Researchers identified 6 distinct FEV1 lung function trajectories, 3 of which were responsible for 75% of the COPD burden.
Proteostasis Therapeutics is developing the combination treatment which includes a novel transmembrane conductance regulator (CFTR) amplifier (PTI-428), a third generation corrector (PTI-801) and a potentiator (PTI-808).
Findings for subsequent allergic disease following infant exposure in the first six months of life.
Lonhala Magnair is available as a 25mcg strength inhalation solution per 1mL vial.
Peak flow meter, microspirometry are optimal, with full spirometry for positive results.
Sleep quality in patients with chronic obstructive pulmonary disease may be a significant predictor of multiple metrics of quality of life.
Study authors concluded, "Combining tiotropium and olodaterol did not reduce exacerbation rate as much as expected compared with tiotropium alone."
Disease management added to recommended care in chronic obstructive pulmonary disease was not superior to recommended care alone.
Four different doses of glycopyrronium delivered via metered dose inhaler were compared for safety and efficacy in the treatment of chronic obstructive pulmonary disease.
Patients with asthma or chronic obstructive pulmonary disease have especially high rates of nonadherence, even in comparison with other chronic diseases.
In children with allergic asthma, SCIT may reduce long-term asthma medication use.
The Smartinhaler sensor is a device installed onto a patient's inhaler to monitor and promote asthma and COPD medication adherence.
Long-acting muscarinic antagonists or long-acting β-agonists plus inhaled corticosteroids lowered the risk for asthma exacerbations vs adjuvant placebo.
Prenatal and early life stress, including societal stress, have been implicated in the development of asthma and other allergic diseases in children.
In children aged 5 to 11 years with mild to moderate persistent asthma who were treated with daily inhaled glucocorticoids, quintupling the dose during the initial signs of worsening asthma control did not reduce the rate of severe exacerbations.
The Clinical COPD Questionnaire cutoff point of 1.4 demonstrated a better agreement with other COPD measures in patients with more symptomatic disease.
Patients with chronic obstructive pulmonary disease with 5% emphysema based on thoracic computed tomography (CT) imaging may be at a greater risk for poor outcomes.
Current tobacco smoke exposure is not associated with airflow obstruction in school-aged children, but prenatal smoking is associated with airflow obstruction in children with asthma.
Bronchial thermoplasty can treat severe asthmatic cough that is unresponsive to conventional therapies.
Patients with cystic fibrosis who took azithromycin had a significantly lower risk for detection of new nontuberculous mycobacteria, methicillin-resistant Staphylococcus aureus, and Burkholderia cepacia complex.
Combination treatment with indacaterol-glycopyrronium may improve cardiac function in patients with chronic obstructive pulmonary disease.
Intermittent use of high-dose glucocorticoids did not increase the risk for fracture in patients with COPD.
Independent predictive factors of lung cancer in chronic obstructive pulmonary disease may include frequency of exacerbations, in addition to airflow obstruction and visual emphysema.
Smokers and nonsmokers had similar symptoms and risk factors present for asthma, but differed in comorbidities.
Researchers used data from the Atherosclerosis Risk in Communities Study to assess associations between dietary pattern and pulmonary assessments.
Long-term continuous cyclic azithromycin therapy for severe chronic obstructive pulmonary disease was associated with reductions in exacerbations and hospitalizations.
According to a systematic literature review, there was inconclusive evidence that single indoor allergen interventions were effective at improving asthma outcomes.
Short-acting beta-agonists for asthma management may reduce fertility rates in women with asthma.
When patients visiting an allergy/immunology outpatient clinic had expectations met regarding diagnosis and testing, they were more likely to be satisfied with their visit.
Spirometry may be underused for the diagnosis and monitoring of asthma in the primary care setting.
Fractional exhaled nitric oxide, periostin, and eosinophils may help identify patients at increased risk for severe asthma exacerbations, according to a post hoc analysis of a phase 2b trial on dupilumab.
Children diagnosed with eczema before the age of 2 years may be at increased risk for early-onset asthma.
Sputum cultures could aid clinicians in choosing an appropriate antibiotic for patients with cystic fibrosis and avoiding allergies and antibiotic resistance.
