnea in Asthma: Gaining Control by Losing Weight

Poor control of asthma and obstructive sleep apnea can feed off one another, according to Michelle Zeidler, MD, pulmonologist at the University of California, Los Angeles, and director of the UCLA Sleep Fellowship Program.

Clinical Effect of Emphysema in Individuals With HIV

Clinical Effect of Emphysema in Individuals With HIV

The clinical significance of emphysema was greater in people living with HIV vs those without HIV.

COPD End-of-Life Management Strategies: Use Could Be Expanded

COPD End-of-Life Management Strategies: Use Could Be Expanded

The use of formal palliative care services among patients with chronic obstructive pulmonary disease increased by 1% per year, going from 5.3% in 2004 to 14.3% in 2014.

Asthma Risk Increased With Early-Onset Persistent Bronchial Hyperresponsiveness

Asthma Risk Increased With Early-Onset Persistent Bronchial Hyperresponsiveness

Children with the early-onset persistent bronchial hyperresponsiveness phenotype had the highest blood eosinophil count and total serum IgE levels as well as sensitization rates.

Subcutaneous Immunotherapy Shows Promise for Allergic Asthma Exacerbations

Subcutaneous Immunotherapy Shows Promise for Allergic Asthma Exacerbations

The mean rate of exacerbations declined significantly after 1 year of subcutaneous immunotherapy in children with moderate to severe allergic asthma exacerbations.

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