Respiratory Symptoms in Young Adults: Prognostic Value for Later Lung Function?

Respiratory Symptoms in Young Adults: Prognostic Value for Later Lung Function?

Respiratory symptoms that develop between the ages of 18 and 30 may hold prognostic value for later decline in lung function.

Guiding COPD Management Using Airway Branch Variation

Guiding COPD Management Using Airway Branch Variation

Researchers examined variation in airway branches to determine whether they have an effect on the course of chronic obstructive pulmonary disease.

COPD Exercise Capacity With Long-Acting Bronchodilators

COPD Exercise Capacity With Long-Acting Bronchodilators

Patients with COPD experienced a weighted mean increase in exercise endurance time following treatment with long-acting bronchodilators.

Oral Prednisolone for the Management of Pediatric Wheezing

Oral Prednisolone for the Management of Pediatric Wheezing

Children who received oral prednisolone vs placebo for virus-associated wheeze had a shorter length of hospital stay.

ABPA Complicating Asthma: Treatment Responses to Prednisolone vs Itraconazole

ABPA Complicating Asthma: Treatment Responses to Prednisolone vs Itraconazole

Prednisolone may be a more effective treatment in individuals with acute allergic bronchopulmonary aspergillosis complicated asthma, but with more adverse effects compared with itraconazole.

Asthma Exacerbations in Young Children Alleviated With Tiotropium

Asthma Exacerbations in Young Children Alleviated With Tiotropium

Researchers found that tiotropium was safe and may reduce the risk for exacerbations in young children with asthma.

COPD Study Supports Concomitant Beta-Blocker Use in Moderate to Severe Disease

COPD Study Supports Concomitant Beta-Blocker Use in Moderate to Severe Disease

Lung function may not differ between individuals who take beta-blockers vs those who do not for moderate to severe chronic obstructive pulmonary disease.

Predicting COPD Exacerbations, Treatment Responses via Eosinophil Counts

Predicting COPD Exacerbations, Treatment Responses via Eosinophil Counts

COPD exacerbation risk and treatment response may be predicted using blood eosinophil counts.

Case: A 55-Year-Old Man With Asthma Presents to the ED With Dyspnea at Rest

Case: A 55-Year-Old Man With Asthma Presents to the ED With Dyspnea at Rest

A 55-year-old man with asthma presents to the emergency department with dyspnea at rest and electrocardiogram findings suggest a prior myocardial infarction.

Procalcitonin-Guided Pneumonia Treatment Associated With Improved Outcomes

Procalcitonin-Guided Pneumonia Treatment Associated With Improved Outcomes

Procalcitonin may decrease mortality rates in patients with acute respiratory infections, including pneumonia.

COPD Mortality Predictions by GOLD 2017 vs Previous Versions

COPD Mortality Predictions by GOLD 2017 vs Previous Versions

Although the 2017 GOLD classification did not better predict mortality in patients with chronic obstructive pulmonary disease overall, it did so when patients were extensively categorized by severity.

COPD Continues to Present Screening Challenges, Research Barriers

COPD Continues to Present Screening Challenges, Research Barriers

No data have demonstrated improved mortality, morbidity, or quality of life as a result of screening for COPD in asymptomatic individuals.

Asthma, Atopic Dermatitis Risk May Be Affected by Timing of Birth

Asthma, Atopic Dermatitis Risk May Be Affected by Timing of Birth

Timing of birth may increase risk for asthma or atopic dermatitis.

Evidence for Immunotherapy in Pediatric Asthma Lacking

Evidence for Immunotherapy in Pediatric Asthma Lacking

Children with allergic asthma do not significantly benefit from subcutaneous or sublingual immunotherapy.

School-based telemedicine enhances asthma management in children

A school-based telemedicine program with directly observed preventive therapy, when compared to enhanced usual care, led to more symptom-free days and fewer emergency department visits or hospitalizations.

Postoperative Pulmonary Complications With Asthma or COPD

Postoperative Pulmonary Complications With Asthma or COPD

Researchers found various risk factors for postoperative pulmonary complications in patients with either asthma or COPD.