Children with asthma who experience chronic oral glucocorticoid exposure may have significant morbidities, including adrenal suppression, recurrent pneumonia, and behavioral problems.
Patients with opioid dependence or abuse may exhibit a higher prevalence of asthma compared with the general population.
Tiotropium, when added to standard asthma maintenance therapy, improves lung function in adult patients with symptomatic asthma regardless of GINA asthma severity.
Researchers examined real-world characteristics of patients receiving albuterol multidose dry powder inhaler or short-acting β2 agonists with short-acting β2 agonists for asthma and chronic obstructive pulmonary disease.
Episodically treating children with recurrent wheezing with inhaled combined salmeterol/fluticasone propionate may be as effective as a daily inhaled fluticasone propionate regimen.
Mepolizumab may be effective in patients with asthma that does not respond to omalizumab.
Researchers investigated whether intravenous reslizumab, a humanized anti-interleukin-5 monoclonal antibody, could aid in the management of asthma and eosinophilia.
Researchers assessed pooled randomized clinical trial data (NAVIGATE I and II; N5641) to examine the change in SF-36v2 and SF-6D from baseline to the end of double blind and to the end of the studies.
Researchers assessed whether the administration of dupilumab improves signs and symptoms of atopic dermatitis in patients with or without comorbid asthma.
A meta-analysis sought to determine whether prebiotics and probiotics improved the immunogenicity of the flu vaccine in adults.
Children who had both parental and sibling asthma in their families had an increased risk for asthma.
Reslizumab reduced the risk for exacerbations and improved lung function in patients with severe eosinophilic asthma.
Children who had both parental and sibling asthma in their families had an increased risk for asthma.
Children with mild to moderate persistent asthma were not more effectively treated with a quintupled dose of inhaled glucocorticoids.
Children who are exposed to antibiotics earlier in life may have an increased risk for allergic diseases, including asthma, atopic dermatitis, and allergic rhinitis.
Tezepelumab improved asthma control in patients with severe or uncontrolled asthma.
A post-hoc pooled analysis of phase 3 SIROCCO and CALIMA trials demonstrated benralizumab to be effective in the treatment of individuals with severe, uncontrolled eosinophilic asthma and nasal polyps.
Researchers assessed the use of dupilumab in adults with chronic rhinosinusitis and nasal polyps who did not respond to treatment with intranasal corticosteroids.
Intranasal corticosteroids are the current guideline-preferred treatment recommendation for nasal congestion.
Data from the Isle of Wight birth cohort study and the Kuwait University Allergy cross-sectional study were used to assess self-reported acetaminophen use and asthma diagnosis.
A cohort from the CANDLE study was assessed to determine if race plays a role in the protective effect of maternal vitamin D levels on childhood asthma.
Rural areas have a significantly higher prevalence of chronic obstructive pulmonary disease.
Researchers performed a literature review and summarized the evidence regarding adverse events associated with the use of inhaled corticosteroids in individuals with asthma.
In an attempt to determine if the presence of S aureus could be used as a marker for more severe disease, investigators assessed the relationship between S aureus-positive bronchiectasis infection and pulmonary function, frequency of exacerbations, and hospital admissions.
The TRIBUTE study was the first long-term trial that specifically compared the effects of the extrafine inhaled corticosteroid-containing triple therapy regimen of beclomethasone dipropionate, formoterol fumarate, and glycopyrronium with the dual bronchodilator combination of indacaterol plus glycopyrronium for COPD.
Patients with COPD and heightened cardiovascular risk received respiratory benefits from long-acting beta-agonist therapy without increasing their cardiovascular risk, regardless of beta-blocker therapy.
A first look at what will be presented at the 2018 Joint Congress of the American Academy of Allergy, Asthma & Immunology and the World Allergy Organization.
The dietary inflammatory index was used to examine the risk for current wheeze with a proinflammatory diet in adults and children.
Researchers evaluated whether duration of breastfeeding was associated with a modified risk for asthma development in children.
Although adherence to asthma guidelines tended to be higher in specialists, both specialists and primary care physicians had low adherence to specific core recommendations.
While there is currently no cure for asthma, treatments are effective at providing symptom relief.
