NT-proBNP may be an independent predictor of respiratory exacerbations in patients with COPD even without overt cardiovascular disease.
Sensitization to Aspergillus fumigatus increased the risk for severe asthma.
Collagen biomarkers were significantly higher at extreme exacerbations, and were also associated with circulating adrenomedullin.
Rates of pulmonary embolism ranged from 3.3% to 29.1% in patients with a clinical diagnosis of an acute exacerbation of COPD.
There were differences in use of steroids and antibiotics noted between teaching and non-teaching hospital staff.
Whole-genome sequencing was valuable in identifying a large number of potentially significant functional variants in severe COPD.
Although COPD has been identified as a risk factor for cardiovascular disease, researchers are less certain about the relationship between COPD and stroke.
Combination therapy with a long-acting β2-agonist plus an inhaled glucocorticoid for asthma was not associated with a significantly higher risk for serious asthma-related events compared with an inhaled glucocorticoid alone.
Frequent asthma, bronchitis, allergy demonstrated the strongest association with , lower FEV1, lower FEV1/forced vital capacity, and increased risk for COPD.
Cytokines produced by mitogen-stimulated immune cells from pregnant women without asthma were shown to be associated with the development of asthma in their children.
Dexamethasone was not effective in reducing the incidence of acute mountain sickness and altitude-related adverse health effects in individuals with mild to moderate COPD.
The US Centers for Disease Control offers steps to minimize exposure to wildfire smoke, particularly for those with chronic conditions.
Regardless of renal impairment, combination therapy with tiotropium/olodaterol was safe and tolerable in patients with moderate to very severe COPD.
No associations were found between free concentration vitamin D3 levels and treatment failure or exacerbation rates in adults with asthma
The eFlow® nebulizer delivered CDP7766 without evidence of degradation, loss of potency, aggregation, or formation of particulates in a model of asthma in cynomolgus macaques.
Study authors performed a post hoc pooled analysis of data from 10 trials to assess the safety and efficacy of umeclidinium/vilanterol in elderly symptomatic patients with COPD.
Patients with severe asthma were more often current smokers at diagnosis and had higher body mass index at follow-up compared with patients with nonsevere asthma and anti-IL-5 therapy-eligible asthma.
Gastroesophageal reflux disease is associated with an increase in bronchitis symptoms in patients with COPD.
Increase in all-cause, cardiovascular disease, cancer, diabetes, kidney disease, suicide, and COPD mortality.
The approval was based on results from a multicenter study (LIBERATE) of 190 patients with severe emphysema.
For patients with advanced COPD, the use of formal palliative care services and long-term oxygen therapy has increased but remains low.
Older adults with asthma and a greater desire for involvement in decision making have higher asthma-related quality of life.
Compared with placebo, the risk for a pulmonary exacerbation was reduced by 44% in participants with cystic fibrosis who received azithromycin.
Bronchiectasis-associated genera included Aspergillus, Cryptococcus, Clavispora, Botrytis, and Alternaria.
Poor control of asthma and obstructive sleep apnea can feed off one another, according to Michelle Zeidler, MD, pulmonologist at the University of California, Los Angeles, and director of the UCLA Sleep Fellowship Program.
The clinical significance of emphysema was greater in people living with HIV vs those without HIV.
The use of formal palliative care services among patients with chronic obstructive pulmonary disease increased by 1% per year, going from 5.3% in 2004 to 14.3% in 2014.
Children with the early-onset persistent bronchial hyperresponsiveness phenotype had the highest blood eosinophil count and total serum IgE levels as well as sensitization rates.
The mean rate of exacerbations declined significantly after 1 year of subcutaneous immunotherapy in children with moderate to severe allergic asthma exacerbations.
A 72-year-old man with a 50 pack-year smoking history and multiple comorbidities, including COPD, presents to the emergency department with left-sided hemiparesis and sensory loss.
A hospital emergency department visit in the prior year was associated with subsequent asthma treatment failure.
Respiratory pathogens were associated with an increased risk for treatment failure in children with asthma exacerbations.
Tralokinumab did not have a significant effect on eosinophilic airway inflammation in moderate to severe asthma that was inadequately controlled on inhaled corticosteroids.
There was as significant change in Bristol COPD Knowledge Questionnaire scores in patients who received a brief education program at the time of an acute exacerbation of COPD.