Independent Risk Factors Associated With Fixed Airflow Obstruction in Older Adults With Asthma

Independent Risk Factors Associated With Fixed Airflow Obstruction in Older Adults With Asthma

Male sex, African American race, and duration of asthma were independently associated with fixed airflow obstruction in older adults with asthma.

Volatile Organic Compound Analysis in Pediatric Asthma: A New Clinical Tool

Volatile Organic Compound Analysis in Pediatric Asthma: A New Clinical Tool

Analyzing volatile organic compounds in pediatric patients with asthma shows promise for disease diagnosis and management.

Stable Hypercapnic COPD May Benefit From At-Home High-Flow Nasal Cannula Oxygen Therapy

Stable Hypercapnic COPD May Benefit From At-Home High-Flow Nasal Cannula Oxygen Therapy

Patients with stable hypercapnic COPD reported improved health-related quality of life after 6 weeks of at-home high-flow nasal cannula oxygen therapy.

Childhood Asthma Risk May Increase With Prenatal Use of Proton Pump Inhibitors

Childhood Asthma Risk May Increase With Prenatal Use of Proton Pump Inhibitors

Researchers found that acid-suppressive drug use in pregnancy was associated with an increased risk for asthma in childhood.

COPD and Asthma Risk in Women With Rheumatoid Arthritis

COPD and Asthma Risk in Women With Rheumatoid Arthritis

Women with rheumatoid arthritis had an increased risk for chronic obstructive pulmonary disease, but did not have an increased risk for asthma compared with women without RA.

Managing Asthma in Children Via School-Based Telemedicine

Managing Asthma in Children Via School-Based Telemedicine

Children in the School-Based Telemedicine Enhanced Asthma Management program had more symptom-free days than children in the usual care group.

Asthma Risk in Offspring of Women With Systemic Lupus Erythematosus

Asthma Risk in Offspring of Women With Systemic Lupus Erythematosus

Systemic lupus erythematosus during pregnancy is associated with an increased risk for asthma in offspring.

Asthma Risk Associated With Prenatal Exposure to Polychlorinated Biphenyls

Asthma Risk Associated With Prenatal Exposure to Polychlorinated Biphenyls

Women who were exposed prenatally to polychlorinated biphenyls may have an increased risk of having children with asthma, hay fever, or eczema.

Asthma Diagnosis Using Fractional Exhaled Nitric Oxide

Asthma Diagnosis Using Fractional Exhaled Nitric Oxide

Fractional exhaled nitric oxide measurement can diagnose asthma in patients 5 years and older.

Efficacy and Safety of Benralizumab in Adults With Eosinophilic Asthma

Efficacy and Safety of Benralizumab in Adults With Eosinophilic Asthma

Asthma exacerbations may be reduced in patients with eosinophilic asthma treated with benralizumab.

Effect of Beta-Blockers on Hospitalization in COPD and Concurrent Heart Failure

Effect of Beta-Blockers on Hospitalization in COPD and Concurrent Heart Failure

Carvedilol may increase the risk for hospitalization in patients with concurrent heart failure and COPD compared with metoprolol/bisoprolol/nebivolol.

A Middle-Aged Man With Worsening COPD

A Middle-Aged Man With Worsening COPD

A middle-aged man diagnosed with COPD presents with shortness of breath at rest with no improvement with nebulizer treatments.

Progression of Emphysema With Regular Aspirin Use

Progression of Emphysema With Regular Aspirin Use

Regular use of aspirin may slow the progression of emphysema.

Effect of Obesity on Asthma in Children

Effect of Obesity on Asthma in Children

Obesity is associated with more asthma symptom days in children not treated with a daily controller and inhaled corticosteroids.

FDA Approves Removal of Box Warning From Advair, Breo Asthma Therapies

FDA Approves Removal of Box Warning From Advair, Breo Asthma Therapies

Updates were also made to the Warnings and Precautions section of labeling for ICS/LABA-class medications.

Precision Medicine May Pave the Way for Better Treatment in Asthma, COPD

Precision Medicine May Pave the Way for Better Treatment in Asthma, COPD

At a research seminar held by the European Respiratory Society in February 2017, a group of investigators discussed how precision medicine may improve treatment in asthma and COPD.

Maintaining Asthma Control With Reduced Daily Inhaled Corticosteroid Dose

Maintaining Asthma Control With Reduced Daily Inhaled Corticosteroid Dose

Daily inhaled corticosteroid dose can be safely reduced in some adult patients with asthma.