Patients with chronic obstructive pulmonary disease had a modest increased risk for hip and upper extremity fractures when taking long-term, high-dose inhaled corticosteroids.
Lung transplantation can improve survival in patients with chronic obstructive pulmonary disease, but several variables can affect the surgery's success.
A new cystic fibrosis transmembrane conductance regulator modulator treatment has been approved by the FDA for use in patients aged 12 years and older.
Maternal prenatal and early childhood intake of sugar-sweetened beverages and fructose is associated with current asthma in midchildhood.
CFTR modulator therapy recommended in certain patients with cystic fibrosis.
Researchers conducted an anonymous survey of medical trainees with a case vignette to determine attitudes regarding palliative care for chronic obstructive pulmonary disease.
Researchers compared the clinical cure and adverse effect rates of multiple antibiotics in the treatment of acute exacerbations in chronic obstructive pulmonary disease.
High levels of C-reactive protein and neutrophils as well as low eosinophil count predicted a poor prognosis in COPD.
Respiratory symptoms that develop between the ages of 18 and 30 may hold prognostic value for later decline in lung function.
Researchers examined variation in airway branches to determine whether they have an effect on the course of chronic obstructive pulmonary disease.
Patients with COPD experienced a weighted mean increase in exercise endurance time following treatment with long-acting bronchodilators.
Children who received oral prednisolone vs placebo for virus-associated wheeze had a shorter length of hospital stay.
Prednisolone may be a more effective treatment in individuals with acute allergic bronchopulmonary aspergillosis complicated asthma, but with more adverse effects compared with itraconazole.
Researchers found that tiotropium was safe and may reduce the risk for exacerbations in young children with asthma.
Lung function may not differ between individuals who take beta-blockers vs those who do not for moderate to severe chronic obstructive pulmonary disease.
COPD exacerbation risk and treatment response may be predicted using blood eosinophil counts.
A 55-year-old man with asthma presents to the emergency department with dyspnea at rest and electrocardiogram findings suggest a prior myocardial infarction.
Procalcitonin may decrease mortality rates in patients with acute respiratory infections, including pneumonia.
Although the 2017 GOLD classification did not better predict mortality in patients with chronic obstructive pulmonary disease overall, it did so when patients were extensively categorized by severity.
No data have demonstrated improved mortality, morbidity, or quality of life as a result of screening for COPD in asymptomatic individuals.
Timing of birth may increase risk for asthma or atopic dermatitis.
Children with allergic asthma do not significantly benefit from subcutaneous or sublingual immunotherapy.
A school-based telemedicine program with directly observed preventive therapy, when compared to enhanced usual care, led to more symptom-free days and fewer emergency department visits or hospitalizations.
Researchers found various risk factors for postoperative pulmonary complications in patients with either asthma or COPD.
Male sex, African American race, and duration of asthma were independently associated with fixed airflow obstruction in older adults with asthma.
Analyzing volatile organic compounds in pediatric patients with asthma shows promise for disease diagnosis and management.
Patients with stable hypercapnic COPD reported improved health-related quality of life after 6 weeks of at-home high-flow nasal cannula oxygen therapy.
Researchers found that acid-suppressive drug use in pregnancy was associated with an increased risk for asthma in childhood.
Women with rheumatoid arthritis had an increased risk for chronic obstructive pulmonary disease, but did not have an increased risk for asthma compared with women without RA.
Children in the School-Based Telemedicine Enhanced Asthma Management program had more symptom-free days than children in the usual care group.
Systemic lupus erythematosus during pregnancy is associated with an increased risk for asthma in offspring.
Women who were exposed prenatally to polychlorinated biphenyls may have an increased risk of having children with asthma, hay fever, or eczema.
Fractional exhaled nitric oxide measurement can diagnose asthma in patients 5 years and older.
Asthma exacerbations may be reduced in patients with eosinophilic asthma treated with benralizumab.
Carvedilol may increase the risk for hospitalization in patients with concurrent heart failure and COPD compared with metoprolol/bisoprolol/nebivolol.
A middle-aged man diagnosed with COPD presents with shortness of breath at rest with no improvement with nebulizer treatments.