Acute COPD exacerbations were associated with an increased risk for myocardial infarction and ischemic stroke.
Identified viral pathogens were not associated with asthma exacerbation severity, but were linked to increased treatment failure.
A nasal immune-response pattern characterized by lower non-interferon antiviral immune response mediators and higher type 2 and type 17 cytokines was significantly associated with recurrent wheeze at 1 year.
In patients with mild asthma, use of the inhaled combined corticosteroid and beta agonist budesonide-formoterol as needed was superior to terbutaline as needed with respect to electronically recorded weeks of well-controlled asthma.
Zephyr® Endobronchial Valve EBV® treatment improved FEV1 in patients with heterogeneous emphysema.
The inclusion of residual volume-to-total lung capacity ratio may add another dimension to COPD not routinely captured by standard airflow indices that could be predictive of lower maximum exercise capacity.
A direct de-escalation from triple therapy to indacaterol/glycopyrronium may be appropriate in patients with infrequent COPD exacerbations.
Ivacaftor decreased the risk for death, transplantation, hospitalization, and pulmonary exacerbation in patients with cystic fibrosis.
Women with a diagnosis of asthma may have a higher risk for preterm birth, and their infants may have an increased risk for perinatal mortality, low birth weight, fetal growth restriction, and asphyxia.
In patients with aspirin exacerbated respiratory disease, treatment with omalizumab resulted in "clinically silent" aspirin desensitization.
Budesonide-formoterol as needed was not inferior compared with budesonide maintenance therapy in terms of severe asthma exacerbation rates, but may be inferior for controlling symptoms.
E-cigarettes are the most commonly used product in middle and high school students with or without asthma.
There was a 60% lower rate of severe asthma exacerbations in individuals treated with budesonide-formoterol compared with individuals treated with terbutaline as needed.
Although clinical presentation was similar in both community-acquired pneumonia and non-pneumonia exacerbations, CRP, glucose, and leukocytes were higher in the former vs the latter.
A definition of a pulmonary vascular phenotype of chronic obstructive pulmonary disease has been proposed.
Recent research suggests that increasing obesity class is independently associated with worse respiratory-specific and general quality of life outcomes in COPD.
Chemicals linked with endocrine disruption and asthma identified in hair products used by black women and children.
Tiotropium may be more effective in reducing the rate of moderate and severe chronic obstructive pulmonary disorder exacerbations when used in combination with olodaterol vs tiotropium alone.
Patients with COPD had a nearly 2-fold increased risk for developing atrial fibrillation compared with patients without COPD.
Researchers evaluated barrier dysfunction by exposing viral models to budesonide, montelukast, formoterol, or a combination.
Inhaled interferon-beta 1 a did not significantly reduce acute asthma exacerbations during respiratory viral infections.
Using e-cigarettes every day or some days increased the likelihood of developing chronic obstructive pulmonary disease.
Longer stay and higher costs were associated with antibiotic administration in adults hospitalized for an asthma exacerbation without documented evidence of a lung infection.
In this study, researchers examined the appropriateness of diagnosis and treatment of chronic obstructive pulmonary disease in individuals with and without HIV.
Inhaled corticosteroids for asthma dosed once daily in the evening appeared to offer some benefit in trough FEV1 and morning peak expiratory flow.
Steroid dosing and glucose levels were not associated with an increase in hospital readmissions related to COPD exacerbations.
Investigators conducted a prospective survey to examine the association between asthma symptom severity and symptoms of depression and anxiety.
Overweight or obese children are more likely to develop new onset asthma compared with normal weight controls.
Researchers examined the association of timing, frequency, and class of antibiotic use during pregnancy on the development of childhood asthma.
No association was found between the degree of lung function impairment and the development of mild cognitive impairment in chronic obstructive pulmonary disease.
The pooled safety analysis included data from the TRILOGY, TRINITY, and TRIBUTE studies.
Sertraline does not prove to be beneficial for relief of chronic breathlessness.
Incident diuretic use was associated with increased rates of respiratory-related morbidity and mortality in older adults with chronic obstructive pulmonary disease.
Subcutaneous dupilumab significantly reduced the use of oral corticosteroids in patients with corticosteroid-dependent severe asthma.
Peak expiratory flow increases were greater with benralizumab than placebo in patients with severe eosinophilic asthma.
Oral contraceptive use in women of reproductive age may increase the risk for lifetime asthma.