Physiotherapy Breathing Retraining Improves Quality of Life in Uncontrolled Asthma

Physiotherapy Breathing Retraining Improves Quality of Life in Uncontrolled Asthma

Nonpharmacological approaches to asthma management may improve patient quality of life.

Asthma May Increase Risk for Type 1 Diabetes in Children

Asthma May Increase Risk for Type 1 Diabetes in Children

While a previous diagnosis of asthma may increase the risk for type 1 diabetes in children, the converse does not appear to be true.

Short-Duration Dexamethasone Effective for Pediatric Asthma Exacerbations

Short-Duration Dexamethasone Effective for Pediatric Asthma Exacerbations

Children with asthma exacerbations may be treated with 2 doses of dexamethasone instead of with prednisolone/prednisone.

Nasal High-Flow Oxygen Corrects Hypoxemia, Reduces Hypercapnia in COPD

Nasal High-Flow Oxygen Corrects Hypoxemia, Reduces Hypercapnia in COPD

Nasal high-flow oxygen therapy may be a safe and effective therapy for patients with normocapnic and hypercapnic COPD.

FDA Approves First Treatment for Eosinophilic Granulomatosis With Polyangiitis

FDA Approves First Treatment for Eosinophilic Granulomatosis With Polyangiitis

Prior to this expanded indication, patients with this challenging, rare disease did not have an FDA-approved treatment option.

Chronic Lung Disease Research in the Pipeline: An Interview With Augustine M.K. Choi, MD

Chronic Lung Disease Research in the Pipeline: An Interview With Augustine M.K. Choi, MD

Pulmonology Advisor sits down with Augustine M.K. Choi, MD, Stephen and Suzanne Weiss Dean of Weill Cornell Medicine to discuss the latest topics in pulmonary medicine.

Examining the Efficacy of Carbon Monoxide Therapy in Idiopathic Pulmonary Fibrosis: An Interview With Augustine M.K. Choi, MD

Examining the Efficacy of Carbon Monoxide Therapy in Idiopathic Pulmonary Fibrosis: An Interview With Augustine M.K. Choi, MD

Pulmonology Advisor sits down with Augustine M.K. Choi, MD, Stephen and Suzanne Weiss Dean of Weill Cornell Medicine to discuss the latest topics in pulmonary medicine.

Role of E-Cigarettes in Asthma Development and Exacerbation

Role of E-Cigarettes in Asthma Development and Exacerbation

Smokers with asthma have been encouraged to switch from conventional to electronic cigarettes, but the latter may still cause respiratory damage.

Food Allergies May Increase Risk for Asthma in Children

Food Allergies May Increase Risk for Asthma in Children

Investigators sought to determine the association between food allergies and the development of asthma.

Identifying New Therapeutics for Pulmonary Diseases: An Interview With Augustine M.K. Choi, MD

Identifying New Therapeutics for Pulmonary Diseases: An Interview With Augustine M.K. Choi, MD

Pulmonology Advisor sits down with Augustine M.K. Choi, MD of Stephen and Suzanne Weiss Dean of Weill Cornell Medicine to discuss the latest topics in pulmonary medicine.

The Potential Pitfalls of Machine Learning Algorithms in Medicine

The Potential Pitfalls of Machine Learning Algorithms in Medicine

The ability of machine learning programs to diagnose medical conditions and predict outcomes is discussed in an opinion article.

Overview of Autophagy Research in COPD: An Interview With Augustine M.K. Choi, MD

Overview of Autophagy Research in COPD: An Interview With Augustine M.K. Choi, MD

Pulmonology Advisor sits down with Augustine M.K. Choi, MD, Stephen and Suzanne Weiss Dean of Weill Cornell Medicine to discuss the latest topics in pulmonary medicine.

FDA Approves First Nebulized Long-Acting Muscarinic Antagonist for COPD

FDA Approves First Nebulized Long-Acting Muscarinic Antagonist for COPD

Adults treated with Lonhala Magnair showed statistically significant and clinically important changes in FEV1 at week 12 vs placebo.