In individuals with asthma and vitamin D deficiency, vitamin D supplementation improved asthma control.
Combination therapy with LABA and LAMA yielded a lower annualized rate of COPD exacerbations compared with triple therapy.
While macrolides had no direct effect on lung function, their use significantly improved asthma control and quality of life in patients with asthma.
The study authors examined data obtained from the 2007-2008 National Survey of Children's Health (NSCH) to determine the prevalence, risk factors, as well as the severity of asthma phenotypes.
The study authors reported, "The most commonly reported problems by youth were: (a) hard to remember when to take the asthma medication (54%) and (b) hard to use asthma medication at school (34%)."
Of the total 573 APFS dispensed, 1 malfunctioned and 1 was considered nonfunctional because it was not returned. The study authors also reported that patient-use error only led to 2 unsuccessful at-home administrations.
The study aimed to determine the association between ICS therapy adherence and the occurrence of asthma exacerbations in patients with high blood eosinophil levels.
The positive association between type 2 biomarkers and severe exacerbations in severe refractory asthma may not extend to mild to moderate asthma.
PHQ-9 and PHQ-2 show factorial validity, invariance, and reliability for measuring depression in patients with chronic obstructive pulmonary disease.
Children living in neighborhoods with low walkability are at increased risk of asthma.
Emerging guidelines for diagnosing and treating asthma COPD overlap syndrome will help clinicians better manage patients and prevent serious adverse effects.
Palliative care consultation was linked to a reduction in hospital costs for hospitalized adults with serious illness, such as COPD.
Physician asthma care education Plus training resulted in improvements in provider confidence, perceived skill in communicating cross culturally, and short-term asthma-specific outcomes.
An asthma care program improved implementation of guidelines as well as provider documentation in 65 community centers in 4 states that serve patients with asthma.
Survival at 6 months was significantly associated with acute respiratory failure and history of COPD.
Patients with severe asthma who were current smokers were distinguishable from ex-smokers based on their sputum proteomic level of colony stimulating factor 2.
A higher proportion of patients with COPD and a blood eosinophil count of ≥0.34×109/L had elevated markers of low-grade systemic inflammation regardless of forced expiratory volume in 1 second.
Children with status asthmaticus who received magnesium sulfate therapy were on continuous albuterol for a longer duration.
Readmission rates were highest during the first 72 hours after admission for an acute exacerbation of chronic obstructive pulmonary disease.
Adding olodaterol to tiotropium did not significantly reduce exacerbations in patients with chronic obstructive pulmonary disease as much as researchers had anticipated.
Asthma and COPD overlap linked to higher prevalence of sleep-related symptoms, including difficulty falling asleep and maintaining sleep, early-morning awakening, and excessive daytime sleepiness.
The drug consists of fluticasone furoate, an inhaled corticosteroid (ICS), umeclidinium, a long-acting muscarinic antagonist, and vilanterol, a long-acting beta2-adrenergic agonist (LABA), delivered via an Ellipta dry powder inhaler.
Early child care attendance increased the risk for wheeze in children ≤2 years of age but decreased the risk for asthma in children 3 to 5 years of age.
In patients with COPD, transcatheter aortic valve replacement was associated with fewer respiratory-related complications than surgical aortic valve replacement.
Statins have anti-inflammatory and anti-oxidative effects, which could reduce exacerbations of both asthma and chronic obstructive pulmonary disease.
Triple therapy with fluticasone furoate, umeclidinium, and vilanterol was associated with a lower rate of exacerbations in chronic obstructive pulmonary disease.
A childhood measles infection may increase the risk for post-bronchodilator airflow obstruction in middle-age adults via its interaction with asthma and smoking.
A 55-year-old man with chronic obstructive pulmonary disease reports having some mild chest pain.
Preterm-born children had significantly more frequent preschool wheeze compared with children born at term.
No significant benefit of long-acting muscarinic antagonists over long-acting beta-agonists in reducing exacerbation risk in uncontrolled, persistent asthma
Adjunct long-acting muscarinic antagonist (LAMA) use with corticosteroids was associated with reduced exacerbation risk compared with placebo in patients with uncontrolled, persistent asthma. However, LAMA, long-acting beta-agonist (LABA), and inhaled corticosteroids (triple therapy) were not associated with lower risk for exacerbations compared with LABA and inhaled corticosteroids alone.