Walking in Polluted Area Blunts Cardiorespiratory Benefits

Walking in Polluted Area Blunts Cardiorespiratory Benefits

Concentrations of black carbon, nitrogen dioxide, and particulate matter were higher in traffic-polluted areas, and linked to more instances of cough, sputum, and shortness of breath.

COPD Adverse Outcomes May Increase With Loop Diuretic Use

COPD Adverse Outcomes May Increase With Loop Diuretic Use

Older patients with COPD who use loop diuretics may be at an increased risk for respiratory-related morbidity and mortality.

Pneumonia Found Infrequently on Chest X-Ray in Children With Acute Asthma Exacerbations

Pneumonia Found Infrequently on Chest X-Ray in Children With Acute Asthma Exacerbations

Chest radiography, a procedure often performed in the emergency department, infrequently changes medical management of children with acute asthma exacerbations.

Asthma Control in Nonobese Patients Improves With Exercise and Diet

Asthma Control in Nonobese Patients Improves With Exercise and Diet

Exercise and diet improves asthma control in nonobese patients with asthma.

Asthma Risk Increased With Atopic Dermatitis Plus Allergic Sensitization

Asthma Risk Increased With Atopic Dermatitis Plus Allergic Sensitization

Atopic dermatitis without concomitant allergic sensitization in children is not associated an increased risk for asthma.

Intranasal Omalizumab Use and Systemic Total Immunoglobulin E Levels

Intranasal Omalizumab Use and Systemic Total Immunoglobulin E Levels

Intranasal administration of omalizumab does not result in relevant change of allergen-specific and total IgE levels in patients with birch pollen allergy.

Unnecessary Antibiotic Prescribing Continues in Young Adults With Acute Bronchitis

Unnecessary Antibiotic Prescribing Continues in Young Adults With Acute Bronchitis

Overprescription for uncomplicated acute bronchitis is common despite guidelines recommending against it.

Omalizumab May Be Stepped-Down or Withdrawn in Severe Allergic Asthma

Omalizumab May Be Stepped-Down or Withdrawn in Severe Allergic Asthma

Omalizumab may be safely withdrawn or stepped down in patients with severe allergic asthma.

Inhaled Corticosteroid Use and Fracture Risk in Pediatric Asthma

Inhaled Corticosteroid Use and Fracture Risk in Pediatric Asthma

A population-based study aimed to determine whether inhaled corticosteroid use increased risk of fracture in children with asthma.

Breastfeeding May Decrease Flexural Dermatitis Risk, But Not Asthma

Breastfeeding May Decrease Flexural Dermatitis Risk, But Not Asthma

Exclusive breastfeeding may have a protective effect against flexural dermatitis development in infants, but appears to have no long-term effect on measures of asthma.

CFTR Modulator Therapy With Tezacaftor-Ivacaftor in Cystic Fibrosis

CFTR Modulator Therapy With Tezacaftor-Ivacaftor in Cystic Fibrosis

Effective cystic fibrosis transmembrane conductance regulator modulator therapy may be of benefit in subsets of patients with cystic fibrosis.

Noninvasive Ventilation for Acute Hypercapnic Respiratory Failure Related to COPD

Noninvasive Ventilation for Acute Hypercapnic Respiratory Failure Related to COPD

Noninvasive ventilation may reduce mortality in patients with acute hypercapnic respiratory failure related to COPD.

Asthma Clinical Trials Need to Include Patient-Reported Outcomes

Asthma Clinical Trials Need to Include Patient-Reported Outcomes

More asthma clinical trials will include patient-reported outcomes as they will help guide clinicians' understanding of their patients' disease.

Benralizumab Approved by FDA for Severe Eosinophilic Asthma

Benralizumab Approved by FDA for Severe Eosinophilic Asthma

A significant improvement in lung function and annual asthma exacerbation rate was noted vs placebo.

COPD Hospitalization Outcomes Affected by Obesity

COPD Hospitalization Outcomes Affected by Obesity

Patients with obesity who are hospitalized for an acute exacerbation of COPD may have longer hospital stays and more often require mechanical ventilation.

Effect of Tobacco Smoke Exposure in Children With Asthma

Effect of Tobacco Smoke Exposure in Children With Asthma

Prenatal tobacco smoke exposure appears to be associated with airflow obstruction in children who have asthma.

Severe Steroid-Dependent Asthma Benefits From Dupilumab

Severe Steroid-Dependent Asthma Benefits From Dupilumab

Patients treated with dupilumab experienced fewer asthma exacerbations than the overall population.

Asthma Control With Mobile Health Initiatives

Asthma Control With Mobile Health Initiatives

Mobile devices may help patients with asthma better manage and control their disease.

Asthma Exacerbations Treated With Injectable Dexamethasone Administered Orally

Asthma Exacerbations Treated With Injectable Dexamethasone Administered Orally

Pediatric patients benefited from orally administered injectable dexamethasone for asthma exacerbations.

Internet-Based Survey Identifies Patients With Labile Asthma Control

Internet-Based Survey Identifies Patients With Labile Asthma Control

A survey that was part of the Severe Asthma Research Program found a specific subgroup of patients with asthma who have highly variable asthma control.

Montelukast Reduces Need for Rescue Medication in Young Children

Montelukast Reduces Need for Rescue Medication in Young Children

Montelukast therapy reduced the need for rescue medication in young children with recurring wheezing illness.

Atopy May Increase Risk for Asthma Relapse

Atopy May Increase Risk for Asthma Relapse

Investigators evaluated respiratory viruses, atypical bacteria, and atopy on the severity of asthma and the effect on recovery.

Effect of Human Rhinovirus Species on Pediatric Asthma Exacerbation Severity

Effect of Human Rhinovirus Species on Pediatric Asthma Exacerbation Severity

The modifying effect of human rhinovirus on asthma exacerbation severity was examined in a pediatric population.

Use of Antibiotic Prophylaxis in Young Children With Cystic Fibrosis

Use of Antibiotic Prophylaxis in Young Children With Cystic Fibrosis

In children with cystic fibrosis, risk for first detection of S aureus and P aeruginosa was greater in those who had received antibiotic prophylaxis.

Biomarkers Useful for Differentiating Between Asthma and COPD

Biomarkers Useful for Differentiating Between Asthma and COPD

Patients with asthma were found to have higher blood eosinophil counts, fractional exhaled nitric oxide levels, and total serum IgE concentrations compared with patients with COPD.

Long-Term Inhaled Corticosteroid Use Associated With Increased Sputum Bacterial Load in COPD

Long-Term Inhaled Corticosteroid Use Associated With Increased Sputum Bacterial Load in COPD

Salmeterol plus fluticasone was associated with a significant increase in sputum bacterial load in chronic obstructive pulmonary disease, compared to salmeterol alone.

COPD Hospitalization Risk With Rheumatoid Arthritis

COPD Hospitalization Risk With Rheumatoid Arthritis

Rheumatoid arthritis increased the risk of COPD-related hospitalization by 47%.

Asthma Management During Pregnancy: How to Benefit Both Mothers and Infants

Asthma Management During Pregnancy: How to Benefit Both Mothers and Infants

Although some pregnant women discontinue their asthma medications for fear of fetal drug toxicity, they may be putting their babies at greater risk.

Once- vs Twice-Daily Treatment for Controlled Asthma: Examining Outcomes

Once- vs Twice-Daily Treatment for Controlled Asthma: Examining Outcomes

Researchers assessed the efficacy of a once-daily treatment option for controlled asthma.

Beta Blockers Linked to Longer Life Expectancy in COPD

Beta Blockers Linked to Longer Life Expectancy in COPD

In a retrospective analysis, researchers examined the efficacy of beta blocker therapy in prolonging patients' lives.

COPD Hospital Readmission, Mortality Risk Predicted by 3-Variable Score

COPD Hospital Readmission, Mortality Risk Predicted by 3-Variable Score

A 3-variable score that encompasses dyspnea score, prednisone use, and prior hospitalization for COPD exacerbations can predict mortality and readmission risk.

Nebulized Glycopyrrolate Improves Lung Function in Severe COPD With CV Risk Factors

Nebulized Glycopyrrolate Improves Lung Function in Severe COPD With CV Risk Factors

A recent study examined whether nebulized glycopyrrolate is safe to use in patients with severe COPD and comorbid cardiovascular risk factors.

COPD: Concurrent Nebulized Glycopyrrolate, Long-Acting Bronchodilators Safe

COPD: Concurrent Nebulized Glycopyrrolate, Long-Acting Bronchodilators Safe

The safety of concurrently administering nebulized glycopyrrolate with long-acting beta agonists was examined in 3 studies.

Asthma Exacerbations May Be Alleviated With Vitamin D Supplementation

Asthma Exacerbations May Be Alleviated With Vitamin D Supplementation

Asthma exacerbations may be reduced with vitamin D supplementation.

Restrictive Spirometry Pattern Associated With Increased Arterial Stiffness

Restrictive Spirometry Pattern Associated With Increased Arterial Stiffness

Both reduced forced vital capacity and a restrictive spirometry pattern was associated with arterial stiffness in both men and women.

Chronic Respiratory Disease Mortality Rates Increase From 1980 to 2014

Chronic Respiratory Disease Mortality Rates Increase From 1980 to 2014

Mortality rates and changes in mortality rates for chronic respiratory diseases in the United States varied by county, sex, and particular disease type.

Inhaled Corticosteroids Do Not Increase Risk for Pneumonia in COPD

Inhaled Corticosteroids Do Not Increase Risk for Pneumonia in COPD

In contrast to previous study findings, inhaled corticosteroids do not appear to increase risk for pneumonia in patients with COPD with moderate airflow limitation.

Cystic Fibrosis: More Access to Advanced Care Planning, Palliative Care Needed

Cystic Fibrosis: More Access to Advanced Care Planning, Palliative Care Needed

Palliative care access may be limited for patients with cystic fibrosis.

Extrafine-Particle vs Fine-Particle ICS Therapy: Improvements in Asthma Control

Extrafine-Particle vs Fine-Particle ICS Therapy: Improvements in Asthma Control

Compared with fine particle inhaled corticosteroids, extrafine particle inhaled corticosteroids helped patients achieve asthma control.

Montelukast Associated With Depression, Nightmares in Children

Montelukast Associated With Depression, Nightmares in Children

Montelukast is associated with depression, aggression, and nightmares in children.

Response to Omalizumab May Depend on Asthma Severity, Eosinophil Counts

Response to Omalizumab May Depend on Asthma Severity, Eosinophil Counts

Patients with clinical markers of greater asthma severity may experience a more significant reduction of exacerbations when treated with omalizumab.

Updated Guidelines for Noninvasive Ventilation in Acute Respiratory Failure

Updated Guidelines for Noninvasive Ventilation in Acute Respiratory Failure

The European Respiratory Society and American Thoracic Society have released updated guidelines on the use of noninvasive ventilation for acute respiratory failure.

Elderly Patients With Asthma May Have a Distinct Phenotype

Elderly Patients With Asthma May Have a Distinct Phenotype

Asthma in elderly patients presents with increased airway obstruction and mixed inflammation, possibly representing a distinct phenotype.

Targeting Blood Eosinophil Counts in COPD Treatment

Targeting Blood Eosinophil Counts in COPD Treatment

Patients with COPD who have elevated blood eosinophilic levels may benefit from treatment with mepolizumab.

Consequences of Discontinuing Inhaled Corticosteroids in Children With Asthma

Consequences of Discontinuing Inhaled Corticosteroids in Children With Asthma

Children who discontinue inhaled corticosteroids for well-controlled asthma may experience worsening symptoms.

Asthma-Related Quality of Life, Sickness Behavior Linked to Self-Rated Health

Asthma-Related Quality of Life, Sickness Behavior Linked to Self-Rated Health

A greater degree of sickness behavior and poorer asthma-related quality of life were both associated with poorer self-rated health in patients with allergic asthma.

Long-term Benefits of Fluticasone Furoate Plus Vilanterol in Asthma Control

Long-term Benefits of Fluticasone Furoate Plus Vilanterol in Asthma Control

Fluticasone furoate plus vilanterol therapy offers long-term asthma control without serious adverse events.

Preventing Childhood Adverse Respiratory Outcomes With Folic Acid in Pregnancy

Preventing Childhood Adverse Respiratory Outcomes With Folic Acid in Pregnancy

Early initiation of folic acid or prenatal vitamin supplementation may protect the offspring of mothers who have a history of atopy from adverse childhood respiratory outcomes.

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